Circuits underlying social function and dysfunction DOI Open Access
Ziwen Wang,

Hannah Yueh,

Mirabella Chau

et al.

Autism Research, Journal Year: 2023, Volume and Issue: 16(7), P. 1268 - 1288

Published: July 1, 2023

Abstract Substantial advances have been made toward understanding the genetic and environmental risk factors for autism, a neurodevelopmental disorder with social impairment as core feature. In combination optogenetic chemogenetic tools to manipulate neural circuits in vivo, it is now possible use model systems test how specific underlie function dysfunction. Here, we review literature that has identified associated interest (sociability), reward, memory, dominance, aggression, outline preliminary roadmap of driving these behaviors. We highlight circuitry underlying each behavioral domain, well develop an interactive map overlap across domains. find some behavior are general involved control multiple aspects, whereas other appear be specialized aspects behavior. Our overlapping circuit therefore helps delineate various domains identify gaps knowledge.

Language: Английский

Neural mechanism underlying depressive-like state associated with social status loss DOI Creative Commons
Zhengxiao Fan, Jiarui Chang, Yilan Liang

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(3), P. 560 - 576.e17

Published: Jan. 23, 2023

Language: Английский

Citations

76
The cognitive impact of light: illuminating ipRGC circuit mechanisms DOI
Heather Mahoney, Tiffany M. Schmidt

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 159 - 175

Published: Jan. 26, 2024

Language: Английский

Citations

22
Behavioural and physiological plasticity in social hierarchies DOI Open Access

Tyler M. Milewski,

W. Lee,

Frances A. Champagne

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 377(1845)

Published: Jan. 10, 2022

Individuals occupying dominant and subordinate positions in social hierarchies exhibit divergent behaviours, physiology neural functioning. Dominant animals express higher levels of dominance behaviours such as aggression, territorial defence mate-guarding. Dominants also signal their status via auditory, visual or chemical cues. Moreover, typically increase reproductive show enhanced spatial cognition well elevated arousal. These biobehavioural changes energetic demands that are met shifting both energy intake metabolism supported by coordinated physiological systems including the hypothalamic–pituitary–adrenal hypothalamic–pituitary–gonadal axes altered gene expression sensitivity circuits regulate these behaviours. Conversely, inhibit often adapted to socially stressful contexts. Phenotypic individuals may be beneficial short-term but lead long-term challenges health. Further, rapid ranks occur ascend descend associated with dynamic modulations brain periphery. In this paper, we provide a broad overview how behavioural phenotypic subordination expressed plasticity. This article is part theme issue ‘The centennial pecking order: current state future prospects for study hierarchies’.

Language: Английский

Citations

57
The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies DOI Creative Commons
Eli D. Strauss, James P. Curley, Daizaburo Shizuka

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 377(1845)

Published: Jan. 10, 2022

A century ago, foundational work by Thorleif Schjelderup-Ebbe described a ‘pecking order’ in chicken societies, where individuals could be ordered according to their ability exert influence over group-mates. Now known as dominance hierarchies, these structures have been shown plethora of individual characteristics and outcomes, situating research pillar the study modern social ecology evolution. Here, we first review some major questions that answered about hierarchies last 100 years. Next, introduce contributions this theme issue summarize how they provide ongoing insight epistemology, physiology neurobiology, hierarchical structure, dynamics dominance. These employ full range approaches available biologists. Cross-cutting themes emerging from include focus on cognitive underpinnings dominance, application network-analytical approaches, utility experimental rank manipulations for revealing causal relationships. Reflection years reveals Schjelderup-Ebbe's early ideas subsequent helped drive shift an essentialist view species recognition rich inter-individual variation social, behavioural physiological phenotypes. This article is part ‘The centennial pecking order: current state future prospects hierarchies’.

Language: Английский

Citations

39
Dynamic influences on the neural encoding of social valence DOI
Nancy Padilla-Coreano, Kay M. Tye, Moriel Zelikowsky

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(9), P. 535 - 550

Published: July 12, 2022

Language: Английский

Citations

38
The dynamics of dominance: open questions, challenges and solutions DOI Creative Commons
Eli D. Strauss, Daizaburo Shizuka

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 377(1845)

Published: Jan. 10, 2022

Although social hierarchies are recognized as dynamic systems, they typically treated static entities for practical reasons. Here, we ask what can learn from a dynamical view of dominance, and provide research agenda the next decades. We identify five broad questions at individual, dyadic group levels, exploring causes consequences individual changes in rank, dynamics underlying dominance relationships, origins impacts instability. challenges remain, propose avenues overcoming them. suggest distinguishing between different types mobility to conceptual clarity about hierarchy level, emphasize need explore how these processes produce trajectories over lifespans impact selection on status-seeking behaviour. At there is scope deeper exploration decision-making leading observed interactions, stable but malleable relationships emerge interactions. Across scales, model systems where rank manipulable will be extremely useful testing hypotheses dynamics. Long-term individual-based studies also critical understanding rare events, interrogating that unfold lifetimes generations. This article part theme issue 'The centennial pecking order: current state future prospects study hierarchies'.

