The association between overactive bladder and systemic immunity-inflammation index: a cross-sectional study of NHANES 2005 to 2018

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 31, 2024

Current research indicate that inflammation is linked to the development of overactive bladder (OAB). The aim this study was examine correlation between OAB and systemic immunity-inflammation index (SII) in USA. We analyzed data from 31,881 participants National Health Nutrition Examination Survey 2005-2018. SII, calculated as platelet count × neutrophil count/lymphocyte count, categorized into quartiles. defined by presence urge urinary incontinence nocturia. Weighted logistic regression models were used independent relationship SII OAB, adjusting for demographic factors, kidney function, diabetes status. results showed each tenfold increase log-transformed associated with an 18% higher odds (OR 1.18, 95% CI 1.08-1.28) fully adjusted model. Compared lowest quartile, highest quartile had a 28% increased risk 1.28, 1.12-1.47). positive association consistently observed across subgroups stratified age, sex, race, marital status, education, poverty level. Our reveals levels indicating are likelihood developing OAB.

Language: Английский

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Association between oxidative balance score, systemic inflammatory response index, and cardiovascular disease risk: a cross-sectional analysis based on NHANES 2007–2018 data

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 5, 2024

There is limited research on the relationship between Systemic Oxidative Stress (SOS) status and inflammatory indices. Adding onto existing literature, this study aimed to examine association dietary Balance Score (OBS) lifestyle OBS (which make up overall OBS), Cardiovascular Disease (CVD) prevalence at different Immune Inflammation Index (SII) Inflammatory Response (SIRI) levels. This involved 9,451 subjects selected from National Health Nutrition Examination Survey (NHANES) 2007-2018. The comprised 20 factors. Statistical methods included Weighted Linear Regression Analysis (WLRA), Logistic (LRA), Sensitivity (SA), Restricted Cubic Spline (RCS) analysis. multivariate WLRA revealed that was significantly negatively correlated with both SII (β = -5.36, p < 0.001) SIRI -0.013, In SA, removing any single component had no significant effect results of SIRI. Further subgroup analyses more impactful in lowering women than men. Additionally, low-age group high-age group. Moreover, RCS analysis confirmed linear relationship. Compared OBS, exerted a Coronary Artery (CAD) (OR: 0.794, 0.002), hypertension 0.738, 0.001), Congestive Heart Failure (CHF) 0.736, 0.005), Myocardial Infarction (MI) 0.785, stroke 0.807, 0.029) prevalence. Furthermore, exhibited interaction CHF (P for 0.001). On other hand, MI 0.05). including were associated Higher reduced risks CAD, hypertension, CHF, MI, stroke.

Language: Английский

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Associations of ω-3, ω-6 polyunsaturated fatty acids intake and ω-6: ω-3 ratio with systemic immune and inflammatory biomarkers: NHANES 1999-2020

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 7, 2024

Background In recent years, diseases caused by abnormal immune-inflammatory responses have become increasingly severe. Dietary intervention involving omega-3 polyunsaturated fatty acids (ω-3 PUFAs) has emerged as a potential treatment. However, research investigating the relationship between ω-3, ω-6 PUFAs, and to ω-3 ratio with inflammatory biomarkers remains controversial. Methods To investigate correlation intake of PUFAs ω-6: inflammation, National Health Nutrition Examination Survey (NHANES) data (1999 2020) was utilized. The systemic immune-inflammation index (SII), platelet-lymphocyte (PLR), neutrophil-lymphocyte (NLR), white blood cell (WBC) were selected study subjects. for collected via two 24-h dietary recall interviews. SII other indicators obtained from routine data. multiple linear regression restricted cubic spline models utilized evaluate association intake, secondary measures. Results This involved total 43,155 American adults. exhibited negative correlations SII, PLR, NLR, WBC. WBC not significant. Furthermore, dose–response showed that an “L” pattern. Conclusion Intake reduces levels several in body exerts immunomodulatory effects.

Language: Английский

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Association between the systemic immune-inflammation index and sarcopenia: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 28, 2024

Sarcopenia is associated with increased morbidity and mortality. The systemic immune-inflammation index (SII) has been correlated to a variety of disorders. present study conducted systematic review meta-analysis investigate the relationship between SII sarcopenia.

