Epigenetics & Chromatin,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Oct. 16, 2024
Cancer
has
arisen
from
both
genetic
mutations
and
epigenetic
changes,
making
epigenetics
a
crucial
area
of
research
for
innovative
cancer
prevention
treatment
strategies.
This
dual
perspective
propelled
into
the
forefront
research.
review
highlights
important
roles
DNA
methylation,
histone
modifications
non-coding
RNAs
(ncRNAs),
particularly
microRNAs
(miRNAs)
long
RNAs,
which
are
key
regulators
cancer-related
gene
expression.
It
explores
potential
epigenetic-based
therapies
to
revolutionize
patient
outcomes
by
selectively
modulating
specific
markers
involved
in
tumorigenesis.
The
examines
promising
biomarkers
early
detection
prognosis.
also
recent
progress
oligonucleotide-based
therapies,
including
antisense
oligonucleotides
(ASOs)
antimiRs,
precisely
modulate
processes.
Furthermore,
concept
editing
is
discussed,
providing
insight
future
role
precision
medicine
patients.
integration
nanomedicine
therapy
been
explored
offers
approaches
improve
therapeutic
efficacy.
comprehensive
advances
seeks
advance
field
oncology,
ultimately
culminating
improved
fight
against
cancer.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 8, 2024
Lactic
acid
was
formerly
regarded
as
a
byproduct
of
metabolism.
However,
extensive
investigations
into
the
intricacies
cancer
development
have
revealed
its
significant
contributions
to
tumor
growth,
migration,
and
invasion.
Post-translational
modifications
involving
lactate
been
widely
observed
in
histone
non-histone
proteins,
these
play
crucial
role
regulating
gene
expression
by
covalently
attaching
lactoyl
groups
lysine
residues
proteins.
This
discovery
has
greatly
enhanced
our
comprehension
lactic
acid's
involvement
disease
pathogenesis.
In
this
article,
we
provide
comprehensive
review
intricate
relationship
between
immunity,
occurrence
lactylation
malignant
tumors,
exploitation
targeted
lactate-lactylation
immunotherapy.
Additionally,
discuss
future
research
directions,
aiming
offer
novel
insights
that
could
inform
investigation,
diagnosis,
treatment
related
diseases.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(8)
Published: Aug. 1, 2024
Abstract
Pancreatic
cancer
is
an
aggressive
with
a
poor
prognosis.
Metabolic
abnormalities
are
one
of
the
hallmarks
pancreatic
cancer,
and
cells
can
adapt
to
biosynthesis,
energy
intake,
redox
needs
through
metabolic
reprogramming
tolerate
nutrient
deficiency
hypoxic
microenvironments.
use
glucose,
amino
acids,
lipids
as
maintain
malignant
growth.
Moreover,
they
also
metabolically
interact
in
tumour
microenvironment
change
cell
fate,
promote
progression,
even
affect
immune
responses.
Importantly,
changes
at
body
level
deserve
more
attention.
Basic
research
clinical
trials
based
on
targeted
therapy
or
combination
other
treatments
full
swing.
A
comprehensive
in-depth
understanding
regulation
will
not
only
enrich
mechanisms
disease
progression
but
provide
inspiration
for
new
diagnostic
therapeutic
approaches.
Cancer Letters,
Journal Year:
2024,
Volume and Issue:
595, P. 217025 - 217025
Published: June 5, 2024
Despite
the
confirmed
role
of
LKB1
in
suppressing
lung
cancer
progression,
its
precise
effect
on
cellular
senescence
is
unknown.
The
aim
this
research
was
to
clarify
and
mechanism
restraining
telomerase
activity
adenocarcinoma.
results
showed
that
induced
apoptosis
either
vitro
or
vivo.
Overexpression
LKB1-deficient
A549
cells
led
inhibition
induction
telomere
dysfunction
by
regulating
reverse
transcriptase
(TERT)
expression
terms
transcription.
As
a
transcription
factor,
Sp1
mediated
TERT
after
overexpression.
lactate
production
inhibited
histone
H4
(Lys8)
(Lys16)
lactylation,
which
further
altered
Sp1-related
transcriptional
activity.
inhibitor
BIBR1532
beneficial
for
achieving
optimum
curative
traditional
chemotherapeutic
drugs
accompanied
glycolysis
2DG.
