Current Problems in Cardiology, Journal Year: 2022, Volume and Issue: 48(6), P. 101112 - 101112
Published: Jan. 7, 2022
Language: Английский
Cardiovascular Diabetology, Journal Year: 2021, Volume and Issue: 20(1)
Published: Nov. 6, 2021
Abstract Type 2 diabetes is one of the most relevant risk factors for heart failure, prevalence which increasing worldwide. The aim review to highlight current perspectives pathophysiology failure as it pertains type diabetes. This summarizes proposed mechanistic bases, explaining myocardial damage induced by diabetes-related stressors and other factors, i.e., cardiomyopathy in We complex pathology individuals with diabetes, including relationship chronic kidney disease, metabolic alterations, failure. also discuss criteria used diagnosis gold standard screening tools Currently approved pharmacological therapies primary use treatment-guiding role NT-proBNP are presented. Finally, influence presence well on COVID-19 severity briefly discussed.
Language: Английский
Citations
74
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15
Published: June 24, 2022
Cardiovascular disease (CVD) is a broad term that incorporated group of conditions affect the blood vessels and heart. CVD foremost cause fatalities around world. Multiple pathophysiological mechanisms are involved in CVD; however, oxidative stress plays vital role generating reactive oxygen species (ROS). Oxidative occurs when concentration oxidants exceeds potency antioxidants within body while producing nitrogen (RNS). ROS generated by disrupts cell signaling, DNA damage, lipids, proteins, thereby resulting inflammation apoptosis. Mitochondria primary source production cells. Increased reduces nitric oxide (NO) bioavailability, which elevates vasoconstriction arteries contributes to development hypertension. has also been linked atherosclerotic plaque. Antioxidants can decrease body; various therapeutic drugs have designed treat damage due CVD. The present review provides detailed narrative generation with focus on biomarker its association We discussed complex relationship between endothelial dysfunction as well stress-induced obesity Finally, we reducing
Language: Английский
Citations
69
European Journal of Heart Failure, Journal Year: 2021, Volume and Issue: 24(3), P. 497 - 509
Published: Dec. 17, 2021
There is an association between heart failure with preserved ejection fraction (HFpEF) and insulin resistance, but less known about the diabetic continuum, in particular pre-diabetes, HFpEF. We examined characteristics outcomes of participants diabetes or pre-diabetes PARAGON-HF.Patients aged ≥50 years left ventricular ≥45%, structural disease elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) were eligible. Patients classified according to glycated haemoglobin (HbA1c): (i) normal HbA1c, <6.0%; (ii) 6.0%-6.4%; (iii) diabetes, ≥6.5% history diabetes. The primary outcome was a composite cardiovascular (CV) death total hospitalizations (HFH). Of 4796 patients, 50% had 18% pre-diabetes. Compared patients more often obese, myocardial infarction lower Kansas City Cardiomyopathy Questionnaire scores, while clinical evidence congestion, similar NT-proBNP concentrations. risks (rate ratio [RR] 1.59, 95% confidence interval [CI] 1.35-1.88), HFH (RR 1.67, CI 1.39-2.02) CV (hazard [HR] 1.35, 1.07-1.71) higher among compared those HbA1c. risk (which intermediate that HbA1c) (HR 1.27, 1.00-1.60) 1.03-1.77), not 1.02, 0.75-1.40). treated worse than not, 'lean diabetes' mortality rates body mass index, HFH.Pre-diabetes common HFpEF associated status greater HFH.ClinicalTrials.gov Identifier NCT01920711.
Language: Английский
Citations
63
Diabetes Obesity and Metabolism, Journal Year: 2022, Volume and Issue: 24(12), P. 2283 - 2296
Published: Aug. 5, 2022
Abstract Insights from epidemiological, clinical and basic research are illuminating the interplay between metabolic disorders, cardiovascular disease (CVD) kidney dysfunction, termed cardio‐renal‐metabolic (CRM) disease. Broadly defined, CRM involves multidirectional interactions diseases such as type 2 diabetes (T2D), various types of CVD chronic (CKD). T2D confers increased risk for heart failure, which—although well known—has only recently come into focus treatment, may differ by ethnicity, whereas atherosclerotic is a well‐established complication T2D. Many people with also have CKD, higher in Asians than their Western counterparts. Furthermore, increases CKD vice versa, notably, present approximately half patients. Molecular mechanisms involved include hyperglycaemia, insulin resistance, hyperactivity renin‐angiotensin‐aldosterone system, production advanced glycation end‐products, oxidative stress, lipotoxicity, endoplasmic reticulum calcium‐handling abnormalities, mitochondrial malfunction deficient energy production, inflammation. Pathophysiological manifestations these processes diabetic cardiomyopathy, vascular endothelial cardiac renal fibrosis, glomerular hyperfiltration, hypoperfusion venous congestion, reduced exercise tolerance leading to calcification plaque. Importantly, recognition interaction would enable more holistic approach care, rather isolated treatment individual conditions, which improve patient outcomes. Finally, aspects East Asian countries Japan, super‐ageing country, potential differences epidemiology, complications prognosis that represent an important avenue future research.
