Mitochondrial related Mendelian randomization identifies causal associations between metabolic disorders and childhood neurodevelopmental disorders DOI Creative Commons

Chenyan Hu,

Junjun Li,

Pengfei Heng

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(46), P. e40481 - e40481

Published: Nov. 15, 2024

Childhood neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder, and Tourette syndrome, are a predominant cause of health-related disabilities in children adolescents. Nevertheless, disease biomarkers still limited. The aim this study was to evaluate the potential, causal relationship between mitochondrial DNA copy number (mtDNA-CN), metabolic disorders, childhood NDDs using two-sample Mendelian randomization (MR) method. Genetic associations with mtDNA-CN, lipoprotein metabolism, iron metabolism were selected as exposures, genome-wide association data from ASD, syndrome utilized outcomes. Results suggested that high degree disordered related increases ASD risk result decrease mtDNA-CN (disordered metabolism–mtDNA: inverse variance weighting β: −0.03, 95% confidence interval: −0.05 −0.02, P = 2.08 × 10 –5 ; mtDNA-CN–ASD: odds ratio: 0.83, 0.69–0.99, .034). research findings implied can mediate potentially influencing development ASD. potential impact results for prevention treatment warrants validation robust randomized clinical trials.

Language: Английский

Genetic Susceptibility to Depression is Associated with Increased Risk of Cardiometabolic Diseases: A Systematic Review and Meta-Analysis of 38 Mendelian Randomisation Studies DOI

Tabinda Jabeen,

Emma Todd, Sarah Gauci

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Association of CBC and CBC-derived Inflammatory Markers with Depression and Post-diabetic Depression: a Large Cohort NHANES Study Spanning 2011-2020 DOI Creative Commons
Wen‐Cheng Chen, Feidan Deng

Archives of Gerontology and Geriatrics Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100131 - 100131

Published: March 1, 2025

Language: Английский

Citations

0
Relationship Between Sarcopenia and the Trajectories of Depressive Symptoms Among Chinese Older Adults: The Mediating Effect of Social Participation DOI
Yixuan Liu, Wenjun Li, Ziqiang Chen

et al.

International Journal of Behavioral Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
Causal relationship between rosacea and psychiatric disorders: a bidirectional two-sample Mendelian randomization study DOI

Yaoying Li,

Tianxing Hu,

Lanlan Jiang

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: April 7, 2025

Language: Английский

Citations

0
Systems, Social, and Individual Factors Influencing Glycemic Control Among American Indian/Alaska Native Adults with Type 2 Diabetes: A Systematic Review DOI
Leandra Bitterfeld, Lauren Hill, Jodiey Bondurant

et al.

Journal of Racial and Ethnic Health Disparities, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
Causality between sarcopenia-related traits and major depressive disorder: A bi-directional, two-sample Mendelian randomized study DOI Creative Commons
Yu Zhang,

Mengfan Yang,

Mingquan Li

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(40), P. e35071 - e35071

Published: Oct. 6, 2023

Observational studies have demonstrated an association between sarcopenia and depression. However, these may be influenced by confounding factors, the causal relationship major depressive disorder (MDD) remains unclear. This study aimed to apply Mendelian randomization (MR) method address factors assess effect of on MDD. A two-way, two-sample MR was employed in this study. Instrumental variables genome-wide significance level were obtained from open large-scale summary data. analysis conducted using inverse variance weighted, MR-Egger, weighted median methods. The reliability results verified heterogeneity test, pleiotropy leave-one-out for sensitivity analysis. Grip strength (right-hand grip strength: odds ratio [OR] = 0.880, 95% confidence interval [CI] 0.786-0.987, P .027; left-hand OR 0.814, CI 0.725-0.913, < .001) usual walking pace (OR 0.673, 0.506-0.896, .007) exhibited a direct MDD had significant appendicular lean mass (β -0.065, -0.110, -0.019, .005). There sarcopenia-related traits Loss muscle strength, rather than skeletal mass, is correlated with increased risk Furthermore, individuals are more likely experience loss mass.

Language: Английский

Citations

8
Association between gastroesophageal reflux disease and stroke: a bidirectional Mendelian randomization study DOI Creative Commons

