Cells,
Journal Year:
2019,
Volume and Issue:
8(10), P. 1158 - 1158
Published: Sept. 27, 2019
Over
the
past
decades,
an
increase
in
incidence
rate
of
cancer
has
been
witnessed.
Although
many
efforts
have
made
to
manage
and
treat
this
life
threatening
condition,
it
is
still
one
leading
causes
death
worldwide.
Therefore,
scientists
attempted
target
molecular
signaling
pathways
involved
initiation
metastasis.
It
shown
that
signal
transducers
activator
transcription
(STAT)
contributes
progression
cells.
This
important
pathway
associated
with
a
number
biological
processes
including
cell
cycle,
differentiation,
proliferation
apoptosis.
appears
dysregulation
STAT
promotes
migration,
viability
malignancy
various
tumor
Hence,
there
attempts
pathway.
However,
seems
currently
applied
therapeutics
may
not
be
able
effectively
modulate
suffer
from
variety
drawbacks
such
as
low
bioavailability
lack
specific
targeting.
In
present
review,
we
demonstrate
how
nanocarriers
can
successfully
for
encapsulation
modulators
therapy.
Frontiers in Neuroscience,
Journal Year:
2020,
Volume and Issue:
14
Published: April 21, 2020
Ferroptosis
is
a
kind
of
regulated
cell
death
(RCD)
caused
by
the
redox
state
disorder
intracellular
microenvironment
controlled
glutathione
peroxidase
4
(GPX4),
which
inhibited
iron
chelators
and
lipophilic
antioxidants.
In
addition
to
classical
regulatory
mechanisms,
new
factors
for
ferroptosis
have
been
discovered
in
recent
years,
such
as
P53
pathway,
ATF3/4
Beclin
1
(BECN1)
some
non-coding
RNA.
closely
related
cancer
treatment,
neurodegenerative
diseases,
ischemia-reperfusion
organ,
neurotoxicity,
other
particular,
field
diseases
treatment
has
aroused
people's
interest.
The
nuclear
factor
E2
2
(Nrf2/NFE2L2)
proved
play
key
role
neurodegeneration
disease
regulation.
promotes
progression
while
expression
Nrf2
its
target
genes
(Ho-1,
Nqo-1,
Trx)
declined
with
aging,
therefore,
there
still
insufficient
evidence
networks
diseases.
this
review,
we
will
provide
brief
overview
well
an
emphasis
on
mechanism
regulating
ferroptosis.
We
also
highlight
during
process
investigate
theoretical
basis
further
research
relationship
between
treatment.
Journal of Experimental Pharmacology,
Journal Year:
2021,
Volume and Issue:
Volume 13, P. 303 - 328
Published: March 1, 2021
Abstract:
Cisplatin
and
other
platinum-based
chemotherapeutic
drugs
have
been
used
extensively
for
the
treatment
of
human
cancers
such
as
bladder,
blood,
breast,
cervical,
esophageal,
head
neck,
lung,
ovarian,
testicular
cancers,
sarcoma.
is
commonly
administered
intravenously
a
first-line
chemotherapy
patients
suffering
from
various
malignancies.
Upon
absorption
into
cancer
cell,
cisplatin
interacts
with
cellular
macromolecules
exerts
its
cytotoxic
effects
through
series
biochemical
mechanisms
by
binding
to
Deoxyribonucleic
acid
(DNA)
forming
intra-strand
DNA
adducts
leading
inhibition
synthesis
cell
growth.
Its
primary
molecular
mechanism
action
has
associated
induction
both
intrinsic
extrinsic
pathways
apoptosis
resulting
production
reactive
oxygen
species
lipid
peroxidation,
activation
signal
transduction
pathways,
p53
signaling
cycle
arrest,
upregulation
pro-apoptotic
genes/proteins,
down-regulation
proto-oncogenes
anti-apoptotic
genes/proteins.
Despite
great
clinical
outcomes,
many
studies
reported
substantial
side
monotherapy,
while
others
shown
drug
resistance
in
some
patients.
Hence,
new
formulations
several
combinational
therapies
tested
purpose
improving
utility
cisplatin.
Therefore,
this
review
provides
comprehensive
understanding
therapy
discusses
therapeutic
approaches
overcome
effects.
Keywords:
cisplatin,
action,
combination
therapy,
Current Molecular Medicine,
Journal Year:
2019,
Volume and Issue:
20(2), P. 116 - 133
Published: Oct. 17, 2019
Curcumin
is
a
naturally
occurring
polyphenol
that
isolated
from
the
rhizome
of
Curcuma
longa
(turmeric).
This
medicinal
compound
has
different
biological
activities,
including
antioxidant,
antibacterial,
antineoplastic,
and
anti-inflammatory.
