Insights into trait-association of selection signatures and adaptive eQTL in indigenous African cattle DOI Creative Commons
Juliane Friedrich, Shuli Liu, Lingzhao Fang

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 19, 2024

Abstract Background African cattle represent a unique resource of genetic diversity in response to adaptation numerous environmental challenges. Characterising the landscape indigenous and identifying genomic regions genes functional importance can contribute targeted breeding tackle loss diversity. However, pinpointing adaptive variant determining underlying mechanisms remains challenging. Results In this study, we use selection signatures from whole-genome sequence data eight breeds combination with gene expression quantitative trait loci (QTL) databases characterise targets artificial identify candidate genes. general, trait-association analyses suggest innate immune system production traits as important targets. For example, large region, identified for all except N’Dama, was located on BTA27, including multiple defensin DEFB coding-genes. Out 22 analysed tissues, under putative were significantly enriched those overexpressed adipose tissue, blood, lung, testis uterus. Our results further that cis -eQTL are themselves targets; most found positive correlation between allele frequency differences effect size, suggesting acts directly regulatory variants. Conclusions By combining information QTL, able reveal compelling did not stand out signature alone (e.g. GIMAP8 tick resistance NDUFS3 heat adaptation). Insights study will help inform maintain locally adapted, hence important, breeds.

Language: Английский

Genomic responses to climatic challenges in beef cattle: A review DOI Creative Commons
Daniele Colombi, Francesco Perini,

Stefano Bettini

et al.

Animal Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Abstract Climate change is a major concern for the near future and livestock breeding. Cattle breeding, due to its greenhouse gas emissions, one of most implicated industries. Consequently, main goals are breed animals resilient climate change, with aim lowering impact on environment selecting that will be able resist different, unsuitable, changing climates. The this literature review compare recent studies response adaptation beef cattle breeds extreme environments, in terms genes pathways involved. Beef breeding just starting implement genomics selection plans, shedding light genomic responses climates could speed up simplify these change. This discusses involved climatic stress responses, including those related extremely cold climates, dual‐purpose breeds. Genes were associated productive traits, coat skin structure development, thermotolerance, cellular physiology DNA repair mechanisms, immune system, fertility traits. knowledge resilience should taken into consideration further promote valorization local adapted environmental conditions. use or enhance social sustainability, animal welfare, production, compared introduction cosmopolitan uncertain uncontrolled areas.

Language: Английский

Citations

4
Evaluation of genetic differences between two autochthonous Spanish cattle breeds DOI Creative Commons

Paolo Milia,

Alberto Cesarani, Clara Díaz

et al.

Italian Journal of Animal Science, Journal Year: 2025, Volume and Issue: 24(1), P. 361 - 375

Published: Jan. 24, 2025

Language: Английский

Citations

0
Divergent adaptation to highland and tropical environments in Bolivian Creole cattle DOI
Olivia Marcuzzi,

Paulo Álvarez Cecco,

Leónidas H. Olivera

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149354 - 149354

Published: Feb. 1, 2025

Language: Английский

Citations

0
Precision of dairy farming: navigating challenges and seizing opportunities for sustainable dairy production in Africa DOI Creative Commons

Etsemeskel Tadele,

Destaw Worku,

Dessie Yigzaw

et al.

Frontiers in Animal Science, Journal Year: 2025, Volume and Issue: 6

Published: March 4, 2025

Precision Dairy Farming encompasses applying sophisticated technologies and data-centric methodologies to enhance the efficiency, productivity, sustainability of dairy production. The objectives this review focus on precision farming; exploring role in transforming Africa’s sector, navigating challenges that hinder adoption Africa, seizing opportunities can be leveraged for sustainable growth farming. include wearable sensors, automated milking systems, feeding systems (automated dispensers), environmental monitoring cooling milk analyzers somatic cell counters, geospatial tools GPS-Enabled Grazing Management, mobile apps farm management data analysis. According different research results technology led a 30% increase yield, 25% reduction feed costs, 20% decrease veterinary expenses. Also, it is important improve animal health monitoring, decision-making, reduce workloads, financial security. farming Africa faces range economic, social, limit its potential, despite significant expansion opportunities. These due high cost technology, limited access finance, infrastructural limitations, low digital literacy training farmers, collection challenges, lack adapted African conditions policy market Constraints making hard small farmers adopt new their productivity. have opportunity such as, improving Animal welfare, empowering smallholder with solutions, supporting economic rural livelihoods, meeting growing demand Products, driving protection, enhancing public-private partnerships strengthening supply chain resilience. By embracing technologies, investing education, cooperative structures, access, frameworks, stakeholders collectively transform sector into resilient industry.

Language: Английский

Citations

0
Whole genome insights into genetic diversity, introgression, and adaptation of Yunnan indigenous cattle of Southwestern China DOI Creative Commons
Xiwen Guan,

Weixuan Xiang,

Kaixing Qu

et al.

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 4, 2025

Yunnan Province, located in Southwestern China, the intricate geography, variable climate, and abundant vegetation of region have collectively contributed to shaping distinctive germplasm characteristics observed indigenous cattle through prolonged domestication. The different breeds exhibit distinct advantageous traits, which are an important source genetic variation because they might carry alleles that enable them adapt local environment tough feeding conditions. However, a comprehensive genomic landscape resources has yet be delineated. Herein, we employed 140 whole-genome sequencing data from across eight elucidate their diversity population structure. Utilizing both uniparental biparental markers, elucidated composition cattle, is closely correlated with geographic environment. A predominant East Asian indicine ancestry gradually diminishes towards north. analysis revealed high among populations low-to-moderate inbreeding coefficient, underscoring rich reservoir breeds. Additionally, gene flow between wild Bos species around was verified, highlighting localized introgression Gayal as critical factor successful adaptation hot humid environments. Our findings established SNPs database for facilitating resource conservation selective breeding. Moreover, these valuable insights into adaptive history contribute significantly our understanding evolutionary dynamics offer foundation future improvement strategies.

