Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study

Journal of Neurology, Journal Year: 2021, Volume and Issue: 269(2), P. 587 - 596

Published: Aug. 12, 2021

Abstract The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may a possible complication in post-COVID individuals. Orthostatic hypotension (OH) postural tachycardia syndrome (POTS) have been suggested to common after SARS-CoV-2 infection, but other components of ANS function also impaired. Composite Autonomic Symptom Scale 31 (COMPASS-31) questionnaire is simple validated tool assess dysautonomic symptoms. aim the present study was administer COMPASS-31 sample patients with without neurological complaints. Participants were recruited among ambulatory services for follow-up evaluation between 4 weeks 9 months from COVID-19 symptoms onset. asked complete referring period disease. Heart rate blood pressure manually taken during an active stand test OH POTS diagnosis. One-hundred eighty participants included analysis (70.6% females, 51 ± 13 years), found 13.8% subjects. Median score 17.6 (6.9–31.4), most domains being orthostatic intolerance, sudomotor, gastrointestinal pupillomotor dysfunction. A higher those ( p < 0.01), due more severe intolerance although urinary 0.01) represented non-neurological group. This confirms importance monitoring as disease that persist post-acute period.

Language: Английский

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The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(6), P. 1241 - 1274

Published: Jan. 25, 2023

Language: Английский

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Future perspectives for PDE5 inhibitors bridging the gap between cardiovascular health and psychological status

Basic and Clinical Andrology, Journal Year: 2025, Volume and Issue: 35(1)

Published: Jan. 26, 2025

Abstract The serendipitous discovery that inhibiting type 5 phosphodiesterase (PDE5) using sildenafil, a potent PDE5 inhibitor (PDE5i) initially developed for cardioprotection, introduced the possibility of orally managing erectile dysfunction (ED) led to an increase in research data, which are currently considered groundbreaking new discipline sexual medicine. Findings from number laboratories and clinics around world unanimously demonstrated following: (i) major cause ED is directly or indirectly related cardiovascular disease (CVD); (ii) CVDs share same risk factors, mainly lifestyle choices; (iii) first therapeutic approach both transform harmful lifestyles into virtuous lifestyles; (iv) PDE5is general, particularly very safe, if not protective, use CVD patients. However, has faced several challenges. Many patients some healthcare providers (HCPs) often misconception these drugs can CVD. Some might desire fulfill unmet need privacy linked stigma being treated be enticed by idea buying online, either because shame cheaper prices, without knowing risks associated with counterfeit drugs. aim this narrative revision current literature demonstrate orodispersible film sildenafil safe CV perspective; it discreet formulation respects privacy; virtually unique PDE5i too expensive produce outside correct channels, making impossible counterfeit.

Language: Английский

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Impact of the SARS‐CoV‐2 virus on male reproductive health

BJU International, Journal Year: 2021, Volume and Issue: 129(2), P. 143 - 150

Published: Aug. 17, 2021

The coronavirus 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome 2 (SARS-CoV-2) has led to more than 160 million infections and 3.5 deaths globally. Men are disproportionately affected COVID-19, having disease with higher mortality rates women. Androgens have been implicated as underlying cause for disease, androgen receptor noted upregulate cell surface receptors that mediate viral entry infection. Unfortunately, despite testosterone's potential role in COVID-19 prognosis, deprivation therapy is neither protective nor a treatment COVID-19. Interestingly, male reproductive organs found be vulnerable moderate illness, leading reports of erectile dysfunction orchitis. particles identified penile testis tissue, both live patients who recovered from post mortem men succumbed disease. Although sexual transmission remains unlikely men, infection can lead germ Leydig depletion, decreased spermatogenesis hypogonadism. objective this review describe impact SARS-CoV-2 on health. There still many unanswered questions specific mechanisms which impacts long-term sequelae

Language: Английский

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Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 113, P. 109428 - 109428

Published: Nov. 7, 2022

Language: Английский

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Microbiota and COVID-19: Long-term and complex influencing factors

