Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139685 - 139685

Published: Jan. 10, 2025

Language: Английский

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Catalase-like Nanozyme-Hybrid Hydrogels Utilizing Endogenous ROS as an Oxygen Source To Synergically Regulate Oxidative Stress and Hypoxia for Enhanced Diabetic Wound Healing

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

High levels of reactive oxygen species (ROS) and hypoxia in diabetic wounds significantly hinder the healing process. In this work, a kind catalase-like nanozyme-hybrid hydrogel was developed to explore potential harnessing endogenous excessive ROS as an source synergistically regulate oxidative stress hypoxia, thereby enhancing wound healing. The hydrogels exhibited rapid degradation controlled release ferrihydrite nanozymes response stress, which continuously catalyzed decomposition H2O2 generate oxygen, effectively scavenging reducing risk local toxicity. relieved intracellular hypoxic microenvironment simultaneously vitro. dressings inhibited damage at sites, promoted epidermis formation collagen deposition, accelerated db/db mice. Therefore, represent promising strategy for dressings, addressing both improve outcomes.

Language: Английский

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3D Printing‐Based Hydrogel Dressings for Wound Healing

Advanced Science, Journal Year: 2024, Volume and Issue: 11(47)

Published: Nov. 18, 2024

Abstract Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of best candidates for ideal wound dressings most feasible choices printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic mechanical properties, 3D can promptly accurately create with complex bioactive structures potential promote tissue regeneration healing. Herein, a comprehensive review multi‐functional printing‐based hydrogel healing is presented. The first summarizes techniques dressings, including photo‐curing, extrusion, inkjet, laser‐assisted printing. Then, properties design approaches series bioinks composed natural, synthetic, composite polymers described. Thereafter, application in variety environments discussed depth, hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, machine learning‐assisted therapy. Finally, challenges prospects

Language: Английский

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Algae-inspired chitosan-pullulan-based multifunctional hydrogel for enhanced wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122751 - 122751

Published: Sept. 15, 2024

Language: Английский

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.

Language: Английский

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Macrochannel-aligned cryogels with oxygen release and antibacterial properties for MRSA-infected diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153299 - 153299

Published: June 18, 2024

Language: Английский

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The Progress and Prospect of calcium peroxide nanoparticles in antibacterial activity

Colloids and Interface Science Communications, Journal Year: 2024, Volume and Issue: 61, P. 100793 - 100793

Published: July 1, 2024

This review provides a comprehensive overview of the advancements and potential applications calcium peroxide nanoparticles (CaO2 NPs) in combating bacterial infections. With rise antibiotic resistance posing significant global health threat, alternative antibacterial agents like CaO2 NPs have garnered increasing attention. The begins by discussing synthesis functionalization NPs, highlighting recent developments nanoparticle engineering techniques. Subsequently, it explores intricate mechanisms emphasizing their ability to generate reactive oxygen species disrupt biofilms. Evaluation NPs' efficacy against broad spectrum pathogens, coupled with discussions on various fields including biomedical environmental remediation, underscores promising role as effective agents. also addresses challenges such stability biocompatibility, proposes future research directions fully exploit therapeutic NPs. Overall, this consolidates current knowledge advocates for continued exploration

Language: Английский

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Next‐Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel‐Based Pharmaceuticals for Inflammation Regulation

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Oral ulcers, affecting 27.9% of adults, can lead to malnutrition and dehydration, especially in individuals with diabetes, cancer, viral infections, autoimmune diseases. Existing treatments-including oral films, sprays, frosts, powders-often fail be effective due rapid dilution clearance the moist environment. This study is first investigate use Cold Atmospheric Plasma (CAP) for treating ulcers its underlying molecular mechanisms. A novel high-bioavailability, mucoadhesive therapy combining handheld three dimensions (3D) multi-microhole CAP developed a nanogel-based pharmaceutical system containing glucose oxidase (GOx) catalase (CAT), termed GCN. These results showed that both alone combined GCN significantly accelerate ulcer healing, modulate immune responses, activate Epidermal Growth Factor Receptor (EGFR) acetic acid-induced outperforming untreated controls conventional medication, Watermelon Frost (WF). Furthermore, CAP+GCN combination enhances therapeutic effects by promoting fibroblast generation. pretreatment also cell permeability nanoparticle uptake, improving tissue adhesion. findings are validated primary Human Gingival Fibroblasts (HGF) Periodontal Ligament Stem Cells (PDLSC) from healthy donors, as well an model rats, demonstrating superior biocompatibility safety.

Language: Английский

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Shape-recoverable chitosan/sodium alginate aerogels with sustained oxygen release and antibacterial activity for diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141005 - 141005

Published: Feb. 16, 2025

Language: Английский

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Chlorella-encapsulated living hydrogel based on gelatin and carrageenan with oxygen production, hemostatic and antibacterial capacity for promoting wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 308, P. 142356 - 142356

Published: March 23, 2025

Language: Английский

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