MODULATION OF IMMUNITY AND BARRIER FUNCTION IN PRE- AND POSTNATAL ANIMAL ONTOGENESIS. PHYSIOLOGICAL ASPECTS OF NATURAL RESISTANCE IN SOWS DOI Open Access
D. М. Masiuk, V. S. Nedzvetsky, А. В. Кокарєв

et al.

Published: Jan. 1, 2023

The main task for the effective breeding of productive animals is obtaining viable offspring and ensuring appropriate functional status organism during all stages ontogenesis 1 .The most important while development a period early postnatal adaptation 234 .In Ukrainian pig farms, this time one periods when high percentage neonatal piglet mortality observed 5 .One reasons problem caused with non-infectious pathology digestive respiratory tracts 6 .This due to low level innate immunity increase some technological limitations, stress induced by various etiologic factors, disruptions in technology rearing sow.The combined effect these factors leads destruction fetal development, lack colostrum quality, accompanied immunodeficiency changes newborn piglets 7 .1 Oster, M.

Language: Английский

Effects of autologous platelet-rich plasma intrauterine perfusion on clinical outcomes in recurrent implantation failure patients with non-thin endometrium undergoing frozen-thawed embryo transfer DOI Creative Commons
Xiaohui Liu,

Lixia He,

Man Li

et al.

Archives of Gynecology and Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

To explore the effects of autologous platelet-rich plasma (PRP) intrauterine perfusion on clinical outcomes in recurrent implantation failure (RIF) patients with non-thin endometrium undergoing frozen-thawed embryo transfer (FET), and PRP used at different times before FET outcomes. A total 160 RIF were retrospectively analyzed. Among them, 82 received 24–72 h (PRP group), 78 did not (non-PRP group). In group, 59 underwent 24–48 (≥ 24 to ≤ 48 23 was 48–72 (> 72 The compared, including β-hCG positive rate, pregnancy abortion ectopic live birth rate incidence adverse events. group significantly higher than those non-PRP (P < 0.05), there no statistical differences between two groups > 0.05). Meanwhile, events occurred group. However, C-type observably day (Χ2 = 8.309, P 0.004), though difference endometrial thickness multiple logistics regression analysis showed that are closely related (OR: 2.379, 95% CI 1.137–4.977, 0.021; OR: 2.107, 1.006–4.412, 0.048). Moreover, we found significant ≥ except for rate. can safely effectively improve possibly by increasing day. addition, does affect outcomes, which will be helpful guide work flexibly.

Language: Английский

Citations

0
Interleukin 17 RA and RC gene polymorphisms and increased preeclampsia risk: Single and combined genetic analysis DOI
Mohammad Amin Norouzi, Danial Jahantigh, Forough Forghani

et al.

Human Immunology, Journal Year: 2025, Volume and Issue: 86(2), P. 111250 - 111250

Published: Feb. 4, 2025

Language: Английский

Citations

0
A Review of Dietary and Lifestyle Management of Pre-Eclampsia and Postpartum Eclampsia DOI Creative Commons
M.Y. Nadeem, Komal Javed,

Hafiz Muhammad Rizwan Abid

et al.

Preventive Nutrition and Food Science, Journal Year: 2025, Volume and Issue: 30(1), P. 1 - 20

Published: Feb. 28, 2025

Eclampsia is a prevailing hypertensive disorder that poses more significant risks to mothers and neonates globally. This review aimed investigate eclampsia [preeclampsia postpartum (posteclampsia)] the supportive role of dietary lifestyle management. The was compiled by searching various engines such as Google Scholar, Research Gate, BASE, PubMed Central, National Center for Biotechnology Information, other related search engines. believed involve genetic nongenetic factors, although precise underlying mechanism remains unclear. Nevertheless, traditional diagnosis typically involves coexistence factors an unhealthy lifestyle, diabetes mellitus, hypertension, low micronutrient levels, obesity, proteinuria. Consuming at least 330 g fresh or 4 dried fruits daily minimizes preeclampsia. Diets high in sugar, fat, salt are associated with higher vulnerability disease. Calcium supplementation beneficial women it helps reduce occurrence Evidence vitamin D inconclusive requires further research. Selenium has shown negative correlation chance Dietary patterns intakes plant-based diet, including micronutrients, healthy significantly risk preeclampsia posteclampsia. Furthermore, clinical trials could explore potential benefits supplements preventing treating eclampsia. There need exploration into personalized medical nutrition therapy Lastly, modern prognostic tools can diagnose disorders promptly help effective medicinal nutritional

Language: Английский

Citations

0
Comparison of immune‐related gene signatures and immune infiltration features in early‐ and late‐onset preeclampsia DOI

Quanfeng Wu,

Ying Xiang,

Weiwei Yu

et al.

