Immune Response after Anti-SARS-CoV-2 mRNA Vaccination in Relation to Cellular Immunity, Vitamin D and Comorbidities in Hemodialysis Patients DOI Creative Commons

Eglė Dalinkevičienė,

Brigita Gradauskienė, Sandra Sakalauskaitė

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 861 - 861

Published: April 25, 2024

In the global threat of SARS-CoV-2, individuals undergoing maintenance dialysis represent a vulnerable population with an increased risk severe COVID-19 outcomes. Therefore, immunization against SARS-CoV-2 is essential component healthcare strategy for these patients. Existing data indicate that they tend to exhibit reduced immune response vaccines compared general population. Our study aimed assess both humoral and cellular responses following two doses anti-SARS-CoV-2 mRNA vaccine, ability maintain adequate antibody titers over time, potential relations vitamin D, comorbidities other factors in hemodialysis patients based on single center experience. A total 41/45 (91.1%) responded second dose vaccine. The titer IgG class antibodies levels T cells three four weeks after vaccination were lower than healthy controls. Antibodies had positive correlation B lymphocytes was related cardiovascular diseases. level CD4+ negative vintage, as did D post-vaccination seroconversion decline during six months vaccination. Hemodialysis decreased amounts CD8+ chronic could lead diminished immunity protection from COVID-19. Comorbidity diseases associated specific titer. Vitamin may be important maintaining stable antibodies, while duration treatment one decreasing determining cell counts.

Language: Английский

From Sunshine to Wellness: Understanding Vitamin D Impact on Menstrual Health DOI Creative Commons

Dhanyaa Muthukumaran,

Jawaher Abdullah Bin Jumah, S. Rajeshkumar

et al.

Advances in Public Health, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Vitamin D, a fat‐soluble nutrient essential for normal bone development and maintenance, plays crucial role in the body’s absorption of calcium, magnesium, phosphate. Recent research has highlighted its significant influence on menstrual health, an area human well‐being that often been overlooked. Objective: This review aims to explore multifaceted vitamin D examining effects various aspects cycle, mood regulation, reproductive as well involvement gene pathways modulation stress. Methods: A comprehensive was conducted using databases such Ovid Medline, OVID EMBASE, Cochrane Library, PubMed, Scopus, Web Science identify peer‐reviewed articles published up 2024. Keywords included “Vitamin D,” “Women’s phases,” “Menstrual cycle,” “Hormonal regulation,” “Reproductive health.” Studies were screened selected based eligibility criteria, including focus relationship between phases women, subjected quality assessment methodological rigour. The results show found have impact regulation cycle phases, alleviation premenstrual syndrome (PMS) symptoms, reduction abdominal pain during menstruation, support health. Additionally, exerts anti‐inflammatory effects, promotes cardiovascular modulatory stress mood. Conclusion: highlights pivotal women’s highlighting potential enhance overall well‐being. findings suggest ensuring adequate levels, whether through sunlight exposure, diet, or supplementation, may offer benefits health related

Language: Английский

Citations

0
Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases DOI
Ayeh Bani Saeid, Vyoma K. Patel,

Samir Mehndiratta

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 56, P. 103205 - 103205

Published: Sept. 26, 2023

Language: Английский

Citations

8
Unveiling the Interplay—Vitamin D and ACE-2 Molecular Interactions in Mitigating Complications and Deaths from SARS-CoV-2 DOI Creative Commons
Sunil J. Wimalawansa

