Emergence of community behaviors in the gut microbiota upon drug treatment DOI Creative Commons
Sarela García‐Santamarina, Michael Kuhn, Saravanan Devendran

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 14, 2023

Summary Pharmaceuticals can directly inhibit the growth of gut bacteria, but degree such interactions manifest in complex community settings is an open question. Here we compared effects 30 drugs on a 32-species synthetic with their each member isolation. While most individual drug–species remained same context, communal behaviors emerged 26% all tested cases. Cross-protection, during which drug-sensitive species became protected community, was 6-times more frequent than cross-sensitization, converse phenomenon. Cross-protection decreased and cross-sensitization increased at higher drug concentrations, suggesting that resilience microbial communities collapse when perturbations get stronger. By metabolically profiling drug-treated communities, showed both biotransformation bioaccumulation contribute mechanistically to protection. As proof-of-principle, molecularly dissected prominent case: expressing specific nitroreductases degraded niclosamide, thereby protecting themselves sensitive members.

Language: Английский

Emergence of community behaviors in the gut microbiota upon drug treatment DOI Creative Commons
Sarela García‐Santamarina, Michael Kuhn, Saravanan Devendran

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(22), P. 6346 - 6357.e20

Published: Sept. 24, 2024

Pharmaceuticals can directly inhibit the growth of gut bacteria, but degree to which such interactions manifest in complex community settings is an open question. Here, we compared effects 30 drugs on a 32-species synthetic with their each member isolation. While most individual drug-species remained same context, communal behaviors emerged 26% all tested cases. Cross-protection during drug-sensitive species were protected was 6 times more frequent than cross-sensitization, converse phenomenon. decreased and cross-sensitization increased at higher drug concentrations, suggesting that resilience microbial communities collapse when perturbations get stronger. By metabolically profiling drug-treated communities, showed both biotransformation bioaccumulation contribute mechanistically protection. As proof principle, molecularly dissected prominent case: expressing specific nitroreductases degraded niclosamide, thereby protecting themselves sensitive members.

Language: Английский

Citations

4
Emergence of community behaviors in the gut microbiota upon drug treatment DOI Creative Commons
Sarela García‐Santamarina, Michael Kuhn, Saravanan Devendran

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 14, 2023

Summary Pharmaceuticals can directly inhibit the growth of gut bacteria, but degree such interactions manifest in complex community settings is an open question. Here we compared effects 30 drugs on a 32-species synthetic with their each member isolation. While most individual drug–species remained same context, communal behaviors emerged 26% all tested cases. Cross-protection, during which drug-sensitive species became protected community, was 6-times more frequent than cross-sensitization, converse phenomenon. Cross-protection decreased and cross-sensitization increased at higher drug concentrations, suggesting that resilience microbial communities collapse when perturbations get stronger. By metabolically profiling drug-treated communities, showed both biotransformation bioaccumulation contribute mechanistically to protection. As proof-of-principle, molecularly dissected prominent case: expressing specific nitroreductases degraded niclosamide, thereby protecting themselves sensitive members.

Language: Английский

Citations

10