Phenolic compounds in hypertension: Targeting gut-brain interactions and endothelial dysfunction

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 104, P. 105531 - 105531

Published: April 5, 2023

Hypertension is a systemic health condition that increases the risk of cardiovascular disease. The etiology hypertension includes pro-inflammatory processes, oxidative stress and sympathetic hyperactivity. Gut microbiota dysbiosis associated with mucosal barrier defects increased intestinal permeability, contributing to activation an inflammatory cascade. Phenolic compounds targeting gut stimulate beneficial strains bacteria increase production metabolites capable influencing gut-brain axis, reducing inflammation improving metabolic outcomes. available literature indicates antihypertensive effects phenolic or phenolic-rich extracts may vary depending on intervention group, type hypertension, dose administered. In general, protect nervous system from neuroinflammation as consequence microbiota, suggesting neuroprotective effect against hypertensive diseases. Further studies should focus development nutraceuticals containing elucidate their composition metabolite repercussions

Language: Английский

---

Phytosterol organic acid esters: Characterization, anti-inflammatory properties and a delivery strategy to improve mitochondrial function

Current Research in Food Science, Journal Year: 2024, Volume and Issue: 8, P. 100702 - 100702

Published: Jan. 1, 2024

Phytosterol organic acid esters are important food resources and the components of biomembrane structure. Due to lack extraction synthesis techniques, more research has been focused on phytosterols, phytosterol have encountered a bottleneck, but confer substantial benefits human health. In this study, stigmasteryl vanillate (VAN), protocatechuate (PRO) sinapate (SIN) were prepared through Steglich reaction. The processes promotable products reach up 95% purity. addition, their stability was evaluated by differential scanning calorimetry thermogravimetric analysis. HPLC analysis revealed an enhancement in water solubility after esterification with phenolic acid. vitro digestion model, bioaccessibility phenolates significantly higher than that stigmasterols (STIs). Regarding anti-inflammatory properties, VAN, PRO, SIN exhibit superior effects against TNF-α induced pro-inflammatory responses compared STI. All supplementation increased ATP production, basal, maximal oxygen consumption rate mitochondrial stress test. Overall, we present method for phenolates. It will contribute development ester analysis, functions utilization food. Moreover, nutrient-stigmasterol hybrids tactic constructed is practical can become targeted delivery strategy enhanced effects.

Language: Английский

---

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 11, 2024

Stress caused by challenging environmental conditions is often associated with the rapid production of reactive oxygen species (ROS) that dramatically alter cellular redox homeostasis. ROS generation tightly connected its utilization, as impaired equilibrium these processes results in oxidative stress having profound consequences for cell physiology. The balanced action both antioxidant enzymes and non-enzymatic antioxidants counterbalances harmful effects ROS. Despite functional system cell, excessive leads to disruption vital which development various lifestyle diseases, mainly cardiovascular cancer. Enhanced consumption foodstuffs high bioactive compounds linked positive beneficial impacting protection resulting health promotion. In this chapter, we present an outline how determine their health-promoting properties.

Language: Английский

---

Regulation and Response Mechanism of Acute Low-Salinity Stress during Larval Stages in Macrobrachium rosenbergii Based on Multi-Omics Analysis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6809 - 6809

Published: June 20, 2024

Macrobrachium rosenbergii is an essential species for freshwater economic aquaculture in China, but the larval process, their salinity requirement high, which leads to stress water. In order elucidate mechanisms regulating response of M. acute low-salinity exposure, we conducted a comprehensive study exposed different salinities’ (0‰, 6‰, and 12‰) data 120 h. The activities catalase, superoxide dismutase, glutathione peroxidase were found be significantly inhibited hepatopancreas muscle following resulting oxidative damage immune deficits rosenbergii. Differential gene enrichment transcriptomics indicated that induced metabolic differences inflammatory dysfunction differential expressions MIH, JHEH, EcR genes inhibition growth, development, molting ability At proteomic level, low affected biological cellular regulation, as well response. Tyramine, trans-1,2-Cyclohexanediol, sorbitol, acetylcholine chloride, chloroquine screened by metabolomics markers. addition, combined multi-omics analysis revealed metabolite was highly correlated with low-salt stress.

Language: Английский

---

Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional synaptic plasticity

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117000 - 117000

Published: June 27, 2024

Alzheimer's disease (AD) is characterized by cognitive impairment, loss of learning and memory, abnormal behaviors. Scopolamine (SCOP) a non-selective antagonist muscarinic acetylcholine receptors that exhibits the behavioral molecular hallmarks AD. Vanillic acid (VA), phenolic compound, obtained from roots traditional plant called Angelica sinensis, has several pharmacologic effects, including antimicrobial, anti-inflammatory, anti-angiogenic, anti-metastatic, antioxidant properties. Nevertheless, VA's neuroprotective potential associated with memory not been thoroughly investigated. Therefore, this study investigated whether VA treatment an ameliorative effect on impairment induced SCOP in rats. Behavioral experiments were utilized to assess performance hippocampus. Using western blotting analysis assay kits, neuronal damage, oxidative stress, acetylcholinesterase activity responses hippocampus evaluated. Additionally, measurement long-term potentiation was used determine function synaptic plasticity organotypic hippocampal slice cultures. In addition, vesicles' density length width postsynaptic evaluated using electron microscopy. Consequently, behavioral, biochemical, electrophysiological, ultrastructural analyses revealed prevents impairments caused The study's findings suggest SCOP-induced linked cholinergic system, plasticity. may be prospective therapeutic agent for treating

