Tissue Engineering Part B Reviews,
Journal Year:
2014,
Volume and Issue:
20(6), P. 683 - 696
Published: June 13, 2014
Type
I
collagen
hydrogels
have
been
used
successfully
as
three-dimensional
substrates
for
cell
culture
and
shown
promise
scaffolds
engineered
tissues
tumors.
A
critical
step
in
the
development
of
viable
tissue
mimics
is
quantitative
characterization
hydrogel
properties
their
correlation
with
fabrication
parameters,
which
enables
to
be
tuned
match
specific
or
fulfill
engineering
requirements.
significant
body
work
has
devoted
hydrogels;
however,
due
breadth
materials
techniques
characterization,
published
data
are
often
disjoint
hence
utility
community
reduced.
This
review
aims
determine
parameter
space
covered
by
existing
identify
key
gaps
literature
so
that
future
use
research
can
most
efficiently
conducted.
divided
into
three
sections:
(1)
relevant
parameters
introduced
several
popular
methods
controlling
regulating
them
described,
(2)
presented
discussed
along
techniques,
(3)
state
recapitulated
directions
proposed.
Ultimately,
this
serve
a
resource
selection
material
methodologies
order
increase
usefulness
collagen-hydrogel-based
studies
experiments.
Biochimica et Biophysica Acta (BBA) - General Subjects,
Journal Year:
2014,
Volume and Issue:
1840(8), P. 2506 - 2519
Published: Jan. 11, 2014
Extracellular
matrix
(ECM)
is
a
dynamic
and
complex
environment
characterized
by
biophysical,
mechanical
biochemical
properties
specific
for
each
tissue
able
to
regulate
cell
behavior.
Stem
cells
have
key
role
in
the
maintenance
regeneration
of
tissues
they
are
located
microenvironment,
defined
as
niche.We
overview
progresses
that
been
made
elucidating
stem
niches
discuss
mechanisms
which
ECM
affects
We
also
summarize
current
tools
experimental
models
studying
ECM-stem
interactions.ECM
represents
an
essential
player
niche,
since
it
can
directly
or
indirectly
modulate
maintenance,
proliferation,
self-renewal
differentiation
cells.
Several
molecules
play
regulatory
functions
different
types
cells,
based
on
its
molecular
composition
be
deposited
finely
tuned
providing
most
appropriate
niche
various
tissues.
Engineered
biomaterials
mimic
vivo
characteristics
provide
suitable
vitro
dissecting
roles
exerted
components
behavior.ECM
component
involved
aspects
behavior,
thus
having
major
impact
homeostasis
under
physiological
pathological
conditions.
This
article
part
Special
Issue
entitled
Matrix-mediated
behaviour
properties.
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2011,
Volume and Issue:
4(1), P. a004903 - a004903
Published: Sept. 21, 2011
Richard
O.
Hynes
and
Alexandra
Naba
Howard
Hughes
Medical
Institute,
Koch
Institute
for
Integrative
Cancer
Research,
Massachusetts
of
Technology,
Cambridge,
02139
Correspondence:
rohynes{at}mit.edu
Science,
Journal Year:
2013,
Volume and Issue:
339(6117), P. 286 - 291
Published: Jan. 17, 2013
There
have
been
substantial
advances
in
cancer
diagnostics
and
therapies
the
past
decade.
Besides
chemotherapeutic
agents
radiation
therapy,
approaches
now
include
targeting
cell-intrinsic
mediators
linked
to
genetic
aberrations
cells,
addition
cell-extrinsic
pathways,
especially
those
regulating
vascular
programming
of
solid
tumors.
More
recently,
immunotherapeutics
entered
clinic
largely
on
basis
recognition
that
several
immune
cell
subsets,
when
chronically
activated,
foster
tumor
development.
Here,
we
discuss
clinical
experimental
studies
delineating
protumorigenic
roles
for
subsets
are
players
cancer-associated
inflammation.
Some
these
cells
can
be
targeted
reprogram
their
function,
leading
resolution,
or
at
least
neutralization,
cancer-promoting
chronic
inflammation,
thereby
facilitating
rejection.
International Journal of Molecular Sciences,
Journal Year:
2018,
Volume and Issue:
19(10), P. 3028 - 3028
Published: Oct. 4, 2018
The
immense
diversity
of
extracellular
matrix
(ECM)
proteins
confers
distinct
biochemical
and
biophysical
properties
that
influence
cell
phenotype.
ECM
is
highly
dynamic
as
it
constantly
deposited,
remodelled,
degraded
during
development
until
maturity
to
maintain
tissue
homeostasis.
ECM’s
composition
organization
are
spatiotemporally
regulated
control
behaviour
differentiation,
but
dysregulation
dynamics
leads
the
diseases
such
cancer.
chemical
cues
presented
by
have
been
appreciated
key
drivers
for
both
cancer
progression.
However,
mechanical
forces
present
due
largely
ignored
recently
recognized
play
critical
roles
in
disease
progression
malignant
behaviour.
Here,
we
review
ways
which
microenvironment
regulation
phenotype
stages
human
Integrative Biology,
Journal Year:
2015,
Volume and Issue:
7(10), P. 1120 - 1134
Published: May 1, 2015
Journal
Article
Human
breast
cancer
invasion
and
aggression
correlates
with
ECM
stiffening
immune
cell
infiltration
Get
access
I.
Acerbi,
Acerbi
Center
for
Bioengineering,
Tissue
Regeneration,
Department
of
Surgery,
UCSF,
San
Francisco,
CA,
USA.
Fax:
+1-415-476-3985;
Tel:
+1-415-476-3826
Search
other
works
by
this
author
on:
Oxford
Academic
Google
Scholar
L.
Cassereau,
Cassereau
Dean,
Dean
Q.
Shi,
Shi
Bay
Area
Physical
Sciences
Oncology
Center,
USADepartment
Stanford
University,
Palo
Alto,
USA
A.
Au,
Au
Pathology,
C.
Park,
Park
Radiation
Oncology,
Y.
Chen,
Chen
J.
Liphardt,
Liphardt
E.
S.
Hwang,
Hwang
Duke
University
Comprehensive
Cancer
Durham,
North
Carolina,
V.
M.
Weaver
+1-415-476-3826Bay
USADepartments
Anatomy
Bioengineering
Therapeutic
Sciences,
Eli
Edythe
Broad
Regeneration
Medicine
Stem
Cell
Research,
UCSF
Helen
Diller
California,
E-mail:
[email protected]
Integrative
Biology,
Volume
7,
Issue
10,
October
2015,
Pages
1120–1134,
https://doi.org/10.1039/c5ib00040h
Published:
11
May
2015
history
Received:
07
February
Accepted:
01
Cold Spring Harbor Perspectives in Medicine,
Journal Year:
2015,
Volume and Issue:
5(4), P. a006098 - a006098
Published: April 1, 2015
Richard
Sever1
and
Joan
S.
Brugge2
1Cold
Spring
Harbor
Laboratory,
Cold
Harbor,
New
York
11724
2Harvard
Medical
School,
Department
of
Cell
Biology,
Boston,
Massachusetts
02115
Correspondence:
joan_brugge{at}hms.harvard.edu
