Comparison of water mobility and distribution in Dioscorea opposita Thunb. cv. Tiegun during hot‐air and microwave drying processes DOI
Lingyun Pang, Shuihuan Guo, Lijuan Zhan

et al.

International Journal of Food Science & Technology, Journal Year: 2024, Volume and Issue: 59(4), P. 2558 - 2569

Published: Feb. 25, 2024

Summary Low‐field nuclear magnetic resonance (LF‐NMR) was employed to investigate changes in mobility as well distribution of water yam slices the course hot‐air drying (HAD) and microwave (MD) processes. Moisture content, effective moisture diffusivity, activity were also analysed. According results, a total three fractions with various T 2 relaxation times observed fresh slices: 21 (0.9–2.6 ms), 22 (30–130 23 (130–1245 ms). With increment temperature rise power drying, there significant decline transverse time peak amplitude . The overall content exhibited good correlation A during both HAD MD processes, coefficients equivalent 0.9194 0.9024, respectively. rising power, corresponding diffusivity. In comparison HAD, rate diffusion evaporation dried by higher. Taking into account efficiency state, suggested preferable technology for dehydrating slices.

Language: Английский

An overview of the nutritional composition, bioactivities and applications of Chinese yam (Dioscoreas Oppositae) DOI
Great Iruoghene Edo, Susan Chinedu Nwachukwu, Patrick Othuke Akpoghelie

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
The gastroprotective effect of Yucca filamentosa standardized crude leaves extract versus its nano-cubosomal formulation in ethanol-induced gastric injury DOI
Sherihan Salaheldin Abdelhamid Ibrahim,

Samar M. Bassam,

Seham S. El‐Hawary

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112440 - 112440

Published: June 12, 2024

Language: Английский

Citations

6
Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy DOI Creative Commons
Lubna Rahman, Ali Talha Khalil,

Syed Ahsan Shahid

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(9), P. 6070 - 6092

Published: June 18, 2024

Abstract Diosmin, a potent bioflavonoid derived from citrus fruits, has gained significant attention for its anticancer potential, reflecting critical need in the ongoing battle against cancer. Amidst increasing cancer incidence, quest safer and more effective treatments brought diosmin to forefront, given unique pharmacological profile distinct other flavonoids. Diosmin's mechanisms are multifaceted, involving apoptosis induction, angiogenesis inhibition, metastasis prevention. Extensive research encompassing cellular studies, animal models, limited clinical trials underscores efficacy not only but also managing chronic venous insufficiency hemorrhoids, attributing anti‐inflammatory properties. Furthermore, exhibits low toxicity complements conventional chemotherapy, proposing utility as an adjunct therapy treatment protocols. The review delves into specific advantages of diosmin, distinguishing it broader flavonoid category. It provides detailed analysis implications preclinical settings, advocating consideration oncological therapeutic arsenal. By juxtaposing with herbal medicines, offers nuanced perspective on role within wider context natural agents, emphasizing further substantiate safety oncology.

Language: Английский

Citations

5
Genome-wide methylation, transcriptome and characteristic metabolites reveal the balance between diosgenin and brassinosteroids in Dioscorea zingiberensis DOI Creative Commons
Zihao Li, Yi Li,

Luyu Geng

et al.

Horticulture Research, Journal Year: 2024, Volume and Issue: 11(4)

Published: Feb. 23, 2024

Diosgenin (DG) is a bioactive metabolite isolated from Dioscorea species, renowned for its medicinal properties. Brassinosteroids (BRs) are class of crucial plant steroidal hormones. Cholesterol and campesterol important intermediates DG BR biosynthesis, respectively. BRs structurally similar components; however, the regulatory network metabolic interplays have not been fully elucidated. In an effort to decode these complex networks, we conducted comprehensive study integrating genome-wide methylation, transcriptome characteristic data zingiberensis. Leveraging data, were able construct linking BRs. Mass spectrometry results enabled us clarify alterations in cholesterol, campesterol, diosgenin, castasterone (one major active BRs). The content decreased by 27.72% at 6 h after brassinolide treatment, whereas increased 85.34% brassinazole treatment. Moreover, pinpointed DG/BR-related genes, such as CASs, CYP90s, B3-ARFs, implicated pathways CASs CYP90s exhibit hypomethylation, which closely related their high transcription. These findings provide robust evidence homeostasis between conclusion, our research revealed existence balance D. Furthermore, work only provides new insights into relationship two but also offers fresh perspective on functions secondary metabolites.

