The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 27, 2023

Periodontitis and inflammatory bowel diseases (IBD) are of the gastrointestinal tract that share common features microbial-induced ecological dysregulation host immune response. The close relationship between periodontitis IBD is characterized by a higher prevalence in patients with severity IBD, indicating different from traditional independent form an “Oral-Gut” axis two, which affect each other thus vicious circle. However, specific mechanisms leading to association two not fully understood. In this article, we describe interconnection terms microbial pathogenesis dysregulation, including ectopic colonization gut pathogenic bacteria associated promotes inflammation activating response, alteration oral microbiota due affects periodontal Among factors, such as Klebsiella , Porphyromonas gingivalis Fusobacterium nucleatum may act bridge while among mechanisms, Th17 cell responses secreted pro-inflammatory factors IL-1β, IL-6 TNF-α play key role development both diseases. This suggests future studies, can look for targets control intervene regulating or intestinal flora through immunological methods.

Language: Английский

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Oral–Gut Microbiota, Periodontal Diseases, and Arthritis: Literature Overview on the Role of Probiotics

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4626 - 4626

Published: Feb. 27, 2023

Periodontal diseases are oral inflammatory affecting the tissues supporting and surrounding teeth include gingivitis periodontitis. Oral pathogens may lead to microbial products spreading into systemic circulation reaching distant organs, while periodontal have been related low-grade inflammation. Gut microbiota alterations might play a role in pathogenesis of several autoimmune including arthritis, considering gut–joint axis regulation molecular pathways involved these conditions. In this scenario, it is hypothesized that probiotics contribute intestinal micro-ecological balance could reduce inflammation typical arthritis. This literature overview aims summarize state-of-the-art ideas about linkages among oral–gut microbiota, diseases, investigating as potential therapeutic intervention for management both musculoskeletal disorders.

Language: Английский

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Using SWATH‐MS to identify new molecular biomarkers in gingival crevicular fluid for detecting periodontitis and its response to treatment

Journal Of Clinical Periodontology, Journal Year: 2024, Volume and Issue: 51(10), P. 1342 - 1358

Published: July 10, 2024

Abstract Aim To identify new biomarkers to detect untreated and treated periodontitis in gingival crevicular fluid (GCF) using sequential window acquisition of all theoretical mass spectra (SWATH‐MS). Materials Methods GCF samples were collected from 44 periodontally healthy subjects 40 with (Stages III–IV). In the latter, 25 improved clinically 2 months after treatment. Samples analysed SWATH‐MS, proteins identified by UniProt human‐specific database. The diagnostic capability was determined generalized additive models distinguish three clinical conditions. Results vs . periodontal health modelling, five showed excellent or good bias‐corrected (bc)‐sensitivity/bc‐specificity values >80%. These GAPDH, ZG16B, carbonic anhydrase 1, plasma protease inhibitor C1 haemoglobin subunit beta. GAPDH MMP‐9, MMP‐8, zinc‐α‐2‐glycoprotein neutrophil gelatinase‐associated lipocalin ZG16B cornulin provided increased bc‐sensitivity/bc‐specificity >95%. For distinguishing health, most these their combinations revealed a predictive ability similar previous modelling. No model obtained relevant results differentiate between Conclusions New single dual protein outstanding discriminating health. Periodontitis conditions indistinguishable. Future research must validate findings.

Language: Английский

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Potential Clinical Application of Organs-on-a-Chip in Periodontal Diseases: A Systematic Review of In Vitro Studies

Dentistry Journal, Journal Year: 2023, Volume and Issue: 11(7), P. 158 - 158

Published: June 26, 2023

The periodontium is a unique organ from the standpoint of building an organ-on-a-chip (OoC) since it system that continually threatened by microorganisms, their noxious compounds, and antigenic components. At same time, periodontal health depends on balanced connection between host bacteria in oral cavity, which complex micro-ecological environment. objective this systematic review vitro studies to revise potential clinical application OoC diseases. PRISMA was used guide analysis. framework made use several databases, including SCOPUS, PubMed/MEDLINE, SCIELO, LILACS as well gray literature. This comprised seven studies. efficacy diseases observed models gingival crevice for research periodontitis, medication analysis, interaction multiple microbial species, pH measurements situ-grown biofilm, testing antimicrobial reagents, evaluation mucosal interactions with device quantitative exploration microorganisms. has advance our understanding providing more accurate representation microenvironment enabling development new treatments.

Language: Английский

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Oral diseases are associated with cognitive function in adults over 60 years old

Oral Diseases, Journal Year: 2023, Volume and Issue: 30(5), P. 3480 - 3488

Published: Oct. 9, 2023

Abstract Objective To investigate the bidirectional association between oral diseases and cognitive function comprehensively. Subjects Methods This cross sectional study utilized data from National Health Nutrition Examination Survey. Oral include periodontitis, dental caries, tooth loss (end point of disease resulting in extraction). Cognitive included three domains: memory, processing speed, executive function. A global score was then derived sum domains. cognition associations were examined using various statistical models: (1) Regress on function; (2) disease; (3) Structural equation modelling treating as latent variables. Results There 2508 participants aged 60+ who had both information. Associations observed (Odds ratio OR cog‐>periodontitis 0.95, 95% Confidence Interval [0.92, 0.99]; β cog‐>caries −0.13, [−0.23, −0.04]; cog‐>tooth −0.03 [−0.04, −0.01]; loss‐>cog −0.04 [−0.06, −0.02]; caries‐>cog periodontitis‐>cog −0.39 [−0.69, −0.10]). Significant correlation also found these structural model ( r −0.22, [−0.34, Conclusions robust approaches among aging population.

