Macrophages as tools and targets in cancer therapy

Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(11), P. 799 - 820

Published: Aug. 16, 2022

Language: Английский

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The inflammatory pathogenesis of colorectal cancer

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(10), P. 653 - 667

Published: April 28, 2021

Language: Английский

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The complex role of tumor-infiltrating macrophages

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(8), P. 1148 - 1156

Published: July 25, 2022

Language: Английский

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Tailoring Materials for Modulation of Macrophage Fate

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(12)

Published: Feb. 9, 2021

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity adaptive hold great promise for broad range of prophylactic therapeutic purposes. This review is focused on design strategies principles immunomodulatory from standpoint materials science to regulate macrophage fate, such activation, polarization, adhesion, migration, proliferation, secretion. It offers comprehensive survey discussion tunability material designs regarding physical, chemical, biological, dynamic cues modulating response. The tailorable encompasses surface properties, topography, mechanics, composition, dynamics. representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating are being exploited cancer immunotherapy, infection regeneration, inflammation resolution, vaccination. A perspective future research directions immunoregulatory also provided.

Language: Английский

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Metabolic orchestration of the wound healing response

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(9), P. 1726 - 1743

Published: Aug. 11, 2021

Language: Английский

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Tumor-associated myeloid cells: diversity and therapeutic targeting

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(3), P. 566 - 578

Published: Jan. 20, 2021

Language: Английский

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Roles of macrophages in tumor development: a spatiotemporal perspective

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(9), P. 983 - 992

Published: July 10, 2023

Abstract Macrophages are critical regulators of tissue homeostasis but also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support development. While we know that TAMs dominant immune cells TME, their vast heterogeneity associated functions only just being unraveled. this review, outline various known TAM populations found thus far delineate specialized roles with main stages cancer progression. We discuss how may prime premetastatic niche enable growth a metastasis then subsequent metastasis-associated can secondary growth. Finally, speculate on challenges remain be overcome research.

Language: Английский

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The cholesterol pathway: impact on immunity and cancer

Trends in Immunology, Journal Year: 2021, Volume and Issue: 43(1), P. 78 - 92

Published: Dec. 22, 2021

Language: Английский

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Functional states of myeloid cells in cancer

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 490 - 504

Published: March 1, 2023

Language: Английский

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Macrophage polarization and metabolism in atherosclerosis

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(10)

Published: Oct. 20, 2023

Abstract Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in inner walls vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke. The development atherosclerosis influenced variety factors, including age, genetics, lifestyle, underlying health conditions high pressure diabetes. Atherosclerotic stable form are slow growth, which leads luminal stenosis, with low embolic potential unstable form, contributes risk for thrombotic rapid clinical onset. In this complex scenario atherosclerosis, macrophages participate whole process, initiation, growth eventually rupture wound healing stages artery plaque formation. Macrophages exhibit heterogeneity plasticity, affect evolving microenvironment, e.g., leading excessive lipid accumulation, cytokine hyperactivation, hypoxia, apoptosis necroptosis. metabolic functional transitions response microenvironmental factors not only influence ongoing imminent responses within lesions but also directly dictate atherosclerotic progression regression. review, we discuss origin plaques, their phenotypic diversity, shifts, fate roles they play dynamic atherosclerosis. It describes how interact other cells, particularly T cells. Ultimately, targeting pathways involved macrophage polarization may innovative promising approaches precision medicine. Further insights into landscape biological features offer valuable information optimizing future treatment macrophages.

Language: Английский

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