Diversity, Mechanisms, and Significance of Macrophage Plasticity

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2019, Volume and Issue: 15(1), P. 123 - 147

Published: Sept. 18, 2019

Macrophages are a diverse set of cells present in all body compartments. This diversity is imprinted by their ontogenetic origin (embryonal versus adult bone marrow-derived cells); the organ context; activation or deactivation various signals contexts microbial invasion, tissue damage, and metabolic derangement; polarization adaptive T cell responses. Classic responses macrophages include tolerance, priming, wide spectrum states, including M1, M2, M2-like. Moreover, can retain long-term imprinting encounters (trained innate immunity). Single-cell analysis mononuclear phagocytes health disease has added new dimension to our understanding macrophage differentiation activation. Epigenetic landscapes, transcription factors, microRNA networks underlie adaptability different environmental cues. Macrophage plasticity, an essential component chronic inflammation, its involvement human diseases, most notably cancer, discussed here as paradigm.

Language: Английский

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The kynurenine pathway: a finger in every pie

Molecular Psychiatry, Journal Year: 2019, Volume and Issue: 25(1), P. 131 - 147

Published: April 12, 2019

Language: Английский

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Changes in Nutritional Status Impact Immune Cell Metabolism and Function

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: May 16, 2018

Immune cell function and metabolism are closely linked. Many studies have now clearly demonstrated that alterations in cellular influence immune that, conversely, determines the metabolic state. Less well understood, however, effects of systemic or whole organism nutritional status on metabolism. Several undernutrition is associated with immunosuppression, which leads to both increased susceptibility infection protection against several types autoimmune disease, whereas overnutrition low-grade, chronic inflammation increases risk cardiovascular promotes autoreactivity, disrupts protective immunity. Here, we review immunity highlight nutrition circulating cytokines populations human mouse models. As T cells critical members system, direct overall response, will focus this function. hormones been identified mediate through expression action key regulatory signaling proteins. Understanding how sensitive inadequate overabundant nutrients may enhance our ability target alter malnutrition obesity.

Language: Английский

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Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

Cell Metabolism, Journal Year: 2020, Volume and Issue: 31(3), P. 518 - 533.e10

Published: Jan. 30, 2020

Language: Английский

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SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(6), P. 1063 - 1075.e7

Published: Dec. 1, 2020

Language: Английский

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Macrophages: friend or foe in idiopathic pulmonary fibrosis?

Respiratory Research, Journal Year: 2018, Volume and Issue: 19(1)

Published: Sept. 6, 2018

Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung disease unknown etiology. Over the past decade, macrophage has been recognized to play significant role in IPF pathogenesis. Depending on local microenvironments, macrophages can be polarized either classically activated (M1) or alternatively (M2) phenotypes. In general, M1 are responsible for wound healing after alveolar epithelial injury, while M2 designated resolve processes terminate inflammatory responses lung. pathological consequence resulted from altered response persistent injury. this review, we intend summarize current state knowledge regarding process polarization and its mediators pathogenesis fibrosis. Our goal update understanding mechanisms underlying initiation progression IPF, by which, expect provide help developing effective therapeutic strategies clinical settings.

Language: Английский

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Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: April 23, 2021

Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend against pathogens; however, their infiltration into tumors has been associated with adverse outcomes. Tumor-associated macrophages (TAMs) represent a significant component of the inflammatory infiltrate in breast tumors, extensive TAMs linked to poor prognosis cancer. Here, we detail how impede productive tumor immunity cycle by limiting antigen presentation reducing activation cytotoxic T lymphocytes (CTLs) while simultaneously supporting cell survival, angiogenesis, metastasis. There is an urgent need overcome TAM-mediated suppression for durable anti-tumor To date, failure fully characterize TAM biology classify multiple subsets hindered advancement therapeutic targeting. In this regard, complexity recently taken center stage owing subset diversity tightly regulated molecular metabolic phenotypes. review, reveal major gaps our knowledge functional phenotypic characterization cancer, before after treatment. Future work subsets, location, crosstalk neighboring will be critical counteract pro-tumor functions identify novel TAM-modulating strategies combinations likely enhance current therapies chemo- immuno-therapy resistance.

Language: Английский

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Iron Metabolism and Immune Regulation

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: March 23, 2022

Iron is a critical element for living cells in terrestrial life. Although iron metabolism strictly controlled the body, disturbance of homeostasis under certain type condition leads to innate and adaptive immune response. In immunity, regulates macrophage polarizations, neutrophils recruitment, NK activity. had an effect on activation differentiation Th1, Th2, Th17 CTL, antibody response B cells. this review, we focused regulation listed specific role polarization, T-cell activation, B-cells addition, correlations between several diseases such as cancer aging degenerative some therapeutic strategies targeting those are also discussed.

Language: Английский

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USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy

Cellular and Molecular Immunology, Journal Year: 2020, Volume and Issue: 18(10), P. 2431 - 2442

Published: Oct. 23, 2020

Language: Английский

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Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis

The Journal of Experimental Medicine, Journal Year: 2020, Volume and Issue: 217(11)

Published: Aug. 12, 2020

It has long been known that in vitro polarized macrophages differ morphology. Stemming from a conventional immunohistology observation, we set out to test the hypothesis morphology of tumor-associated (TAMs) colorectal liver metastasis (CLM) represents correlate functional diversity with prognostic significance. Density and morphological metrics TAMs were measured correlated clinicopathological variables. While density did not survival CLM patients, cell area identified small (S-TAM) large (L-TAM) associated 5-yr disease-free rates 27.8% 0.2%, respectively (P < 0.0001). RNA sequencing morphologically distinct LXR/RXR as most enriched pathway macrophages, up-regulation genes involved cholesterol metabolism, scavenger receptors, MERTK, complement. In single-cell analysis mononuclear phagocytes tissues, S-TAM L-TAM signatures differentially individual clusters. These results suggest morphometric characterization can serve simple readout TAM strong

Language: Английский

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