Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus

Neuropharmacology, Journal Year: 2018, Volume and Issue: 143, P. 163 - 175

Published: Sept. 28, 2018

Language: Английский

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Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment

Life Sciences, Journal Year: 2019, Volume and Issue: 224, P. 120 - 127

Published: March 22, 2019

Language: Английский

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Gender Differences in Risk Factors for Adolescent Binge Drinking and Implications for Intervention and Prevention

Frontiers in Psychiatry, Journal Year: 2017, Volume and Issue: 8

Published: Dec. 21, 2017

Alcohol use, particularly binge drinking, is a major public health concern among adolescents. Recent national data show that the gender gap in alcohol use lessening, and drinking girls rising. Considering increase adolescent girls, as well females' increased risk of experiencing more severe biopsychosocial negative effects consequences from current review sought to examine differences factors for drinking. The highlights (1) developmental-related neurobiological vulnerability (2) psychiatric comorbidity phenotypes (3) social-related adolescents, considerations prevention intervention. Most information gleaned thus far has come preclinical research. However, it expected that, with recent advances clinical imaging technology, observed lower mammals will be confirmed humans vice versa. A synthesis literature males females experience unique paths development, although there debate regarding specific nature these differences, suggests turn influence For one, are susceptible stress, depression, other internalizing behaviors, turn, symptoms contribute their On hand, males, given across lifespan driven by an externalizing phenotype part, due development occur adolescence. With respect social domains, peer influences important both females, differences. example, may sensitive pressure peers fit impress others, while male role stereotypes factor boys. Given female further research exploring factors, tailoring intervention prevention, necessary. Although

Language: Английский

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Cannabinoid Regulation of Fear and Anxiety: an Update

Current Psychiatry Reports, Journal Year: 2019, Volume and Issue: 21(6)

Published: April 27, 2019

Anxiety- and trauma-related disorders are prevalent debilitating mental illnesses associated with a significant socioeconomic burden. Current treatment approaches often have inadequate therapeutic responses, leading to symptom relapse. Here we review recent preclinical clinical findings on the potential of cannabinoids as novel therapeutics for regulating fear anxiety.Evidence from studies has shown that non-psychotropic phytocannabinoid cannabidiol endocannabinoid anandamide acute anxiolytic effects also regulate learned by dampening its expression, enhancing extinction disrupting reconsolidation. The relevant literature still very preliminary but nonetheless encouraging. Based this evidence, larger-scale placebo-controlled warranted investigate in particular an adjunct psychological therapy or medication determine utility treating anxiety-related future.

Language: Английский

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Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Oct. 2, 2020

Abstract Background Cannabis has been documented for use in alleviating anxiety. However, certain research also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ 9 -tetrahydrocannabinol (THC) associated with an anxiogenic response, while anxiolytic activity attributed mainly to cannabidiol (CBD). animal studies, the effects THC are highly dose-dependent, biphasic cannabinoids on anxiety-related responses have extensively documented. A more precise assessment is required both potentials phytocannabinoids, aim towards development ‘holy grail’ cannabis research, a medicinally-active formulation which may assist treatment anxiety or mood disorders without eliciting any effects. Objectives To systematically review studies assessing cannabinoid interventions (e.g. CBD whole interventions) animals as well recent epidemiological reporting from consumption. Method The articles selected this were identified up January 2020 through searches electronic databases OVID MEDLINE, Cochrane Central Register Controlled Trials, PubMed, PsycINFO. Results Acute doses found reduce having effect at higher doses. Epidemiological tend support consumption either THC, plant cannabis. Conversely, available human clinical demonstrate common response (especially doses). Conclusion Based current data, therapies (containing primarily CBD) provide suitable people pre-existing potential adjunctive role managing stress-related disorders. further needed explore other phytochemical constituents present terpenes) interventions. Future trials involving patients warranted due small number studies.

Language: Английский

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Cannabinoids in the landscape of cancer

Journal of Cancer Research and Clinical Oncology, Journal Year: 2021, Volume and Issue: 147(9), P. 2507 - 2534

Published: July 14, 2021

Cannabinoids are a group of terpenophenolic compounds derived from the Cannabis sativa L. plant. There is growing body evidence cell culture and animal studies in support cannabinoids possessing anticancer properties.A database search peer reviewed articles published English as full texts between January 1970 April 2021 Google Scholar, MEDLINE, PubMed Web Science was undertaken. References relevant literature were searched to identify additional construct narrative review oncological effects pre-clinical clinical various cancer types.Phyto-, endogenous synthetic demonstrated antitumour both vitro vivo. However, these dependent on type, concentration preparation cannabinoid abundance receptor targets. The mechanism action cannabinoids, (-)-trans-Δ9-tetrahydrocannabinol (Δ9-THC) cannabidiol (CBD) has mainly been described via traditional receptors; CB1 CB2, but reports have also indicated activity through GPR55, TRPM8 other ion channels including TRPA1, TRPV1 TRPV2.Cannabinoids shown be efficacious single agent combination with antineoplastic drugs. These occurred receptors ligands modulation signalling pathways involved hallmarks pathology. need for further characterise its mode at molecular level delineate dosage route administration addition synergistic regimes.

