Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(5)
Published: May 20, 2024
Backgrounds:
Melanogenesis,
regulated
by
genetic,
hormonal,
and
environmental
factors,
occurs
in
melanocytes
the
basal
layer
of
epidermis.
Dysregulation
this
process
can
lead
to
various
skin
disorders,
such
as
hyperpigmentation
hypopigmentation.
Therefore,
present
study
investigated
effect
ultrasonic-assisted
ethanol
extract
(SHUE)
from
Sargassum
horneri
(S.
horneri),
brown
seaweed
against
melanogenesis
α-melanocyte-stimulating
hormone
(MSH)-stimulated
B16F10
murine
melanocytes.
Methods:
Firstly,
yield
proximate
compositional
analysis
samples
were
conducted.
The
SHUE
on
cell
viability
has
been
evaluated
using
3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium
bromide
(MTT)
assay.
After
that,
melanin
content
cellular
tyrosinase
activity
α-MSH-stimulated
examined.
Western
blot
was
carried
out
investigate
protein
expression
levels
microphthalmia-associated
transcription
factor
(MITF),
tyrosinase,
tyrosinase-related
protein-1
(TRP1),
protein-2
(TRP2).
In
addition,
extracellular
signal-regulated
kinase
(ERK)
assessed
via
blotting.
Results:
As
per
analysis,
contained
highest
average
a
dry
basis
at
28.70
±
3.21%.
findings
showed
that
reduced
Additionally,
MITF,
TRP1,
TRP2
significantly
downregulated
treatment
Moreover,
upregulated
phosphorylation
ERK
AKT
experiments
conducted
inhibitor
(PD98059)
revealed
depends
signaling
cascade.
Conclusion:
These
results
suggest
an
anti-melanogenic
be
used
material
formulation
cosmetics
related
whitening
lightening.
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(8), P. 1315 - 1315
Published: Aug. 21, 2021
Vitamin
B3
(nicotinic
acid,
niacin)
deficiency
causes
the
systemic
disease
pellagra,
which
leads
to
dermatitis,
diarrhea,
dementia,
and
possibly
death
depending
on
its
severity
duration.
is
used
in
synthesis
of
NAD
Natural Products and Bioprospecting,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Nov. 28, 2022
The
global
cosmetics
market
reached
US$500
billion
in
2017
and
is
expected
to
exceed
US$800
by
2023,
at
around
a
7%
annual
growth
rate.
industry
emerging
as
one
of
the
fastest-growing
industries
past
decade.
Data
shows
that
Chinese
was
US$60
2021.
It
be
world's
number
consumer
2050,
with
size
approximately
US$450
billion.
influence
social
media
internet
has
raised
awareness
risks
associated
usage
many
chemicals
health
benefits
natural
products
derived
from
plants
other
resources.
As
result,
cosmetic
now
paying
more
attention
products.
present
review
focus
on
possible
applications
various
biological
sources
skin
care
cosmetics,
including
topical
products,
fragrances,
moisturizers,
UV
protective,
anti-wrinkle
In
addition,
mechanisms
targets
for
evaluation
active
ingredients
these
bioactive
compounds
rejuvenation
health,
their
potential
role
are
also
discussed.
Dermatology and Therapy,
Journal Year:
2022,
Volume and Issue:
12(9), P. 1989 - 2012
Published: July 29, 2022
Melasma
is
a
prevalent
chronic
relapsing
pigmentary
disorder
that
affects
photoexposed
areas,
especially
in
women
of
childbearing
age.
Although
there
currently
no
curative
treatment
available
for
melasma,
this
manuscript
critically
reviews
the
knowledge
regarding
photoprotection,
topical
and
oral
therapies,
procedures
such
as
peelings,
laser,
microneedling
represent
main
strategies
control
prevention
disease.
As
pathogenesis
melasma
not
entirely
understood,
are
prospects
development
new
therapeutic
might
act
on
pathways
promote
sustained
pigmentation
rather
than
merely
decreasing
melanin
synthesis
removing
from
epidermis.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(24), P. 8786 - 8786
Published: Dec. 11, 2022
Arbutin,
a
hydroquinone
glucoside,
has
been
detected
in
ca.
50
plant
families,
especially
the
plants
of
Asteraceae,
Ericaceae,
Proteaceae
and
Rosaceae
families.
It
is
one
most
widely
used
natural
skin-whitening
agents.
In
addition
to
its
skin
whitening
property,
arbutin
possesses
other
therapeutically
relevant
biological
properties,
e.g.,
antioxidant,
antimicrobial
anti-inflammatory,
as
well
anticancer
potential.
This
review
presents,
for
first
time,
comprehensive
overview
distribution
kingdom
critically
appraises
therapeutic
potential
an
agent
based
on
literature
published
until
end
August
2022,
accessed
via
several
databases,
Web
Science,
Science
Direct,
Dictionary
Natural
Products,
PubMed
Google
Scholar.
The
keywords
search
were
arbutin,
cancer,
anticancer,
hydroquinone.
