Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 27, 2022

SARS-CoV-2 infected pregnant women are at increased risk of severe COVID-19 than non-pregnant and have a higher adverse pregnancy outcomes like intrauterine/fetal distress preterm birth. However, little is known about the impact infection on maternal neonatal immunological profiles. In this study, we investigated inflammatory humoral responses to in cord blood paired samples. Thirty-six were recruited delivery Hospital Sant Joan de Déu, Barcelona, Spain, between April-August 2020, before having available vaccines. Maternal variables, as well perinatal outcomes, recorded questionnaires. Nasopharyngeal swabs samples collected for detection by rRT-PCR serology, respectively. We measured IgM, IgG IgA levels 6 antigens (spike [S], S1, S2, receptor-binding domain [RBD], nucleocapsid [N] full-length C-terminus), N from 4 human coronaviruses (OC43, HKU1, 229E NL63), concentrations 30 cytokines, chemokines growth factors Luminex. Mothers classified or non-infected based serology results. Sixty-four % with (positive during third trimester and/or just after delivery). None newborns tested positive rRT-PCR. mothers had virus-specific antibodies several cytokines. Those symptoms cytokine levels. IFN-α was mothers, symptomatic EGF, FGF, IL-17 IL-15 increased, whereas RANTES decreased. showed correlations their counterparts blood. lower transfer SARS-CoV-2-specific IgGs, stronger effect when closer delivery. carrying male fetus antibody IL-7 concentrations. Our results show that induces robust response causes significant reduction IgGs transplacental transfer, negative

Language: Английский

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The effects of COVID-19 on placental morphology

Placenta, Journal Year: 2023, Volume and Issue: 138, P. 88 - 96

Published: May 17, 2023

Language: Английский

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Perinatal Outcomes of Newborns of COVID-19-Infected Pregnant Women: An Updated Systematic Review and Meta-Analysis

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 16, 2024

In this systematic review and meta-analysis, we aimed to the characteristics outcomes of newborns Coronavirus disease 2019 (COVID-19) infected pregnant women. We conducted an online bibliographic search using following electronic databases: MEDLINE via PubMed, Scopus, Web Science, Cochrane Central. Studies were deemed eligible if they recruited from mothers with confirmed COVID-19 reported perinatal neonatal cases. A total 20 studies included. Neonates born positive results have been shown significantly lower birth weights (mean difference, MD = -48.54 g, p 0.04), increased risks fetal distress (odds ratio, OR 1.76, < 0.00001), respiratory (OR 1.96, 0.006), premature 2.08, death 2.20, 0.004), a 5-minute Apgar score 1.44, 0.02). Additionally, more likely be admitted intensive care unit (NICU) 2.25, 0.007) test for themselves 9.88, 0.03). However, other parameters, such as malformations, mechanical ventilation, hypoglycemia, sepsis, appeared comparable between two groups. Maternal infection during pregnancy is associated several outcomes, some which are adverse others that do not show significant deviation norms. While our meta-analysis clearly illustrates heightened birth, reduced weight, challenges, it also emphasizes all can directly attributed maternal SARS-CoV-2 infection.

Language: Английский

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Guidelines for Pregnancy Management During the COVID-19 Pandemic: A Public Health Conundrum

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(21), P. 8277 - 8277

Published: Nov. 9, 2020

Pregnant women seem to be at risk for developing complications from COVID-19. Given the limited knowledge about impact of COVID-19 on pregnancy, management guidelines are fundamental. Our aim was examine obstetrics released December 2019 April 2020 compare their recommendations and assess how useful they could maternal health workers. We reviewed 11 management, assessing four domains: (1) timeliness: time between declaration pandemics by WHO a guideline release update; (2) accessibility: readiness access searching it common browser; (3) completeness: amount foundational topics covered; (4) consistency: agreement among different guidelines. In terms timeliness, Royal College Obstetricians Gynaecologists (RCOG) first organization recommendation. Only were accessible with one click, while only 6/11 covered more than 80% 30 we identified. For consistency, study highlights existence 10 points conflict recommendations. The present research revealed lack uniformity resulting in potentially challenging decisions healthcare providers.

Language: Английский

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Pregnancy alters interleukin-1 beta expression and antiviral antibody responses during severe acute respiratory syndrome coronavirus 2 infection

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 225(3), P. 301.e1 - 301.e14

Published: March 30, 2021

Severe acute respiratory syndrome coronavirus 2, the disease-causing pathogen of disease 2019 pandemic, has resulted in morbidity and mortality worldwide. Pregnant women are more susceptible to severe at higher risk preterm birth than uninfected pregnant women. Despite this evidence, immunologic effects 2 infection during pregnancy remain understudied.

