Aberrant intrinsic functional brain topology in methamphetamine-dependent individuals after six-months of abstinence DOI Creative Commons
Xiang Li, Jinyu Cong,

Kunmeng Liu

et al.

Mathematical Biosciences & Engineering, Journal Year: 2023, Volume and Issue: 20(11), P. 19565 - 19583

Published: Jan. 1, 2023

Our aim was to explore the aberrant intrinsic functional topology in methamphetamine-dependent individuals after six months of abstinence using resting-state magnetic imaging (rs-fMRI). Eleven methamphetamines (MA) abstainers who have abstained for and eleven healthy controls (HC) were recruited rs-fMRI examination. The graph theory connectivity (FC) analysis employed investigate brain between two groups at multiple levels. Compared with HC group, characteristic shortest path length ($ {L}_{p} $) showed a significant decrease global level, while efficiency {E}_{glob} local {E}_{loc} an increase considerably. After FDR correction, we found group differences nodal degree regional level ventral attentional network (VAN), dorsal (DAN), somatosensory (SMN), visual (VN) default mode (DMN). In addition, NBS method presented aberrations edge-based FC, including frontoparietal (FPN), subcortical (SCN), VAN, DAN, SMN, VN DMN. Moreover, FC large-scale networks revealed within SCN networks. These findings suggest that some functions, e.g., processing skills, object recognition memory, may not fully recover withdrawal. This leads possibility relapse behavior when confronted MA-related cues, which contribute explaining mechanism. We also provide basis revealing neural mechanism MA-dependency abstinence.

Language: Английский

Altered functional connectivity of the default mode and frontal control networks in patients with insomnia DOI Creative Commons
Hui Zheng, Qin Zhou, Junjie Yang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(8), P. 2318 - 2326

Published: March 21, 2023

The purpose of this study was to investigate the association between spontaneous regional activity and brain functional connectivity, which maybe can distinguish insomnia while being responsive repetitive transcranial magnetic stimulation (rTMS) treatment effects in patients.

Language: Английский

Citations

18
Electroencephalography connectome changes in chronic insomnia disorder are correlated with neurochemical signatures DOI
Liyong Yu, Wei Peng, Wenting Lin

et al.

SLEEP, Journal Year: 2024, Volume and Issue: 47(7)

Published: March 23, 2024

Abstract Study Objectives This study aimed to investigate the alterations in resting-state electroencephalography (EEG) global brain connectivity (GBC) patients with chronic insomnia disorder (CID) and explore correlation between macroscale connectomic variances microscale neurotransmitter distributions. Methods We acquired 64-channel EEG from 35 female CID 34 healthy females. signals were source-localized using individual anatomy orthogonalized mitigate volume conduction. Correlation coefficients band-limited source-space power envelopes of DK 68 atlas computed averaged across regions determine specific GBC values. A support vector machine (SVM) classifier utilizing features was employed differentiate controls. further used Neurosynth a 3D receptors/transporters assess cognitive functions landscape associated cortical abnormality maps, respectively. Results exhibited elevated within medial prefrontal cortex limbic cortex, particularly at gamma carrier frequency, compared controls (pFDR < .05). patterns found effectively distinguish precision 90.8% SVM model. The maps significantly correlated meta-analytic terms like “cognitive control” “emotion regulation.” Notably, profiles (pspin .05), systems such as norepinephrine, dopamine, serotonin making significant contributions. Conclusions work characterizes profile CID, facilitating cost-effective clinical translation EEG-derived markers. Additionally, linkage distribution offers promising avenues for developing targeted treatment strategies CID.

Language: Английский

Citations

5
Why is vestibular migraine associated with many comorbidities? DOI
Yanmin Ma,

Daopei Zhang,

Huailiang Zhang

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Language: Английский

Citations

4
Aberrant regional neural fluctuations and functional connectivity in insomnia comorbid depression revealed by resting-state functional magnetic resonance imaging DOI
Shuang Wang, Bo Li,

Minghe Xu

et al.

Cognitive Neurodynamics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 6, 2025

Language: Английский

Citations

0
Repetitive Transcranial Magnetic Stimulation and Tai Chi Chuan for Older Adults With Sleep Disorders and Mild Cognitive Impairment DOI Creative Commons
Zhizhen Liu, Lin Zhang,

Linxin Bai

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(1), P. e2454307 - e2454307

Published: Jan. 10, 2025

Importance Sleep disorders and mild cognitive impairment (MCI) commonly coexist in older adults, increasing their risk of developing dementia. Long-term tai chi chuan has been proven to improve sleep quality adults. However, adherence extended training regimens can be challenging. Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulation technique that may enhance the benefits exercise. Objective To investigate whether 1-Hz rTMS right dorsolateral prefrontal cortex could clinical improving function among adults with MCI. Design, Setting, Participants This 2-arm, sham-controlled, assessor-masked randomized trial was conducted at university hospital China between October 2022 February 2024. Adults aged 60 75 years MCI were eligible. Data analysis performed from May Intervention 1:1 ratio an experimental group (tai rTMS) or sham rTMS). Each participant received 30 sessions personalized targeting cortex, underwent same procedure. The 2 groups minutes 24-form simplified chuan, 5 times per week for 6 weeks. Main Outcomes Measures primary outcomes subjective assessed by Pittsburgh Quality Index (PSQI), which scores range 0 21, lower indicating healthier quality, global Montreal Cognitive Assessment (MoCA), 30, higher less impairment. secondary included measures objective actigraphy, anxiety depression scales, other subdomains. Assessments baseline, weeks after intervention, 12-week follow-up. Results A total 110 participants (mean [SD] age, 67.9 [4.6] years; 68 female [61.8%]) (n = 55) intention-to-treat analysis. At compared group, showed PSQI score (between-group mean difference, −3.1 [95% CI, −4.2 −2.1]; P < .001) MoCA 1.4 0.7-2.1]; .001). per-protocol dataset analyses follow-up similar results. generalized estimated equation model revealed interaction effect −2.1 −0.1]; 0.9 0.1-1.6]; .01). There 7 nonserious, unrelated adverse events (experimental group: 2; 5) no significant difference groups. Conclusions Relevance In this trial, findings suggest enhanced MCI, related alterations neural plasticity. These provide novel data on nonpharmacologic strategies rehabilitation delay even prevent Trial Registration Chinese Clinical Registry Identifier: ChiCTR2200063274

