Journal of Cell Science,
Journal Year:
2014,
Volume and Issue:
127(4), P. 709 - 717
Published: Feb. 14, 2014
ABSTRACT
The
Hippo-YAP
pathway
mediates
the
control
of
cell
proliferation
by
contact
inhibition
as
well
other
attributes
physical
state
cells
in
tissues.
Several
mechanisms
sense
spatial
and
organization
cells,
function
through
distinct
upstream
modules
to
stimulate
signaling:
adherens
junction
or
cadherin–catenin
complexes,
epithelial
polarity
tight
FAT-Dachsous
morphogen
pathway,
shape,
actomyosin
mechanotransduction.
Soluble
extracellular
factors
also
regulate
Hippo
signaling,
often
inhibiting
its
activity.
Indeed,
a
reciprocal
relationship
between
mitogenic
signaling.
As
result,
at
edges
colony,
wound
tissue
tumor
are
more
sensitive
ambient
levels
growth
likely
proliferate,
migrate
differentiate
YAP
and/or
TAZ-dependent
process.
Thus,
senses
responds
tissues
coordinates
these
cues
with
classic
growth-factor-mediated
signaling
pathways.
This
Commentary
is
focused
on
biological
significance
how
regulatory
interact
produce
outcomes.
Nature Communications,
Journal Year:
2015,
Volume and Issue:
6(1)
Published: Oct. 5, 2015
Abstract
The
Hippo
pathway
plays
a
central
role
in
tissue
homoeostasis,
and
its
dysregulation
contributes
to
tumorigenesis.
Core
components
of
the
include
kinase
cascade
MST1/2
LATS1/2
transcription
co-activators
YAP/TAZ.
In
response
stimulation,
phosphorylate
inhibit
YAP/TAZ,
main
effectors
pathway.
Accumulating
evidence
suggests
that
are
not
required
for
regulation
Here
we
show
deletion
but
abolishes
YAP/TAZ
phosphorylation.
We
have
identified
MAP4K
family
members—Drosophila
Happyhour
homologues
MAP4K1/2/3
Misshapen
MAP4K4/6/7—as
direct
LATS1/2-activating
kinases.
Combined
MAP4Ks
MST1/2,
neither
alone,
suppresses
phosphorylation
wide
range
signals.
Our
results
demonstrate
act
parallel
partially
redundant
with
establish
as
expanded
Frontiers in Cell and Developmental Biology,
Journal Year:
2018,
Volume and Issue:
6
Published: Feb. 7, 2018
The
presence
of
single,
non-motile
'primary'
cilia
on
the
surface
epithelial
cells
has
been
well
described
since
1960s.
However,
for
decades
these
organelles
were
believed
to
be
vestigial,
with
no
remaining
function,
having
lost
their
motility.
It
wasn't
until
2003,
discovery
that
proteins
responsible
transport
along
primary
cilium
are
essential
hedgehog
signaling
in
mice,
fundamental
importance
signal
transduction
was
realised.
Little
more
than
a
decade
later,
it
is
now
clear
vast
majority
pathways
vertebrates
function
through
cilium.
This
led
adoption
term
'the
cells's
antenna'
as
description
Primary
particularly
important
during
development,
playing
roles
embryonic
patterning
and
organogenesis,
suite
inherited
developmental
disorders
known
'ciliopathies'
resulting
from
mutations
genes
encoding
proteins.
review
summarises
our
current
understanding
role
fascinating
wide
range
pathways.
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2017,
Volume and Issue:
10(4), P. a029181 - a029181
Published: June 9, 2017
Cell-cell
junctions
link
cells
to
each
other
in
tissues,
and
regulate
tissue
homeostasis
critical
cell
processes
that
include
barrier
function,
proliferation,
migration.
Defects
cell-cell
give
rise
a
wide
range
of
abnormalities
disrupt
are
common
genetic
cancers.
Here,
we
discuss
the
organization
function
primarily
involved
adhesion
(tight
junction,
adherens
desmosomes)
two
different
epithelial
tissues:
simple
epithelium
(intestine)
stratified
(epidermis).
Studies
these
tissues
reveal
similarities
differences
functions
meet
requirements
for
specialized
tissue.
We
junction
responses
environmental
perturbations
provide
further
insights
into
their
roles
maintaining
homeostasis.
Cell Reports,
Journal Year:
2018,
Volume and Issue:
25(5), P. 1304 - 1317.e5
Published: Oct. 1, 2018
Hippo
signaling
has
been
recognized
as
a
key
tumor
suppressor
pathway.
Here,
we
perform
comprehensive
molecular
characterization
of
19
core
genes
in
9,125
samples
across
33
cancer
types
using
multidimensional
"omic"
data
from
The
Cancer
Genome
Atlas.
We
identify
somatic
drivers
among
and
the
related
microRNA
(miRNA)
regulators,
functional
genomic
approaches,
experimentally
characterize
YAP
TAZ
mutation
effects
miR-590
miR-200a
regulation
for
TAZ.
pathway
activity
is
best
characterized
by
YAP/TAZ
transcriptional
target
signature
22
genes,
which
shows
robust
prognostic
power
types.
Our
elastic-net
integrated
modeling
further
reveals
cancer-type-specific
regulators
associated
drivers.
results
highlight
importance
squamous
cell
cancers,
frequent
amplification
YAP/TAZ,
high
expression
heterogeneity,
significant
patterns.
This
study
represents
systems-biology
approach
to
characterizing
pathways
post-genomic
era.
Cell,
Journal Year:
2013,
Volume and Issue:
154(6), P. 1194 - 1205
Published: Sept. 1, 2013
An
adult
animal
consists
of
cells
vastly
different
size
and
activity,
but
the
regulation
cell
remains
poorly
understood.
Recent
studies
uncovering
some
signaling
pathways
important
for
size/growth
control,
together
with
identification
diseases
resulting
from
aberrations
in
these
pathways,
have
renewed
interest
this
field.
This
Review
will
discuss
our
current
understanding
how
a
sets
its
size,
it
can
adapt
to
changing
environment,
processes
are
relevant
human
disease.
