Angiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 12, 2025
This
retrospective
study
aimed
to
investigate
the
association
between
carotid
artery
plaque
characteristics
evaluated
by
virtual
histology
intravascular
ultrasound
(VH-IVUS)
and
high-risk
coronary
plaques
determined
computed
tomography
angiography
(CCTA)
among
patients
(n
=
72)
who
underwent
stenting
(CAS).
VH-IVUS
examination
was
performed
during
CAS
CCTA
before
CAS.
Logistic
regression
models
were
used
explore
plaque.
Of
72
patients,
46
(63.9%)
diagnosed
as
having
plaques.
The
necrotic
core
(NC)
area,
NC
percentage,
dense
calcium
(DC)
symptomatic
stenosis
significantly
associated
with
(all
P
<
.05).
Isolated
upper-NC
area
combined
upper-DC
Compared
lower-NC
lower-DC
groups,
participants
had
12.53
times
higher
odds
ratio
of
showed
that
DC
Participants
both
might
have
a
risk
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 7910 - 7910
Published: April 26, 2023
Recent
advances
have
greatly
improved
our
understanding
of
the
molecular
mechanisms
behind
atherosclerosis
pathogenesis.
However,
there
is
still
a
need
to
systematize
this
data
from
general
pathology
perspective,
particularly
with
regard
atherogenesis
patterns
in
context
both
canonical
and
non-classical
inflammation
types.
In
review,
we
analyze
various
typical
phenomena
outcomes
cellular
pro-inflammatory
stress
atherosclerosis,
as
well
role
endothelial
dysfunction
local
systemic
manifestations
low-grade
inflammation.
We
also
present
features
immune
development
productive
stable
unstable
plaques,
along
their
similarities
differences
compared
There
are
numerous
factors
that
act
inducers
inflammatory
process
including
vascular
endothelium
aging,
metabolic
dysfunctions,
autoimmune,
some
cases,
infectious
damage
factors.
Life-critical
complications
such
cardiogenic
shock
severe
strokes,
associated
acute
hyperinflammation.
Additionally,
critical
atherosclerotic
ischemia
lower
extremities
induces
paracoagulation
chronic
Conversely,
sepsis,
other
conditions,
diseases
contribute
atherogenesis.
summary,
can
be
characterized
an
independent
form
inflammation,
sharing
but
having
fundamental
variants
(classic
vasculitis).
Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: May 27, 2023
The
atherogenic
index
of
plasma
(AIP)
is
an
important
alternative
metabolic
biomarker
atherosclerosis
and
cardiovascular
diseases.
Nevertheless,
the
correlation
between
AIP
carotid
unknown
among
general
population.A
total
52,380
community
residents,
aged
≥
40
years
who
underwentcervical
vascular
ultrasound
from
December
2017
to
2020
in
Hunan
China,
were
selected
for
retrospective
analysis.
was
calculated
as
a
logarithmically
converted
ratio
triglycerides
(TG)
high-density
lipoprotein-cholesterol
(HDL-C).
participants
divided
into
quartile
groups
(Q1-Q4).
Logistic
regression
models
restricted
cubic
spline
analyses
used
examine
association
with
atherosclerosis.
Stratified
applied
control
confounding
factors.
incremental
predictive
value
further
assessed.After
adjusting
traditional
risk
factors,
increased
associated
higher
rate
(CA),
intima-media
thickness
(CIMT),
plaques
[odds
ratio,
OR
(95%
confidence
interval,
CI):
1.06
(1.04,
1.08),
1.07
(1.05,
1.09),
1.04
(1.02,
1.06)
per
1-SD
increase
AIP,
respectively].
Compared
those
1
group,
4
group
had
greater
CA
[OR
1.18,
95%
CI
(1.12,
1.25)],
CIMT
1.20,
(1.13,
1.26)],
1.13,
(1.06,
1.19)].
However,
we
did
not
observe
stenosis
[0.97
(0.77,
1.23),
p
trend
=
0.758].
Restricted
also
showed
cumulative
CA,
CIMT,
but
severity
(>
50%)
AIP.
Subgroup
that
more
significant
prevalence
detected
younger
subjects
(aged
<
60
years)
body
mass
(BMI)
24
fewer
comorbidities.
Additionally,
provided
capacity
over
established
factors
shown
by
improvement
net
reclassification
(NRI)
integrated
discrimination
(IDI)
(all
P
0.05).An
elevated
community-based
population
CA.
could
serve
potential
assessment.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(4), P. 1508 - 1524
Published: Jan. 20, 2024
Macrophage
senescence,
manifested
by
the
special
form
of
durable
cell
cycle
arrest
and
chronic
low-grade
inflammation
like
senescence-associated
secretory
phenotype,
has
long
been
considered
harmful.
Persistent
senescence
macrophages
may
lead
to
maladaptation,
immune
dysfunction,
finally
development
age-related
diseases,
infections,
autoimmune
malignancies.
However,
it
is
a
ubiquitous,
multi-factorial,
dynamic
complex
phenomenon
that
also
plays
roles
in
remodeled
processes,
including
wound
repair
embryogenesis.
In
this
review,
we
summarize
some
general
molecular
changes
several
specific
biomarkers
during
macrophage
which
bring
new
sight
recognize
senescent
different
conditions.
Also,
take
an
in-depth
look
at
functional
macrophages,
metabolism,
autophagy,
polarization,
phagocytosis,
antigen
presentation,
infiltration
or
recruitment.
Furthermore,
degenerations
diseases
associated
with
as
well
mechanisms
relevant
genetic
regulations
are
integrated,
not
only
emphasizing
possibility
regulating
benefit
age-associated
but
implication
on
finding
potential
targets
drugs
clinically.
