Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
161, P. 114505 - 114505
Published: March 13, 2023
Multidrug
resistance
(MDR)
promotes
tumor
recurrence
and
metastasis
heavily
reduces
anticancer
efficiency,
which
has
become
a
primary
reason
for
the
failure
of
clinical
chemotherapy.
The
mechanisms
MDR
are
so
complex
that
conventional
chemotherapy
usually
fails
to
achieve
an
ideal
therapeutic
effect
even
accelerates
occurrence
MDR.
In
contrast,
combination
with
dual-drug
significant
advantages
in
therapy.
A
novel
codelivery
nanosystem,
combines
administration
nanotechnology,
can
overcome
application
limitation
free
drugs.
Both
characteristics
nanoparticles
synergistic
dual
drugs
contribute
circumventing
various
drug-resistant
cells.
Therefore,
developing
nanosystems
different
multidrug-resistant
important
reference
value
reversing
enhancing
antitumor
effect.
this
review,
advantages,
principles,
common
nanocarriers
systems
summarized.
molecular
designed
based
on
mainly
introduced.
Meanwhile,
development
prospects
challenges
also
discussed,
provide
guidelines
exploit
optimized
combined
strategies
future.
Cells,
Journal Year:
2023,
Volume and Issue:
12(4), P. 659 - 659
Published: Feb. 19, 2023
Doxorubicin
(DOX)
constitutes
the
major
constituent
of
anti-cancer
treatment
regimens
currently
in
clinical
use.
However,
precise
mechanisms
DOX’s
action
are
not
fully
understood.
Emerging
evidence
points
to
pleiotropic
anticancer
activity
DOX,
including
its
contribution
DNA
damage,
reactive
oxygen
species
(ROS)
production,
apoptosis,
senescence,
autophagy,
ferroptosis,
and
pyroptosis
induction,
as
well
immunomodulatory
role.
This
review
aims
collect
information
on
DOX
influence
anti-tumor
immune
response,
providing
a
rationale
behind
importance
modern
cancer
therapy.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(3), P. 627 - 627
Published: Jan. 26, 2022
Recent
advances
have
increased
survival
rates
of
children
and
adults
suffering
from
cancer
thanks
to
effective
anti-cancer
therapy,
such
as
chemotherapy.
However,
during
treatment
later
in
life
they
are
frequently
confronted
with
the
severe
negative
side-effects
their
life-saving
treatment.
The
occurrence
numerous
features
accelerated
aging,
seriously
affecting
quality
life,
has
now
become
one
most
pressing
problems
associated
(pediatric)
Chemotherapies
target
damage
DNA,
causing
mutations
or
genome
instability,
a
major
hallmark
both
aging.
there
types
chemotherapeutic
drugs
that
genotoxic
interfere
DNA
metabolism
different
ways,
each
own
biodistribution,
kinetics,
biological
fate.
Depending
on
type
lesion
produced
(e.g.,
interference
replication
RNA
transcription),
organ
cell
inflicted
cycle
differentiation
status,
metabolic
state,
activity
clearance
detoxification
mechanisms,
cellular
condition
micro-environment),
degree
exposure,
outcomes
can
largely
differ.
These
considerations
provide
conceptual
framework
which
classes
chemotherapeutics
contribute
development
toxicities
aging
systems.
Here,
we
summarize
observed
ex-cancer
patients
discuss
might
be
responsible.
Clinical Epigenetics,
Journal Year:
2021,
Volume and Issue:
13(1)
Published: July 8, 2021
Abstract
Transcriptionally
active
chromatin
is
marked
by
tri-methylation
of
histone
H3
at
lysine
4
(H3K4me3)
located
after
first
exons
and
around
transcription
start
sites.
This
epigenetic
mark
typically
restricted
to
narrow
regions
the
5`end
gene
body,
though
a
small
subset
genes
have
broad
H3K4me3
domain
which
extensively
covers
coding
region.
Although
most
studies
focus
on
mark,
associated
with
plethora
modifications
(e.g.,
acetylated
K27)
therein
termed
domain.
Genes
are
involved
in
cell
identity
essential
functions
clinical
potential
as
biomarkers
for
patient
stratification.
Reducing
expression
may
increase
metastatic
cancer
cells.
Enhancers
super-enhancers
interact
forming
hub
interactions
involving
nucleosome-depleted
regions.
Together,
regulatory
elements
coalesce
factors,
modifying/remodeling
enzymes,
coactivators,
Mediator
and/or
Integrator
complex
into
factory
be
analogous
liquid–liquid
phase-separated
condensate.
The
has
dynamic
structure
supports
frequent
bursts.
In
this
review,
we
present
current
knowledge
domains.
Drug Discovery Today,
Journal Year:
2021,
Volume and Issue:
27(2), P. 436 - 455
Published: Oct. 7, 2021
P-glycoprotein
(P-gp)
is
a
drug
efflux
transporter
that
triggers
doxorubicin
(DOX)
resistance.