Language: Английский

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Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials

Frontiers in Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: July 24, 2018

Post-traumatic stress disorder (PTSD) is characterized by poor adaptation to a traumatic experience. This affects approximately 10% of people at some point in life. Current pharmacological therapies for PTSD have been shown be inefficient and produce considerable side effects. Since the discovery involvement endocannabinoid (eCB) system emotional memory processing, manipulation eCB signaling has become therapeutic possibility treatment PTSD. Cannabidiol (CBD), phytocannabinoid constituent Cannabis sativa without psychoactive effects Δ9-tetrahydrocannabinol, gained particular attention. Preclinical studies different rodent behavioral models that CBD can both facilitate extinction aversive memories block their reconsolidation, possibly through potentialization system. These results, combined with currently available treatments being limited, necessitated testing use same purpose humans as well. Indeed, observed rodents, recent confirmed ability alter important aspects promote significant improvements symptomatology The goal this review was highlight potential disorders related inappropriate retention memories, assessing evidence from preclinical human experimental studies.

Language: Английский

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Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview

Epidemiology and Psychiatric Sciences, Journal Year: 2018, Volume and Issue: 27(4), P. 327 - 335

Published: May 23, 2018

Cannabidiol (CBD) represents a new promising drug due to wide spectrum of pharmacological actions. In order relate CBD clinical efficacy its mechanisms action, we performed bibliographic search on PUBMED about all studies investigating the use as treatment psychiatric symptoms. Findings date suggest that (a) may exert antipsychotic effects in schizophrenia mainly through facilitation endocannabinoid signalling and cannabinoid receptor type 1 antagonism; (b) administration exhibit acute anxiolytic patients with generalised social anxiety disorder modification cerebral blood flow specific brain sites serotonin 1A agonism; (c) reduce withdrawal symptoms cannabis/tobacco dependence modulation endocannabinoid, serotoninergic glutamatergic systems; (d) preclinical pro-cognitive still lack significant results disorders. conclusion, current evidences has ability psychotic, by means several hypothesised properties. However, further should include larger randomised controlled samples investigate impact biological measures correlate CBD's potential modifications neurotransmitters structural functional changes.

Language: Английский

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Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation

Journal of Neuroscience, Journal Year: 2019, Volume and Issue: 39(44), P. 8762 - 8777

Published: Sept. 30, 2019

Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) differentially regulate salience attribution psychiatric risk. The ventral hippocampus (vHipp) relays emotional via control of dopamine (DA) neuronal activity states, which are dysregulated in psychosis schizophrenia. Using vivo electrophysiology male Sprague Dawley rats, we demonstrate intra-vHipp THC strongly increases tegmental area (VTA) DA frequency bursting rates, decreases GABA frequency, amplifies VTA beta, gamma ε oscillatory magnitudes modulation local extracellular signal-regulated kinase phosphorylation (pERK1–2). Remarkably, whereas also potentiates morphine place-preference fear conditioning assays, CBD coadministration reverses these changes by downregulating pERK1–2 signaling, as pharmacological reactivation blocked inhibitory properties CBD. These results identify vHipp signaling a critical neural nexus point mediating THC-induced affective disturbances suggest potential mechanism may counteract psychotomimetic psychotropic side effects THC. SIGNIFICANCE STATEMENT Strains marijuana with high levels delta-9-tetrahydrocannabinol low have been shown to underlie neuropsychiatric risks associated high-potency cannabis use. However, mechanisms mitigates not identified. We induces cognitive abnormalities resembling symptoms directly hippocampus, while dysregulating states amplifying frequencies (ERK) pathway. In contrast, ERK phosphorylation, prevented behavioral abnormalities. findings novel molecular account for how functionally

Language: Английский

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Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms

Molecules, Journal Year: 2019, Volume and Issue: 24(14), P. 2583 - 2583

Published: July 16, 2019

Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment substance use disorders. In the present work, authors describe scarce preclinical human research about actions of CBD on effects stimulant drugs, mainly methamphetamine (METH). Additionally, possible mechanisms underlying therapeutic potential disorders reviewed. has reversed toxicity seizures induced by cocaine, behavioural sensitization amphetamines, motivation self-administer METH, context- stress-induced reinstatement priming-induced METH seeking behaviours. also potentiated extinction cocaine- amphetamine-induced conditioned place preference (CPP), impaired reconsolidation CPP prevented CPP. Observational suggest may reduce problems related with crack-cocaine addiction, such as withdrawal symptoms, craving, impulsivity paranoia (Fischer et al., 2015). The involved in protective drugs include prevention drug-induced neuroadaptations (neurotransmitter intracellular signalling pathways changes), erasure aberrant drug-memories, reversion cognitive deficits alleviation mental comorbid abuse. Further, future clinical trials necessary fully evaluate an intervention addictive

Language: Английский

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