The alarming link between environmental microplastics and health hazards with special emphasis on cancer

Life Sciences, Journal Year: 2024, Volume and Issue: 355, P. 122937 - 122937

Published: Aug. 3, 2024

Language: Английский

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Eco-friendly hydrophobic ZIF-8/sodium alginate monolithic adsorbent: An efficient trap for microplastics in the aqueous environment

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 661, P. 259 - 270

Published: Jan. 28, 2024

Language: Английский

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Plastics and Micro/Nano-Plastics (MNPs) in the Environment: Occurrence, Impact, and Toxicity

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(17), P. 6667 - 6667

Published: Aug. 28, 2023

Plastics, due to their varied properties, find use in different sectors such as agriculture, packaging, pharmaceuticals, textiles, and construction, mention a few. Excessive of plastics results lot plastic waste buildup. Poorly managed (as shown by heaps on dumpsites, free spaces, along roads, marine systems) the landfills, are just fraction environment. A complete picture should include micro nano-plastics (MNPs) hydrosphere, biosphere, lithosphere, atmosphere, current extreme weather conditions (which effects climate change), wear tear, other factors promote MNP formation. MNPs pose threat environment more than pristine counterparts. This review highlights entry occurrence primary secondary soil, water air, together with aging. Furthermore, uptake internalization, plants, animals, humans discussed, toxicity effects. Finally, future perspective conclusion given. The material utilized this work was acquired from published articles internet using keywords waste, degradation, microplastic, aging, toxicity.

Language: Английский

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Could Microplastics Be a Driver for Early Onset Colorectal Cancer?

Cancers, Journal Year: 2023, Volume and Issue: 15(13), P. 3323 - 3323

Published: June 24, 2023

The incidence of colorectal cancer in those under 50 years age (early onset (EOCRC)) is increasing throughout the world. This has predominantly been an increase distal colonic and rectal cancers, which are biologically similar to late (LOCRC) but with higher rates mucinous or signet ring histology, poorly differentiated cancers. epidemiology this change suggests that it a cohort effect since 1960, most likely driven by environmental cause. We explore possible role microplastics as driver for change.

Language: Английский

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The Known and Unknown: Investigating the Carcinogenic Potential of Plastic Additives

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(24), P. 10445 - 10457

Published: June 3, 2024

Microplastics are routinely ingested and inhaled by humans other organisms. Despite the frequency of plastic exposure, little is known about its health consequences. Of particular concern additives─chemical compounds that intentionally or unintentionally added to plastics improve functionality as residual components production. Additives often loosely bound polymer may be released during exposures. To better understand effects additives, we performed a comprehensive literature search compile list 2,712 additives. Then, an integrated toxicogenomic analysis these utilizing cancer classifications carcinogenic expression pathways primary focus. Screening substances across two chemical databases revealed key observations: (1) over 150 additives have carcinogenicity (2) majority (∼90%) lack data on end points. Analyses additive usage patterns pinpointed specific polymers, functions, products in which reside. Based published chemical–gene interactions, both with unknown impacted similar biological pathways. The predominant involved DNA damage, apoptosis, immune response, viral diseases, cancer. This study underscores urgent need for systematic assessment regulatory responses mitigate potential risks exposure.

Language: Английский

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Microplastic residues in clinical samples: A retrospection on sources, entry routes, detection methods and human toxicity

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 173, P. 117618 - 117618

Published: March 6, 2024

Language: Английский

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Microplastics and nanoplastics in haemodialysis waters: Emerging threats to be in our radar

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 102, P. 104253 - 104253

Published: Aug. 20, 2023

Microplastics are present in the environment, drinking water, human blood and there is evidence of nanoplastics tap water. The objective this work was to analyze possibility hemodialysis patients being contaminated by micro (MNPs) during dialysis treatments. motivation for investigation fact that use about 300-600 L water per week, which may be MNPs. A literature review, a field London hospital an estimation MNPs intake were carried out. results showed potential points risk contamination hemodialysis. It also estimated filtration efficiency 99% MNPs, amount microplastics can penetrate kidneys 0.0021 3,768 particles/week. assessment concludes at high MNP contamination.

Language: Английский

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Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(11), P. 1657 - 1678

Published: March 17, 2024

Abstract Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) 1–100‐nm size, thereby littering the environment and posing a threat to wildlife human health. Research on NPL contamination has up now focused ecotoxicology effects pollution rather than health risks. This review aimed speculate about possible properties carcinogenic neurotoxic as pollutants. Given their low‐dimensional size high surface ratio, NPLs can easily penetrate biological membranes cause functional structural damage in cells. Once inside cell, interrupt autophagy flux cellular debris, alter proteostasis, provoke mitochondrial dysfunctions, induce endoplasmic reticulum stress. Harmful metabolic processes induced by include oxidative stress (OS), ROS generation, pro‐inflammatory reactions. Depending cell cycle status, may direct DNA damage, tumorigenesis, lately carcinogenesis tissues with self‐renewal capabilities like epithelia. In cells able live longest neurons, could trigger neurodegeneration promoting toxic proteinaceous aggregates, OS, chronic inflammation. genotoxicity neurotoxicity are discussed based gathered evidence, when available, within context intracellular uptake these newcomer nanoparticles. summary, this explains how risk evaluation for benefit from accurately monitoring toxicokinetics toxicodynamics at resolution level.

Language: Английский

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Impacts of micro and nanoplastics on human health

Bulletin of the National Research Centre/Bulletin of the National Research Center, Journal Year: 2024, Volume and Issue: 48(1)

Published: Oct. 22, 2024

Abstract Background Plastics are the most flexible products developed with a wide range of applications. They have been incorporated into almost every aspect daily life due to their strength and low weight. However, widespread use inadequate waste management resulted in accumulation tiny plastic particles throughout environment. Main text Microplastics found oceans, rivers, sediments, sewers, soil, agricultural products, even table salts. Human beings affected by microplastics through food ingestion inhalation. Incorporated may accrue within body affect gastrointestinal, immune, endocrine, brain, respiratory systems. It also interferes functions major organs causes chromosomal abnormalities. Conclusion Addressing issue micro nanoplastics requires interdisciplinary research, sustainable solutions, improved The main focus this review is cover harmful effects impact on human health stress need for combating strategies.

Language: Английский

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Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

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