Combined fine needle aspiration cytology and core needle biopsy in the same setting: A two‐years’ experience

Cytopathology, Journal Year: 2023, Volume and Issue: 35(1), P. 78 - 91

Published: Oct. 24, 2023

Fine needle aspiration cytology (FNAC) combined with rapid on-site evaluation (ROSE) and ancillary techniques is an accurate diagnostic tool for many pathologies. However, in some cases, it may not be sufficient actionable diagnoses or molecular testing, especially cases that require large immunohistochemical panels which histological features are mandatory the diagnosis. Core biopsy (CNB), on contrary, provides samples suitable all studies. CNB often performed by radiologists clinicians without direct participation of cytopathologists, can lead to missed delayed diagnoses. This study reports experience combining FNAC one setting cytopathologists. The aim was evaluate impact efficiency procedures.One hundred forty-two procedures same over a period 2 years were analysed. compared integrated subsequent categorized as follows: non-contributory, inadequate samples; confirmed, when same; improved, diagnosis consistent further specified corresponding entity; allowed, produced could reached FNAC; changed, changed previous diagnosis.CNB confirmed 40.1% (n = 57/142). improved 47.2% 67/142). allowed 2.1% 3/142). non-contributory 8.4% 12/142). positive whole procedure 51.4% total 73/142). resulted 91.5% 130/142). A complete assessment successfully 14.7% 21/142) utilizing either material.The use improves accuracy both procedures. approach exploits advantages each procedure, enhancing final

Language: Английский

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Parsonage–Turner Syndrome following COVID-19 Vaccination: A Systematic Review

Vaccines, Journal Year: 2024, Volume and Issue: 12(3), P. 306 - 306

Published: March 14, 2024

Background: Parsonage–Turner syndrome (PTS) is an inflammatory condition of the brachial plexus, with more than half patients presenting a trigger, such as infection or vaccination. Our objective was to synthesize clinical and paraclinical features, therapeutic responses, outcomes PTS post-COVID-19 Methods: We systematically reviewed two databases (LitCOVID WHO database on COVID-19) up January 2024 following published protocol (OSF registries). Results: included 59 cases. occurred frequently in males (61.1% mRNA group, 83.3% viral vector group). Patients group were younger (41.7% between 41 50 years vs. 38.9% 61 70 years). Most cases had sudden pain within weeks. Unilateral present 94.4% all vector-vaccinated Symptoms (97.1% 92.3%, respectively), usually followed weeks by motor deficits (97.2% 94.1%, amyotrophy (30% 81.8%, paresthesia (50% 27.3%, sensory loss (33.3% 38.5%, respectively). Viral vaccine recipients nerve involvement outside plexus. Ancillary investigations revealed CSF albuminocytological dissociation 100%, respectively) ipsilateral axillary lymphadenopathy. Two worsened after second dose, another recurred influenza One patient well tolerated dose vaccine, but symptoms reemerged another. Conclusions: Current evidence suggests may occur COVID-19 types, some subgroup differences. Also, might recur subsequent similar unrelated vaccines.

Language: Английский

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Pitfalls in Lymph Node Fine Needle Aspiration Cytology

Acta Cytologica, Journal Year: 2023, Volume and Issue: 68(3), P. 260 - 280

Published: Dec. 20, 2023

Fine needle aspiration cytology (FNAC) is an accurate, minimally invasive, and cost-effective biopsy method for enlarged lymph nodes. While the role of node FNAC in diagnosis infectious or reactive conditions metastatic malignancy unquestioned, differing views still exist on its lymphoma. Nevertheless, regardless practice setting, pitfalls potential error exist, it incumbent upon pathologist to be aware these pitfalls, as this first line defence against errors.

Language: Английский

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Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses

International Journal of Surgical Pathology, Journal Year: 2023, Volume and Issue: 32(6), P. 1123 - 1128

Published: Nov. 19, 2023

SARS-CoV-2 vaccines have been administered in many countries after the COVID-19 pandemic. Lymphadenopathy is a side effect of vaccine. We report rare example Kikuchi disease cervical lymph nodes vaccination. A 41-year-old man complained swollen neck and fever 9 days first dose mRNA-1273 Computed tomography revealed enlarged nodes. Fine needle aspiration resection were performed, clinicopathological diagnosis was consistent with disease. Histologically, resected lost their polarity, histiocytes aggregated karyorrhectic nuclear debris apoptosis. positive cells small lymphocytes detected by immunohistochemistry. This that demonstrated expression post-SARS-CoV-2