Published
outputs
suggest
that
properties
against
bladder,
bone,
brain,
breast,
cervix,
colon,
liver,
prostate
cancers
low
level
acute
or
chronic
toxicity.
Applied Sciences,
Journal Year:
2022,
Volume and Issue:
12(6), P. 3177 - 3177
Published: March 21, 2022
The
use
of
bleaching
products
can
have
a
medical
or
cosmetic
purpose;
in
the
latter
case,
skin
whitening
is
most
widespread
countries
where
darker
tones
prevail
and
be
driven
by
psychosocial,
cultural
economic
reasons.
Skin-whitening
containing
highly
toxic
active
ingredients
(in
particular
mercury
derivatives,
hydroquinone
corticosteroids)
are
easily
found
on
market;
these
depigmenting
agents
followed
variety
adverse
effects,
with
very
serious
sometimes
fatal
complications,
currently
an
emerging
health
concern
many
countries.
This
article
concisely
discusses
reasons
for
current
prevalence
lightening
provides
overview
that
pose
threat
to
human
health.
review
also
reports
market
surveillance
data
circulation
banned
lighteners
Europe,
obtained
through
Safety
Gate
system.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(21), P. 15930 - 15930
Published: Nov. 3, 2023
In
recent
years,
skin
aging
has
received
increasing
attention.
Many
factors
affect
aging,
and
research
shown
that
metabolism
plays
a
vital
role
in
but
there
needs
to
be
more
systematic
review.
This
article
reviews
the
interaction
between
from
perspectives
of
glucose,
protein,
lipid
explores
relevant
strategies
for
regulation.
We
found
affects
three
major
substances,
which
are
lipids,
substances
also
process
aging.
Some
drugs
or
compounds
can
regulate
metabolic
disorders
mentioned
above
exert
anti-aging
effects.
Currently,
variety
products,
most
them
focus
on
improving
collagen
levels.
Skin
is
closely
related
metabolism,
they
interact
with
each
other.
Regulating
specific
an
important
strategy.
Research
development
have
focused
levels,
while
regulation
other
glycosylation
including
key
membrane
cytoskeleton
proteins
relatively
rare.
Further
expected.
Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(1), P. 23 - 23
Published: Feb. 6, 2024
Catechins
are
a
type
of
flavonoid
known
for
their
beneficial
functions
as
antioxidants
and
antibacterials.
Recent
research
indicates
the
antioxidant
potential
catechins
on
skin.
Catechin
epigallocatechin
reported
to
have
significant
in
preventing
ageing.
Epigallocatechin
gallate,
gallocatechin
can
inhibit
hyperpigmentation
processes.
Additionally,
exhibit
UV
protection
inflammation
inhibition
acne.
Consequently,
now
being
used
cosmetics
industry,
with
formulations
containing
active
ingredient
developed
produce
various
products
such
soap,
sunscreen,
creams,
etc.
Herein,
this
paper
reviews
use
cosmetic
current
status
clinical
trials
cosmetics.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 2, 2024
Melasma
is
a
chronic
hyperpigmentation
skin
disorder
that
more
common
in
the
female
gender.
Although
melasma
multifactorial
disorder,
however,
sun-exposure
and
genetic
predisposition
are
considered
as
main
etiologic
factors
occurrence.
numerous
topical
systemic
therapeutic
agents
also
non-pharmacologic
procedural
treatments
have
been
management,
commonly
available
options
several
limitations
including
lack
of
sufficient
clinical
effectiveness,
risk
relapse,
high
rate
unwanted
adverse
drug
reactions.
Recruitment
nanotechnology
for
delivery
management
can
lead
to
enhanced
penetration,
targeted
site
action,
longer
deposition
at
area,
limit
absorption
therefore
availability
In
current
review,
first
all,
etiology,
pathophysiology,
severity
classification
considered.
Then,
various
pharmacologic
treatment
discussed.
Afterward,
usage
types
nanoparticles
purpose
was
end,
studies
controlled
trials
on
assessment
effectiveness
these
novel
formulations
summarized.
Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
66(7), P. 5099 - 5117
Published: March 20, 2023
Excessive
melanin
deposition
may
lead
to
a
series
of
skin
disorders.
The
production
is
carried
out
by
melanocytes,
in
which
the
enzyme
tyrosinase
performs
key
role.
In
this
work,
we
identified
novel
inhibitor
hybrids
with
dihydrochalcone
skeleton
and
resorcinol
structure,
can
inhibit
activity
reduce
content
skin.
Compound
11c
possessed
most
potent
against
tyrosinase,
showing
IC50
values
at
nanomolar
concentration
ranges,
along
significant
antioxidant
low
cytotoxicity.
Furthermore,
vitro
permeation
tests,
supported
HPLC
analysis
3D
OrbiSIMS
imaging
visualization,
revealed
excellent
11c.
More
importantly,
compound
reduced
on
UV-induced
pigmentation
guinea
pig
model
vivo.
These
results
suggest
that
serve
as
promising
for
development
potential
therapy
treat
hyperpigmentation.
