Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936 DOI Creative Commons
Gergő Baranyi, Colin R. Buchanan, Eleanor L.S. Conole

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(11), P. 3483 - 3494

Published: May 21, 2024

Abstract Neighbourhood disadvantage may be associated with brain health but the importance of exposure at different stages life course is poorly understood. Utilising Lothian Birth Cohort 1936, we explored relationship between residential neighbourhood deprivation from birth to late adulthood, and global local neuroimaging measures age 73. A total 689 participants had least one valid (53% male); maximise sample size structural equation models full information maximum likelihood were conducted. Residing in disadvantaged neighbourhoods mid- adulthood was smaller ( β = −0.06; SE 0.02; size[ N ] 658; number pairwise complete observations[ n ]=390), grey matter −0.11; 0.03; 390), normal-appearing white volumes −0.07; thinner cortex −0.14; 0.06; 636; 379), lower general fractional anisotropy −0.19; 665; 388). We also found some evidence on accumulating impact 73 276) −0.10; 0.04; 276). Local analysis identified affected focal cortical areas specific tracts. Among individuals belonging social classes, brain-neighbourhood associations particularly strong, volumes, across course. Our findings suggest that living deprived course, especially adverse morphologies, class amplifying vulnerability.

Language: Английский

Rethinking minority stress: A social safety perspective on the health effects of stigma in sexually-diverse and gender-diverse populations DOI
Lisa M. Diamond, Jenna Alley

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 138, P. 104720 - 104720

Published: June 2, 2022

Language: Английский

Citations

218
Associations Between Neighborhood Disadvantage, Resting-State Functional Connectivity, and Behavior in the Adolescent Brain Cognitive Development Study: The Moderating Role of Positive Family and School Environments DOI
Divyangana Rakesh, Caio Seguin, Andrew Zalesky

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2021, Volume and Issue: 6(9), P. 877 - 886

Published: March 23, 2021

Language: Английский

Citations

139
Socioeconomic status and the developing brain – A systematic review of neuroimaging findings in youth DOI
Divyangana Rakesh, Sarah Whittle

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 130, P. 379 - 407

Published: Aug. 30, 2021

Language: Английский

Citations

130
Food Insecurity and Child Development: A State-of-the-Art Review DOI Open Access
Danielle Gallegos, Areana Eivers, Peter Sondergeld

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(17), P. 8990 - 8990

Published: Aug. 26, 2021

Converging research indicates that household food insecurity impedes children from reaching their full physical, cognitive, and psychosocial potential. This state-of-the-art review examines the last decade of to: (1) describe impact severity persistence on child development; (2) use a socio-ecological framework to examine significant proximal distal factors which may interplay; (3) outline directions for future research. We conducted systematic six databases published papers 2011 June 2021. The search was limited high-income countries aged birth 12 years. From 17,457 papers, 17 studies were included in final review. Transitioning between security had lasting effect academic/cognitive function behavior (i.e., externalizing), however less clear relationships seen outcomes other behaviors examined internalizing). There variation measurement thresholds used define both development outcomes. Subsequently, comparisons across are difficult. Several recommendations, including incorporation factors, is provided. In conclusion, this supports link sub-optimal however, there an imperative improve extend current understanding ameliorate causes insecurity.

Language: Английский

Citations

109
Racial Disparities in Adversity During Childhood and the False Appearance of Race-Related Differences in Brain Structure DOI

Nathalie M. Dumornay,

Lauren A. M. Lebois, Kerry J. Ressler

et al.

American Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 180(2), P. 127 - 138

Published: Feb. 1, 2023

Objective: Black Americans in the United States are disproportionately exposed to childhood adversity compared with White Americans. Such disparities may contribute race-related differences brain structures involved regulating emotional response stress, such as amygdala, hippocampus, and prefrontal cortex (PFC). The authors investigated neuroanatomical consequences of racial adversity. Methods: sample included 7,350 American 1,786 children (ages 9–10) from Adolescent Brain Cognitive Development Study (public data release 2.0). Structural MRI data, parent child self-reports adversity-related measures, U.S. Census neighborhood were used investigate relationship between exposure structure. Results: experienced more traumatic events, family conflict, material hardship on average children, their parents or caregivers had lower educational attainment, income, unemployment those children. showed PFC gray matter volumes but not also varied metrics adversity, income being most common predictor volume differences. Accounting for attenuated magnitude some volume. Conclusions: results suggest that key regions associated threat-related processes. alterations these linked cognitive-affective dysfunction observed disorders posttraumatic stress disorder. More granular assessments structural inequities across racial/ethnic identities needed a thorough understanding impact brain. Together, present findings provide insight into potential systemic contributors disparate rates psychiatric disease among individuals States.

Language: Английский

Citations

86
A research agenda for understanding how social inequality is linked to brain structure and function DOI
Mark L. Hatzenbuehler, Katie A. McLaughlin, David G. Weissman

et al.

