Periodontal disease: A systemic condition

Periodontology 2000, Journal Year: 2024, Volume and Issue: 96(1), P. 7 - 19

Published: Oct. 1, 2024

Abstract For decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in oral cavity. Initially, associations with multitude noncommunicable diseases were each studied separately, and relationships shown. The morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory have demonstrated. As most studies cross‐sectional nature, questions about causality cannot univocally answered. And an independent risk factor for one systemic disease, becomes even more difficult assess since recently also associated multimorbidity. Periodontitis many share environmental, lifestyle genetic factors, immunopathology. Moreover, suffering from common may increase susceptibility another chronic disease; effects condition various factors disease. overarching effect any is it causing pro‐inflammatory state individual; this shown periodontitis. prothrombotic elevated immunological activity such, when we consider can affect progression other importantly, vice versa. this, not surprising that variety diseases. medical definition includes different organs systems. Thus, aim opinion paper propose should its own right affects individual's wellbeing. dental profession researchers alike, adapt paradigm shift, advancing out isolated anatomical location into total being some conditions comorbid and, versa, comorbidities initiation

Language: Английский

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Role of oxidative stress in the relationship between periodontitis and systemic diseases

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: July 12, 2023

Periodontitis is a common inflammatory disease. It characterized by destruction of the supporting structures teeth and could lead to tooth loss systemic inflammation. Bacteria in inflamed gingival tissue virulence factors are capable entering bloodstream induce response, thus influencing pathological process many diseases, such as cardiovascular diabetes, chronic kidney disease, well liver injury. An increasing body evidence show complex interplay between oxidative stress inflammation disease pathogenesis. When periodontitis occurs, increased reactive oxygen species accumulation leads stress. Oxidative contributes major cellular components damage, including DNA, proteins, lipids. In this article, focus will be on periodontal relationship inflammation, impact therapy parameters.

Language: Английский

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Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample Mendelian randomization study

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 28, 2023

Abstract Background Recent research has established the correlation between gut microbiota and periodontitis via oral-gut axis. Intestinal dysbiosis may play a pivotal bridging role in extra-oral inflammatory comorbidities caused by periodontitis. However, it is unclear whether link merely correlative or orchestrated causative mechanistic interactions. This two-sample Mendelian randomization (MR) study was performed to evaluate potential bidirectional causal relationships Materials Methods A MR analysis using summary statistics from genome-wide association studies (GWAS) for (n = 18,340) (cases 12,251; controls 22,845). The inverse-variance weighted (IVW) method used primary analysis, we employed sensitivity analyses assess robustness of main results. PhenoScanner database then searched pleiotropy SNPs associated with confounders. In order identify possibly influential SNPs, further conducted leave-one-out analysis. Finally, reverse possibility links genetically predicted alternation. Results 2,699 single nucleotide polymorphisms (SNPs) 196 genera were selected as instrumental variables (IVs). IVW suggested that Enterobacteriales (OR: 1.35, 95% CI 1.10–1.66), family Bacteroidales S24.7group 1.22, 1.05–1.41), genus Lachnospiraceae UCG008 1.16, 1.03–1.31), Prevotella 7 1.11, 1.01–1.23), Pasteurellales 1.12, 1.00–1.26) be higher risk periodontitis, while Ruminiclostridium 6 linked lower 0.82, 0.70–0.95). heterogeneity yielded no indication horizontal heterogeneity. Only likelihood remained consistent across all alternative approaches. four down-regulated whereas two up-regulated. Conclusions present demonstrated Our provided fresh insights prevention management Future required support finding our current study.

Language: Английский

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Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 21, 2025

The first 1, 000 days of life, from the fetal stage a woman's pregnancy to 2 years age after baby is born, critical period for microbial colonization body and development immune system. system microbiota exhibit great plasticity at this play crucial role in subsequent future health. Two-way communication interaction between helpful maintain human microecological balance homeostasis. Currently, there growing interest important newborn, it believed that absence or dysbiosis commensal early life can have lasting health consequences. Thus, paper summarizes research advances establishment oral intestinal microbiome emphasizing substantial impact diversity prenatal postnatal periods, maternal microbes, mode delivery, feeding practices, antibiotics, probiotics, environment shape infants their association with

Language: Английский

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The Role of Vitamin C and Vitamin D in the Pathogenesis and Therapy of Periodontitis—Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6774 - 6774

Published: April 5, 2023

Periodontitis is a common disorder affecting the bone and soft tissues of periodontal complex. When untreated, it may lead to severe mobility or even loss teeth. The pathogenesis periodontitis complex, with crucial factors being chronic inflammation in gingival oral microbiome alterations. However, recent studies highlight alleged role vitamins, such as vitamin C (VitC) D (VitD), development disease. VitC regulates numerous biochemical reactions, but foremost, involved synthesizing collagen. It was reported that deficiency could damage ligaments. supplementation improves postoperative outcomes patients periodontitis. VitD steroid derivative can be produced skin under ultraviolet radiation later transformed into an active form other tissues, kidneys. established decrease expression proinflammatory cytokines gingiva regulate proper mineral density Moreover, associated better results nonsurgical treatment In this review, we summarize knowledge on vitamins

