Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 20, 2024
The
complex
relationship
between
periodontitis
(PD)
and
inflammatory
bowel
disease
(IBD)
has
received
significant
attention
in
recent
studies.
Emerging
evidence
suggests
that
the
oral-gut
axis
plays
a
pivotal
role
their
interaction.
This
review
provides
comprehensive,
up-to-date
analysis
of
original
research
from
2003
to
2023
on
PD-IBD
aims
be
reference
for
future
research.
Relevant
literature
was
sourced
PubMed
database
using
keywords
"periodontitis"
"inflammatory
disease".
Additionally,
manual
library
search
bibliographies
were
conducted.
Of
297
articles
retrieved,
27
studies
chosen
final
review.
Out
these,
21
(78%),
including
both
vitro
vivo
research,
indicated
an
association
PD
IBD.
While
many
confirm
bi-directional
relationship,
others
refute
it
or
deem
clinically
irrelevant.
There
is
need
more
accessible
studies,
such
as
randomized
trials,
which
also
investigate
factors
could
influence
outcomes
clarify
exact
molecular
mechanisms
clinical
implications
this
relationship.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 12, 2023
Periodontitis
is
a
common
inflammatory
disease.
It
characterized
by
destruction
of
the
supporting
structures
teeth
and
could
lead
to
tooth
loss
systemic
inflammation.
Bacteria
in
inflamed
gingival
tissue
virulence
factors
are
capable
entering
bloodstream
induce
response,
thus
influencing
pathological
process
many
diseases,
such
as
cardiovascular
diabetes,
chronic
kidney
disease,
well
liver
injury.
An
increasing
body
evidence
show
complex
interplay
between
oxidative
stress
inflammation
disease
pathogenesis.
When
periodontitis
occurs,
increased
reactive
oxygen
species
accumulation
leads
stress.
Oxidative
contributes
major
cellular
components
damage,
including
DNA,
proteins,
lipids.
In
this
article,
focus
will
be
on
periodontal
relationship
inflammation,
impact
therapy
parameters.
Periodontology 2000,
Journal Year:
2024,
Volume and Issue:
96(1), P. 7 - 19
Published: Oct. 1, 2024
Abstract
For
decades,
periodontitis
has
been
considered
to
be
a
local
inflammatory
disease
of
the
periodontal
tissues
in
oral
cavity.
Initially,
associations
with
multitude
noncommunicable
diseases
were
each
studied
separately,
and
relationships
shown.
The
morbidities,
such
as
cardiovascular
diseases,
rheumatoid
arthritis,
diabetes
mellitus,
respiratory
have
demonstrated.
As
most
studies
cross‐sectional
nature,
questions
about
causality
cannot
univocally
answered.
And
an
independent
risk
factor
for
one
systemic
disease,
becomes
even
more
difficult
assess
since
recently
also
associated
multimorbidity.
Periodontitis
many
share
environmental,
lifestyle
genetic
factors,
immunopathology.
Moreover,
suffering
from
common
may
increase
susceptibility
another
chronic
disease;
effects
condition
various
factors
disease.
overarching
effect
any
is
it
causing
pro‐inflammatory
state
individual;
this
shown
periodontitis.
prothrombotic
elevated
immunological
activity
such,
when
we
consider
can
affect
progression
other
importantly,
vice
versa.
this,
not
surprising
that
variety
diseases.
medical
definition
includes
different
organs
systems.
Thus,
aim
opinion
paper
propose
should
its
own
right
affects
individual's
wellbeing.
dental
profession
researchers
alike,
adapt
paradigm
shift,
advancing
out
isolated
anatomical
location
into
total
being
some
conditions
comorbid
and,
versa,
comorbidities
initiation
Frontiers in Pediatrics,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 21, 2025
The
first
1,
000
days
of
life,
from
the
fetal
stage
a
woman's
pregnancy
to
2
years
age
after
baby
is
born,
critical
period
for
microbial
colonization
body
and
development
immune
system.
system
microbiota
exhibit
great
plasticity
at
this
play
crucial
role
in
subsequent
future
health.
