Oridonin suppresses gastric cancer SGC‐7901 cell proliferation by targeting the TNF‐alpha/androgen receptor/TGF‐beta signalling pathway axis

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 27(18), P. 2661 - 2674

Published: July 11, 2023

Statistics provided by GLOBOCAN list gastric cancer as the sixth most common, with a mortality ranking of third highest for year 2020. In China, herb called Rabdosia rubescens (Hemsl.) H.Hara, has been used local residents treatment digestive tract hundreds years. Oridonin, main ingredient herb, curative effect cancer, but mechanism not previously clarified. This study mainly aimed to investigate role TNF-alpha/Androgen receptor/TGF-beta signalling pathway axis in mediating proliferation inhibition oridonin on SGC-7901 cells. MTT assay, cell morphology observation assay and fluorescence were adopted efficacy proliferation. The network pharmacology was predict regulated oridonin. Western blot verify TNF-α/Androgen receptor/TGF-β regulation results showed Oridonin could inhibit cells, change cause nuclear fragmentation. A total 11signaling pathways annotated pharmacology, among them, Tumour necrosis factor alpha (TNF-α) pathway, androgen receptor (AR) transforming growth (TGF-β) account largest proportion. can regulate protein expression three pathways, which is consistent predicted pharmacology. These findings indicated that cells regulating TNF-α /AR /TGF-β axis.

Language: Английский

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Inhibition of hepatocellular carcinoma cell proliferation through regulation of the Cell Cycle, AGE-RAGE, and Leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, and oroxylin A derived from Andrographis Paniculata(Burm.f.) Nees

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118001 - 118001

Published: March 11, 2024

Language: Английский

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Polysaccharides from Lonicera japonica Thunb.: Extraction, purification, structural features and biological activities—A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136472 - 136472

Published: Oct. 15, 2024

Language: Английский

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Unveiling polysaccharides of Houttuynia cordata Thunb.: Extraction, purification, structure, bioactivities, and structure–activity relationships

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156436 - 156436

Published: Jan. 1, 2025

Language: Английский

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Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(5), P. 3046 - 3067

Published: Feb. 1, 2024

Abstract Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases and 10 cancer‐related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of will increase to 30.2 individuals annually. Considering invasive characteristics its diagnostic procedures therapeutic methods side effects, scientists searching for different solutions, including using plant‐derived bioactive compounds, could reduce probability occurrence make treatment more comfortable. this regard, oridonin (ORI), an ent‐kaurane diterpenoid, naturally found in leaves Rabdosia rubescens species, has been have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, apoptosis induction properties. Extensive research performed on ORI find various mechanisms involved anticancer activities. This review article provides overview ORI's effectiveness murine human populations from 1976 2022 insight into future application therapies.

Language: Английский

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Rabdosia rubescens (Hemsl.) H. Hara: A Potent Anti-Tumor Herbal Remedy - Botany, Phytochemistry, and Clinical Breakthroughs

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119200 - 119200

Published: Dec. 3, 2024

Language: Английский

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Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules

Cancer Biology & Therapy, Journal Year: 2024, Volume and Issue: 25(1)

Published: March 4, 2024

Salidroside inhibited the proliferation of cancer cell. Nevertheless, mechanism has not been completely clarified. The purpose study is to explore mechanisms salidroside against gastric cancer. To analyze changes microRNA (miRNA) in cells under treatment salidroside, miRNA expression was analyzed by using RNA-seq for 24 h after treatment. differentially expressed miRNAs were clustered and their target genes analyzed. Selected mRNA further verified q-PCR. expressions detected immunohistochemistry. Cancer cell apoptotic index significantly increased blocked at S-phase cycle. 44 changed cells. Bioinformatic analysis showed that there 1384 mRNAs corresponding miRNAs. Surprisingly, up-regulated tumor suppressor miR-1343-3p, down-regulated MAP3K6, STAT3 MMP24-related genes. suppressed growth inducing apoptosis, arresting cycle down-regulating related signal transduction pathways. are treatment, playing important roles regulating metastasis. may suppress up-regulating miR-1343-3p MAP3K6 MMP24 molecules.

Language: Английский

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Hederagenin improves renal fibrosis in diabetic nephropathy by regulating Smad3/NOX4/SLC7A11 signaling-mediated tubular cell ferroptosis

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 135, P. 112303 - 112303

Published: May 21, 2024

Language: Английский

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Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113935 - 113935

Published: Jan. 5, 2025

Language: Английский

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Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Hand.-Mazz. herb pair

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

The Prunella vulgaris L. (PVL) and Taraxacum mongolicum Hand.-Mazz. (TH) herb pair, which is commonly used in traditional Chinese medicine (TCM), has been applied for the treatment of breast cancer. Although its efficacy validated, synergistic anti-breast cancer compound combinations within this pair their underlying mechanisms action remain unclear. This study aimed to identify validate PVL-TH using large-scale biomedical data, artificial intelligence experimental methods. first step was investigate effects various PVL TH extracts vitro cellular assays most effective superior extracts. These were subjected liquid chromatography-mass spectrometry (LC-MS) analysis constituent compounds. A deep learning-based prediction model, DeepMDS, predict multi-compound combinations. predicted experimentally validated at actual content ratios found Preliminary bioinformatics analyses conducted explore these We also compared from different geographical origins analyzed contents compounds assess representation anti-tumor effect corresponding TCM. results revealed that LC-MS identified 27 21 (50% ethanol extracts) TH, respectively. Based on compounds, DeepMDS model such as F973 (caffeic acid, rosmarinic p-coumaric esculetin), T271 (chlorogenic cichoric caffeic acid), T1685 scopoletin) single PVL, combinations, concentrations extracts, demonstrated activity could regulate tumor-related pathways synergistically, inhibiting tumor cell growth, inducing apoptosis, blocking cycle progression. Furthermore, concentration ratio total closely associated with origins. combination represent pair. provides insights into exploring representative complex

Language: Английский

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