Language: Английский

Citations

4
Exploring the molecular mechanism of Dioscorea alata L. for the treatment of Menstrual disorders using network pharmacology and molecular docking. DOI Creative Commons

Rajendran Silambarasan,

Ajay Nair,

Gomathi Maniyan

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42582 - e42582

Published: Feb. 1, 2025

Menstrual disorders (MDs), including premenstrual syndrome, amenorrhea, and dysmenorrhea, affect women globally. Dioscorea alata L., a traditional yam species, has been used medicinally, but its potential in treating MDs remains understudied. This study employs network pharmacology approach to examine the effects of D. alata's secondary metabolites on via multi-target mechanisms. Compounds were identified from literature PubChem, while disease-related targets gathered GeneCards, DisGeNET, CTD databases. Swiss target prediction was link compounds targets. A protein-protein interaction (PPI) constructed using STRING, Gene Ontology (GO) KEGG enrichment analyses conducted predict functional pathways. Eighteen bioactive 120 therapeutic specific identified. analysis revealed 20 significant pathways related menstrual disturbances. Among targets, TNF α, PPARG, ESR1, AKT1 highlighted as key Molecular docking showed strong interactions between Daidzein Diosgenin Alatanin AKT1, PPARG. The findings suggest that compounds, such Diosgenin, Daidzein, Genistin, Cycloartane, Alatanin, could modulate involved ovarian follicle formation, hormone regulation, estrogen receptor signaling, stress-activated MAP kinase pathway. provides new insights into for disorders, supporting further investigation development.

Language: Английский

Citations

0
Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation DOI

Zhengcai Ma,

Juan Li,

Jianyu Zhu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114405 - 114405

Published: March 13, 2025

Language: Английский

Citations

0
MOLECULAR AND AGRO-MORPHOLOGICAL EVALUATIONS OF INTERSPECIFIC HYBRIDISATION IN TWO WILD YAMS (Dioscorea spp.) FOR GENETIC IMPROVEMENT. DOI
Femi Patrick Oyedoyin, Odunayo Joseph Olawuyi, Paterne A. Agre

et al.

Ecological Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown, P. 100345 - 100345

Published: March 1, 2025

Language: Английский

Citations

0
Establishment of in vitro root cultures and hairy roots of Dioscorea composita for diosgenin production DOI

Guadalupe Cristina Sánchez-López,

David Carranza-Ojeda,

Lemuel Pérez‐Picaso

et al.

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2025, Volume and Issue: 161(1)

Published: April 1, 2025

Language: Английский

Citations

0
Yam as functional food: bioactive properties, health benefits, and applications DOI Creative Commons
Muhammad Burhan Khan Tareen, Nahla Saeed,

Muhammad Tauseef Sultan

et al.

Food, Nutrition and Health., Journal Year: 2025, Volume and Issue: 2(1)

Published: April 23, 2025

Abstract The growing focus on balanced diets and health-enhancing foods has underscored the importance of functional crops like yam ( Dioscorea spp.), which serves as both a nutritional staple source medicinal bioactives. Yam is consumable subterranean rhizomes or tubers, derived from plant sources in genus. More than 90 roughly 600 species found world are East Asia. Additionally, contains bioactive compounds, non-nutritive components with vital health benefits, including phenolic saponins, tannins, flavonoids, contribute to its diverse therapeutic potential. Despite numerous benefits inherent yams, they also offer huge healthy perks, antioxidants, anti-inflammatory, hypoglycemic, antimicrobial, anti-tumor outcomes, making them important food candidates nutraceutical pharma sectors. This review synthesizes current knowledge composition, properties, extraction methods, potentials, biological properties administration. Strategies enhance utilization for greater impact discussed. highlights potential food, emphasizing role promoting dietary diversity contributing prevention management non-communicable diseases, while exploring associated challenges, emerging applications, future research directions. Graphical

Language: Английский

Citations

0
An HD-ZIP I Transcription Factor DZHDZ32 Upregulates Diosgenin Biosynthesis in Dioscorea zingiberensis DOI Open Access
Huan Yang, Yi Li,

Zixuan Hu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4185 - 4185

Published: April 28, 2025

Diosgenin, a crucial precursor for steroidal drug production, has poorly understood regulatory pathways. Diosgenin is the primary active component of Dioscorea zingiberensis. Notably, D. zingiberensis also possesses highest diosgenin content among species, reaching up to 16.15% dry weight. This study identified DZHDZ32 as potential regulator biosynthesis in through transient overexpression. To validate its function, we developed an optimized genetic transformation method and generated two DZHDZ32-overexpressing lines. The transcription factor belongs HD-ZIP I subfamily localized nucleus. overexpression resulted significant increase transcript levels leaves (264.59- 666.93-fold), leading elevated biosynthetic intermediates, including cholesterol β-sitosterol. Specifically, increased by 41.68% 68.07%, 10.29% 16.03%, β-sitosterol 12.33% 19.49% compared wild-type plants. Yeast one-hybrid dual-luciferase assays demonstrated that directly binds promoters ACAT GPPS1, consistent with upregulation GPPS1 expression (3.69- 4.87-fold 4.75- 6.53-fold, respectively) overexpressing established key biosynthesis. discovery implications enhancing production advancing development.

Language: Английский

Citations

0