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 831 - 831

Published: Oct. 16, 2024

The interaction of the SARS-CoV-2 spike protein with membrane-bound angiotensin-converting enzyme-2 (ACE-2) receptors in epithelial cells facilitates viral entry into human cells. Despite this, ACE-2 exerts significant protective effects against coronaviruses by neutralizing viruses circulation and mitigating inflammation. While reduces expression, vitamin D increases it, counteracting virus's harmful effects. Vitamin D's beneficial actions are mediated through complex molecular mechanisms involving innate adaptive immune systems. Meanwhile, status [25(OH)D concentration] is inversely correlated severity, complications, mortality rates from COVID-19. This study explores which inhibits replication, including suppression transcription enzymes, reduced inflammation oxidative stress, increased expression antibodies antimicrobial peptides. Both hypovitaminosis elevate renin levels, rate-limiting step renin-angiotensin-aldosterone system (RAS); it ACE-1 but expression. imbalance leads to elevated levels pro-inflammatory, pro-coagulatory, vasoconstricting peptide angiotensin-II (Ang-II), leading widespread It also causes membrane permeability, allowing fluid infiltrate soft tissues, lungs, vascular system. In contrast, sufficient suppress reducing RAS activity, lowering ACE-1, increasing levels. cleaves Ang-II generate Ang

Language: Английский

Citations

3
Pectolinarigenin and its derivatives: Bridging the gap between chemical properties and pharmacological applications DOI Creative Commons

Neeraj Patel,

Rashi Kulshrestha, Asif Ahmad Bhat

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 10, P. 100378 - 100378

Published: Feb. 2, 2024

Pectolinarigenin (PG), derived from the Chinese herb Chromolaena odorata exhibits diverse biological activities, including apoptosis induction (cytotoxicity), anti-inflammatory, anti-allergic, and antitumour effects. PG its derivatives are present in edible plants like Cirsium japonicum DC, chanroenicum Nakai, setidens (Dunn) Nakai Clerodendrum volubile. A literature search on PubMed, Web of Science, Google Scholar, Springer, Elsevier using term "Pectolinarigenin" was conducted. This review analysed studies PG's physiochemical properties, pharmacokinetics, pharmacological action, derivatives. PG, isolated or synthesised flavonoids, exhibit characteristics, antioxidant, hyperlipidaemia, immunomodulatory, melanogenesis, anti-cancer, neuroprotective, hepatoprotective properties. Evidence suggests that holds significant potential formulating drugs supplements for preventing treating conditions such as cancer, inflammation, diabetes, various brain-related illnesses.

Language: Английский

Citations

2
Vitamina D: Una terapia coadyuvante en el manejo de covid-19 DOI Open Access
Edith Yesenia Yanez-Chicaiza, Cinthia Katherine Galarza Galarza

Revista Arbitrada Interdisciplinaria de Ciencias de la Salud Salud y Vida, Journal Year: 2024, Volume and Issue: 8(15), P. 65 - 79

Published: Jan. 1, 2024

Objetivo: determinar como la Vit-D actúa a nivel de sistema inmunológico reduciendo el riesgo gravedad por COVID-19. Método: Descriptivo observacional. Resultados y conclusiones: El papel defensivo frente infecciones relacionadas con respiratorio se demuestra en ensayos clínicos. Se sugiere administración suplementos para mantener los niveles óptimos circulación cuerpo. Existen evidencias una asociación significativa entre insuficiencia/deficiencia susceptibilidad al COVID-19 su gravedad. Por tanto, tomar un suplemento concentración sérica mayor 30 ng/mL reducir infección SARS-CoV-2 sus consecuencias.

Citations

2
Targeting Toll-Like Receptors for the Treatment of Lung Cancer DOI
Sarita Rawat,

Karuna Dhaundhiyal,

Ishwar Singh Dhramshaktu

et al.

