Estradiol and cognitive function: Past, present and future

Hormones and Behavior, Journal Year: 2014, Volume and Issue: 66(4), P. 602 - 618

Published: Sept. 1, 2014

A historical perspective on estradiol's enhancement of cognitive function is presented, and research, primarily in animals, but also humans, reviewed. Data regarding the mechanisms underlying enhancements are discussed. Newer studies showing rapid effects estradiol consolidation memory through membrane interactions activation inter-cellular signaling pathways reviewed as well focused traditional genomic mechanisms. Recent demonstrations intra-neuronal synthesis possible actions a neurosteroid to promote This information applied critical issue current lack effective hormonal (or other) treatments for decline associated with menopause aging. Finally, period hypothesis discussed along novel strategies hormone/drug development. Overall, record documents that positively impacts some aspects function, therapeutic interventions using this hormone have yet be realized.

Language: Английский

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The cognitive cell: bacterial behavior reconsidered

Frontiers in Microbiology, Journal Year: 2015, Volume and Issue: 6

Published: April 14, 2015

Research on how bacteria adapt to changing environments underlies the contemporary biological understanding of signal transduction, and transduction provides foundation information-processing approach that is hallmark 'cognitive revolution,' which began in mid-20th century. Yet cognitive scientists largely remain oblivious research into microbial behavior might provide insights problems their own domains, while microbiologists seem equally unaware potential importance work capacities multicellular organisms, including vertebrates. Evidence for encompassed by concept cognition reviewed. Parallels exist not only at heuristic level functional analogue, but also molecular mechanism, evolution ecology, where fruitful cross-fertilization among disciplines be found.

Language: Английский

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Calcium signaling in Alzheimer's disease & therapies

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2018, Volume and Issue: 1865(11), P. 1745 - 1760

Published: July 29, 2018

Language: Английский

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Molecular Mechanisms of the Memory Trace

Trends in Neurosciences, Journal Year: 2018, Volume and Issue: 42(1), P. 14 - 22

Published: Oct. 31, 2018

Language: Английский

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HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: May 18, 2020

DNA damage contributes to brain aging and neurodegenerative diseases. However, the factors stimulating repair stave off functional decline remain obscure. We show that HDAC1 modulates OGG1-initated 8-oxoguanine (8-oxoG) in brain. HDAC1-deficient mice display age-associated accumulation cognitive impairment. stimulates OGG1, a glycosylase known remove 8-oxoG lesions are associated with transcriptional repression. deficiency causes impaired OGG1 activity, at promoters of genes critical for function, Moreover, we observe elevated along reduced activity downregulation similar gene set 5XFAD mouse model Alzheimer's disease. Notably, pharmacological activation alleviates deleterious effects aged wild-type mice. Our work uncovers important roles highlights therapeutic potential counter neurodegeneration.

Language: Английский

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Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer’s Disease

Molecular Neurobiology, Journal Year: 2021, Volume and Issue: 59(1), P. 354 - 385

Published: Oct. 26, 2021

Language: Английский

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Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(6), P. 1051 - 1063

Published: April 9, 2024

Abstract RNA isoforms influence cell identity and function. However, a comprehensive brain isoform map was lacking. We analyze single-cell across regions, subtypes, developmental time points species. For 72% of genes, full-length expression varies along one or more axes. Splicing, transcription start polyadenylation sites vary strongly between types, protein architecture associate with disease-linked variation. Additionally, neurotransmitter transport synapse turnover genes harbor cell-type variability anatomical regions. Regulation cell-type-specific splicing is pronounced in the postnatal day 21-to-postnatal 28 adolescent transition. Developmental regulation stronger than regional for same type. Cell-type-specific mice mostly maintained human hippocampus, allowing extrapolation to brain. Conversely, harbors additional specificity, suggesting gain-of-function isoforms. Together, this detailed atlas development, regions species reveals an unappreciated degree multiple

Language: Английский

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The roles of protein expression in synaptic plasticity and memory consolidation

Frontiers in Molecular Neuroscience, Journal Year: 2014, Volume and Issue: 7

Published: Nov. 12, 2014

The amount and availability of proteins are regulated by their synthesis, degradation, transport. These processes can specifically, locally, temporally regulate a protein or population proteins, thus affecting numerous biological in health disease states. Accordingly, malfunction the turnover localization underlies different neuronal diseases. However, as early century ago, it was recognized that there is specific need for normal macromolecular synthesis fragment learning process, memory consolidation, which takes place minutes to hours following acquisition. Memory consolidation process fragile short-term converted into stable long-term memory. It accepted today synaptic plasticity cellular mechanism processes. Interestingly, similar molecular mechanisms subserve both consolidation. In this review, we survey current view on connection between proteostasis, i.e., maintaining contents at neuron synapse. addition, describe technical obstacles possible new methods determine proteostasis function better explain

Language: Английский

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CaMKII Isoforms in Learning and Memory: Localization and Function

Frontiers in Molecular Neuroscience, Journal Year: 2018, Volume and Issue: 11

Published: Dec. 4, 2018

Calcium/calmoudlin-dependent protein kinase II (CaMKII) is a key in neural plasticity and memory, as have been shown several studies since the first evidence long-term potentiation (LTP) 30 years ago. However, most of were focused mainly one four isoforms this kinase, CaMKIIα. Here we review characteristics role each learning, memory plasticity, considering well known local α β dendritic terminals recent findings about γ isoform calcium signals transducers from synapse to nucleus δ required for more persistent trace.

Language: Английский

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An update on contextual fear memory mechanisms: Transition between Amygdala and Hippocampus

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 92, P. 43 - 54

Published: May 9, 2018

Language: Английский

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