Advances in oral peptide therapeutics

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 19(4), P. 277 - 289

Published: Dec. 17, 2019

Language: Английский

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Tight Junction Structure and Function Revisited

Trends in Cell Biology, Journal Year: 2020, Volume and Issue: 30(10), P. 805 - 817

Published: Sept. 2, 2020

Language: Английский

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Tensile Forces and Mechanotransduction at Cell–Cell Junctions

Current Biology, Journal Year: 2018, Volume and Issue: 28(8), P. R445 - R457

Published: April 1, 2018

Language: Английский

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Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 11, 2021

Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases animals and man. The gut epithelium efficient barrier that prevents absorption liposaccharide (LPS). Structural changes to intestinal response dietary alterations allow LPS enter bloodstream, resulting increase plasma levels (termed endotoxemia). activates Toll-like receptor-4 (TLR4) leading production numerous pro-inflammatory cytokines and, hence, low-grade systemic inflammation. Thus, can lead several inflammatory conditions. Obesity, diabetes, non-alcoholic fatty liver disease (NAFLD) also cause permeability potential pharmacological interventions could be used reduce inflammation associated with endotoxemia.

Language: Английский

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Regulation of Transmembrane Signaling by Phase Separation

Annual Review of Biophysics, Journal Year: 2019, Volume and Issue: 48(1), P. 465 - 494

Published: April 5, 2019

Cell surface transmembrane receptors often form nanometer- to micrometer-scale clusters initiate signal transduction in response environmental cues. Extracellular ligand oligomerization, domain-domain interactions, and binding multivalent proteins all contribute cluster formation. Here we review the current understanding of mechanisms driving formation a series representative receptor systems: glycosylated receptors, immune cell adhesion Wnt tyrosine kinases. We suggest that these share properties systems undergo liquid-liquid phase separation could be investigated this light.

Language: Английский

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Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics

ACS Nano, Journal Year: 2020, Volume and Issue: 14(9), P. 11452 - 11462

Published: Aug. 21, 2020

Nature has always inspired robotic designs and concepts. It is conceivable that biomimic nanorobots will soon play a prominent role in medicine. The "Terminator" the science fiction film cybernetic organism with living tissue over metal endoskeleton, which us to develop natural-killer-cell-mimic aggregation-induced emission (AIE) characteristics (NK@AIEdots) by coating natural kill cell membrane on an AIE-active polymeric PBPTV, highly bright NIR-II conjugated polymer. Owing AIE soft-matter of as-prepared NK@AIEdots maintained superior brightness (quantum yield ∼7.9% water) good biocompatibility. Besides, they can serve as tight junction (TJ) modulator trigger intracellular signaling cascade, causing TJ disruption actin cytoskeleton reorganization form intercellular "green channel" help them cross blood–brain barrier (BBB) silently. Furthermore, initiatively accumulate glioblastoma cells complex brain matrix for high-contrast through-skull tumor imaging. growth was also greatly inhibited these under NIR light illumination. As far we know, quantum PBPTV highest among existing luminescent polymers. NK-cell biomimetic showed great potential BBB-crossing active delivery.

Language: Английский

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More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: April 28, 2020

Allergic bronchial asthma is a chronic disease of the airways that characterized by symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute episodes broncho-obstruction. This symptom-complex arises on basis allergic inflammation airway wall. Consequently, epithelium central to pathogenesis this disease, because its multiple abilities directly have an impact inflammatory response thus formation disease. In turn, structure functions are markedly impaired inflammation. Hence, represents sealed, self-cleaning barrier, prohibits penetration inhaled allergens, pathogens, other noxious agents into body. barrier covered with mucus further contains antimicrobial peptides antibodies either produced or specifically transported in order trap these particles remove them from body process called mucociliary clearance. Once first line defense lung overcome, epithelial cells get contact be damaged infected. Therefore, release plethora chemokines cytokines not only induce reaction but also alignment following immune reaction. case asthma, all already existing per se weakens integrity making it more vulnerable allergens as well infection bacteria viruses. Recent studies indicate history allergy- pathogen-derived insults can leave some kind memory described imprinting trained immunity. Thus, center processes lead formation, progression exacerbation asthma.

Language: Английский

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Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway

Phytomedicine, Journal Year: 2021, Volume and Issue: 92, P. 153743 - 153743

Published: Sept. 10, 2021

Language: Английский

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Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

MedComm, Journal Year: 2022, Volume and Issue: 3(2)

Published: May 18, 2022

Abstract Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their junctions and polarity while acquiring mesenchymal properties invasive ability. Originally defined as an embryogenesis event, EMT has been recognized crucial process in tumor progression. During EMT, cell–cell cell–matrix attachments are disrupted, the cytoskeleton remodeled to enhance mobility of cells. This phenotype largely driven by group key transcription factors, typically Snail, Twist, ZEB, through epigenetic repression markers, transcriptional activation matrix metalloproteinases, reorganization cytoskeleton. Mechanistically, orchestrated multiple pathways, especially those involved such TGFβ, Wnt, Hedgehog, Hippo, suggesting intrinsic link between embryonic development cancer In addition, redox signaling also emerged critical modulator. confers with increased metastatic potential drug resistant capacity, which accounts for recurrence most clinic cases. Thus, targeting can be therapeutic option providing chance cure patients. Here, we introduce brief history summarize recent advances understanding mechanisms, well highlighting opportunities treatment.

Language: Английский

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Synthetic extracellular matrices with function-encoding peptides

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(7), P. 518 - 536

Published: April 25, 2023

Language: Английский

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