Published: Jan. 1, 2024

Lung cancer (LC) remains a significant concern for the community, causing greatest number of fatalities linked to globally. Toll-like receptors (TLRs) are widely found in immune-related cells including plasmacytoid dendritic cells, monocytes, and B lymphocytes, as well lower concentrations throughout human pulmonary epithelial cells. Newer investigations have displayed crucial role TLRs activating innate immunity. Therefore, stimulating immune system externally through may offer potential approach combat cancer. However, this activation could also contribute underlying chronic inflammation, ultimately promoting progression carcinoma. Cancerous possess distinct characteristics, their ability multiply indefinitely resist programmed cell death (apoptosis). highly active most native lung infiltrating lymphocytes with myeloid lymphoid origins. Notably, 1, 2, 3, 4, 5, 6, 9 prominently expressed enhance LC proliferation by transmitting signals that promote growth or prevent apoptosis. Surprisingly, exhibit higher levels TLR2, TLR4, TLR7/TLR8, TLR9 expression compared "normal" TLR4 TLR9, particular, well-known associated development LC. has been demonstrated adenocarcinoma line A549 time- dose-related upon stimulation ligand LPS. This chapter delves into pathways which TLR ligands potentially facilitate and/or spread Overall, understanding complex interplay between is devising strategies leverage these therapeutic purposes while mitigating negative consequences inflammation.

Language: Английский

Citations

2
Exploring Bioactive Phytomedicines for Advancing Pulmonary Infection Management: Insights and Future Prospects DOI Creative Commons

Joyce Siaw Syuen Ho,

Teh Li Ping,

Keshav Raj Paudel

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Pulmonary infections have a profound influence on global mortality rates. Medicinal plants offer promising approach to address this challenge, providing nontoxic alternatives with higher levels of public acceptance and compliance, particularly in regions where access conventional medications or diagnostic resources may be limited. Understanding the pathophysiology viruses bacteria enables researchers identify biomarkers essential for triggering diseases. This knowledge allows discovery biological molecules capable either preventing alleviating symptoms associated these infections. In review, medicinal that an effect COVID-19, influenza A, bacterial viral pneumonia, tuberculosis are discussed. Drug delivery has been briefly discussed as well. It examines bioactive constituents synthesizes findings from vitro, vivo, clinical studies conducted over past decade. conclusion, many can used treat pulmonary infections, but further in-depth needed most current only at preliminary stages. Extensive investigation warranted fully elucidate their mechanisms action optimize use practice.

Language: Английский

Citations

1
Short-Term Outcomes in Patients With Coexistence of COVID-19 Infection and Vitamin D Deficiency: A Large Cohort Study DOI Open Access
Yap‐Hang Chan,

Chia‐Chen Chen,

Jheng‐Yan Wu

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

Vitamin D deficiency (VDD) is prevalent worldwide and may influence the severity of infectious diseases, including COVID-19. This study aimed to evaluate association between VDD 30-day clinical outcomes in patients with

Language: Английский

Citations

1
Calcitriol prevents SARS-CoV Spike-induced inflammation in human trophoblasts through downregulating ACE2 and TMPRSS2 expression DOI
Rafael Vargas-Castro, Janice García‐Quiroz, Andrea Olmos‐Ortiz

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 245, P. 106625 - 106625

Published: Nov. 6, 2024

Language: Английский

Citations

1
The effects of vitamin D levels on physical, mental health, and sleep quality in adults: a comprehensive investigation DOI Creative Commons
Anurag Singh,

Sachin Kumar,

Shivang Mishra

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 15, 2024

Background Vitamin D, essential hormone for endocrine, autocrine, and paracrine functions. A billion people are deficient globally which contributing to numerous health issues. This study explores the link between vitamin D levels sleep quality, impacting mental physical in adults. Methods prospective cross-sectional was conducted at Nims Hospital, Jaipur, involving 484 adults’ participants. Blood samples were collected serum 25(OH) measurements. Data gathered using SF-36 ISI questionnaires assess quality. Results Higher strongly linked better health, including function ( r = 0.642, p < 0.001), general 0.560, PCS score 0.441, 0.001). also positively impacted social functioning 0.096, 0.035) negatively related scores −0.112, 0.014). Conclusion The highlights a strong higher improved with significant negative correlation scores. underscores importance of adequate overall well-being. findings call urgent measures address deficiency further research into its impacts.

Language: Английский

Citations

1