Language: Английский

Citations

0
Whole Genome Scan Uncovers Candidate Genes Related to Milk Production Traits in Barka Cattle DOI Open Access
Wondossen Ayalew,

Xiaoyun Wu,

Getinet Mekuriaw Tarekegn

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6142 - 6142

Published: June 2, 2024

In this study, our primary aim was to explore the genomic landscape of Barka cattle, a breed recognized for high milk production in semi-arid environment, by focusing on genes with known roles traits. We employed genome-wide analysis and three selective sweep detection methods (ZFST, θπ ratio, ZHp) identify candidate associated composition Notably, ACAA1, P4HTM, SLC4A4 were consistently identified all methods. Functional annotation highlighted their crucial biological processes such as fatty acid metabolism, mammary gland development, protein synthesis. These findings contribute understanding genetic basis presenting opportunities enhancing dairy cattle tropical climates. Further validation through association studies transcriptomic analyses is essential fully exploit these breeding improvement cattle.

Language: Английский

Citations

2
Genomic Reference Resource for African Cattle: Genome Sequences and High-Density Array Variants DOI Creative Commons
Abdulfatai Tijjani, Sumaya Kambal, Endashaw Terefe

et al.

Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: July 19, 2024

Abstract The diversity in genome resources is fundamental to designing genomic strategies for local breed improvement and utilisation. These also support gene discovery enhance our understanding of the mechanisms resilience with applications beyond breeds. Here, we report sequences 555 cattle (208 which comprise new data) high-density (HD) array genotyping 1,082 samples (537 samples) from indigenous African populations. have an average coverage ~30X, three times higher than (~10X) over 300 already public domain. Following variant quality checks, identified approximately 32.3 million sequence variants 661,943 HD autosomal mapped Bos taurus reference (ARS-UCD1.2). datasets were generated as part Centre Tropical Livestock Genetics Health (CTLGH) Genomic Reference Resource Cattle (GRRFAC) initiative, aspires facilitate generation this livestock resource hopes its utilisation complete characterisation sustainable global improvement.

Language: Английский

Citations

2
Reproduction Efficiency of Native and Imported Algerian Cattle Under Challenging Climatic Conditions DOI Creative Commons
Aziza Ferag, Djallel Eddine Gherissi, Tarek Khenenou

et al.

Published: Nov. 14, 2024

This study examined the impact of climate change, specifically Temperature–Humidity Index (THI), on local "Brune de l'Atlas" cows and imported dairy breeds (Prim'Holstein Montbéliarde) in Algeria. Data from 24,773 artificial insemination records 12,726 between 2016 2019 were analyzed for fertility traits such as conception rate at first AI (CR1stAI), services per conception, reproductive period (RP). The results indicated no significant THI CR1stAI breed, though > 72 lowered breeds. significantly increased number but did not affect RP. Local showed superior efficiency under high THI, likely due to genetic differences.

Language: Английский

Citations

1
Genome-wide local ancestry and the functional consequences of admixture in African and European cattle populations DOI Creative Commons
Gillian P. McHugo, James A. Ward, Said I. Ng’ang’a

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Abstract Bos taurus (taurine) and indicus (indicine) cattle diverged at least 150,000 years ago and, since that time, substantial genomic differences have evolved between the two lineages. During last millennia, genetic exchange in Africa has resulted a complex tapestry of taurine-indicine ancestry, with most populations exhibiting varying levels admixture. Similarly, there are several Southern European also show evidence for historical gene flow from indicine cattle, highest which found Central Italian White breeds. Here we use different software tools (MOSAIC ELAI) local ancestry inference (LAI) genome-wide high-and low-density SNP array data sets hybrid African obtained broadly similar results despite critical LAI methodologies used. Our analyses identified regions elevated retained or introgressed taurine, Asian Functional enrichment genes underlying these peaks highlighted biological processes relating to immunobiology olfaction, some may relate differing susceptibilities infectious diseases, including bovine tuberculosis, East Coast fever, tropical theileriosis. Notably, taurine admixed trypanotolerant observed associated haemoglobin oxygen transport. This reflect positive selection variants enhance control severe anaemia, debilitating feature trypanosomiasis disease, severely constrains agriculture across much sub-Saharan Africa.

Language: Английский

Citations

0
Genome-wide local ancestry and the functional consequences of admixture in African and European cattle populations DOI Creative Commons
David E. MacHugh, Gillian P. McHugo, James A. Ward

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Bos taurus (taurine) and indicus (indicine) cattle diverged at least 150,000 years ago and, since that time, substantial genomic differences have evolved between the two lineages. During last millennia, genetic exchange in Africa has resulted a complex tapestry of taurine-indicine ancestry, with most populations exhibiting varying levels admixture. Similarly, there are several Southern European also show evidence for historical gene flow from indicine cattle, highest which found Central Italian White breeds. Here we use different software tools (MOSAIC ELAI) local ancestry inference (LAI) genome-wide high- low-density SNP array data sets hybrid African obtained broadly similar results despite critical LAI methodologies used. Our analyses identified regions elevated retained or introgressed taurine, Asian Functional enrichment genes underlying these peaks highlighted biological processes relating to immunobiology olfaction, some may relate differing susceptibilities infectious diseases, including bovine tuberculosis, East Coast fever, tropical theileriosis. Notably, taurine admixed trypanotolerant observed associated haemoglobin oxygen transport. This reflect positive selection variants enhance control severe anaemia, debilitating feature trypanosomiasis disease, severely constrains agriculture across much sub-Saharan Africa.

Language: Английский

Citations

0