The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 3, 2022

Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions patients, thus severely impacting their quality life long-term survival. Although several advances have been made investigations on pathogenetic mechanism sepsis-induced skeletal atrophy, underlying mechanisms remain unclear. Findings from recent studies suggest that nucleotide-binding oligomerisation domain (NOD)-like receptor family pyrin containing 3 (NLRP3) inflammasome, regulator inflammation, may be crucial development atrophy. NLRP3 inhibitors contribute to inhibition catabolic processes, cachexia-induced inflammation. Here, we review by mediates these responses analyse how wasting during

Language: Английский

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Effects of Oral Glucose-Lowering Agents on Gut Microbiota and Microbial Metabolites

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: July 13, 2022

The current research and existing facts indicate that type 2 diabetes mellitus (T2DM) is characterized by gut microbiota dysbiosis disturbed microbial metabolites. Oral glucose-lowering drugs are reported with pleiotropic beneficial effects, including not only a decrease in glucose level but also weight loss, antihypertension, anti-inflammation, cardiovascular protection, the underlying mechanisms still clear. Evidence can be found showing oral might modify microbiome thereby alter gastrointestinal metabolites to improve host health. Although connections among communities, metabolites, T2DM complex, figuring out how antidiabetic agents shape vital for optimizing treatment, meaningful instruction probiotic therapy transplantation T2DM. In this review, we focused on literatures its metabolite profile alterations from drugs, trying provide implications future study developing field of these such as combination therapies, pre- probiotics intervention T2DM, subjects pregestational gestational mellitus.

Language: Английский

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Pathophysiological changes of muscle after ischemic stroke: a secondary consequence of stroke injury

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(4), P. 737 - 746

Published: Sept. 4, 2023

Sufficient clinical evidence suggests that the damage caused by ischemic stroke to body occurs not only in acute phase but also during recovery period, and latter has a greater impact on long-term prognosis of patient. However, current studies have typically focused lesions central nervous system, ignoring secondary this disease. Such phenomenon arises from slow progress pathophysiological examining system. Further, appropriate therapeutic time window benefits thrombolytic therapy are still controversial, leading scholars explore more pragmatic intervention strategies. As treatment measures targeting limb symptoms can greatly improve patient’s quality life, they become critical strategy. most vital component limbs, skeletal muscles potential points concern. Despite this, best our knowledge, there no comprehensive reviews changes treatments for post-stroke muscle. The review seeks fill gap understanding pathological processes mechanisms muscle wasting atrophy, inflammation, neuroregeneration, mitochondrial changes, nutritional dysregulation survivors. In addition, challenges, as well optional solutions individualized rehabilitation programs patients based motor function discussed.

Language: Английский

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SUMOylation and DeSUMOylation: Prospective therapeutic targets in cancer

Life Sciences, Journal Year: 2023, Volume and Issue: 332, P. 122085 - 122085

Published: Sept. 16, 2023

Language: Английский

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Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2514 - 2514

Published: Feb. 21, 2024

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in substantia nigra pars compacta (SNpc), resulting reduced dopamine levels striatum and eventual onset motor symptoms. Linalool (3,7-dimethyl-1,6-octadien-3-ol) monoterpene aromatic plants exhibiting antioxidant, antidepressant, anti-anxiety properties. The objective this study to evaluate neuroprotective impacts linalool on SH-SY5Y cells, primary mesencephalic cortical treated with 1-methyl-4-phenylpyridinium ion (MPP

Language: Английский

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New insights into the function of the NLRP3 inflammasome in sarcopenia: mechanism and therapeutic strategies

Metabolism, Journal Year: 2024, Volume and Issue: 158, P. 155972 - 155972

Published: July 6, 2024

Language: Английский

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Bacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut‐renal muscle axis

Journal of Cellular and Molecular Medicine, Journal Year: 2022, Volume and Issue: 26(24), P. 6066 - 6078

Published: Dec. 1, 2022

Abstract Chronic kidney disease (CKD) affects approximately 10% of the global population. Muscle atrophy occurs in patients with almost all types CKD, and gut microbiome is closely related to protein consumption during chronic renal failure (CRF). This study investigated effects Bacteroides plebeius on energy rats our results suggest that may combat muscle through Mystn/ActRIIB/SMAD2 pathway. A total 5/6 Nx were used as a model wasting CKD. The administered (2 × 10 8 cfu/0.2 ml) for weeks. showed administration significantly inhibited High‐throughput 16 S rRNA pyrosequencing revealed supplementation rescued disturbances microbiota. could also enhance barrier function intestinal mucosa. modulate reduce by increasing abundance probiotics reducing damage mucosal barrier. Our findings

Language: Английский

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Quercetin and tanshinone prevent mitochondria from oxidation and autophagy to inhibit KGN cell apoptosis through the SIRT1/SIRT3-FOXO3a axis

Cellular and Molecular Biology, Journal Year: 2024, Volume and Issue: 70(2), P. 257 - 263

Published: Feb. 29, 2024

Language: Английский

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Plant‐Derived Treatments for Different Types of Muscle Atrophy

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

With the development of medicine and chemistry, an increasing number plant-derived medicines have been shown to exert beneficial therapeutic on treatment various physical psychological diseases. In particular, by using chemistry methods, we are able examine chemical components plants effects these substances human body. Muscle atrophy (MA) is characterized decreased muscle mass function, caused multiple factors severely affects quality life patients. The multifactorial complex pathogenesis MA hinders drug research disease treatment. However, phytotherapy has achieved significant results in MA. We searched PubMed Web Science for articles related atrophy. After applying exclusion inclusion criteria, 166 79 met respectively. A total 173 were included study after excluding duplicates. important role phytoactives such as curcumin, resveratrol, ginsenosides (e.g., maintaining a positive nitrogen balance muscles exerting anti-inflammatory antioxidant effects) extensively studied. Unfortunately, dose not single cause, each cause its own unique mechanism injury. This review focuses mechanisms active plant provides insights into personalized

Language: Английский

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Utilizing zebrafish models to elucidate mechanisms and develop therapies for skeletal muscle atrophy

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123357 - 123357

Published: Jan. 1, 2025

Language: Английский

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