Language: Английский

---

Modulation of Antioxidant Compounds in Fruits of Citrus reticulata Blanco Using Postharvest LED Irradiation

Biology, Journal Year: 2023, Volume and Issue: 12(7), P. 1029 - 1029

Published: July 21, 2023

Phlegrean mandarin fruits are already known for health-promoting properties due to the high concentration of phytochemicals in peel, pulp, and seed. Biotic abiotic factors, including light, may modulate their biosynthesis, metabolism, accumulation. In this context, light-emitting diodes (LED) have recently been applied control nutritional traits, ripening process, senescence, fruit shelf-life, pathogenic microbial spoilage fruits. This study investigated effect seven-day exposure two LED regimes, white (W) red-blue (RB), test possibility that storage under specific light wavelengths be used as green preservation technology enhances phytochemical properties. To pursue aim, antioxidant activity polyphenolic profile pulp peel mandarins W RB regimes were evaluated compared with Control not exposed treatment. Our results indicated treatments modulates content differently. Compared W, regime increases ascorbic acid, flavonoid, anthocyanin, carotenoid concentrations, while polyphenol analysis reveals number important phytochemicals, i.e., quercetin rutinoside, chlorogenic sinensetin, rutin, higher W. The overall data demonstrated postharvest irradiation is a valid tool modifying properties, which also boosts bioactive compounds.

Language: Английский

---

Ovary metabolome and cecal microbiota changes in aged laying hens supplemented with vitamin E

Poultry Science, Journal Year: 2024, Volume and Issue: 103(6), P. 103760 - 103760

Published: April 10, 2024

This study was aimed to evaluate the effect of vitamin E (VE) on laying performance, VE deposition, antioxidant capacity, immunity, follicle development, estrogen secretion, ovary metabolome, and cecal microbiota hens. One hundred twenty XinYang Black-Feathered hens (70 weeks old) were randomly assigned 2 groups (6 replicates 20 birds), fed a basal diet (containing mg/kg VE, control (CON) group) supplemented with (VE group). The experiment lasted for 10 weeks. Results showed that supplementation increased as evidenced by (P < 0.05) performance (laying rate), (glutathione peroxidase, total superoxide dismutase, catalase) immune (immunoglobulins) parameters, decreased feed/egg ratio malondialdehyde. Meanwhile, group had higher pre-grade follicles, index serum levels than CON group. 16S rRNA sequencing altered composition increasing Bacteroides, Rikenellaceae_RC9_gut_group, Prevotellaceae_UCG-001 Megamonas abundances reducing Christensenellaceae_R-7_group abundance (at genus level), which are mainly associated production short-chain fatty acids. Metabolomic profiling revealed major metabolites related anti-inflammatory, antioxidant, phototransduction, bile acid synthesis, nutrient transport. Furthermore, changes in level) highly correlated parameters. In summary, contributed aged enhancing immune, ovarian functions, promoting development regulating gut metabolites. These findings will provide new perspective mechanisms egg poultry ovaries.

Language: Английский

---

In Vitro Digestion Assessment (Standard vs. Older Adult Model) on Antioxidant Properties and Mineral Bioaccessibility of Fermented Dried Lentils and Quinoa

Molecules, Journal Year: 2023, Volume and Issue: 28(21), P. 7298 - 7298

Published: Oct. 27, 2023

The growing number of older adults necessitates tailored food options that accommodate the specific diseases and nutritional deficiencies linked with ageing. This study aims to investigate influence age-related digestive conditions in vitro on phenolic profile, antioxidant activity, bioaccessibility minerals (Ca, Fe, Mg) two types unfermented, fermented, fermented dried quinoa lentils. Solid-state fermentation, combined drying at 70 °C, significantly boosted total content Castellana Pardina lentils from 5.05 6.6 10.5 7.5 mg gallic acid/g dry weight, respectively, bioaccessible fraction following standard digestion model, compared unfermented samples. profile post-digestion revealed elevated levels vanillic caffeic acids lentils, acid while were not detected fraction. highest potency composite index was observed digested white samples exhibiting above 80%. Mineral greater ones. Finally, changes occur ageing did affect mineral bioaccessibility, but compromised activity.

Language: Английский

---

Plant phenolic acids modulating the renin-angiotensin system in the management of cardiovascular diseases

Studies in natural products chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 285 - 314

Published: Jan. 1, 2024

Language: Английский

---

Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health and Disease

Reviews in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 24(7), P. 190 - 190

Published: July 3, 2023

A variety of vegetable and fruit derived food oils are considered beneficial for human health due to their content functional components including positive effects in cardiovascular system. In addition the favorable ratio unsaturated versus saturated fatty acids, some these include also other compounds such as vitamins, minerals, pigments, enzymes phenolic compounds. Particularly polyphenols have been documented exert numerous system anti-hypertensive, anti-atherogenic well cardio- vasculo- protective subjects suffering from various cardiometabolic diseases, likely via antioxidant, anti-inflammatory, anti-coagulant, anti-proliferative anti-diabetic properties. However, it has not proven so far whether polyphenol-rich are, what measure, attributed content. Thus, current review aims summarize main major olive, flaxseed, soybean, sesame coconut oils, uncover role effects.

Language: Английский

---