Language: Английский

Citations

0
Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD DOI Creative Commons

Maojia Ran,

Hang Zhang,

Meijiang Jin

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 3, 2025

Objective Adolescents with major depressive disorder (MDD) exhibit abnormal dynamic functional connectivity (dFC) patterns, but it remains unclear whether these aberrant dFC patterns are linked to antidepressant treatment. The aim of this study is investigate will be changed by treatment, as well baseline pattern could predict treatment response in adolescent MDD patients. Method We included 35 drug-naïve, first-episode adolescents (age 14.40 ± 1.24; 8 males and 27 females) 24 healthy controls (HCs, age 14.21 1.41; 11 13 females). All received 6 weeks Resting state T1 MRI data were collected before after HCs. Independent component analysis (ICA) was used compare the different between HCs at baseline, which adolescents. Finally, Pearson correlation multivariate linear regression analyses explore associations score BDI Results mean value right inferior frontal gyrus (IFG) bilateral insular cortex (IC; right, r = −0.461, p -FDR 0.012; left, −0.518, 0.007) negatively correlated reduction. left pole (FP) superior parietal lobule (SPL) positively reduction ( 0.442, 0.014). And values IFG IC (right, β −1.563, 0.021; −1.868, 0.012) response. Conclusion These findings demonstrate that some brain areas a prospective factor for predicting

Language: Английский

Citations

0
Sleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men DOI Creative Commons
Guangfei Li, Dandan Zhong, Bao Li

et al.

The International Journal of Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 26(12), P. 879 - 889

Published: Oct. 31, 2023

Abstract Background The basal nucleus of Meynert (BNM), a primary source cholinergic projections to the cortex, plays key roles in regulating sleep-wake cycle and attention. Sleep deficit is associated with impairment cognitive emotional functions. However, whether or how circuit, sleep, cognitive/emotional dysfunction are inter-related remains unclear. Methods We curated Human Connectome Project data explored BNM resting state functional connectivities (rsFC) relation sleep deficit, based on Pittsburgh Quality Index (PSQI), performance, subjective reports states 687 young adults (342 women). Imaging were processed published routines evaluated at corrected threshold. assessed correlation between rsFC, PSQI, clinical measurements Pearson regressions their inter-relationships mediation analyses. Results In whole-brain age alcohol use severity as covariates, men showed lower rsFC posterior cingulate cortex (PCC) PSQI score. No clusters identified women same Both BNM-PCC score significantly correlated anxiety, perceived stress, neuroticism scores men. Moreover, analyses that mediated relationship these measures negative emotions bidirectionally Conclusions PCC. Negative related through poor quality. These findings specific men, suggesting potential sex differences neural circuits states.

Language: Английский

Citations

7
The association between insomnia symptoms and cognitive flexibility among undergraduates: An event-related potential study DOI Creative Commons
Muyu Chen, Xinpeng Zhang, Xinyu Liu

et al.

Sleep Medicine, Journal Year: 2024, Volume and Issue: 121, P. 343 - 351

Published: July 15, 2024

To explore the association between insomnia symptoms and cognitive flexibility among undergraduates, along with its potential neural mechanisms.

Language: Английский

Citations

2
Fractional amplitude of low-frequency fluctuation alterations in patients with cervical spondylotic myelopathy: a resting-state fMRI study DOI

Kaifu Wu,

Han Li, Yuanliang Xie

et al.

Neuroradiology, Journal Year: 2024, Volume and Issue: 66(5), P. 847 - 854

Published: March 26, 2024

Language: Английский

Citations

1
Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI DOI Creative Commons
Ke Dai, Xianwei Liu, Jun Hu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 29, 2024

Introduction Insomnia is a common comorbidity symptom in major depressive disorder (MDD) patients. Abnormal brain activities have been observed both MDD and insomnia patients, however, the central pathological mechanisms underlying co-occurrence of patients are still unclear. This study aimed to explore differences spontaneous activity between with without insomnia, as well different level insomnia. Methods A total 88 first-episode drug-naïve including 44 (22 high 22 low insomnia) healthy controls (HC), were enrolled this study. The depression evaluated by HAMD-17, adjusted HAMD-17 its sleep disturbance subscale all subjects. Resting-state functional structural magnetic resonance imaging data acquired from participants then preprocessed software DPASF. Regional homogeneity (ReHo) values regions calculated REST compared. Finally, receiver operating characteristic (ROC) curves conducted determine abnormal for identifying evaluating severity Results Analysis variance showed that there significant ReHo left middle frontal gyrus, pallidum, right superior medial gyrus rectus among three groups. Compared HC, increased triangular inferior calcarine fissure orbital decreased occipital pallidum temporal cingulate hippocampus, putamen. demonstrated anterior postcentral fusiform pallidum. In addition, had insula when compared those Moreover, exhibited lingual parietal ROC analysis impaired region might be helpful Conclusion These findings suggested wider abnormalities prefrontal-limbic circuits prefrontal cortex, which compensatory mechanism MDD. associated occurrence frontal–parietal network cause more serious related

Language: Английский

Citations

1