The association of body roundness index and body mass index with frailty and all-cause mortality: a study from the population aged 40 and above in the United States

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 30, 2025

The relationship between body roundness index (BRI), a new obesity index, and frailty has not been established. This study aims to compare the associations of traditional mass (BMI) BRI with risk all-cause mortality. clinical data 15,157 participants over 40 years old from National Health Nutrition Examination Survey (NHANES) 2003 2018 were analyzed. Based on weighted logistic regression, COX regression restricted cubic spline, BMI odds mortality estimated. receiver operating characteristic curve (ROC) concordance used evaluate ability predict survival. Weighted showed that trend increasing increase (P for < 0.0001, respectively). After adjusting all confounding factors, association was stronger (OR: 1.20, 95% CI: 1.13–1.27, P 0.0001), slightly weaker 1.14, 1.08–1.21, 0.0001). ROC area under (AUC) predicting 0.628, while AUC 0.603, difference two significant (PDeLong 0.001). In addition, in survival analysis, U-shaped Piecewise based inflection point shows when 7.33, an reduces (HR: 0.85, 0.78–0.92, ≥ increases 1.19, 1.03–1.38, = 0.02); 33.57, 0.84, 0.78–0.91, 1.18, 1.04–1.34, 0.01). Moreover, time-dependent c-index frail people comparable BMI. American population old, both are independently positively associated frailty. than have individuals, abilities

Language: Английский

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Cognitive Frailty and Functional Disability Among Community-Dwelling Older Adults: A Systematic Review

Innovation in Aging, Journal Year: 2023, Volume and Issue: 7(2)

Published: Jan. 23, 2023

Abstract Background and Objectives This review aimed to summarize the association between cognitive frailty (presence of impairment) risk disabilities in activities daily living (ADL), instrumental ADL (IADL), mobility, or other functional among older adults. Research Design Methods PubMed, Embase, CINAHL Plus, PsycINFO were searched from January 2001 May 14, 2022, for observational studies that reported community-dwelling individuals aged 60 years above. Results narratively synthesized. Eleven encompassing 44 798 participants included, with a prevalence ranging 1.4% 39.3%. Individuals more likely develop IADL compared robust (absence individuals. Significant disability burden elevated combined ADL/IADL physical limitation reported. There was limited evidence on mobility disability. Discussion Implications at higher developing incurring than individuals, but remains those prefrailty impairment. Further research this gap standardization assessments would facilitate comparisons across populations. PROSPERO Registration CRD42021232222

Language: Английский

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To Be Frail or Not to Be Frail: This Is the Question—A Critical Narrative Review of Frailty

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(3), P. 721 - 721

Published: Jan. 26, 2024

Many factors have contributed to rendering frailty an emerging, relevant, and very popular concept. First, many pandemics that affected humanity in history, including COVID-19, most recently, had more severe effects on frail people compared non-frail ones. Second, the increase human life expectancy observed developed countries, Italy has led a rise percentage of older population is likely be frail, which why much common concern among geriatricians other various health-care professionals. Third, stratification according occurrence degree allows healthcare decision makers adequately plan for allocation available professional economic resources. Since considered fully preventable, there are relevant consequences terms potential benefits both clinical outcome costs. Frailty becoming popular, pervasive, almost omnipresent concept different contexts, medicine, physical health, lifestyle behavior, mental health policy, socio-economic planning sciences. The emergence new “science frailty” been recently acknowledged. However, still debate exact definition frailty, pathogenic mechanisms involved, appropriate method assess consequently, who should frail. This narrative review aims analyze from aspects points view, with special focus proposed mechanisms, assessment emerging role biomarkers early recognition particularly mitochondria. According extensive literature this topic, it clear complex syndrome, involving domains affecting multiple physiological systems. Therefore, its management directed towards comprehensive multifaceted holistic approach personalized intervention strategy slow down progression or even completely reverse course condition.