Language: Английский

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Pregnant people deserve the protection offered by SARS-CoV-2 vaccines

Vaccine, Journal Year: 2020, Volume and Issue: 39(2), P. 171 - 172

Published: Dec. 4, 2020

Language: Английский

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Dysregulated immunity in SARS-CoV-2 infected pregnant women

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: Nov. 16, 2020

Abstract Importance The effects of SARS-CoV-2 infection on immune responses during pregnancy have not been systematically evaluated. Objective To assess the impact inflammatory and humoral in maternal fetal samples compare antibody to among pregnant non-pregnant women. Design Immune were analyzed using from women who had either tested positive or negative for SARS-CoV-2. We measured, proinflammatory placental cytokine mRNAs, neonatal Fc receptor (FcRn) expression, tetanus transfer cord blood samples. Additionally, we measured anti-spike (S) IgG, anti-S-receptor binding domain (RBD) neutralizing (nAb) serum plasma collected women, blood. Setting Johns Hopkins Hospital (JHH) Participants Pregnant recruited through JHH outpatient obstetric clinics Labor & Delivery unit. Non-pregnant after receiving testing within Health System, USA. Adult with RT-PCR results SARS-CoV-2, age range 18-48 years, included study. Exposures Main Outcomes Measures Participant demographic characteristics, titers, mRNA FcRn expression. Results SARS-COV-2 expressed more IL1β , but IL6 14 days versus > a confirmed test, similar patterns observed side placentas, particularly asymptomatic also reduced anti-S-RBD IgG titers less likely detectable nAb as compared Although did disrupt expression placenta, was inhibited by pregnancy. Conclusions Relevance characterized inflammation antiviral responses, which may efficacy COVID-19 therapeutics long-term implications health requires greater consideration.

Language: Английский

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Maternal COVID-19 and neonatal hearing loss: a multicentric survey

European Archives of Oto-Rhino-Laryngology, Journal Year: 2021, Volume and Issue: 279(7), P. 3435 - 3438

Published: Oct. 2, 2021

Language: Английский

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SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface

NeuroImmunoModulation, Journal Year: 2021, Volume and Issue: 28(1), P. 1 - 21

Published: Jan. 1, 2021

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has devastating effects on the population worldwide. Given this scenario, extent of impact more vulnerable individuals, such as pregnant women, is great concern. Although pregnancy may be a risk factor in virus infections, there are no considerable differences regarding COVID-19 severity observed between and nonpregnant women. In these circumstances, an emergent concern possibility neurodevelopmental neuropsychiatric harm for offspring infected mothers. Currently, stronger evidence indicating vertical transmission SARS-CoV-2; however, exacerbated inflammatory response could lead to several impairments offspring’s brain. Furthermore, face historical knowledge possible long-term consequences progeny’s brain after infection viruses, we must consider that might another deleterious facet COVID-19. light neuroimmune interactions at maternal-fetal interface, review here harmful outcomes brains mothers SARS-CoV-2.

Language: Английский

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Genome-wide neonatal epigenetic changes associated with maternal exposure to the COVID-19 pandemic

BMC Medical Genomics, Journal Year: 2023, Volume and Issue: 16(1)

Published: Oct. 30, 2023

Abstract Background During gestation, stressors to the fetus, including viral exposure or maternal psychological distress, can fundamentally alter neonatal epigenome, and may be associated with long-term impaired developmental outcomes. The impact of in utero COVID-19 pandemic on newborn epigenome has yet described. Methods This study aimed determine whether there are unique epigenetic signatures newborns who experienced otherwise healthy pregnancies that occurred during (Project RESCUE). pre-pandemic control cohorts RESCUE) included this part a prospective observational longitudinal cohort evaluates elevated prenatal stress early childhood neurodevelopment. Using buccal swabs collected at birth, differential DNA methylation analysis was performed using Infinium MethylationEPIC arrays linear regression analysis. Pathway gene ontology enrichment were resultant lists. Results Widespread found between neonates exposed neonates. In contrast, no apparent differences infection pregnancy. Differential observed among genomic sites underpin important neurological pathways have been previously reported literature differentially methylated because stress, such as NR3C1 . Conclusions present reveals potential associations pregnancy subsequent changes epigenome. While finding warrants further investigation, it is point should considered any assessing studies obtained period, even pregnancies.

Language: Английский

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