Language: Английский

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Inflammatory indexes in emergency patients with hypertensive pulmonary Oedema: A critical insight

The American Journal of Emergency Medicine, Journal Year: 2025, Volume and Issue: 91, P. 93 - 99

Published: Feb. 20, 2025

Language: Английский

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Multimodal Data‐Driven Prognostic Model for Predicting Long‐Term Prognosis in Patients With Ischemic Cardiomyopathy and Heart Failure With Preserved Ejection Fraction After Coronary Artery Bypass Grafting: A Multicenter Cohort Study

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Background Limited data from the literature are available to assess efficacy of coronary artery bypass grafting in patients with ischemic cardiomyopathy and heart failure preserved ejection fraction. Therefore, our objective was use machine learning techniques integrating clinical features, biomarker data, echocardiography enhance comprehension risk stratification diagnosed fraction who have undergone surgery. Methods Results For this study, 294 underwent surgery were assigned development cohort (n=176) independent validation (n=118). A total 52 variables extracted for each patient. The principal end point incidence major adverse cardiovascular events, encompassing cardiac mortality, acute myocardial infarction, failure, graft failure. From least absolute shrinkage selection operator regression, 4 predictors selected final prediction nomogram: diabetes, hypertension, systemic immune‐inflammation index, NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide). nomogram achieved satisfactory performance both (C 0.768 [95% CI, 0.701–0.835]) 0.633 0.521–0.745]). Adequate calibration noted likelihood events cohorts. Decision curve analysis confirmed usefulness established nomogram. Conclusions clinically feasible prognostic model, based on preoperative multimodal developed receive Registration https://www.chictr.org.cn ; Unique identifier: ChiCTR2300074439.

Language: Английский

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Association Between Systemic Immune-Inflammation Index and Adverse Outcomes in Patients With Acute Coronary Syndrome: A Meta-Analysis

Angiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 21, 2024

The systemic immune-inflammation index (SII) has been developed for the risk prognostication of acute coronary syndrome (ACS) patients. This meta-analysis aimed to assess value SII predicting adverse outcomes in ACS Relevant studies were identified by searching PubMed, Web Science, and Embase databases. Studies that investigated association with all-cause mortality or major cardiovascular events (MACEs) patients eligible. short-term defined as occurring during hospital within 30 days. 11 16,596 eligible analysis. A random effect indicated a higher level significantly predicted death (hazard ratios [HR] 2.60; 95% confidence intervals [CI] 1.29-5.25) long-term (HR 2.40; CI 1.25-4.59), even after adjusting traditional confounding factors. Additionally, was also associated an increased MACEs 1.61; 1.28-2.03) 2.43; 1.74-3.40). These findings suggest strong prognostic both ACS. Determining potential improve

Language: Английский

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Hemoglobin-to-red blood cell distribution width ratio as a protective factor against coronary artery disease: a cross-sectional analysis of NHANES (2011-2018)

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Background Coronary artery disease (CAD) is the leading cause of death worldwide, and inflammation a significant factor in its development. While hemoglobin-to-red blood cell distribution width ratio (HRR), an indicator inflammation, has been linked to various diseases, association with CAD not well established. Methods We conducted analysis using data from National Health Nutrition Examination Survey (NHANES) spanning 2011 2018. After excluding participants due age, missing data, potential confounding factors, 6,881 individuals were included our study. was identified through self-reported questionnaires, HRR determined laboratory measurements. controlled for factors such as hypertension, waist circumference, systolic pressure, fasting plasma glucose, others logistic regression explore relationship between CAD. Results found that higher levels associated lower risk In fully adjusted model, odds ratios second, third, fourth quartiles 0.38, 0.42, 0.51, respectively, compared first quartile (P &lt; 0.001). An increase by one unit 49% decrease likelihood Furthermore, linear models indicated 74% reduction each one-unit = 0.0002). There notable threshold at 1.02; beyond this point, 91% odds. This suggests above 1.02, strategies body water content reduce viscosity could potentially their developing Conclusion Our study revealed inverse risk, indicating may serve protective against

Language: Английский

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The Association Between Systemic Immune-Inflammation Index and Cardiovascular Diseases: An In-depth Umbrella Review of Meta-Analyses with Grade Assessment

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42736 - e42736

Published: Feb. 1, 2025

Language: Английский

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Association of serum inflammatory markers in early-pregnancy with the risk for gestational diabetes mellitus: a prospective cohort in Shenzhen, China

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

The systemic immune-inflammation index (SII) and inflammation response (SIRI) have recently been reported as novel inflammatory markers of diabetes. However, the associations SII SIRI with risk gestational diabetes mellitus (GDM) are unclear. In our study, we explored association between in early pregnancy GDM pregnant women. A prospective cohort 1,505 women were recruited at 6-13 weeks gestation 2019 2020 Shenzhen, China. determined by calculating composite indicators from routine blood test results gestation, an oral glucose tolerance was conducted 24-28 to diagnose GDM. Logistic regression used analyse correlations incidence SIRI. Using a restriction cubic spline baseline continuous variables, dose-response explored. Following Ln-transformation SIRI, multivariate models showed that Ln (odds ratio [OR] = 1.759; 95% confidence interval [CI]: 1.272-2.432) (OR 1.556; CI: 1.187-2.042) positively associated dose-dependent manner. OR for highest quartile compared lowest 2.080 (95% 1.447-2.990), 1.694 1.170-2.452). restricted model confirmed linear (p-nonlinear > 0.05). Higher increased As novel, valuable, convenient inflammation, could be potential predictor pregnancy.

Language: Английский

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