PubMed,
Journal Year:
2018,
Volume and Issue:
41(2), P. 83 - 92
Published: Feb. 28, 2018
The
biological
significance
and
deregulation
of
the
Hippo
pathway
during
organ
growth
tumorigenesis
have
received
a
surge
interest
in
past
decade.
core
kinases,
MST1/2
LATS1/2,
are
tumor
suppressors
that
inhibit
oncogenic
nuclear
function
YAP/TAZ
TEAD.
In
addition
to
earlier
studies
highlight
role
size
control,
cell
proliferation,
development,
recent
evidence
demonstrates
its
critical
cancer
stem
biology,
including
EMT,
drug
resistance,
self-renewal.
Here
we
provide
brief
overview
regulatory
mechanisms
pathway,
promising
therapeutic
interventions.
Annual Review of Biochemistry,
Journal Year:
2018,
Volume and Issue:
88(1), P. 577 - 604
Published: Dec. 19, 2018
The
Hippo
pathway
was
initially
discovered
in
Drosophila
melanogaster
as
a
key
regulator
of
tissue
growth.
It
is
an
evolutionarily
conserved
signaling
cascade
regulating
numerous
biological
processes,
including
cell
growth
and
fate
decision,
organ
size
control,
regeneration.
core
the
mammals
consists
kinase
cascade,
MST1/2
LATS1/2,
well
downstream
effectors,
transcriptional
coactivators
YAP
TAZ.
These
components
control
programs
involved
proliferation,
survival,
mobility,
stemness,
differentiation.
tightly
regulated
by
both
intrinsic
extrinsic
signals,
such
mechanical
force,
cell-cell
contact,
polarity,
energy
status,
stress,
many
diffusible
hormonal
factors,
majority
which
act
through
G
protein-coupled
receptors.
Here,
we
review
current
understanding
molecular
mechanisms
signals
regulate
with
emphasis
on
mechanotransduction
effects
this
basic
biology
human
diseases.
Molecular Cancer,
Journal Year:
2022,
Volume and Issue:
21(1)
Published: Jan. 12, 2022
Abstract
Metabolic
reprogramming
is
one
of
the
main
characteristics
malignant
tumors,
which
due
to
flexible
changes
cell
metabolism
that
can
meet
needs
growth
and
maintain
homeostasis
tissue
environments.
Cancer
cells
obtain
metabolic
adaptation
through
a
variety
endogenous
exogenous
signaling
pathways,
not
only
promote
cancer
cells,
but
also
start
transformation
process
adapt
tumor
microenvironment.
Studies
show
m6A
RNA
methylation
widely
involved
in
recombination
cells.
In
eukaryotes,
most
abundant
modification
mRNA,
almost
all
cycle
stages,
including
regulation
transcription,
maturation,
translation,
degradation
stability
mRNA.
M6A
be
physiological
pathological
processes,
cancer.
this
review,
we
discuss
role
plays
metabolism-related
molecules
aiming
importance
targeting
regulating
metabolism.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2020,
Volume and Issue:
39(1)
Published: July 6, 2020
Abstract
Liver
cancer
has
become
the
sixth
most
diagnosed
and
fourth
leading
cause
of
death
worldwide.
Hepatocellular
carcinoma
(HCC)
is
responsible
for
up
to
75–85%
primary
liver
cancers,
sorafenib
first
targeted
drug
advanced
HCC
treatment.
However,
resistance
common
because
resultant
enhancement
aerobic
glycolysis
other
molecular
mechanisms.
Aerobic
was
firstly
found
in
HCC,
acts
as
a
hallmark
regulation
proliferation,
immune
evasion,
invasion,
metastasis,
angiogenesis,
HCC.
The
three
rate-limiting
enzymes
glycolytic
pathway,
including
hexokinase
2
(HK2),
phosphofructokinase
1
(PFK1),
pyruvate
kinases
type
M2
(PKM2)
play
an
important
role
can
be
regulated
by
many
mechanisms,
such
AMPK,
PI3K/Akt
HIF-1α,
c-Myc
noncoding
RNAs.
Because
importance
progression
targeting
key
factors
its
pathway
inhibition
HK2,
PFK
or
PKM2,
represent
potential
new
therapeutic
approaches
treatment
Cells,
Journal Year:
2020,
Volume and Issue:
9(10), P. 2308 - 2308
Published: Oct. 16, 2020
Aberrant
metabolism
is
a
major
hallmark
of
cancer.
Abnormal
cancer
metabolism,
such
as
aerobic
glycolysis
and
increased
anabolic
pathways,
has
important
roles
in
tumorigenesis,
metastasis,
drug
resistance,
stem
cells.
Well-known
oncogenic
signaling
phosphoinositide
3-kinase
(PI3K)/AKT,
Myc,
Hippo
pathway,
mediate
metabolic
gene
expression
increase
enzyme
activities.
Vice
versa,
deregulated
pathways
contribute
to
defects
cellular
signal
transduction
which
turn
provide
energy,
building
blocks,
redox
potentials
for
unrestrained
cell
proliferation.
Studies
clinical
trials
are
being
performed
that
focus
on
the
inhibition
enzymes
by
small
molecules
or
dietary
interventions
(e.g.,
fasting,
calorie
restriction,
intermittent
fasting).
Similar
genetic
heterogeneity,
phenotypes
cancers
highly
heterogeneous.
This
heterogeneity
results
from
diverse
cues
tumor
microenvironment
mutations.
Hence,
overcoming
plasticity
an
goal
modern
therapeutics.
review
highlights
recent
findings
elucidates
interactions
between
pathways.
We
also
novel
rationales
designing
next-generation
drugs.