Two-way
communication
interaction
between
helpful
maintain
human
microecological
balance
homeostasis.
Currently,
there
growing
interest
important
newborn,
it
believed
that
absence
or
dysbiosis
commensal
early
life
can
have
lasting
health
consequences.
Thus,
paper
summarizes
research
advances
establishment
oral
intestinal
microbiome
emphasizing
substantial
impact
diversity
prenatal
postnatal
periods,
maternal
microbes,
mode
delivery,
feeding
practices,
antibiotics,
probiotics,
environment
shape
infants
their
association
with
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6774 - 6774
Published: April 5, 2023
Periodontitis
is
a
common
disorder
affecting
the
bone
and
soft
tissues
of
periodontal
complex.
When
untreated,
it
may
lead
to
severe
mobility
or
even
loss
teeth.
The
pathogenesis
periodontitis
complex,
with
crucial
factors
being
chronic
inflammation
in
gingival
oral
microbiome
alterations.
However,
recent
studies
highlight
alleged
role
vitamins,
such
as
vitamin
C
(VitC)
D
(VitD),
development
disease.
VitC
regulates
numerous
biochemical
reactions,
but
foremost,
involved
synthesizing
collagen.
It
was
reported
that
deficiency
could
damage
ligaments.
supplementation
improves
postoperative
outcomes
patients
periodontitis.
VitD
steroid
derivative
can
be
produced
skin
under
ultraviolet
radiation
later
transformed
into
an
active
form
other
tissues,
kidneys.
established
decrease
expression
proinflammatory
cytokines
gingiva
regulate
proper
mineral
density
Moreover,
associated
better
results
nonsurgical
treatment
In
this
review,
we
summarize
knowledge
on
vitamins
Journal of Oral Microbiology,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Feb. 25, 2025
Objective
Helicobacter
pylori
(H.
pylori)
infection
affects
approximately
50%
of
the
global
population.
The
predominant
route
H.
transmission
is
through
oral
pathway,
making
cavity
highly
significant
in
its
infection.
This
review
focuses
on
relationship
between
and
diseases,
influence
microbiota,
potential
mechanisms
involving
certain
pathogens.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 28, 2023
Abstract
Background
Recent
research
has
established
the
correlation
between
gut
microbiota
and
periodontitis
via
oral-gut
axis.
Intestinal
dysbiosis
may
play
a
pivotal
bridging
role
in
extra-oral
inflammatory
comorbidities
caused
by
periodontitis.
However,
it
is
unclear
whether
link
merely
correlative
or
orchestrated
causative
mechanistic
interactions.
This
two-sample
Mendelian
randomization
(MR)
study
was
performed
to
evaluate
potential
bidirectional
causal
relationships
Materials
Methods
A
MR
analysis
using
summary
statistics
from
genome-wide
association
studies
(GWAS)
for
(n
=
18,340)
(cases
12,251;
controls
22,845).
The
inverse-variance
weighted
(IVW)
method
used
primary
analysis,
we
employed
sensitivity
analyses
assess
robustness
of
main
results.
PhenoScanner
database
then
searched
pleiotropy
SNPs
associated
with
confounders.
In
order
identify
possibly
influential
SNPs,
further
conducted
leave-one-out
analysis.
Finally,
reverse
possibility
links
genetically
predicted
alternation.
Results
2,699
single
nucleotide
polymorphisms
(SNPs)
196
genera
were
selected
as
instrumental
variables
(IVs).
IVW
suggested
that
Enterobacteriales
(OR:
1.35,
95%
CI
1.10–1.66),
family
Bacteroidales
S24.7group
1.22,
1.05–1.41),
genus
Lachnospiraceae
UCG008
1.16,
1.03–1.31),
Prevotella
7
1.11,
1.01–1.23),
Pasteurellales
1.12,
1.00–1.26)
be
higher
risk
periodontitis,
while
Ruminiclostridium
6
linked
lower
0.82,
0.70–0.95).
heterogeneity
yielded
no
indication
horizontal
heterogeneity.
Only
likelihood
remained
consistent
across
all
alternative
approaches.
four
down-regulated
whereas
two
up-regulated.
