Oxidative stress in the skin: Impact and related protection

International Journal of Cosmetic Science, Journal Year: 2021, Volume and Issue: 43(5), P. 495 - 509

Published: July 27, 2021

Abstract Skin, our first interface to the external environment, is subjected oxidative stress caused by a variety of factors such as solar ultraviolet, infrared and visible light, environmental pollution, including ozone particulate matters, psychological stress. Excessive reactive species, oxygen species nitrogen exacerbate skin pigmentation aging, which further lead tone unevenness, pigmentary disorder, roughness wrinkles. Besides these, microbiota are also very important factor ensuring proper functions skin. While UV pollutants impact compositions, dysbiosis results in various conditions. In this review, we summarize generation from exogenous endogenous sources. We introduce current knowledge on possible roles specifically with emphasis pigmentation. Meanwhile, science rationale using three well‐known antioxidants, namely vitamin C, resveratrol ferulic acid, treatment hyperpigmentation. Finally, discuss strategy for preventing stress‐induced aging.

Language: Английский

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Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

Cosmetics, Journal Year: 2019, Volume and Issue: 6(4), P. 57 - 57

Published: Oct. 1, 2019

One of the most common approaches for control skin pigmentation involves inhibition tyrosinase, a copper-containing enzyme which catalyzes key steps melanogenesis. This review focuses on tyrosinase properties series natural and synthetic, bioinspired phenolic compounds that have appeared in literature last five years. Both mushroom human inhibitors been considered. Among first class, flavonoids, particular chalcones, occupy prominent role as inhibitors, followed by hydroxystilbenes (mainly resveratrol derivatives). A more complex from variety sources, all belonging to Moraceae family, also described potent inhibitors. As synthetic compounds, hydroxycinnamic acids chalcones again appear exploited scaffolds. Several mechanisms reported pointing copper chelating and/or hydrophobic moieties structural requirements achieve good properties. Emerging trends search novel depigmenting agents, including development assays could distinguish between potentially toxic substrates well formulations aimed at improving bioavailability hence effectiveness well-known addressed.

Language: Английский

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Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Cells, Journal Year: 2019, Volume and Issue: 8(8), P. 803 - 803

Published: July 31, 2019

The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation, migration, survival, as well angiogenesis metabolism. Dysregulation these is frequently with genetic/epigenetic alterations predicts poor treatment outcomes in a variety human cancers including cutaneous malignancies like melanoma non-melanoma skin cancers. Recently, the enhanced understanding molecular genetic basis dysfunction patients has provided strong for development novel therapeutic strategies obdurate groups This review summarizes recent advances roles PI3K/Akt/mTOR their targets progression broad spectrum discusses current progress preclinical clinical studies targeted therapies nutraceuticals synthetic small molecule inhibitors.

Language: Английский

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Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging

Journal of Investigative Dermatology, Journal Year: 2020, Volume and Issue: 141(4), P. 1119 - 1126

Published: Dec. 19, 2020

Language: Английский

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Arbutin as a Skin Depigmenting Agent with Antimelanogenic and Antioxidant Properties

Antioxidants, Journal Year: 2021, Volume and Issue: 10(7), P. 1129 - 1129

Published: July 15, 2021

Arbutin is a compound of hydroquinone and D-glucose, it has been over 30 years since there have serious studies on the skin lightening action this substance. In meantime, debates validation about mechanism substance as well its efficacy safety. Several analogs or derivatives arbutin developed studied for their melanin synthesis inhibitory action. Formulations to improve stability, transdermal delivery, release arbutin, device usage promote absorption developed. Substances that inhibit synergistically with explored. The alone in combination other active ingredients clinically evaluated. Combined therapy laser could give enhanced depigmenting efficacy. use causes dermatitis rarely, caution recommended arbutin-containing products, especially from viewpoint may be generated during product use. Studies antioxidant properties are emerging, these proposed contribute arbutin. It hoped review will help understand pros cons cosmetic ingredient, lead future research directions developing advanced protecting products.