It
also
therapeutic
effects
on
neurodegenerative
disorders,
renal
diabetes
mellitus.
safe
well-tolerated
at
high
concentrations
without
inducing
toxicity.
seems
curcumin
capable
targeting
Nrf2
signaling
pathway
in
protecting
cells
against
oxidative
damage.
Besides,
this
strategy
advantageous
cancer
therapy.
Accumulating
data
demonstrates
applies
four
distinct
ways
to
stimulate
pathway,
inhibition
Keap1,
affecting
upstream
mediators
Nrf2,
influencing
expression
target
genes,
finally,
improving
nuclear
translocation
Nrf2.
In
present
review,
exert
its
activities
been
discussed.
Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(10), P. 936 - 936
Published: Sept. 29, 2020
Since
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
outbreak
emerged,
countless
efforts
are
being
made
worldwide
to
understand
molecular
mechanisms
underlying
disease
2019
(COVID-19)
in
an
attempt
identify
specific
clinical
characteristics
of
critically
ill
COVID-19
patients
involved
its
pathogenesis
and
provide
therapeutic
alternatives
minimize
severity.
Recently,
has
been
closely
related
sepsis,
which
suggests
that
most
deceases
intensive
care
units
(ICU)
may
be
a
direct
consequence
SARS-CoV-2
infection-induced
sepsis.
Understanding
oxidative
stress
inflammation
contributing
progression
phenotypes
such
as
sepsis
is
current
need
effort
improve
therapies
infected
patients.
This
article
aims
review
relationship
with
inflammation,
can
contribute
progression.
We
also
overview
potential
antioxidant
active
trials
might
prevent
or
reduce
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 23, 2024
The
damage
to
the
central
nervous
system
and
dysfunction
of
body
caused
by
spinal
cord
injury
(SCI)
are
extremely
severe.
pathological
process
SCI
is
accompanied
inflammation
nerve
cells.
Current
evidence
suggests
that
oxidative
stress,
resulting
from
an
increase
in
production
reactive
oxygen
species
(ROS)
imbalance
its
clearance,
plays
a
significant
role
secondary
during
SCI.
transcription
factor
nuclear
erythroid
2-related
2
(Nrf2)
crucial
regulatory
molecule
for
cellular
redox.
This
review
summarizes
recent
advancements
regulation
ROS-Nrf2
signaling
focuses
on
interaction
between
ROS
different
modes
neuronal
cell
death
after
SCI,
such
as
apoptosis,
autophagy,
pyroptosis,
ferroptosis.
Furthermore,
we
highlight
pathways
through
which
materials
science,
including
exosomes,
hydrogels,
nanomaterials,
can
alleviate
modulating
clearance.
provides
valuable
insights
directions
reducing
alleviating
stress.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 1, 2024
Melatonin
(N-acetyl-5-methoxytryptamine)
is
an
indolamine
hormone
with
many
physiological
and
biological
roles.
antioxidant,
anti-inflammatory,
free
radical
scavenger,
circadian
rhythm
regulator,
sleep
hormone.
However,
its
most
popular
role
the
ability
to
regulate
through
rhythm.
Interestingly,
recent
studies
have
shown
that
melatonin
important
essential
during
pregnancy,
specifically
in
placenta.
This
primarily
due
placenta’s
synthesize
own
rather
than
depending
on
pineal
gland.
During
acts
as
antioxidant
which
necessary
ensure
a
stable
environment
for
both
mother
fetus.
It
placenta
because
it
reduces
oxidative
stress
by
constantly
scavenging
radicals,
i.e.,
maintain
integrity.
In
healthy
maternal
immune
system
altered
accommodate
needs
of
growing
fetus,
key
anti-inflammatory
regulating
homeostasis
early
late
gestation.
literature
review
aims
identify
summarize
melatonin’s
powerful
inflammation
favorable
homeostatic
throughout
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
23(1), P. 218 - 218
Published: Dec. 25, 2021
Obesity
and
its
complications
have
become
a
prominent
global
public
health
problem
that
severely
threatens
human
health.
Melatonin,
originally
known
as
an
effective
antioxidant,
is
endogenous
hormone
found
throughout
the
body
serves
various
physiological
functions.
In
recent
decades,
increasing
attention
has
been
paid
to
unique
function
in
regulating
energy
metabolism,
especially
glucose
lipid
metabolism.
Accumulating
evidence
established
relationship
between
melatonin
obesity;
nevertheless,
not
all
preclinical
clinical
indicates
anti-obesity
effect
of
melatonin,
which
makes
it
remain
conclude
fight
against
obesity.
this
review,
we
summarized
current
knowledge
obesity-related
symptoms,
with
emphasis
on
underlying
mechanisms.
The
role
profile,
adipose
tissue,
oxidative
stress,
inflammation,
well
interactions
circadian
rhythm,
gut
microbiota,
sleep
disorder,
α7nAChR,
opioidergic
system,
exosomes,
make
promising
agent
open
new
avenues
intervention