Language: Английский

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Prevalence and determinants of periodontitis among a population with knee osteoarthritis at the Douala General Hospital (Littoral, Cameroon)

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Background Osteoarthritis (OA) is a slowly evolving multifactorial disorder that affects joints, particularly the knee. Periodontitis an infection of tissues supporting teeth, leading to significant tooth loss. Recent studies suggest association between Knee OA (KOA) and periodontitis, with prevalence periodontitis increasing severity KOA. We aimed determine distribution KOA in subjects living Patients methods: A cross-sectional study was conducted outpatient clinic at Rheumatology unit Douala General Hospital October 2022 June 2023. Data were collected using questionnaire, endo-buccal examination grid, radiological images medical records. multivariate analysis logistic regression performed, including relevant variables bivariate analysis. Results included 253 participants (201 women) median age 63 years [54–70]. The mean VAS 52.7 ± 27.9 mm. Lequesne index 12.25 5.03. Kellgren Lawrence (K&L) grade 2 predominant (61.7%), as tricompartimental (85.4%). 62.5%. significantly associated K&L 4 (OR: 5.39 [1.27–28.98]; p = 0.03), poor oral hygiene 34 [7.46277.71]; < 0.001), visits dentist [in case problems] 8.54 [3.09–28.58]; 0.001) brushing time 21.93 [5.66-123.24]; 0.001). Conclusion common patients Cameroon hygiene.

Language: Английский

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Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data

Clinical Oral Investigations, Journal Year: 2025, Volume and Issue: 29(2)

Published: Feb. 14, 2025

Language: Английский

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Grading the strength and certainty of the scientific evidence of the bidirectional association between periodontitis and noncommunicable diseases: an umbrella review

Evidence-Based Dentistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Objective Periodontitis and various noncommunicable diseases (NCDs) have been proposed to a bidirectional relationship. The purpose of this umbrella review is (1) synthesize the evidence (2) grade strength certainty scientific regarding association between periodontitis NCDs. Data sources Electronic databases were systematically searched from January 2021 July 2024; MEDLINE (via PubMed), Embase SciELO. selection extraction Potential epidemiologic systematic reviews with meta-analysis that studied NCDs identified by two independent reviewers filtered title abstract according criteria. quality was assessed Grading Recommendations, Assessment, Development Evaluations (GRADE) guide. 561,554 potential results identified. After removing duplicates excluding records deemed ineligible automated filters, 450 screened abstract. This process led 41 being appraised in full-text. Of these, 17 further excluded leaving total 24 met inclusion synthesis 32 consolidated. Risk bias assessment indicated 21 (87.5%) demonstrated low (high quality), 2 had medium bias, 1 exhibited high (low quality). Key issues included formulation explicit research questions, critical appraisal, data extraction, publication bias. strong review, moderate 8, weak 10 absent 7 reviews. 6 3 size reported effect (odds ratio/risk ratio/hazard ratio) broader increasing strength. Although supports some NCDs, lesser extent periodontitis, classified as very low. Conclusions There that, varying degrees certainty, provide may be risk factor for vice versa.

Language: Английский

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Periodontal disease and the incident risk of diabetes mellitus in Japanese men and women: a 12-year cohort study

Diabetology International, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

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Genome-wide association studies on periodontitis: A systematic review

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0306983 - e0306983

Published: Sept. 6, 2024

Objectives This study aims to systematically review the existing literature and critically appraise evidence of genome-wide association studies (GWAS) on periodontitis. also synthesise findings genetic risk variants periodontitis from included GWAS. Methods A systematic search was conducted PubMed, GWAS Catalog, MEDLINE, GLOBAL HEALTH EMBASE via Ovid for Only exploring single-nucleotide polymorphisms(SNPs) associated with were eligible inclusion. The quality assessed using Q-genie tool. Information such as population, ethnicity, genomic data source, phenotypic characteristics(definition periodontitis), methods(quality control, analysis stages) extracted. SNPs that reached conventional or suggestive significance level(5e-8 5e-06) extracted synthesized. Results total 15 good-quality (Q-genie scores ranged 38–50). There huge heterogeneities among studies. 11 identified (rs242016, rs242014, rs10491972, rs242002, rs2978951, rs2738058, rs4284742, rs729876, rs149133391, rs1537415, rs12461706) at significant level ( p<5x10 -8 ), 41 -6 but no common found between Three (rs4284742 [G], rs11084095 [A], rs12461706 [T]) three large same gene region–SIGLEC5. Conclusion showed high heterogeneity methodology used provided limited statistics, making identifying reliable challenging. clear guidance in dental research requirement expectation make statistics available other investigators are needed.

Language: Английский

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