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 12, 2022

The coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory syndrome 2 (SARS-CoV-2). According to the World Health Organization statistics, more than 500 million individuals have been infected and 6 deaths resulted worldwide. Although COVID-19 mainly affects system, considerable evidence shows that digestive, cardiovascular, nervous, reproductive systems can all be involved. Angiotensin-converting enzyme (AEC2), target of SARS-CoV-2 invasion host distributed in gastrointestinal tract. Studies found microbiota contributes onset progression many diseases, including COVID-19. Here, we firstly conclude characterization respiratory, gut, oral microbial dysbiosis, bacteria, fungi, viruses. Then explore potential mechanisms involvement Microbial dysbiosis could influence complex interactions with immunity. Moreover, may impact on through their metabolites or modulation ACE2 expression. Subsequently, generalize as diagnostic markers for patients its possible association post-acute (PACS) relapse after recovery. Finally, proposed directed microbiota-targeted treatments from perspective gut microecology such probiotics prebiotics, fecal transplantation antibiotics, other interventions traditional Chinese medicine, vaccines, ACE2-based treatments.

Language: Английский

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Tip of the iceberg: erectile dysfunction and COVID-19

International Journal of Impotence Research, Journal Year: 2022, Volume and Issue: 34(2), P. 152 - 157

Published: Feb. 12, 2022

Language: Английский

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Could SARS‐CoV‐2 infection affect male fertility and sexuality?

Apmis, Journal Year: 2022, Volume and Issue: 130(5), P. 243 - 252

Published: Feb. 3, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the cause of infectious disease (COVID‐19) and has rapidly spread worldwide, causing serious problems to healthcare systems many countries hundreds thousand deaths. In this review we discuss data from literature understand whether various districts male reproductive system may represent another vulnerable target for SARS‐CoV‐2. Studies were searched electronic databases such as Google Scholar, PubMed, Scopus, COVID‐19 specific LitCovid, until July 31, 2021. It appears that SARS‐CoV‐2 virus infection not only causes damage system, but could have a impact on patients modulating physiological processes. Like some other infections, also leads worsening semen quality an increase in oxidative stress (OS) levels. However, due limited number studies, it unclear deterioration parameters temporary or lasts over time. certainly important patients' function monitored after avoid health future.

Language: Английский

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Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 46(1), P. 89 - 101

Published: Aug. 9, 2022

Abstract Purpose While SARS-CoV-2 infection appears not to be clinically evident in the testes, indirect inflammatory effects and fever may impair testicular function. To date, few long-term data of semen parameters impairment after recovery comprehensive andrological evaluation recovered patients has been published. The purpose this study was investigate whether affect male reproductive health. Methods Eighty were recruited three months COVID-19 recovery. They performed physical examination, ultrasound, analysis, sperm DNA integrity (TUNEL), anti-sperm antibodies (ASA) testing, sex hormone profile (Total testosterone, LH, FSH). In addition, all administered International Index Erectile Function questionnaire (IIEF-15). Sperm compared with two age-matched healthy pre-COVID-19 control groups normozoospermic (CTR1) primary infertile (CTR2) subjects. Results Median values from subjects within WHO 2010 fifth percentile. Mean percentage fragmentation (%SDF) 14.1 ± 7.0%. Gelatin Agglutination Test ( GAT ) positive 3.9% blood serum samples, but no plasma sample found. Only five (6.2%) had total testosterone levels below laboratory reference range. bilateral volume 31.5 9.6 ml. dysfunction detected 30% Conclusion Our remark that does seem cause direct damage function, while transient. It is possible counsel couples postpone research parenthood or ART procedures around infection.

Language: Английский

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Long-COVID Syndrome and the Cardiovascular System: A Review of Neurocardiologic Effects on Multiple Systems

Current Cardiology Reports, Journal Year: 2022, Volume and Issue: 24(11), P. 1711 - 1726

Published: Sept. 30, 2022

Language: Английский

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