Language: Английский

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Epigenetic regulation of melanogenesis

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 69, P. 101349 - 101349

Published: May 10, 2021

Language: Английский

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The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1671 - 1671

Published: June 20, 2023

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated inflammatory and hyperproliferative dermatoses such as acne, atopic dermatitis, alopecia, psoriasis, wounds, vitiligo, is associated with poor treatment outcomes. Improved comprehension the consequences PI3K/Akt/mTOR patients resulted development novel therapeutic approaches. Nonetheless, more studies are necessary to validate regulatory role this create effective preventive methods for a wide range skin diseases. Several have revealed that certain natural products synthetic compounds can obstruct expression/activity PI3K/Akt/mTOR, underscoring their potential managing common persistent disorders. This review summarizes recent advances understanding activated components discusses bioactive products, scaffolds, biologic agents prevention treatment. However, further research develop therapies

Language: Английский

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Tyrosinase Inhibitors Naturally Present in Plants and Synthetic Modifications of These Natural Products as Anti-Melanogenic Agents: A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 378 - 378

Published: Jan. 2, 2023

Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis. In the current review, different derivatives are explored which have been used as anti-melanogenic compounds. These compounds naturally present in plants and semi-synthetic synthetic inspired by these natural products, such kojic acid produced several species of fungi; arbutin—a glycosylated hydroquinone extracted from bearberry plant; vanillin—a phenolic aldehyde vanilla bean, etc. After inhibition screening, various showed therapeutic effects tyrosinase inhibitors with values constant IC50. We show how appropriately designed scaffolds structures develop novel inhibitors. review results numerous studies, could lead development effective anti-tyrosinase agents increased efficiency safety near future, many applications food, pharmaceutical cosmetics industries.

Language: Английский

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New Mechanistic Insights of Melasma

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2023, Volume and Issue: Volume 16, P. 429 - 442

Published: Feb. 1, 2023

Abstract: Melasma is a common acquired disorder of pigmentation that negatively impacts quality life. Present treatments show poor therapeutic effect with frequent recurrence. This in large part due to the currently limited understanding disease's etiology. It urgent elucidate pathogenesis melasma further discovery new strategies. Recent studies triggered or aggravated by variety factors, including genetic susceptibility, ultraviolet radiation, and sex hormone dysregulation. Ultraviolet B radiation upregulates expression several melanocyte-specific genes stimulates release key factors participate synthesis melanin. There significant increase melanin both epidermal dermal layers affected skin, possibly abnormalities crosstalk between melanocytes other cells. Melanogenesis regulated through various signaling networks Wnt/β-catenin, PI3K/Akt, cAMP/PKA, SCF/c-kit-mediated pathways. In addition, inflammatory mediators, oxidative stress, neuroactive molecules, sebocytes, etc, have also been proved be related melasma. review provides comprehensive update on current Keywords: predisposition, hormone, melanocyte, melasma,

Language: Английский

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Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications

Antioxidants, Journal Year: 2019, Volume and Issue: 8(9), P. 332 - 332

Published: Aug. 22, 2019

Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found many edible plants such as Vitis vinifera, its inhibitory effects on the catalytic activity, gene expression, posttranslational modifications of tyrosinase, key enzyme melanin biosynthetic pathway, provide mechanistic basis for antimelanogenic seen melanocytic cells, three-dimensionally reconstituted models, vivo animal models. As potent antioxidant modulator nuclear factor erythroid 2-related 2 (Nrf2), sirtuin 1, resveratrol can also regulate multiple signaling pathways inflammation premature aging. Recent clinical studies have supported efficacy analogs, resveratryl triacetate (RTA) triglycolate (RTG), human lightening antiaging. These findings suggest that analogs potentially antiaging agents cosmetics.

Language: Английский

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