Proceedings of The Nutrition Society,
Journal Year:
2018,
Volume and Issue:
77(4), P. 412 - 422
Published: April 30, 2018
The
aim
of
the
present
review
paper
is
to
survey
literature
related
DNA
methylation,
and
its
association
with
cancer
ageing.
will
outline
key
factors,
including
diet,
which
modulate
methylation.
Our
rationale
for
conducting
this
that
ageing
diseases,
cancer,
are
often
accompanied
by
aberrant
a
epigenetic
process,
crucial
regulation
gene
expression.
Significantly,
it
has
been
observed
age
certain
disease
states,
methylation
status
can
become
disrupted.
For
instance,
broad
array
cancers
associated
promoter-specific
hypermethylation
concomitant
silencing.
This
highlights
hypermethylation,
silencing,
EN1
promoter,
homeobox
gene,
detected
in
various
forms
cancer.
led
region
being
proposed
as
potential
biomarker
diseases
such
We
conclude
describing
recently
developed
novel
electrochemical
method
be
used
quantify
level
within
promoter
emphasise
growing
trend
use
techniques
detection
Cancer Science,
Journal Year:
2020,
Volume and Issue:
111(9), P. 3142 - 3154
Published: June 14, 2020
Abstract
Colorectal
cancer
(CRC)
is
a
public
health
problem.
It
the
third
most
common
in
world,
with
nearly
1.8
million
new
cases
diagnosed
2018.
The
only
curative
treatment
surgery,
especially
for
early
tumor
stages.
When
there
locoregional
or
distant
invasion,
chemotherapy
can
be
introduced,
particular
5‐fluorouracil
(5‐FU).
However,
disease
become
tolerant
to
these
pharmaceutical
treatments:
resistance
emerges,
leading
recurrence.
Different
mechanisms
explain
this
5‐FU
resistance.
Some
are
disease‐specific,
whereas
others,
such
as
drug
efflux,
evolutionarily
conserved.
These
numerous
and
complex
occur
simultaneously
cells
exposed
5‐FU.
In
review,
we
construct
global
outline
of
different
from
disruption
5‐FU‐metabolic
enzymes
classic
cellular
processes
(apoptosis,
autophagy,
glucose
metabolism,
oxidative
stress,
respiration,
cell
cycle
perturbation)
transporters
epithelial‐mesenchymal
transition
induction.
Particular
interest
directed
microenvironment
function
well
epigenetic
alterations
miRNA
dysregulation,
which
more
promising
that
will
subject
much
research
future.