Language: Английский
Citations
61
Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8
Published: Dec. 2, 2021
Background: Insulin resistance (IR) represents a critical regulator in the development and progress of coronary artery disease (CAD). Triglyceride-glucose (TyG) index, novel surrogate biomarker IR, has been implicated several cardiovascular diseases. Accordingly, we conduct meta-analysis to elucidate relationship between TyG index adverse events patients with CAD. Methods: To identify studies examining predictive capacity for setting CAD, performed comprehensive literature retrieval Scopus, PubMed, EMBASE, Web Science, from inception databases October 5, 2021. We pooled adjusted hazard ratio (HR) along 95% CI using random-effects model. The primary outcome was composite major (MACEs), including all-cause death, death (CV death), myocardial infarction (MI), stroke, hospitalization unstable angina or heart failure, revascularization. secondary outcomes were CV MI, Additionally, conducted subgroup analyses stratified by diabetes status, age, body mass (BMI), low-density lipoprotein cholesterol (LDL-C), category sample size, follow-up duration, study design. Results: About 12 involving 28,795 CAD finally taken into quantitative analysis. Our findings showed that there 2.14-fold higher risk MACEs among populations highest group compared those lowest (HR: 2.14, CI: 1.69-2.71, P < 0.001). A greater observed participants BMI than lower (P = 0.03 interaction). In analysis outcomes, also markedly increased revascularization group. No evidence significant association mortality identified. Conclusions: elevated is promising factor Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO, identifier: CRD42021228521.
Language: Английский
Citations
38
Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9
Published: June 10, 2022
Background The prognostic nutritional index (PNI) has been proposed as a marker of malnutrition and associated with the prognosis cardiovascular disease. However, whether PNI can serve potential biomarker for heart failure (HF) upon those established risk factors were still controversial. This meta-analysis aimed to generate comprehensive evidence on value in patients HF. Methods Multiple databases (PubMed, Embase, Cochrane Library, Google Scholar) searched related studies up January 31, 2022. Observational accessed associations between levels HF included meta-analysis. hazard ratios (HRs) 95% confidence intervals (CI) calculated. Results Fourteen studies, comprising 19,605 median follow-up duration was 18.5 months. Compared higher (normal status), lower (malnourished) all-cause mortality (HR 1.53, CI 1.27–1.85) composite major adverse cardiac outcomes (MACEs; HR 2.26, 1.54–3.31) multivariable-adjusted model. Furthermore, when defined per 1 increment continuous metric, decrease (per PNI: 0.94, 0.88–0.96) MACEs 0.97, 0.95–0.98). Conclusions an easily calculated bedside “malnutrition-inflammation” Lower worse
Language: Английский
Citations
25
Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)
Published: Sept. 28, 2024
Language: Английский
Citations
5
Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8
Published: Sept. 21, 2021
Background: Chronic inflammation in type 2 diabetes mellitus (T2DM) is an essential contributor to the development of diabetic retinopathy (DR). The monocyte–to–high-density lipoprotein cholesterol (HDL-C) ratio (MHR) a novel and simple measure related inflammatory oxidative stress status. However, little known regarding role MHR evaluating DR. Methods: A total 771 patients with T2DM 607 healthy controls were enrolled this cross-sectional study. determination eye examination performed. association prevalence DR was analyzed. Results: significantly higher than that both non-DR ( P < 0.05) 0.01). No significance observed different severity grades. Moreover, similar between non-macular oedema those macular oedema. Logistic regression analysis demonstrated independently associated [odds (OR) = 1.438, 95% confidence interval (CI): 1.249–1.655, 0.01]. After additional stratification by HbA1c level duration, still Conclusions: Our study suggests can be used as marker indicate T2DM.
Language: Английский
Citations
30
Therapeutic Advances in Chronic Disease, Journal Year: 2022, Volume and Issue: 13
Published: Jan. 1, 2022
Adequate intake of long-chain (LC) omega-3 polyunsaturated fatty acids (n-3 PUFAs) is considered important for cardiovascular health. However, the effects LC n-3 PUFAs on risk heart failure (HF) remain unclear. This systematic review and meta-analysis aimed to determine role in incidence HF.Electronic databases were searched studies up 31 July 2021. Studies included if they reported adjusted associations between different dietary intakes or circulating concentrations HF. A random-effect model was used calculate pooled estimated hazard ratios (HRs) 95% confidence intervals (CIs) higher PUFA concentrations.Thirteen meta-analysis. Eight comprising 316,698 individuals (11,244 incident HF cases), with a median follow-up 10.7 years, showed that associated lower (highest versus lowest quintile: HR = 0.84, CI 0.75-0.94). Six studies, 17,163 participants (2520 cases) 9.7 0.59, 0.39-0.91). Higher docosahexaenoic acid decreased (top bottom 0.44, 0.26-0.77). The eicosapentaenoic (HR 0.58, 0.26-1.25), 0.66, 0.24-1.82), not significant.High measured by biomarkers are developing
Language: Английский
Citations
22
Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9
Published: April 25, 2022
The estimated global latent tuberculosis infection (LTBI) burden indicates a large reservoir of population at risk developing active (TB). Previous studies suggested diabetes mellitus (DM) might associate with LTBI, though still controversial. We aimed to systematically assess the association between DM and LTBI.We searched PubMed, Embase, Cochrane Library Web Science. Observational reporting number LTBI non-LTBI individuals without were included. Random-effects or fixed-effects models used estimate pooled effect by ratios (RRs) odds (ORs) its 95% confidence interval (CI), using original participants involved.20 involving 4,055,082 showed significant (for cohort studies, RR = 1.62, CI: 1.02-2.56; for cross-sectional OR 1.55, 1.30-1.84). was high in healthcare workers (5.27, 1.52-8.20), refugees (2.88, 1.93-4.29), sample size 1,000-5,000 (1.99, 1.49-2.66), male accounted less than 40% (2.28, 1.28-4.06). Prediabetes also associated (OR 1.36, 1.01-1.84).The found be 60% increase patients, compared non-DM patients. screening among patients could vital importance. More are needed explore appropriate strategies targeted
Language: Английский
Citations
21