In
this
review,
we
highlight
the
molecular
avenues
regulating
P-gp,
such
as
Nrf2,
HIF-1α,
miRNAs,
and
long
noncoding
(lnc)RNAs,
to
reveal
their
participation
in
DOX
These
antitumor
compounds
genetic
tools
synergistically
reduce
P-gp
expression.
Furthermore,
ATP
depletion
impairs
activity
enhance
of
DOX.
Nanoarchitectures,
including
liposomes,
micelles,
polymeric
nanoparticles
(NPs),
solid
lipid
nanocarriers,
have
been
developed
for
co-delivery
with
anticancer
genes
enhancing
cytotoxicity.
Surface
modification
instance
hyaluronic
acid
(HA),
can
promote
selectivity
toward
cancer
cells.
We
discuss
these
aspects
focus
on
expression
activity.
Molecular Aspects of Medicine,
Journal Year:
2023,
Volume and Issue:
93, P. 101205 - 101205
Published: July 27, 2023
Anthracyclines
have
been
important
and
effective
treatments
against
a
number
of
cancers
since
their
discovery.
However,
use
in
therapy
has
complicated
by
severe
side
effects
toxicity
that
occur
during
or
after
treatment,
including
cardiotoxicity.
The
mode
action
anthracyclines
is
complex,
with
several
mechanisms
proposed.
It
possible
high
due
to
the
large
set
processes
involved
anthracycline
action.
development
resistance
major
barrier
successful
treatment
when
using
anthracyclines.
This
based
on
series
studied
addressed
recent
years.
work
provides
an
overview
used
cancer
therapy.
discusses
activity,
toxicity,
chemoresistance,
as
well
approaches
improve
decrease
overcome
resistance.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(4), P. 663 - 663
Published: March 30, 2022
Among
gynaecologic
malignancies,
ovarian
cancer
is
one
of
the
most
dangerous,
with
a
high
fatality
rate
and
relapse
due
to
occurrence
chemoresistance.
Many
researchers
demonstrated
that
oxidative
stress
involved
in
tumour
occurrence,
growth
development.
Nuclear
factor
erythroid
2-related
2
(NRF2)
an
important
transcription
factor,
playing
role
protecting
against
damage.
Increased
levels
Reactive
Oxygen
Species
(ROS)
activate
NRF2
signalling,
inducing
expression
antioxidant
enzymes,
such
as
haem
oxygenase
(HO-1),
catalase
(CAT),
glutathione
peroxidase
(GPx)
superoxide
dismutase
(SOD),
protect
cells
stress.
However,
activation
responsible
for
development
chemoresistance,
inactivating
drug-mediated
normally
leads
cells’
death.
In
this
review,
we
report
evidence
from
literature
describing
effect
on
cancer,
focus
its
function
drug
resistance,
natural
synthetic
modulators
protective
normal
preservation.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(4), P. 1320 - 1320
Published: Feb. 15, 2022
Doxorubicin
is
a
widely
used
and
promising
anticancer
drug;
however,
severe
dose-dependent
cardiotoxicity
hampers
its
therapeutic
value.
may
cause
acute
chronic
issues,
depending
on
the
duration
of
toxicity.
In
clinical
practice,
accumulative
toxic
dose
up
to
400
mg/m2
increasing
will
increase
probability
cardiac
Several
molecular
mechanisms
underlying
pathogenesis
doxorubicin
have
been
proposed,
including
oxidative
stress,
topoisomerase
beta
II
inhibition,
mitochondrial
dysfunction,
Ca2+
homeostasis
dysregulation,
intracellular
iron
accumulation,
ensuing
cell
death
(apoptosis
necrosis),
autophagy,
myofibrillar
disarray
loss.
Natural
products
flavonoids
studied
both
in
cell,
animal,
human
models
which
proves
that
alleviate
toxicity
caused
by
doxorubicin.
This
review
comprehensively
summarizes
cardioprotective
activity
quercetin,
luteolin,
rutin,
apigenin,
naringenin,
hesperidin
against
doxorubicin,
vitro
vivo
models.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(14), P. 4478 - 4478
Published: July 13, 2022
The
scarcity
of
novel
and
effective
therapeutics
for
the
treatment
cancer
is
a
pressing
alarming
issue
that
needs
to
be
prioritized.
number
cases
deaths
are
increasing
at
rapid
rate
worldwide.
Doxorubicin,
an
anticancer
agent,
currently
used
treat
several
types
cancer.
It
disrupts
myriad
processes
such
as
histone
eviction,
ceramide
overproduction,
DNA-adduct
formation,
reactive
oxygen
species
generation,
Ca2+,
iron
hemostasis
regulation.
However,
its
use
limited
by
factors
drug
resistance,
toxicity,
congestive
heart
failure
reported
in
some
patients.
combination
doxorubicin
with
other
chemotherapeutic
agents
has
been
option
few
side
effects.
Thus,
hybridization
drugs
regarded
promising
approach
can
lead
agents.
This
review
gives
update
on
hybrid
compounds
containing
scaffolds
derivatives
potent