Language: Английский

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The development and validation testing of a comprehensive frailty assessment in women with breast cancer

BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 3, 2025

Women with breast cancer are known to suffer from disease and treatment, the generic measurement tools may underestimate their frailty. A specific instrument comprehensively measuring frailty among women has not yet been developed. This study aims develop validate tool of comprehensive scale (BCCFS). descriptive explorative design was used. We collected data through systematic literature modified Delphi method. After an initial search screening process, a total 33 articles were included for review consideration in item design. Ten experts invited generate items. The validity assessed using sample 205 Taiwan. Its then tested analysis, exploratory factor confirmatory criterion-related areas under receiver-operating characteristic, while its reliability evaluated internal consistencies test-retest analyses. three-factor solution 16 items chosen accounted approximately 58.57% variance by analysis (KMO = 0.85; Bartlett's Test Sphericity: χ2 2881.34, p < 0.001). factors interpreted as (1) deterioration body mobility, (2) negative emotions, (3) cognitive impairment. goodness fit indices follows: chi-square 234.498 (p 0.01), normed 2.322, SRMR 0.055, RMSEA 0.08, CFI 0.930, LI 0.917. Cronbach's alpha calculated BCCFS (16 items) 0.91 (95% confidence interval: 0.89 0.93), coefficient 0.60. Using G8 standard indicator frailty, receiver operating characteristic curve showed that 31.5 best cut point (area 0. 816, 95% 0.757 0.874) sensitivity 63.5% specificity 84.4%. exhibited acceptable psychometric properties, proving it be valuable evaluating cancer. Further assessments reliability, validity, generality health providers' views different contexts cultures recommended.

Language: Английский

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The Impact of a Nutritional Intervention on Glycemic Control and Cardiovascular Risk Markers in Type 2 Diabetes

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1378 - 1378

Published: May 1, 2024

Introduction: Nutritional management plays a crucial role in treating patients with type 2 diabetes (T2D), working to prevent and control the progression of chronic non-communicable diseases. Objectives: To evaluate effects individualized nutritional interventions on weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), fasting blood glucose (FBG), hemoglobin A1c (HbA1c), total cholesterol (TC), LDL (LDL-C), HDL (HDL-C), triglycerides (TGs), systolic pressure (SBP), diastolic (DBP), heart rate (HR)} over 12 months subsequently at follow-up (15 months). Methods: This longitudinal experimental study (without randomization blinding) enrolled 84 sedentary participants T2D (both sexes, aged 18–80 years). They were divided into group 40 who received only medical consultations, an intervention 44 same care along assessment. Consultations occurred quarterly from August 2020 November 2022 (first–twelfth month), six nine per session. Subsequently, was conducted December 2023, during which had (during 12th–15th Personalized dietary planning inspired by Mediterranean/DASH diets adapted Brazilian foods socioeconomic cultures. Statistical Analysis: Normal variables compared between groups for each time point also within across different points using two-way ANOVA (repeated measures intragroup) followed Šídák post hoc test. Non-normal Kruskal–Wallis Dunn test, Friedman Data Gaussian distribution presented as mean ± standard deviation (SD), data non-Gaussian median interquartile range (IQR). For all cases, α < 0.05 p adopted. Results: In group, significant reductions observed first twelfth month parameters (p 0.05), (except TC), increase HDL-C = 0.0105). Conversely, there HbA1c, BMI, FBG, WHR 0.05) months. Regarding comparison groups, difference analyzed month. follow-up, differences except BMI > 0.05). Conclusion: The improved eating habits, anthropometric, biochemical, cardiovascular markers months, sustained results follow-up. plan Mediterranean DASH demonstrated good adaptation food culture patients’ contexts. Consistent monitoring personalized are essential optimizing long-term outcomes. However, more clinical trials necessary order optimize level evidence interventions.

Language: Английский

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Effects of Virtual Reality Motor-Cognitive Training for Older People With Cognitive Frailty: Multicentered Randomized Controlled Trial

Journal of Medical Internet Research, Journal Year: 2024, Volume and Issue: 26, P. e57809 - e57809

