The Development and Validation of the Food Memory Bias Test for a Large-Scale Epidemiological Study in a Multiethnic Asian Population DOI
Irving Yu Le Shua,

Rahmania Putri Dewinta,

Vedhavaishnavi Sugumaran

et al.

Published: Jan. 1, 2024

Language: Английский

Life stage impact on the human skin ecosystem: lipids and the microbial community DOI Creative Commons
Martin Pagac, Bala Davient,

Luca Antonio Plado

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 13, 2025

Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between oxylipins and on the superficial of pre-pubescent children (N = 36) adults 100), including pre- 25) post-menopausal females 25). Lipidomics metagenomics revealed that Malassezia restricta positively correlated with oxylipin 9,10-DiHOME adult negatively its precursor, 9,10-EpOME, skin. Co-culturing keratinocytes demonstrated a link pro-inflammatory cytokines IL-1β IL-6 production. We also observed strong other microbial taxa, highlighting life stage differences in sebum production community composition. Our findings imply complex host-microbe communication system mediated metabolism occurring human skin, warranting further research role health disease paving way towards novel therapeutic targets treatments.

Language: Английский

Citations

1
Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations DOI Creative Commons
Pritesh Jain,

Hong Kiat Ng,

Darwin Tay

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

To identify biomarkers and pathways to Type-2 diabetes (T2D), a major global disease, we completed array-based epigenome-wide association in whole blood 5,709 Asian people. We found 323 Sentinel CpGs (from 314 genetic loci) that predict future T2D. The reveal coherent, nuclear regulatory disturbances canonical immune activation pathways, as well metabolic networks involved insulin signalling, fatty acid metabolism lipid transport, which are causally linked development of have potential clinical utility biomarkers. An composite Methylation Risk Score (MRS) is predictive for T2D (RR: 5.2 Q4 vs Q1; P=7x10 -25 ), additive risk. Targeted methylation sequencing revealed multiple additional predicting T2D, synthesis sequencing-based MRS strongly 8.3 P=1.0x10 -11 ). Importantly, varies between ethnic groups, way explains large fraction the difference risk populations. thus provide new insights into precede sequence-based DNA markers inform stratification prevention.

Language: Английский

Citations

0
National Scale Genomic Engine for Precision Medicine: Singapore PRECISE-SG100K Experience DOI Creative Commons
Claire Bellis,

Gabriel Kolle,

Jacklyn Yong

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract Precision medicine (PM) research in recent years has witnessed a remarkable surge large-scale population genomics programs. In 2017, Singapore initiated the National Medicine (NPM) program, three-phase national strategy driving PM research, innovation, and enterprise capitalizing on Singapore’s unique multi-ancestral Asian population. Coordinated by Health Research, (PRECISE), NPM Phase I assembled an reference genome of 10,000 individuals completed using highly manual laborious laboratory sample workflows. II, targeting 100,000 cohort (PRECISE-SG100K), required transformation sequencing workflow to production-scale operation leveraging high-throughput automation robotics. Here we share detailed technical blueprints for implementing maintaining PRECISE-SG100K Genomic Engine , learning from overcoming I’s pain-points bottlenecks. The allowed successful scale up genomic throughput, enabling anticipated completion whole genomes three years.

Language: Английский

Citations

0
Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore DOI
Theresia Mina, Wubin Xie, Dorrain Yanwen Low

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2024, Volume and Issue: 12(10), P. 704 - 715

Published: Aug. 29, 2024

Language: Английский

Citations

3
The Development and Validation of the Food Memory Bias Test for a Large-Scale Epidemiological Study in a Multiethnic Asian Population DOI
Irving Yu Le Shua,

Rahmania Putri Dewinta,

Vedhavaishnavi Sugumaran

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0