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(1), P. 20 - 31

Published: Jan. 3, 2024

Language: Английский

Citations

17
Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience DOI
Dylan G. Gee

American Journal of Psychiatry, Journal Year: 2021, Volume and Issue: 178(11), P. 998 - 1013

Published: Nov. 1, 2021

Adversity early in life is common and a major risk factor for the onset of psychopathology. Delineating neurodevelopmental pathways by which adversity affects mental health critical identification targeted treatment approaches. A rapidly growing cross-species literature has facilitated advances identifying mechanisms linking with psychopathology, specific dimensions timing-related factors that differentially relate to outcomes, protective buffer against effects adversity. Yet, vast complexity heterogeneity environments trajectories contribute challenges understanding resilience context In this overview, author highlights progress four areas—mechanisms, heterogeneity, developmental timing, factors; synthesizes key challenges; provides recommendations future research can facilitate field. Translation across species ongoing refinement conceptual models have strong potential inform prevention intervention strategies reduce immense burden psychopathology associated

Language: Английский

Citations

91
An ecological approach to understanding the developing brain: Examples linking poverty, parenting, neighborhoods, and the brain. DOI
Luke W. Hyde, Arianna M. Gard, Rachel C. Tomlinson

et al.

American Psychologist, Journal Year: 2020, Volume and Issue: 75(9), P. 1245 - 1259

Published: Dec. 1, 2020

We describe an ecological approach to understanding the developing brain, with a focus on effects of poverty-related adversity brain function. articulate how combining multilevel models from developmental science and psychopathology human neuroscience can inform our risk resilience. To illustrate this approach, we associations between poverty function, roles parents neighborhoods play in context, potential impact timing. also major challenges needed advances these areas research better understand why may including need for: population greater attention sampling representation, genetically informed causal designs, assessing context caution interpretation effects, Work area has implications for policy prevention, which are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Language: Английский

Citations

87
Similar but distinct – Effects of different socioeconomic indicators on resting state functional connectivity: Findings from the Adolescent Brain Cognitive Development (ABCD) Study® DOI Creative Commons
Divyangana Rakesh, Andrew Zalesky, Sarah Whittle

et al.

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 51, P. 101005 - 101005

Published: Aug. 14, 2021

Early socioeconomic status (SES) has consistently been associated with child health and cognitive outcomes, in addition to alterations brain function connectivity. The goal of the present study was probe effects different facets SES (parent education, income, neighborhood disadvantage), that likely represent varying aspects environment, on resting state functional connectivity (rsFC). We investigated this question a large sample 9475 children (aged 9-10 years) from Adolescent Brain Cognitive Development (ABCD) Study. Specifically, we analyzed association between household income-to-needs ratio) disadvantage, system-level rsFC using within-sample split-half replication. then tested whether associations were unique each measure, disadvantage had interactive rsFC. measures both common distinct rsFC, sensory-motor systems (e.g., sensorimotor network) networks front-parietal particularly implicated. Further, network less pronounced presence high income-to-needs. Findings demonstrate have interacting highlighting importance considering indicators when studying brain.

Language: Английский

Citations

77
Association of Local Variation in Neighborhood Disadvantage in Metropolitan Areas With Youth Neurocognition and Brain Structure DOI
Daniel A. Hackman, Dora Cserbik,

Jiu‐Chiuan Chen

et al.

JAMA Pediatrics, Journal Year: 2021, Volume and Issue: 175(8), P. e210426 - e210426

Published: May 3, 2021

Neighborhood disadvantage is an important social determinant of health in childhood and adolescence. Less known about the association neighborhood with youth neurocognition brain structure, particularly whether associations are similar across metropolitan areas attributed to local differences disadvantage.To test associated neurocognitive performance global regional measures structure after adjusting for family socioeconomic status perceptions characteristics, assess these (1) pervasive or limited, (2) vary areas, (3) variation within areas.This cross-sectional study analyzed baseline data from Adolescent Brain Cognitive Development (ABCD) Study, a cohort conducted at 21 sites US. Participants were children aged 9.00 10.99 years enrollment. They their parent caregiver completed visit between October 1, 2016, 31, 2018.Neighborhood factor based on US census tract characteristics.Neurocognition was measured NIH Toolbox Cognition Battery, T1-weighted magnetic resonance imaging used whole-brain structure. Linear mixed-effects models examined outcomes sociodemographic factors.Of 11 875 ABCD Study cohort, 8598 (72.4%) included this analysis. The sample had mean (SD) age 118.8 (7.4) months 4526 boys (52.6%). Every 1-unit increase lower 6 7 subtests, such as Flanker Inhibitory Control Attention (unstandardized Β = -0.5; 95% CI, -0.7 -0.2; false discovery rate (FDR)-corrected P .001) List Sorting Working Memory -0.7; -1.0 -0.3; FDR-corrected < .001), well all composite neurocognition, Total Composite -0.9 .001). Each cortical surface area -692.6 mm2; -1154.9 -230.4 .007) subcortical volume -113.9 mm3; -198.5 -29.4 .03) differences, primarily frontal, parietal, temporal lobes. Associations largely remained safety both consistent explained by each area.This found that, US, smaller young people. findings demonstrate that environmental risk neurodevelopmental population enhancing context promising approach improving development adolescents.

Language: Английский

Citations

76