Published: Sept. 11, 2024

Background Cognitive frailty refers to a clinical syndrome in which physical and mild cognitive impairment coexist. Motor-cognitive training virtual reality (VR) have been used launch various therapeutic modalities promote health older people. The literature advocates that motor-cognitive VR are effective promoting the function of However, effects on people with unclear. Objective This study examined (VRMCT) global function, frailty, walking speed, visual short-term memory, inhibition interference, executive frailty. Methods multicentered, assessor-blinded, 2-parallel-group randomized controlled trial design. Participants were recruited face-to-face 8 adult community centers. Eligible participants aged ≥60 years, dwelling, lived had no dementia, not mobility restricted. In intervention group, received VRMCT led by interventionists 16 one-hour sessions delivered twice per week for weeks. control usual care provided centers investigators did interfere with. primary outcome was function. secondary outcomes included verbal Data collected at baseline (T0) after (T1). Generalized estimating equations examine time, interaction (time × group) outcomes. Results total, 293 eligible enrolled study. mean age 74.5 (SD 6.8) years. Most female (229/293, 78.2%), completed education (152/293, 52.1%), married (167/293, 57.2%), friends (127/293, 43.3%), experience (232/293, 79.5%). 81.6% (119/146) attended >80% (13/16, 81%) total number sessions. A negligible experienced sickness symptoms (1/146, 0.7% 5/146, 3%). (interaction effect: P=.03), marginally P=.07), reducing P=.03). statistically significant other Conclusions is functions well tolerated accepted as evidenced its high attendance rate symptoms. Further studies should efficacy components (eg, vs non-VR or dual task single task) outcomes, effect using technology adherence, long-term level daily living. Trial Registration ClinicalTrials.gov NCT04730817; https://clinicaltrials.gov/study/NCT04730817

Language: Английский

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Definition and assessment of psychological frailty in older adults: A scoping review

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102442 - 102442

Published: July 29, 2024

The confusion surrounding psychological frailty and its components prompts the need for a standardized conceptual definition. To address this, we aimed to (1) identify variables included in multicomponent assessment instruments used with older adults examine their operationalization; (2) formulate thorough conceptualization of based on identified.

Language: Английский

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Frailty and transplant-free survival of patients with liver cirrhosis: A meta-analysis

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0302836 - e0302836

Published: May 9, 2024

Background Frailty is a common condition among patients with liver cirrhosis. Nonetheless, its role in predicting transplant-free survival (TFS) remains unclear. Aim This systematic review and meta-analysis were conducted to elucidate the relationship between frailty TFS Methods Cohort studies addressing objective of this extracted from PubMed, Embase, Web Science databases. Between-study heterogeneity was assessed Cochrane Q test, I^2 statistic estimated. Random-effect models, considering potential heterogeneity, employed combine results. Results The encompassed 17 cohort involving 6273 cirrhosis, whom 1983 (31.6%) classified as frail at baseline. follow-up periods included ranged 3 29 months, an average duration 11.5 months. analysis revealed that significantly associated poor (risk ratio [RR]: 2.07, 95% confidence interval: 1.72 2.50, p <0.001; I 2 = 51%). Sensitivity analyses sequentially omitted one dataset consistently supported these findings (RR: 1.95 2.17, <0.05 all cases). Subgroup based on variables such study design, mean age patients, baseline Model for End-Stage Liver Disease score, tool used evaluation, duration, quality score also yielded congruent Conclusions evidence suggests may be independent risk factor thus emphasizing importance early identification management population.

Language: Английский

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The relationship between cognitive frailty, physical frailty and malnutrition in Turkish older adults

Nutrition, Journal Year: 2024, Volume and Issue: 126, P. 112504 - 112504

Published: June 2, 2024

Language: Английский

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Prevalence and associated factors of cognitive frailty in older patients with chronic kidney disease: a cross-sectional study

BMC Geriatrics, Journal Year: 2022, Volume and Issue: 22(1)

Published: Aug. 17, 2022

Chronic kidney disease (CKD) is prevalent in older adults. In the aging CKD population, cognitive frailty more common, but its prevalence and associated risk factors need to be further investigated.This a cross-sectional study that enrolled patients aged ≥ 60 years with diagnosis of from January 2018 February 2021. Patients were assessed for cognition FRAIL Mini-Mental State Examination (MMSE) scales divided into non-cognitive groups. Risk identified by univariate multivariate logistic regression analyses. A prediction model was built nomogram plotted. The performance evaluated using concordance index (C-index) calibration plots.A total 1015 enrolled, among whom 607 (59.8%) males 408 (40.2%) females, an age ranging 98 years, 15.2%. varied stages 1-5, rates 4.7%, 7.5%, 13.8%, 18.5%, 21.4%, respectively. Multivariate analysis showed (OR = 1.11, 95%CI 1.08-1.14, p < 0.001), depression 2.52, 1.54-4.11, low social support 2.08, 1.28-3.39, 0.003), Charlson comorbidity (CCI) 1.92, 1.70-2.18, eGFR 0.98, 0.96-0.99, 0.001) albuminuria 5.93, 3.28-10.74, independent affecting association CKD. assessing established well-calibrated C-index 0.91 (95%CI 0.89-0.94).The higher having Advanced age, comorbidity, depression, support, accompanied frailty.

Language: Английский

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