Advances in Nutrition,
Journal Year:
2023,
Volume and Issue:
14(6), P. 1416 - 1435
Published: Aug. 23, 2023
The
importance
of
nicotinamide
adenine
dinucleotide
(NAD+)
in
human
physiology
is
well
recognized.
As
the
NAD+
concentration
skin,
blood,
liver,
muscle
and
brain
are
thought
to
decrease
with
age,
finding
ways
increase
status
could
possibly
influence
ageing
process
associated
metabolic
sequelae.
Nicotinamide
mononucleotide
(NMN)
a
precursor
for
biosynthesis,
vitro/in
vivo
studies
have
demonstrated
that
NMN
supplementation
increases
mitigate
ageing-related
disorders
such
as
oxidative
stress,
DNA
damage,
neurodegeneration
inflammatory
responses.
promotion
an
anti-ageing
health
supplement
has
gained
popularity
due
findings;
however,
since
most
evaluating
effects
been
conducted
cell
or
animal
models,
concern
remains
regarding
safety
physiological
population.
Nonetheless,
dozen
clinical
trials
currently
underway.
This
review
summarizes
current
progress
these
NMN/NAD+
biology
clarify
potential
shed
light
on
future
study
directions.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(5), P. 675 - 675
Published: May 21, 2023
The
present
study
aims
to
provide
a
narrative
review
of
the
molecular
mechanisms
Western
diet-induced
obesity
and
obesity-related
carcinogenesis.
A
literature
search
Cochrane
Library,
Embase
Pubmed
databases,
Google
Scholar
grey
was
conducted.
Most
that
induce
are
also
involved
in
twelve
Hallmarks
Cancer,
with
fundamental
process
being
consumption
highly
processed,
energy-dense
diet
deposition
fat
white
adipose
tissue
liver.
generation
crown-like
structures,
macrophages
surrounding
senescent
or
necrotic
adipocytes
hepatocytes,
leads
perpetual
state
chronic
inflammation,
oxidative
stress,
hyperinsulinaemia,
aromatase
activity,
activation
oncogenic
pathways
loss
normal
homeostasis.
Metabolic
reprogramming,
epithelial
mesenchymal
transition,
HIF-1α
signalling,
angiogenesis
host
immune-surveillance
particularly
important.
Obesity-associated
carcinogenesis
is
closely
related
metabolic
syndrome,
hypoxia,
visceral
dysfunction,
oestrogen
synthesis
detrimental
cytokine,
adipokine
exosomal
miRNA
release.
This
important
pathogenesis
oestrogen-sensitive
cancers,
including
breast,
endometrial,
ovarian
thyroid
cancer,
but
‘non-hormonal’
obesity-associated
cancers
such
as
cardio-oesophageal,
colorectal,
renal,
pancreatic,
gallbladder
hepatocellular
adenocarcinoma.
Effective
weight
interventions
may
improve
future
incidence
overall
cancer.
Clinical Nutrition,
Journal Year:
2024,
Volume and Issue:
43(10), P. 2289 - 2295
Published: Aug. 23, 2024
Recent
studies
have
demonstrated
that
very
high
high-density
lipoprotein
cholesterol
(HDL-C)
level
was
paradoxically
linked
with
higher
risk
of
cardiovascular
mortality,
all-cause
and
several
age-related
diseases.
However,
whether
HDL-C
is
associated
a
sarcopenia
in
older
adults
remains
unclear.
We
aimed
to
investigate
the
association
between
developing
low
grip
strength
over
time
adults.
Lipids in Health and Disease,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 24, 2025
Ageing
results
in
diminished
adaptability,
as
well
declines
physiological
and
psychological
functions
resilience.
The
epigenetic
clock
'Phenotypic
Age'
(PhenoAge)
represents
'preclinical
ageing'.
Phenotypic
Age
Acceleration
(PhenoAgeAccel)
is
defined
the
residual
from
a
linear
regression
model
predicting
PhenoAge
on
basis
of
chronological
age.
Abdominal
subcutaneous
adipose
tissue,
visceral
Homeostasis
Model
Assessment
Insulin
Resistance
(HOMA-IR),
high-density
lipoprotein
cholesterol
(HDL-C)
have
all
been
shown
to
correlate
with
ageing;
however,
connections
between
these
factors
are
still
insufficiently
investigated.
Data
for
this
study
were
sourced
National
Health
Nutrition
Examination
Survey
(2015–2018),
comprising
2580
participants.
Complex
survey
designs
considered.
To
examine
association
body
fat
area
PhenoAgeAccel,
logistic
was
applied.
Additionally,
subgroup
analysis
used
identify
variations
population
characteristics.
dose‒response
relationship
PhenoAgeAccel
determined
via
restricted
cubic
spline
analysis.
Mediation
interaction
analyses
further
employed
investigate
roles
HOMA-IR
HDL-C
association.
In
nonelderly
adults,
relationships
differed
For
abdominal
(SFA),
nonlinear
individuals
aged
18–44
years
45–59
years,
thresholds
2.969
m²
3.394
m²,
respectively.
contrast,
(VFA)
observed
while
0.769
1.220
effect
revealed
that
had
more
pronounced
mediation
accounting
13.4%
VFA
6.9%
SFA
PhenoAgeAccel.
Conversely,
greater
mediating
21.7%
11.6%
≥
2.73
or
>
0.925
3.137
accelerated
PhenoAge,
whereas
1.60
<
≤
3.90
mmol/L
combined
decelerated
PhenoAge.
study,
among
SFA,
VFA,
elucidated,
characteristic
across
different
age
groups
identified.
emphasize
complex
influence
distribution
ageing
process
refine
various
cohorts.
These
findings
provide
biological
future
screening
appropriate
intervention
high-risk
populations
offer
valuable
insights
guiding
personalized
clinical
interventions
health
management
strategies.