Language: Английский

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Peripheral lymphadenopathy of unknown origin in adults: a diagnostic approach emphasizing the malignancy hypothesis

Schweizerische medizinische Wochenschrift, Journal Year: 2024, Volume and Issue: 154(7), P. 3549 - 3549

Published: July 31, 2024

The term lymphadenopathy refers to an abnormality in size, consistency or morphological aspect of one several lymph nodes. Although lymphadenopathies are commonly observed everyday clinical practice, the difficulty differentiating benign and malignant disease may delay therapeutic approaches. present review aims update diagnostic algorithms different situations based on currently available literature. A literature was performed assess current knowledge approach. short vignette used as example a typical presentation. This case metastatic with incomplete patient history demonstrates how misleading such be, leading delayed diagnosis even fatal outcome. Any persisting for more than 2 weeks should be considered suspicious deserves further investigation. Precise examination, meticulous history-taking search associated symptomatology still cornerstones diagnosing origin condition. next step depends anatomical region specific patient’s situation. Imaging starts ultrasound, while computed tomography (CT) magnetic resonance imaging (MRI) allow assessment surrounding structures. If remains uncertain, tissue sampling histological analyses performed. Except head neck loco-regional lymphadenopathy, there no methodical guidelines persistent lymphadenopathy. clarifies confusing complex situations. accuracy fine needle aspiration cytology could increased by using core biopsy immunocytologic flow cytometric methods. Notably, except area, open best option when lymphoma is suspected inconclusive results previous obtained. incidence varies its location various strategies. In unknown primary origin, European Society Medical Oncology (ESMO) modern methods like next-generation sequencing (NGS) help manage cases.

Language: Английский

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COVID-19 vaccine-associated lymphadenopathy: a review

Infezioni in Medicina, Journal Year: 2024, Volume and Issue: 32(2)

Published: May 30, 2024

Following the introduction of RNA-based vaccines, COVID-19 vaccine-associated clinical lymphadenopathy (C19-LAP) has been reported as a side effect. Moreover, subclinical detected on imaging (SLDI) also observed, mainly incidental findings while performing screening tests oncological patients. In these cases, surgical lymphadenectomy, fine-needle aspiration cytology (FNAC) and core needle biopsy (CNB) have used valuable diagnostic tool for SLDI C19-LAP. this review clinical, histologic cytologic features C19-LAP investigated. A search studies that histopathology cytopathology was performed PubMed Google Scholar, 11 January 2023. Thirty-one reports were retrieved included in pooled analysis. total, we 54 patients with median age 47 years. our research, excision, CNB and/or FNAC or enlarged lymph nodes cases. Of all only two metastases diagnosed one case reactive hyperplasia atypical follicles. The remaining cases (28 cases), follicular (13 Kikuchi-Fujimoto disease (6 granulomatous lymphadenitis (2 eosinophilic node abscesses (1 case), Langherans cell histiocytosis Rosai-Dorfman case). represented dilemma, especially oncologic role different tools discussed.

Language: Английский

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Distinguishing Axillary Lymphadenopathy after COVID-19 Vaccination from Malignant Lymphadenopathy

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3387 - 3387

Published: June 9, 2024

Objectives: To study the differences between malignant hypermetabolic axillary lymphadenopathy (MHL) and COVID-19 vaccine-associated (VAHL) using clinical imaging. Methods: A total of 1096 patients underwent Positron Emission Tomography-Computed Tomography (PET-CT) 1 June 2021 30 April 2022 at Ehime University Hospital. In total, 188 with after vaccination were evaluated. The classified into three groups such as VAHL (n = 27), MHL 21), equivocal (EqHL; n 140). Differences in lymph node (LN) swellings statistically analyzed imaging (echography, CT, 18F-FDG PET). Results: included a higher female population (90.5%) owing to frequency breast cancer (80.9%). Axillary LNs did not show any LN fatty hilums (0%); however, those EqHL (15.8 36%, respectively). After logistic regression analysis who had without hilums, minor axis length ellipticity (minor axis/major axis) largest LN, SUVmax, Tissue-to-Background Ratio (TBR) useful distinguishing lymphadenopathies. receiver-operating characteristic (ROC) indicated that cut-off value ≥7.3 mm for (sensitivity: 0.714, specificity: 0.684) ≥0.671 (0.667 0.773, respectively) highest SUVmax TBR predictive MHL. Conclusions: may be suspicious malignancy, even have received vaccination. Further examinations, PET, are recommended patients.

Language: Английский

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