Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: Feb. 18, 2021
The
Pacific
oyster
(
Crassostreae
gigas
)
has
been
introduced
from
Asia
to
numerous
countries
around
the
world
during
20th
century.
C.
is
main
species
farmed
worldwide
and
represents
more
than
98%
of
production.
severity
disease
outbreaks
that
affect
,
which
primarily
impact
juvenile
oysters,
increased
dramatically
since
2008.
most
prevalent
disease,
mortality
syndrome
(POMS),
become
panzootic
a
threat
industry.
Recently,
major
steps
towards
understanding
POMS
have
achieved
through
integrative
molecular
approaches.
These
studies
demonstrated
infection
by
Ostreid
herpesvirus
type
1
µVar
(OsHV-1
µvar)
first
critical
step
in
infectious
process
leads
an
immunocompromised
state
altering
hemocyte
physiology.
This
followed
dysbiosis
microbiota,
secondary
colonization
opportunistic
bacterial
pathogens,
turn
results
death.
Host
environmental
factors
e.g.
genetics
age,
temperature,
food
availability,
microbiota)
shown
influence
permissiveness.
However,
we
still
do
not
understand
mechanisms
these
different
control
expression.
present
review
discusses
current
knowledge
this
polymicrobial
multifactorial
explores
research
avenues
must
be
investigated
fully
elucidate
complexity
POMS.
discoveries
will
help
decision-making
facilitate
development
tools
applied
innovations
for
sustainable
integrated
management
aquaculture.
Aquaculture Reports,
Journal Year:
2022,
Volume and Issue:
28, P. 101459 - 101459
Published: Dec. 31, 2022
Vibrio-associated
ailments
are
important
globally,
not
only
among
marine
aquaculture
systems
but
also
wild
fish
populations.
Vibriosis
leads
to
significant
economic
losses
in
farms.
The
disease
is
generally
characterised
by
external
skin
lesions,
haemorrhages,
and
septicaemia.
Fish
or
shellfish
of
any
age
group
susceptible
the
infection
but,
young
animals
more
prone.
starts
with
crucial
initial
attachment
bacterium
host
tissue,
which
brought
about
various
virulence
factors.
This
followed
proliferation
invasion
into
internal
organ
through
blood
circulation.
However,
defence
provide
barriers
against
physical,
cellular
chemical
mechanisms.
Nevertheless,
environmental
stress
might
tilt
balance
successful
establishment.
Therefore,
basic
knowledge
on
pathology
pathogenesis
vibriosis,
factors
organism
mechanisms
attempts
control
emergence
vibriosis.
In
this
review,
current
pathology,
histopathology,
Vibrio
discussed.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: Feb. 18, 2021
The
increasing
number
of
data
studies
on
the
biological
impact
anthropogenic
chemicals
in
marine
environment,
together
with
great
development
invertebrate
immunology,
has
identified
bivalves
as
a
key
group
for
immunological
responses
to
pollutant
exposure.
Available
effects
contaminants
bivalve
immunity,
evaluated
different
functional
and
molecular
endpoints,
underline
that
individual
parameters
(cellular
or
humoral)
expression
selected
immune-related
genes
can
distinctly
react
depending
conditions
Therefore,
measurement
suite
immune
biomarkers
hemocytes
hemolymph
is
needed
correct
evaluation
overall
contaminant
exposure
organism's
immunocompetence.
Recent
advances
-omics
technologies
are
revealing
complexity
players
response
species.
Although
represent
extremely
powerful
tools
understanding
pollutants
physiological
function
such
defense,
approach
only
been
utilized
this
area
investigation
last
few
years.
In
work,
available
information
obtained
from
application
evaluate
immunity
summarized.
shows
knowledge
subject
still
quite
limited
understand
environmental
relevance
any
change
homeostasis
induced
by
contaminants,
combination
both
assays
cutting-edge
technology
(transcriptomics,
proteomics,
metabolomics)
required.
addition,
utilization
metagenomics
may
explain
how
complex
interplay
between
system
its
associated
bacterial
communities
be
modulated
pollutants,
turn
affect
homeostatic
processes
host,
host-pathogen
interactions,
increased
susceptibility
disease.
Integrating
approaches
will
contribute
mechanism
responsible
dysfunction
ecologically
economically
relevant
species
further
their
sensitivity
multiple
stressors,
thus
resulting
health
Cell Death and Disease,
Journal Year:
2022,
Volume and Issue:
13(5)
Published: May 24, 2022
Gasdermin
(GSDM)
is
a
family
of
pore-forming
proteins
that,
after
cleavage
by
caspase
(CASP),
induce
type
programmed
necrotic
cell
death
called
pyroptosis.
E
(GSDME)
the
only
pyroptosis-inducing
member
GSDM
existing
in
teleost.
To
date,
regulation
and
function
teleost
GSDME
response
to
bacterial
infection
remain
elusive.
In
this
study,
we
observed
activation
GSDME,
as
well
multiple
CASPs,
turbot
Scophthalmus
maximus
during
pathogen
Vibrio
harveyi.
Turbot
has
two
orthologs
named
SmGSDMEa
SmGSDMEb.
We
found
that
was
specifically
cleaved
CASP
(SmCASP)
3/7
SmCASP6,
which
produced
different
N-terminal
(NT)
fragments.
Only
NT
fragment
SmCASP3/7
able
Ectopically
expressed
activated
SmGSDMEa,
resulting
pyroptotic
death.
contrast,
SmCASP6
inactivated
destructive
domain,
thus
nullifying
effect
SmCASP3/7.
Unlike
SmGSDMEb
SmCASP8
unable
V.
harveyi
dramatically
promoted
production
but
not
SmGSDMEb,
caused
pyroptosis
turbot.
Interference
with
activity
significantly
enhanced
invasiveness
lethality
model.
Together,
these
results
revealed
previously
unrecognized
bi-directional
mode
GSDME-mediated
pyroptosis,
functional
difference
between
GSDMEa
GSDMEb
immune
defense
against
infection.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Dec. 19, 2023
Abstract
Vibrio
spp.,
known
human
foodborne
pathogens,
thrive
in
freshwater,
estuaries,
and
marine
settings,
causing
vibriosis
upon
ingestion.
The
rising
global
cases
due
to
climate
change
necessitate
a
deeper
understanding
of
epidemiology
transmission.
This
review
delves
into
contamination
seafood,
scrutinizing
its
sources
pathways.
We
comprehensively
assess
the
human‐pathogenic
seafood
chain,
covering
raw
materials
processed
products.
A
“
Farm‐to‐Fork”
approach,
aligned
with
One
Health
concept,
is
essential
for
grasping
complex
nature
contamination.
’s
widespread
presence
natural
farmed
aquatic
environments
establishes
them
as
potential
entry
points
chain.
Environmental
factors,
including
climate,
activities,
wildlife,
influence
routes,
underscoring
need
understand
origin
transmission
pathogens
seafood.
Once
within
formation
protective
biofilms
on
various
surfaces
production
processing
poses
significant
food
safety
risks,
necessitating
proper
cleaning
disinfection
prevent
microbial
residue.
In
addition,
inadequate
handling,
from
inappropriate
procedures
cross‐contamination
via
pests
or
handlers,
significantly
contributes
contamination,
thus
warranting
attention
reduce
risks.
Information
presented
here
support
imperative
proactive
measures,
robust
research,
interdisciplinary
collaboration
order
effectively
mitigate
risks
posed
by
pathogenic
safeguarding
public
health
security.
serves
crucial
resource
researchers,
industrials,
policymakers,
equipping
knowledge
develop
biosecurity
measures
associated
‐contaminated