Language: Английский

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Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1416 - 1416

Published: Aug. 29, 2024

Periodontitis can disrupt oral and gut microbiota, leading to dysbiosis that affects overall systemic health. Besides the spread of periodontal pathogens by hematogenous route, they also be translocated into gastrointestinal tract, possibly intervening in neoplastic process tract. This manuscript reviews relationship between microbiota due periodontitis, discussing health implications potential links cancer. article highlights significance effect gut, emphasizing importance maintaining prevent diseases. Lastly, it will go through therapeutic innovations such as probiotics analysis tools for disease detection. These findings mark integration management clinical practice lower risk improve patient outcomes.

Language: Английский

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The oral-gut microbiome axis in inflammatory bowel disease: from inside to insight

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Inflammatory bowel disease (IBD) is an idiopathic and persistent inflammatory illness of the bowels, leading to a substantial burden on both society patients due its high incidence recurrence. The pathogenesis IBD multifaceted, partly attributed imbalance immune responses toward gut microbiota. There correlation between severity in oral microbiota, which has been discovered recent research highlighting role microbes development IBD. In addition, various conditions, such as angular cheilitis periodontitis, are common extraintestinal manifestations (EIMs) associated with colonic inflammation. However, it still unclear exactly how microbiota contributes This review sheds light probable causal involvement intestinal inflammation by providing overview evidence, developments, future directions regarding relationship Changes can serve markers for IBD, aiding early diagnosis predicting progression. Promising advances probiotic-mediated microbiome modification antibiotic-targeted eradication specific pathogens hold potential prevent

Language: Английский

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Efficacy of a mouthwash containing ε-poly-L-lysine, funme peptides and domiphen in reducing halitosis and supragingival plaque: a randomized clinical trial

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 3, 2024

Abstract Objective To evaluate the antibacterial effectiveness of a combination ε-poly-L-lysine (ε-PL), funme peptide (FP) as well domiphen against oral pathogens, and assess efficacy BOP® mouthwash supplemented with this in reducing halitosis supragingival plaque clinical trial. Materials methods The minimum inhibitory concentration (MIC) bactericidal (MBC) compound Fusobacterium nucleatum , Porphyromonas gingivalis Streptococcus mutans Aggregatibacter actinomycetemcomitans were determined by gradient dilution method. Subsequently, CCK-8 assay was used to detect toxicity on human gingival fibroblastst, analyzed randomized, double-blind, parallel-controlled Results exhibited significant effects tested pathogens MIC < 1.56% (v/v) MBC 3.13% (v/v), containing did not inhibit viability fibroblasts at test concentrations. trial showed that group displayed notably lower volatile sulfur compounds (VSCs) 0, 10, 24 h, 7 d post-mouthwash ( P 0.05), compared baseline. After days, VSC levels control groups reduced 50.27% 32.12%, respectively, cutting severe 57.03% group. Additionally, Plaque Index (PLI) decreased 54.55% 8.38%, there difference PLI between two after days 0.01). Conclusions ε-PL, FP demonstrated potent newly formulated added anti-dental anti-halitosis properties safe. Trial registration randomized controlled registered Chinese Clinical Registry (No. ChiCTR2300073816, Date: 21/07/2023).

Language: Английский

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Oral microbiota shifts following tooth loss affect gut health

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 10, 2025

Language: Английский

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Immune-Mediated Bidirectional Causality Between Inflammatory Bowel Disease and Chronic Periodontitis: Evidence from Mendelian Randomization and Integrative Bioinformatics Analysis

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 476 - 476

Published: Feb. 15, 2025

Background/Objectives: A bidirectional association between inflammatory bowel disease (IBD) and periodontitis has been observed, yet their causal relationship remains unclear. This study aimed to investigate the potential links these two conditions through comprehensive genetic molecular analyses. Methods: We conducted a Mendelian randomization (MR) analysis integrated with bioinformatics approaches. The relationships were primarily evaluated using inverse variance weighting (IVW), complemented by multiple sensitivity analyses assess robustness of findings. Additionally, we performed differential gene expression RNA sequencing data identify co-expressed genes shared mediators IBD periodontitis, followed pathway enrichment analysis. Results: Bidirectional MR revealed significant associations (p-value < 0.05). Sensitivity demonstrated consistency findings, no evidence heterogeneity or horizontal pleiotropy > Integrated identified key immune regulators, particularly interleukin 1 beta (IL1B) C-X-C motif chemokine receptor 4 (CXCR4), signaling pathways, including tumor necrosis factor (TNF-α) 17 (IL17), as mechanisms underlying conditions. Conclusions: Our findings provide supporting periodontitis. Transcriptomic pathological crucial regulatory factors common both diseases. These insights enhance our understanding interplay potentially informing new therapeutic strategies for

Language: Английский

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