Understanding the subtypes of visual hypersensitivity: Four coherent factors and their measurement with the Cardiff Hypersensitivity Scale (CHYPS) DOI Creative Commons
Alice Price, Petroc Sumner,

Georgina Powell

et al.

Vision Research, Journal Year: 2025, Volume and Issue: 233, P. 108610 - 108610

Published: May 19, 2025

Subjective visual sensitivity or discomfort has been reported in many separate literatures, and includes a wide range of triggers (e.g., repeating patterns, bright lights, motion, flicker) across neurological, psychiatric, mental health, developmental conditions areas neurodiversity migraine, traumatic brain injury, functional neurological disorder, PPPD, PTSD, anxiety, depression, anorexia, OCD, autism, ADHD, dyslexia, dyspraxia, synaesthesia). To unite this research disciplines to allow progress mechanistic understanding, we aimed provide definitive answer whether there are different subtypes (factors) hypersensitivity. In Study 1, generated questions from large qualitative dataset (n = 765), existing questionnaires, iteratively participant feedback. We found four theoretically coherent factors replicated five cohorts (n's 349, 517, 417, 797 1817). These were: brightness sunlight), patterns stripes), strobing flashing, screen motion), intense environments supermarkets, traffic). There was also general factor. Based on produced novel 20-item questionnaire (the Cardiff Hypersensitivity Scale, CHYPS), with good reliability (α > 0.8, ω 0.8) convergent validity (correlations other scales r 0.6). discuss how these can be related causal theories

Language: Английский

A multicenter Phase II randomized, placebo-controlled single-blind trial with the SV2A ligand seletracetam in photosensitive epilepsy patients DOI Creative Commons

Dorotheé Kasteleijn‐Nolst Trenité,

Armel Stockis, Édouard Hirsch

et al.

Epilepsy & Behavior, Journal Year: 2025, Volume and Issue: 164, P. 110241 - 110241

Published: Jan. 18, 2025

Language: Английский

Citations

2
Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Oct. 25, 2023

Abstract Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles the lysosomes for degradation elimination. The mechanistic target of rapamycin (mTOR) main negative regulator autophagy. mTOR pathway involved in regulating neurogenesis, synaptic plasticity, neuronal development excitability. Exaggerated activity associated with temporal lobe epilepsy, genetic acquired experimental epilepsy. In particular, complex 1 (mTORC1) mainly epileptogenesis. investigation autophagy’s involvement epilepsy has recently been conducted, focusing on critical role rapamycin, autophagy inducer, reducing severity induced seizures animal model studies. induction could be innovative therapeutic strategy managing Despite protective against epileptogenesis its status epilepticus (SE) perplexing might beneficial or detrimental. Therefore, present review aims revise possible

Language: Английский

Citations

31
Clinical adoption of virtual reality in mental health is challenged by lack of high-quality research DOI Creative Commons
Benjamin Selaskowski, Annika Wiebe, Kyra Kannen

et al.

npj Mental Health Research, Journal Year: 2024, Volume and Issue: 3(1)

Published: May 16, 2024

Virtual reality has been found effective for some mental disorders, while many others weak methodology prevents conclusive evidence. Similar to other digital technologies, the field particular demands conducting clinical research which currently remain poorly addressed. In this commentary, we discuss unique issues associated with incorporation of virtual in research. addition, elaborate on possibility that these challenges may also be consequences current funding and publication schemes, speculate specific improvement approaches might more compatible characteristics

Language: Английский

Citations

9
The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy DOI Creative Commons

Raed AlRuwaili,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 49(3), P. 533 - 547

Published: Nov. 25, 2023

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) implicated in pathogenesis epileptogenesis and epilepsy, BDNF may have neuroprotective effect against epilepsy. Thus, goal present review was to highlight protective detrimental roles In this review, we also try find relation with other signaling pathways cellular processes including autophagy, mTOR pathway, progranulin (PGN), α-Synuclein (α-Syn) which negatively positively regulate BDNF/tyrosine kinase receptor B (TrkB) pathway. Therefore, assessment levels epilepsy should be related neuronal types both preclinical clinical studies. conclusion, there strong controversy concerning potential role preclinical, molecular, studies are warranted regard.

Language: Английский

Citations

19
Barriers to Photosensitive Accessibility in Virtual Reality DOI Creative Commons
Laura South, Caglar Yildirim, Amy Pavel

et al.

Published: May 11, 2024

Virtual reality (VR) systems have grown in popularity as an immersive modality for daily activities such gaming, socializing, and working. However, this technology is not always accessible people with photosensitive epilepsy (PSE) who may experience seizures or other adverse symptoms when exposed to certain light stimuli (e.g., flashes strobes). How can VR be made more inclusive safer PSE? In paper, we report on a series of semi-structured interviews about current perceptions accessibility among PSE. We identify 12 barriers that fall into four categories: physical equipment, interfaces content, specific applications, individual differences sensitivity. Our findings allow researchers practitioners better understand the meaning context VR, provide step towards enabling PSE enjoy benefits offered by technology.

Language: Английский

Citations

7
Feasibility and psychophysical effects of immersive virtual reality-based mirror therapy DOI Creative Commons
Chris Heinrich,

Nadine Morkisch,

Tobias Langlotz

et al.