Conclusions
present
demonstrated
Our
provided
fresh
insights
prevention
management
Future
required
support
finding
our
current
study.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 26, 2024
Inflammatory
bowel
disease
(IBD)
is
an
idiopathic
and
persistent
inflammatory
illness
of
the
bowels,
leading
to
a
substantial
burden
on
both
society
patients
due
its
high
incidence
recurrence.
The
pathogenesis
IBD
multifaceted,
partly
attributed
imbalance
immune
responses
toward
gut
microbiota.
There
correlation
between
severity
in
oral
microbiota,
which
has
been
discovered
recent
research
highlighting
role
microbes
development
IBD.
In
addition,
various
conditions,
such
as
angular
cheilitis
periodontitis,
are
common
extraintestinal
manifestations
(EIMs)
associated
with
colonic
inflammation.
However,
it
still
unclear
exactly
how
microbiota
contributes
This
review
sheds
light
probable
causal
involvement
intestinal
inflammation
by
providing
overview
evidence,
developments,
future
directions
regarding
relationship
Changes
can
serve
markers
for
IBD,
aiding
early
diagnosis
predicting
progression.
Promising
advances
probiotic-mediated
microbiome
modification
antibiotic-targeted
eradication
specific
pathogens
hold
potential
prevent
Medicina,
Journal Year:
2024,
Volume and Issue:
60(9), P. 1416 - 1416
Published: Aug. 29, 2024
Periodontitis
can
disrupt
oral
and
gut
microbiota,
leading
to
dysbiosis
that
affects
overall
systemic
health.
Besides
the
spread
of
periodontal
pathogens
by
hematogenous
route,
they
also
be
translocated
into
gastrointestinal
tract,
possibly
intervening
in
neoplastic
process
tract.
This
manuscript
reviews
relationship
between
microbiota
due
periodontitis,
discussing
health
implications
potential
links
cancer.
article
highlights
significance
effect
gut,
emphasizing
importance
maintaining
prevent
diseases.
Lastly,
it
will
go
through
therapeutic
innovations
such
as
probiotics
analysis
tools
for
disease
detection.
These
findings
mark
integration
management
clinical
practice
lower
risk
improve
patient
outcomes.
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: May 3, 2024
Abstract
Objective
To
evaluate
the
antibacterial
effectiveness
of
a
combination
ε-poly-L-lysine
(ε-PL),
funme
peptide
(FP)
as
well
domiphen
against
oral
pathogens,
and
assess
efficacy
BOP®
mouthwash
supplemented
with
this
in
reducing
halitosis
supragingival
plaque
clinical
trial.
Materials
methods
The
minimum
inhibitory
concentration
(MIC)
bactericidal
(MBC)
compound
Fusobacterium
nucleatum
,
Porphyromonas
gingivalis
Streptococcus
mutans
Aggregatibacter
actinomycetemcomitans
were
determined
by
gradient
dilution
method.
Subsequently,
CCK-8
assay
was
used
to
detect
toxicity
on
human
gingival
fibroblastst,
analyzed
randomized,
double-blind,
parallel-controlled
Results
exhibited
significant
effects
tested
pathogens
MIC
<
1.56%
(v/v)
MBC
3.13%
(v/v),
containing
did
not
inhibit
viability
fibroblasts
at
test
concentrations.
trial
showed
that
group
displayed
notably
lower
volatile
sulfur
compounds
(VSCs)
0,
10,
24
h,
7
d
post-mouthwash
(
P
0.05),
compared
baseline.
After
days,
VSC
levels
control
groups
reduced
50.27%
32.12%,
respectively,
cutting
severe
57.03%
group.
Additionally,
Plaque
Index
(PLI)
decreased
54.55%
8.38%,
there
difference
PLI
between
two
after
days
0.01).
Conclusions
ε-PL,
FP
demonstrated
potent
newly
formulated
added
anti-dental
anti-halitosis
properties
safe.
Trial
registration
randomized
controlled
registered
Chinese
Clinical
Registry
(No.
ChiCTR2300073816,
Date:
21/07/2023).