These
data
reveal
new
regulates
through
lactylation-dependent
inhibition,
therefore,
provide
insights
into
effects
LKB1-mediated
Our
has
opened
up
possibilities
creation
treatments.
Biological reviews/Biological reviews of the Cambridge Philosophical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 16, 2024
ABSTRACT
In
recent
years,
a
significant
breakthrough
has
emerged
in
biology,
the
identification
of
lactylation,
novel
post‐translational
process.
This
intriguing
modification
is
not
limited
to
specific
class
proteins
but
occurs
across
diverse
range,
including
histones,
signalling
molecules,
enzymes,
and
substrates.
It
can
exert
broad
regulatory
role
various
diseases,
ranging
from
developmental
anomalies
neurodegenerative
disorders
inflammation
cancer.
Thus,
it
presents
exciting
opportunities
for
exploring
innovative
treatment
approaches.
As
result,
there
been
surge
research
interest,
leading
deeper
understanding
molecular
mechanisms
functions
underlying
lactylation
within
physiological
pathological
processes.
Here,
we
review
detection
biological
disease
effects,
providing
systematic
overview
this
modification.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 4, 2024
Lactylation
is
a
process
where
lactate,
cellular
metabolism
byproduct,
added
to
proteins,
altering
their
functions.
In
the
realm
of
macrophage
activation,
lactylation
impacts
inflammatory
response
and
immune
regulation.
Understanding
effects
on
activation
vital
in
lung
diseases,
as
abnormal
function
are
pivotal
conditions
like
pneumonia,
pulmonary
fibrosis,
COPD,
cancer.
This
review
explores
concept
lactylation,
its
regulation
recent
research
progress
diseases.
It
offers
new
insights
into
disease
pathogenesis
potential
therapeutic
targets.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 10, 2025
Lactate,
long
viewed
as
a
byproduct
of
glycolysis
and
metabolic
waste.
Initially
identified
within
the
context
yogurt
fermentation,
lactate's
role
extends
beyond
culinary
applications
to
its
significance
in
biochemical
processes.
Contemporary
research
reveals
that
lactate
functions
not
merely
terminal
product
but
also
nexus
for
initiating
physiological
pathological
responses
body.
Lysine
lactylation
(Kla),
novel
post-translational
modification
(PTM)
proteins,
has
emerged
pivotal
mechanism
by
which
exerts
regulatory
influence.
This
epigenetic
potential
alter
gene
expression
patterns,
thereby
impacting
Increasing
evidence
indicates
correlation
between
adverse
prognosis
various
malignancies.
Consequently,
this
review
article
aims
encapsulate
proteins
interact
with
lactate,
elucidate
tumorigenesis
progression,
explore
therapeutic
targets
afforded
modulation
lactylation.
The
objective
is
clarify
oncogenic
provide
strategic
framework
future
directions
burgeoning
field.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Abstract
The
decrease
in
fibroblast
collagen
is
a
primary
contributor
to
skin
aging.
Lactate
can
participate
synthesis
through
lysine
lactylation
by
regulating
gene
transcription.
However,
the
precise
mechanism
which
lactate
influences
requires
further
investigation.
This
study
demonstrates
that
depletion
of
macrophages
mitigates
stimulating
effect
on
fibroblasts.
Through
joint
CUT&Tag
and
RNA‐sequencing
analyses,
feedback
loop
between
H4K12
(H4K12la)
histone
deacetylase
3
(HDAC3)
drives
lactate‐induced
are
identified.
Macrophages
uptake
extracellular
via
monocarboxylate
transporter‐1
(MCT1),
leading
an
up‐regulation
H4K12la
levels
KAT5‐KAT8‐dependent
response
Poly‐L‐Lactic
Acid
(PLLA)
stimulation,
source
low
concentration
persistent
lactate,
thereby
promoting
Furthermore,
enriched
at
promoters
TGF‐β1
TGF‐β3,
enhancing
their
Hyperlactylation
inhibits
expression
eraser
HDAC3,
while
activation
HDAC3
reduces
suppresses
In
conclusion,
this
illustrates
play
critical
role
skin,
targeting
lactate‐H4K12la‐HDAC3‐TGF‐β
axis
may
represent
novel
approach
for
production
combat
