Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2021, Volume and Issue: 1868(3), P. 166326 - 166326
Published: Dec. 20, 2021
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Jan. 1, 2024
Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination
Language: Английский
Citations
130
Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 93, P. 101205 - 101205
Published: July 27, 2023
Anthracyclines have been important and effective treatments against a number of cancers since their discovery. However, use in therapy has complicated by severe side effects toxicity that occur during or after treatment, including cardiotoxicity. The mode action anthracyclines is complex, with several mechanisms proposed. It possible high due to the large set processes involved anthracycline action. development resistance major barrier successful treatment when using anthracyclines. This based on series studied addressed recent years. work provides an overview used cancer therapy. discusses activity, toxicity, chemoresistance, as well approaches improve decrease overcome resistance.
Language: Английский
Citations
118
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 12, 2024
Abstract Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer strategies are evolving due to innate acquired capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells survive progress under unfavorable conditions. Although the mechanism of drug being widely studied generate new target-based drugs with better potency than existing ones. However, broader flexibility in resistance, advanced therapeutic options efficacy need be explored. Combination therapy an alternative a success rate though risk amplified side effects commonplace. Moreover, recent groundbreaking precision immune ways overcome has revolutionized anticancer greater extent only limitation individual-specific needs further attention. This review will focus on challenges opted withstand current therapies at molecular level also highlights emerging -like immunological, stem cell-based may prove have potential challenge problem resistance.
Language: Английский
Citations
101
Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)
Published: June 8, 2022
Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.
Language: Английский
Citations
93
Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106553 - 106553
Published: Nov. 16, 2022
Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response
Language: Английский
Citations
85
Life, Journal Year: 2022, Volume and Issue: 12(6), P. 897 - 897
Published: June 15, 2022
P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype cancer cells. P-gp protein that regulates ATP-dependent efflux of wide range anticancer medicines and confers resistance. Due to its specificity, several attempts have been made block action restore efficacy drugs. The goal has create molecules either compete with for transport or function as direct inhibitor. Despite significant vitro success, there are presently no drugs available clinic can "block" P-gp-mediated Toxicity, unfavourable pharmacological interactions, variety pharmacokinetic difficulties might all be reason failure. On other hand, effect body. It protects vital organs from entry foreign bodies toxic chemicals. Hence, inhibitors should not hinder normal To develop an effective inhibitor P-gp, thorough background knowledge needed this field. main aim review article was set forth merits demerits on cells well influence drug delivery contribution activating were also mentioned.
Language: Английский
Citations
82
Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 249, P. 108488 - 108488
Published: July 11, 2023
Language: Английский
Citations
71
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 503 - 522
Published: Jan. 20, 2023
Language: Английский
Citations
55
Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(5), P. 1115 - 1125
Published: July 29, 2023
Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for significant proportion cancer-related deaths worldwide. Although conventional therapies, such as surgical excision, chemotherapy, radiation, have been used to treat malignant melanoma, their efficacy often limited due the development resistance adverse side effects. Therefore, there growing interest in developing alternative treatment options melanoma are more effective less toxic. Terpenes, diverse group naturally occurring compounds plant origin, emerged potential anticancer agents ability inhibit tumor growth induce apoptosis cells. In this review, current understanding effects terpenes (including, thymoquinone, β-elemene, carvacrol, limonene, α-pinene, β-caryophyllene, perillyl alcohol, taxol, betulinic acid, α-bisabolol, ursolic linalool, lupeol, artesunate) was summarized, with special focus on therapeutic melanoma.
Language: Английский
Citations
42
Aging and Disease, Journal Year: 2024, Volume and Issue: 15(2), P. 640 - 640
Published: Jan. 1, 2024
Various diseases, including cancers, age-associated disorders, and acute liver failure, have been linked to the oncogene, MYC. Animal testing clinical trials shown that sustained tumor volume reduction can be achieved when MYC is inactivated, different combinations of therapeutic agents inhibitors are currently being developed. In this review, we first provide a summary multiple biological functions oncoprotein in cancer treatment, highlighting equilibrium points MYC/MAX, MIZ1/MYC/MAX, MAD (MNT)/MAX complexes further potential treatment could used restrain oncogene expression its tumorigenesis. We also discuss multifunctional capacity various cellular processes, influences on immune response, metabolism, cell cycle, apoptosis, autophagy, pyroptosis, metastasis, angiogenesis, multidrug resistance, intestinal flora. Moreover, summarize therapy patent landscape emphasize as druggable target, using herbal medicine modulators. Finally, describe pending challenges future perspectives biomedical research, involving development approaches modulate or targeted genes. Patients with cancers driven by signaling may benefit from therapies targeting these pathways, which delay cancerous growth recover antitumor responses.
Language: Английский
Citations
18