Cited by G protein-coupled estrogen receptor activation by bisphenol-A disrupts lipid metabolism and induces ferroptosis in the liver

Addressing the environmental and health impacts of microplastics requires open collaboration between diverse sectors DOI

Scott Coffin, Holly Wyer, J. C. Leapman

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(3), P. e3000932 - e3000932

Published: March 30, 2021

Public concern over the environmental and public health impacts of emerging contaminant class "microplastics" has recently prompted government agencies to consider mitigation efforts. Microplastics do not easily fit within traditional risk-based regulatory frameworks because their persistence extreme diversity (of size, shape, chemical properties associated with sorbed chemicals) result in high levels uncertainty hazard exposure estimates. Due these serious complexities, addressing microplastics' requires open collaboration between scientists, regulators, policymakers. Here we describe ongoing international efforts, California as a case study, draw lessons from similarly diverse environmentally persistent contaminants (per- polyfluoroalkyl substances) that is already disrupting paradigms, discuss strategies address challenges developing health-protective regulations policies related microplastics, suggest ways maximize research.

Language: Английский

Citations

Photoaging of Baby Bottle-Derived Polyethersulfone and Polyphenylsulfone Microplastics and the Resulting Bisphenol S Release DOI

Yang Li, Yuan Liu, Shengdong Liu

et al.

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(5), P. 3033 - 3044

Published: Feb. 10, 2022

This study evaluated the release of bisphenol S (BPS) from polyethersulfone (PES) and polyphenylsulfone microplastics (MPs) derived baby bottles under UV irradiation. Released BPS fluctuates over time because it undergoes photolysis UV254 Under UV365 irradiation, highest released concentration at 50 °C was 1.7 3.2 times that 35 25 °C, respectively, as activation energy photochemical reactions responsible for MP decay reduced high temperatures. Low concentrations humic acid (HA, ≤10 mg·L–1) promote HA acts a photosensitizer. A (10∼50 decreases shields MPs light scavenges reactive radicals are produced via reactions. For example, hydroxyl (•OH) attack results in breakage ether bonds formation phenyl (Ph•) phenoxy (Ph–O•).The•OH addition hydrogen extractions further produce decayed MPs. leaching kinetics model developed calibrated by experimental data. The predicts equilibrium level varies with surface coverage density rate constants. provides groundwork deepens our understanding environmental aging chemical

Language: Английский

Citations

Does Bisphenol A Confer Risk of Neurodevelopmental Disorders? What We Have Learned from Developmental Neurotoxicity Studies in Animal Models DOI

Chloe Welch,

Kimberly A. Mulligan

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2894 - 2894

Published: March 7, 2022

Substantial evidence indicates that bisphenol A (BPA), a ubiquitous environmental chemical used in the synthesis of polycarbonate plastics and epoxy resins, can impair brain development. Clinical epidemiological studies exploring potential connections between BPA neurodevelopmental disorders humans have repeatedly identified correlations early exposure developmental disorders, such as attention deficit/hyperactivity disorder autism spectrum disorder. Investigations using invertebrate vertebrate animal models revealed to multiple aspects neuronal development, including neural stem cell proliferation differentiation, synapse formation, synaptic plasticity-neuronal phenotypes are thought underpin fundamental changes behavior-associated disorders. Consistent with caused by BPA, behavioral analyses BPA-treated animals shown significant impacts on endophenotypes related altered locomotor activity, learning memory deficits, anxiety-like behavior. To contextualize humans, this review summarizes current literature neurotoxicity laboratory an emphasis phenotypes, molecular mechanisms, outcomes. The collective works described here predominantly support notion gestational should be regarded risk factor for

Language: Английский

Citations

Derivatives of Plastics as Potential Carcinogenic Factors: The Current State of Knowledge DOI

Jacek Baj, James Curtis Dring, Marcin Czeczelewski

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(19), P. 4637 - 4637

Published: Sept. 24, 2022

Micro- and nanoplatics have been already reported to be potential carcinogenic/mutagenic substances that might cause DNA damage, leading carcinogenesis. Thus, the effects of micro- nanoplastics exposure on human health are currently being investigated extensively establish clear relationships between those consequences. So far, it has observed there exists a definite correlation nanoplastic particles onset several cancers. Therefore, we conducted research using PubMed, Web Science, Scopus databases, searching for all papers devoted cancers could potentially related subject nano- microplastics. Ultimately, in this paper, discussed cancers, including hepatocellular carcinoma, pancreatic cancer, ductal adenocarcinoma, biliary tract some endocrine-related

Language: Английский

Citations

G protein-coupled estrogen receptor activation by bisphenol-A disrupts lipid metabolism and induces ferroptosis in the liver DOI

Wanqiu He,

Zhangshan Gao,

Shuhui Liu

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 334, P. 122211 - 122211

Published: July 14, 2023

Language: Английский

Citations