Language: Английский

Citations

32
Sex-dependent control of pheromones on social organization within groups of wild house mice DOI Creative Commons
Noga Zilkha,

Silvia Chuartzman,

Yizhak Sofer

et al.

Current Biology, Journal Year: 2023, Volume and Issue: 33(8), P. 1407 - 1420.e4

Published: March 13, 2023

Dominance hierarchy is a fundamental social phenomenon in wide range of mammalian species, critically affecting fitness and health. Here, we investigate the role pheromone signals control hierarchies individual personalities within groups wild mice. For this purpose, combine high-throughput behavioral phenotyping with computational tools freely interacting house mice, males females, an automated, semi-natural system. We show that mice form dominance both sexes but use sex-specific strategies, displaying distinct male-typical female-typical were also associated ranking. Genetic disabling VNO-mediated detection generated opposite effects groups, enhancing interactions reducing them females. Behavioral mutated displayed mixtures behaviors, thus blurring sex differences. In addition, rank-associated abolished despite fact mutant formed stable hierarchies. These findings suggest group organization governed by pheromone-mediated neural circuits pave way to mechanisms underlying sexual dimorphism under naturalistic settings.

Language: Английский

Citations

19
Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning DOI Creative Commons
Joeri Bordes, Lucas Miranda, Bertram Müller‐Myhsok

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 151, P. 105243 - 105243

Published: May 22, 2023

Social behavior is naturally occurring in vertebrate species, which holds a strong evolutionary component and crucial for the normal development survival of individuals throughout life. Behavioral neuroscience has seen different influential methods social behavioral phenotyping. The ethological research approach extensively investigated natural habitats, while comparative psychology was developed utilizing standardized univariate tests. advanced precise tracking tools, together with post-tracking analysis packages, recently enabled novel phenotyping method, that includes strengths both approaches. implementation such will be beneficial fundamental but also enable an increased understanding influences many factors can influence behavior, as stress exposure. Furthermore, future increase number data modalities, sensory, physiological, neuronal activity data, thereby significantly enhance our biological basis guide intervention strategies abnormalities psychiatric disorders.

Language: Английский

Citations

18
A systematic review and meta-analysis of how social memory is studied DOI Creative Commons
Meghan Cum, Jocelyn Pérez,

Erika Wangia

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 26, 2024

Abstract Social recognition is crucial for survival in social species, and necessary group living, selective reproduction, pair bonding, dominance hierarchies. Mice rats are the most commonly used animal models memory research, however current paradigms do not account complex dynamics they exhibit wild. To assess range of memories being studied, we conducted a systematic analysis neuroscience articles testing mice published within past two decades analyzed their methods. Our results show that despite these rodent’s rich capabilities, majority papers explore short-term familiarity levels with minimal exposure between subject familiar stimuli—a narrow type memory. We have identified several key areas currently understudied or underrepresented: kin relationships, mates, ranks, sex variabilities, effects aging. Additionally, reporting on stimulus variables such as housing history, strain, age, limited, which may impede reproducibility. Overall, our data highlight large gaps diversity studied mechanisms.

Language: Английский

Citations

8
Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function DOI Creative Commons
Sriparna Ghosal, Elias Gebara, Eva Ramos‐Fernández

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(7), P. 112776 - 112776

Published: July 1, 2023

The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with competitiveness, and mitochondrial fusion protein mitofusin 2 (Mfn2) neurons regulates anxiety-related behaviors. However, it remains unexplored whether accumbal Mfn2 levels also affect behavior actions emotional domain are driven by distinct cell types. Here, we found that subordinate-prone highly anxious rats show decreased overexpression promotes dominant behavior. In mice, selective downregulation dopamine D2 receptor-expressing medium spiny (D2-MSNs) induced subordination, accompanied functions excitability D2-MSNs. Instead, D1-MSN-targeted affected competitive ability only transiently likely because of an increase anxiety-like Our results assign dissociable cell-type specific roles to modulating dominance anxiety.

Language: Английский

Citations

15