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2022, Volume and Issue: 19(1)

Published: Oct. 7, 2022

Abstract Background Virtual reality (VR) has been used as a technological medium to deliver mirror therapy interventions with people after stroke in numerous applications promising results. The recent emergence of affordable, off-the-shelf head-mounted displays (like the Oculus Rift or HTC Vive) opened possibility for novel and cost-effective approaches immersive interventions. We have developed one such system, ART-VR, which allows carry out clinically-validated protocol an virtual environment within clinical setting. Methods A case cohort 11 upper limb paresis following first time at in-patient rehabilitation facility received three over week period. Participants carried BeST using our VR system adjunct their standard program. Our feasibility study investigated intervention outcomes, acceptance user experience. Results results show that combination is feasible use. 9 participants showed some improvement affected hand intervention. vast majority (9/11) reported experiencing psycho-physical effects, tingling paraesthesia, during Conclusions findings VR-based shows effects comparable those conventional therapy. Trial Registration was registered ISRCTN Registry (ISRCTN34011164) on December 3, 2021, retrospectively

Language: Английский

Citations

27
Data Augmentation Effects on Highly Imbalanced EEG Datasets for Automatic Detection of Photoparoxysmal Responses DOI Creative Commons
Fernando Moncada Martins, Víctor M. González, José R. Villar

et al.

Sensors, Journal Year: 2023, Volume and Issue: 23(4), P. 2312 - 2312

Published: Feb. 19, 2023

Photosensitivity is a neurological disorder in which person's brain produces epileptic discharges, known as Photoparoxysmal Responses (PPRs), when it receives certain visual stimuli. The current standardized diagnosis process used hospitals consists of submitting the subject to Intermittent Photic Stimulation and attempting trigger these phenomena. activity measured by an Electroencephalogram (EEG), clinical specialists manually look for PPRs that were provoked during session. Due nature this disorder, long EEG recordings may contain very few PPR segments, meaning highly imbalanced dataset available. To tackle problem, research focused on applying Data Augmentation (DA) create synthetic segments from real ones, improving balance and, thus, global performance Machine Learning techniques applied automatic detection. K-Nearest Neighbors One-Hidden-Dense-Layer Neural Network employed evaluate DA stage. results showed able improve models, making them more robust generalize. A comparison with obtained previous experiment also improvement around 20% Accuracy Specificity measurements without Sensitivity suffering any losses. This project currently being carried out subjects at Burgos University Hospital, Spain.

Language: Английский

Citations

15
Levetiracetam, from broad-spectrum use to precision prescription: A narrative review and expert opinion DOI Creative Commons

Adriana Celdran de Castro,

Fábio A. Nascimento, Álvaro Beltrán‐Corbellini

et al.

Seizure, Journal Year: 2023, Volume and Issue: 107, P. 121 - 131

Published: March 24, 2023

Language: Английский

Citations

14
Response to photic stimulation as a measure of cortical excitability in epilepsy patients DOI Creative Commons
Michaela Vranic‐Peters,

Patrick O’Brien,

Udaya Seneviratne

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 5, 2024

Studying states and state transitions in the brain is challenging due to nonlinear, complex dynamics. In this research, we analyze brain's response non-invasive perturbations. Perturbation techniques offer a powerful method for studying dynamics, though their translation human data under-explored. This involves applying small inputs, case via photic stimulation, system measuring its response. Sensitivity perturbations can forewarn transition. Therefore, biomarkers of perturbation or “cortical excitability” could be used indicate seizure transitions. However, perturbing often invasive intracranial surgeries expensive equipment such as transcranial magnetic stimulation (TMS) which only accessible minority patient groups, animal model studies. Photic widely diagnostic technique epilepsy that paradigm probe dynamics during routine electroencephalography (EEG) studies humans. changing frequency strobing light, sometimes triggering photo-paroxysmal (PPR), an electrographic event studied transition state. We investigate alterations these patients with genetic generalized (GGE), ( n = 10) without PPR, psychogenic non-epileptic seizures (PNES; 10), compared resting controls 10). Metrics EEG time-series were evaluated including variance, autocorrelation, phase-based synchrony measures. observed considerable differences all group biomarker distributions controls. particular, variance autocorrelation demonstrated greater changes epochs close PPR earlier epochs. Comparison spontaneous morphology found them indistinguishable, suggesting valid proxy Also, expected, posterior channels greatest change measures, possibly reflecting underlying pathophysiologic mechanisms. clearly demonstrate observable at level cortical excitability data. Our work re-frames capable inducing measurable

Language: Английский

Citations

4
Health Consequences of Intensive E-Gaming: A Systematic Review DOI Open Access

Yinhao Shen,

Antonio Cicchella

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(3), P. 1968 - 1968

Published: Jan. 20, 2023

The aim of this review is to examine the links among different factors that determine harmful or even deadly events in professional and semiprofessional intensive Esports players. Cases serious injuries death young (<35 years old) male players are reported every year. Fatalities (PEGS) have only affected players, these mostly been concentrated Asia. Studies literature several causes mechanisms injuries. Links between previous comorbidities emerged from extant literature; obesity and/or metabolic disorders, seizures (associated with overstimulation eyes), heart malfunctions, high basal abrupt increases systolic blood pressure (SBP), prolonged stress, poor posture associated Several clinical signs identified question emerges whether not self-regulation by associations public health authorities necessary.

Language: Английский

Citations

10