The Journal of Gene Medicine, Journal Year: 2024, Volume and Issue: 26(2)

Published: Feb. 1, 2024

Abstract Background Preeclampsia, a severe pregnancy syndrome, is widely accepted divided into early‐ and late‐onset preeclampsia (EOPE LOPE) based on the onset time of preeclampsia, with distinct pathophysiological origins. However, molecular mechanism especially immune‐related mechanisms for EOPE LOPE currently obscure. In present study, we focused placental immune alterations between search biomarkers that could potentially serve as potential therapeutic targets through bioinformatic analysis. Methods The gene expression profiling data was obtained from Gene Expression Omnibus database. ESTIMATE algorithm Set Enrichment Analysis were employed to evaluate status. intersection differentially expressed genes in GSE74341 series set screened genes. Protein–protein interaction network random forest used identify hub validation by quantitative real‐time PCR. Kyoto Encyclopedia Genes Genomes pathways, Ontology variation analysis utilized conduct biological function pathway enrichment analyses. Single‐sample CIBERSORTx tools calculate cell infiltration score. Correlation analyses evaluated Pearson correlation Hub genes‐miRNA performed NetworkAnalyst online tool. Results Immune score stromal all lower samples. system‐related significantly downregulated compared Four ( IL15 , GZMB IL1B CXCL12 ) identified protein–protein forest. Quantitative polymerase chain reaction validated levels four found innate adaptive cells apparent lacking samples Cytokine‐cytokine receptor, para‐inflammation, major histocompatibility complex class I T co‐stimulation pathways deficient highly correlated We constructed regulatory network, revealing hsa‐miR‐374a‐5p, hsa‐miR‐203a‐3p, hsa‐miR‐128‐3p, hsa‐miR‐155‐3p, hsa‐miR‐129‐2‐3p hsa‐miR‐7‐5p. Conclusions systems severely impaired placentas EOPE. closely pathogenesis result our study may provide new basis discriminating acknowledging role landscape eventual interference tailored treatment

Language: Английский

Citations

2
Bridging the divide: unveiling mutual immunological pathways of cancer and pregnancy DOI

Teodora Maria Toadere,

Andra Țichindeleanu,

Daniela Andreea Bondor

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(5), P. 793 - 807

Published: March 16, 2024

Language: Английский

Citations

2
Unveiling immune tolerance pathways in preeclampsia placenta: implications for molecular targets and discovery of potential biomarkers DOI Creative Commons
Yantuanjin Ma, Xingli Deng,

Ru Shen

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 4, 2024

During pregnancy, there is a link between disruption of maternal immune tolerance and preeclampsia, but the molecular mechanisms that regulate fetal remain unclear. This study employs bioinformatics to identify new markers related placental explore their potential role in predicting preeclampsia. Analyzing preeclampsia-related gene expression profiles Gene Expression Omnibus (GEO) dataset reveals 211 differentially expressed genes (DEGs) placenta, mainly influencing cell differentiation response pathways. Employing weighted co-expression network analysis (WGCNA) lasso regression, four target (ANKRD37, CRH, LEP, SIGLEC6) are identified for prediction Validation using GSE4707 confirmed diagnostic predictive these candidate genes. RT-qPCR verified up-regulation while ELISA showed correlation with factors associated tolerance. As result this study, identifies biomarkers immunity contributes understanding mechanism

Language: Английский

Citations

2
Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders DOI Creative Commons
Jun Zhou, Ping Yan, Wenxue Ma

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
Vitamin D regulates microflora and ameliorates LPS-induced placental inflammation in rats DOI
Yantuanjin Ma, Yuhang Zhang,

Qiuyue He

et al.

Physiological Genomics, Journal Year: 2023, Volume and Issue: 55(7), P. 286 - 296

Published: April 24, 2023

Preeclampsia is a pregnancy-specific disease, which has become an essential cause of perinatal and neonatal death. Gut microflora becomes the regulator host immunity through metabolic pathway. Epidemiological studies provide convincing evidence that vitamin D supplementation can prevent onset preeclampsia. However, research on microbial mechanisms effective treatment strategies for placental inflammation induced by lipopolysaccharide lacking. In this study, pregnant rats were LPS to establish rat model Sixteen-sequence analysis was used determine composition in feces. addition, protective effect LPS-preeclampsia evaluated. The results showed blood pressure creatinine group significantly higher than those control group. disturbed intestinal community reduced diversity. Vitamin improves symptoms preeclampsia, increases abundance beneficial flora, normalizes level inflammatory factors LPS-induced inhibiting TLR4/MYD88/NF-κB pathway, effectively resists disturbance uterine spiral artery remodeling LPS. This study established D-mediated their inhibition are potential therapeutic targets

Language: Английский

Citations

6
Combined maternal KIR2DL4 and fetal HLA-G polymorphisms were associated with preeclampsia in a Han Chinese population DOI Creative Commons
Yantuanjin Ma, Yuan Qian, Hong Jiang

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: July 31, 2024

Preeclampsia is the main cause of maternal and infant mortality morbidity during pregnancy. Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) human leukocyte antigen G (HLA-G) play crucial roles in immune tolerance at maternal-fetal interface. In this case‒control study, 154 maternal–fetal pairs were recruited, including 74 with preeclampsia (56 from family triads) 80 a normal pregnancy (78 triads). SNaPshot technology was used to detect genetic polymorphisms for 7 TagSNPs KIR2DL4 HLA-G genes. Among fetal gene polymorphisms, rs9380142 (A vs. G: OR = 2.802, 95% CI 1.761–4.458) rs1063320 (G C: 1.807, 1.144–2.852) differed between group control group. The transmission disequilibrium test (TDT) suggested that differences rs9380142G/A polymorphism foetuses triads due parents ( P 0.001). There no significant difference distribution alleles or genotype frequency Gene‒gene interaction analysis revealed combined genotypes rs649216-CC rs9380142-GG, rs1051456-CG/GG rs34785252-CC rs9380142-AA/GA, rs34785252-CC/AA rs9380142-GG associated significantly lower risk preeclampsia. Therefore, study combination Han Chinese population.

Language: Английский

Citations

1
The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring DOI Creative Commons

Chunxiang Shen,

Xinyi Zhu, Hao Chang

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(10), P. 114787 - 114787

Published: Sept. 24, 2024

Language: Английский

Citations

1