Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Journal of Diabetes, Journal Year: 2023, Volume and Issue: 15(4), P. 299 - 312
Published: March 9, 2023
Diabetic foot ulcers (DFUs) are associated with complex pathogenic factors and considered a serious complication of diabetes. The potential mechanisms underlying DFUs have been increasingly investigated. Previous studies focused on the three aspects diabetic peripheral vascular disease, neuropathy, wound infections. With advances in technology, researchers gradually conducting using immune cells, endothelial keratinocytes, fibroblasts, as they involved healing. It has reported that upregulation or downregulation molecular signaling pathways is essential for healing DFUs. recent increase awareness epigenetics, its regulatory role become much sought-after trend treatment This review focuses four pathogenesis DFUs: physiological pathological mechanisms, cellular pathway epigenetics. Given challenge DFUs, we hopeful our will provide new ideas peers.糖尿病足溃疡(DFUs)与复杂的病理因素有关，被认为是糖尿病的严重并发症。目前，潜在的DFUs机制已经越来越受到研究关注。以往的研究主要集中在糖尿病周围血管疾病、神经病变和创伤感染三个方面。随着技术的进步，研究人员逐渐开始使用免疫细胞、内皮细胞、角质细胞和成纤维细胞进行研究，因为它们参与了创伤愈合过程。报道称，分子信号通路的上调或下调对DFUs的愈合至关重要。随着对表观遗传学认识的增强，它在创伤愈合中的调控作用成为治疗DFUs的热门趋势。本综述关注DFUs发病机制涉及的四个方面:生理和病理机制、细胞机制、分子信号通路机制和表观遗传学。鉴于DFUs治疗的挑战，我们希望本综述能为同行提供新思路。.
Language: Английский
Citations
91
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129300 - 129300
Published: Jan. 11, 2024
Language: Английский
Citations
28
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)
Published: April 1, 2024
Abstract Nonhealing diabetic wounds are predominantly attributed to the inhibition of angiogenesis, re‐epithelialization, and extracellular matrix (ECM) synthesis caused by hypoxia. Although oxygen therapy has demonstrated efficacy in promoting healing, its therapeutic impact remains suboptimal due unsustainable oxygenation. Here, this work proposes an oxygen‐releasing hydrogel patch embedded with polyethylene glycol‐modified calcium peroxide microparticles, which sustainably releases for 7 days without requiring any supplementary conditions. The released effectively promotes cell migration angiogenesis under hypoxic conditions as validated vitro. vivo tests mice models show that significantly facilitates ECM, induces decreases expression inflammatory cytokines, achieving a wound healing rate 84.2% on day 7, outperforming existing approaches. Moreover, proposed is designed porous, soft, antibacterial, biodegradable, storage stability 15 days. expected be promising clinics treating wounds.
Language: Английский
Citations
17
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: Jan. 7, 2025
Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy conventional treatments, highlighting need for alternative therapeutic strategies. Natural products, known their antimicrobial, anti-inflammatory, wound-healing properties, have garnered attention as potential treatments DFIs. This review examines key natural compounds, including eugenol, thymol, carvacrol, curcumin, Aloe vera, mechanisms action combating diabetic infections. We analyze antimicrobial these ability inhibit biofilm formation, role wound healing. also explores challenges integrating products into clinical practice use alongside or place traditional antibiotic therapies. Our findings suggest that could play crucial developing sustainable effective treatment strategies DFIs, especially face rising resistance.
Language: Английский
Citations
2
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 314, P. 120924 - 120924
Published: April 23, 2023
Language: Английский
Citations
35
Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)
Published: Nov. 15, 2023
Abstract Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by structural and functional abnormalities within the intricate network microvessels beyond well-known documented target organs, i.e., retina, kidney, peripheral nerves. Indeed, an intact microvascular bed crucial for preserving each organ’s specific functions achieving physiological balance to meet their respective metabolic demands. Therefore, diabetes-related dysfunction leads widespread multiorgan consequences in still-overlooked non-traditional organs such as brain, lung, bone tissue, skin, arterial wall, heart, or musculoskeletal system. All these are vulnerable physiopathological mechanisms that cause damage diabetes (i.e., hyperglycaemia-induced oxidative stress, inflammation, endothelial dysfunction) collectively contribute microvessels’ structure function, compromising blood flow tissue perfusion. However, microcirculatory networks differ between due variations haemodynamic, vascular architecture, affected cells, resulting spectrum clinical presentations. The aim this review focus on multifaceted nature impairment through available evidence often overlooked organs. A better understanding microangiopathy non-target provides broader perspective systemic disease, underscoring importance recognising comprehensive range complications classic sites.
Language: Английский
Citations
27
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124955 - 124955
Published: May 26, 2023
Language: Английский
Citations
26
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4242 - 4261
Published: Jan. 1, 2024
Clerodendrum glandulosum extract reduced silver nanoparticles were prepared by in situ technique within chitosan-PEG hydrogel matrix and characterized for its vitro vivo diabetic wound healing activities.
Language: Английский
Citations
16
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 3, 2025
The purpose of this study was to investigate the clinical efficacy antibiotic-loaded bone cement (ALBC) combined with Negative pressure wound therapy (NPWT) aspiration technique in treatment multidrug-resistant diabetic foot ulcers (MDRO-DFUs). A retrospective analysis data 80 patients MDROs-DFU who were used Vacuum sealing drainage (VSD) as NPWT excipient and met inclusion criteria from January 2019 2024 at our hospital. Patients divided into an experimental group a control group, 40 cases each. received conventional treatment, routine debridement, while ALBC addition plan group. Measurements blood inflammatory indicators, hemodynamic bacterial clearance time, healing hospital stay taken before after for both groups. Inflammatory indexes, Vascular endothelial growth factor(VEGF), internal diameter dorsalis pedis arteriosus groups significantly better than those improvement more obvious that group; had shorter time trauma turnover, trauma, hospitalization compared (P<0.05).
Language: Английский
Citations
1
Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
Citations
1