Decheng Meng,

Xin Zhang, Wenfei Yu

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 23, 2024

Objective Some previous studies have suggested a potential link between stroke and gastroesophageal reflux disease (GERD). We used two-sample bidirectional Mendelian randomization (MR) method to explore the causal relationship GERD. Design Summary-level data derived from published genome-wide association (GWAS) were employed for analyses. Single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) ( n = 446,696) its common subtypes ischemic (IS) 440,328), large vessel (LVS) 410,484), small (SVS) 198,048), cardioembolic (CES) 413,304) obtained MEGASTROKE consortium. The on intracerebral hemorrhage (ICH) 721,135) come UK Biobank. Instrumental lacunar (LS) 474,348) GERD 602,604) screened publicly available genetic summary data. inverse variance weighted (IVW) was main MR method. Pleiotropy detected by MR-Egger intercept test, pleiotropy residual sum outlier, leave-one-out analysis. Cochran Q statistics supplements detect pleiotropy. Results found that can causally increase risk of [IVW odds ratio (OR): 1.22, 95% confidence interval (CI): 1.13–1.32, p 1.16 × 10 −6 ] IS (OR: 1.19, CI: 1.10–1.30, 3.22 −5 ), LVS 1.49, 1.21–1.84, 1.47 −4 LS 1.20, 1.001–1.44, 0.048). Several important factors also been implicated in above relationship, including type 2 diabetes, sleep apnea syndrome, high body mass index, waist-to-hip ratio, elevated serum triglyceride levels. In reverse analysis, we overall 1.09, 1.004–1.19, 0.039) 1.10, 1.03–1.17, 0.007) enhance risk. Conclusion This study provides evidence supporting some subtypes. need further interconnected mechanisms these two diseases better prevent treat them.

Language: Английский

Citations

2
The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study DOI Creative Commons
Xiao Ma, Haoran Xu,

Jinghui Xie

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Dec. 15, 2023

Background A potential link between asthma and frailty has been suggested in previous studies. However, the nature of causal relationship these two conditions warrants further investigation. Therefore, this study assessed bidirectional causality risk using two-sample Mendelian randomization (MR). Methods The data were obtained from genome-wide association (GWAS) dataset, with 337,159 samples representing 175,226 frailty. disorders was by selecting single nucleotide polymorphisms (SNPs), significantly associated both inverse variance weighting (IVW) method used as main analytical to estimate possible influence causality. Sensitivity analysis also performed Mr-Egger intercept, funnel plot, “leave-one-out,” Cochran Q test. In addition, mediators investigated factor analysis. Result IVW showed an increased due genetic susceptibility factors number (OR = 2.325, 95%CI:1.958–2.761; p 6.527498e-22), while no horizontal pleiotropy observed for intercept ( 0.609) plot. value 72.858, 0.024, there heterogeneity Q-value. No SNP “leave-one-out” that had a biasing effect on instrumental variables. 1.088, 95%CI:1.058–1.119; 4.815589e-09). described above, several are complex, leading significant reduction physical activity endurance. Conclusion Our findings suggest probable positive developing frailty, potentially mediated reduced At same time, exists asthma. assessment strategies should include vice versa.

Language: Английский

Citations

4
Association of mental disorders with sepsis: a bidirectional Mendelian randomization study DOI Creative Commons

Yuanzhi Hu,

Zihui Xiong,

Pinge Huang

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 17, 2024

Background Substantial research evidence supports the correlation between mental disorders and sepsis. Nevertheless, causal connection a particular psychological disorder sepsis remains unclear. Methods For investigating relationships sepsis, genetic variants correlated with disorders, including anorexia nervosa (AN), attention-deficit hyperactivity (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), panic (PD), posttraumatic stress (PTSD), schizophrenia (SCZ), tourette syndrome (TS), were all extracted from Psychiatric Genomics Consortium (PGC). The estimates direction these evaluated employing two-sample bidirectional MR strategy. inverse variance weighted (IVW) method was primary approach utilized. Various sensitivity analyses performed to confirm validity of effect. Meta-analysis, multivariable MR, mediation conducted ensure credibility depth this research. Results presence AN in relation greater likelihood (OR 1.08, 95% CI 1.02–1.14; p = 0.013). A meta-analysis validation cohorts supported observation 1.06, 1.02–1.09). None investigated appeared be impacted when set as exposure factor. Even after adjusting for confounding factors, remained statistically significant 1.02–1.15; Mediation analysis indicated N-formylmethionine levels (with mediated proportion 7.47%), cystatin D (2.97%), ketogluconate Metabolism (17.41%) N10-formyl-tetrahydrofolate biosynthesis (20.06%) might serve mediators pathogenesis AN-sepsis. Conclusion At gene prediction level, revealed that had association an increased In addition, levels, metabolism may function potential pathophysiology Our contribute investigation novel therapeutic strategies illness

Language: Английский

Citations

1
Major depressive disorder elevates the risk of dentofacial deformity: a bidirectional two-sample Mendelian randomization study DOI Creative Commons

Jinhan Nie,

Yi Zhang, Jun Ma

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

Background The association between psychiatric disorders and dentofacial deformities has attracted widespread attention. However, their relationship is currently unclear controversial. Methods A two-sample bidirectional MR analysis was performed to study the causal deformity eight disorders, including major depressive disorder, panic schizophrenia, bipolar attention deficit hyperactivity Alzheimer’s disease, autism spectrum neuroticism. Inverse variance weighted, weighted median, MR-Egger regression, mode four methods, further sensitivity analyses were conducted. Results disorder affected deformity, with an OR = 1.387 (95% CI 1.181-1.629, P 6.77×10 -5 ). No other found be associated deformity. In turn, neuroticism, 1.050 1.008-1.093, 0.018). And there no evidence that would increase risk of disorders. Conclusions Major might elevate deformities, conditions incidence

Language: Английский

Citations

1