Associations between self‐reported periodontal disease and nutrient intakes and nutrient‐based dietary patterns in the UK Biobank

Journal Of Clinical Periodontology, Journal Year: 2022, Volume and Issue: 49(5), P. 428 - 438

Published: Feb. 16, 2022

To examine the cross-sectional associations between single nutrient intakes and posteriori nutrient-based dietary patterns periodontal disease risk in a subset of UK Biobank cohort.Dietary data were collected by 24-h recall on up to five separate occasions over 16 months. A touchscreen questionnaire was used collect oral health information. Participants considered at high if they reported having painful gums and/or bleeding loose teeth. Principal component analysis identified four from 20 nutrients. Logistic regression estimate odds ratio for nutrients patterns.A total 9476 participants (mean age 56.2 years [SD 8.0]) included analysis. Higher vitamin B6, B12, C, E, folate, iron, potassium, magnesium, polyunsaturated fatty acids, sugar associated with lower disease. intake saturated fat an increased risk. pattern characterized micronutrients fibre low disease.Within this sample middle-aged older adults, "high micronutrient fibre" reduced

Language: Английский

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The impact of study factors in the association of periodontal disease and cognitive disorders: systematic review and meta-analysis

Age and Ageing, Journal Year: 2023, Volume and Issue: 52(2)

Published: Feb. 1, 2023

Abstract Aim The aim was to assess study factors that impact the association of cognitive disorders in people with periodontal disease (PD). Method Medline, EMBASE and Cochrane databases were searched until February 2022 using keywords MeSH: (periodon* OR tooth loss missing teeth) AND (dementia Alzheimer’s Disease cognitive*). Observational studies reporting prevalence or risk decline, dementia (AD) PD compared healthy controls included. Meta-analysis quantified (relative risk[RR]) dementia/AD, respectively. Meta-regression/subgroup analysis explored including severity classification type, gender. Results Overall, 39 eligible for meta-analysis: 13 cross-sectional 26 longitudinal studies. demonstrated increased risks (cognitive decline—RR = 1.33, 95% CI 1.13–1.55; dementia/AD—RR 1.22, 1.14–1.31). Risk decline (moderate—[RR] 1.14, confidence interval [CI] 1.07–1.22; severe—RR 1.25, 1.18–1.32). For every 10% population increase females, by 34% (RR 1.34, 1.16–1.55). Self-reported showed a lower clinical 0.77, 0.65–0.91; 0.86, 0.77–0.96). Conclusion estimates can be influenced gender, its severity. Further homologous evidence taking these into consideration is needed form robust conclusions.

Language: Английский

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PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 30, 2024

Progranulin (PGRN), a multifunctional growth factor, plays indispensable roles in the regulation of cancer, inflammation, metabolic diseases, and neurodegenerative diseases. Nevertheless, its immune regulatory role periodontitis is insufficiently understood. This study attempts to explore effects PGRN on macrophage polarization microenvironment.

Language: Английский

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Systemic Multimorbidity Clusters in People with Periodontitis

Journal of Dental Research, Journal Year: 2022, Volume and Issue: 101(11), P. 1335 - 1342

Published: June 9, 2022

This study aimed to identify systemic multimorbidity clusters in people with periodontitis via a novel artificial intelligence-based network analysis and explore the effect of associated factors. utilized cross-sectional data 3,736 participants across 3 cycles National Health Nutrition Examination Survey (2009 2014). Periodontal examination was carried out by trained dentists for aged ≥30 y. The extent represented proportion sites clinical attachment loss (CAL)≥ mm, split into 4 equal quartiles. A range diseases reported during survey were also extracted. Hypergraph eigenvector centralities applied single-disease influence overall population when stratified CAL quartile. Individual factors that could affect explored In population, top prevalent hypertension (63.9%), arthritis (47.6%), obesity (45.9%). total 106 unique identified population. Hypertension most centralized disease (centrality [C]: 0.50), followed closely (C: 0.45) 0.42). Diabetes had higher centrality highest quartile 0.31) than lowest 0.26). "Hypertension, obesity" largest weighted cluster has revealed common periodontitis. People are more likely present together, diabetes is influential severe Factors such as ethnicity, deprivation, smoking status may pattern clusters.

Language: Английский

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Periodontitis and risk of immune‐mediated systemic conditions: A systematic review and meta‐analysis

Community Dentistry And Oral Epidemiology, Journal Year: 2022, Volume and Issue: 51(5), P. 705 - 717

Published: Nov. 15, 2022

Abstract Introduction The aim of this review is to examine and quantify the long‐term risk immune‐mediated systemic conditions in people with periodontitis compared without periodontitis. Methods Medline, EMBASE Cochrane databases were searched up June 2022 using keywords MeSH headings. ‘Risk Bias Non‐Randomised Studies Interventions’ tool was used assess bias. Cohort studies comparing incident metabolic/autoimmune/inflammatory diseases healthy controls included. Meta‐analysis meta‐regression quantified risks showed impact diagnosis type severity. Results search retrieved 3354 studies; 166 eligible for full‐text screening, 30 included review. Twenty‐seven meta‐analysis. diabetes, rheumatoid arthritis (RA) osteoporosis increased (diabetes—relative [RR]: 1.22, 95% CI: 1.13–1.33; RA—RR: 1.27, 1.07–1.52; osteoporosis—RR: 1.40, 1.12–1.75). Risk diabetes gradient increase by severity (moderate—RR = 1.20, CI 1.11–1.31; severe—RR 1.34, 1.10–1.63). Conclusion People moderate‐to‐severe cases have highest developing while effect periodontal on other requires further investigation. More homologous evidence required form robust conclusions regarding periodontitis‐multimorbidity associations.

Language: Английский

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Mendelian randomization highlights the causal association of obesity with periodontal diseases

Journal Of Clinical Periodontology, Journal Year: 2022, Volume and Issue: 49(7), P. 662 - 671

Published: May 15, 2022

Abstract Aim The underlying mechanisms connecting obesity and periodontal diseases remain unclear. This study investigates the potential causal association of with using Mendelian randomization (MR). Materials Methods Single‐nucleotide polymorphisms traits including body mass index (BMI), waist circumference (WC), WC adjusted for BMI (WCadjBMI) from large‐scale genome‐wide studies were screened instrumental variables. single trait periodontitis combined comprising loose teeth adopted as surrogates diseases. Inverse‐variance weighted (IVW), series sensitivity analyses multivariable MR employed to determine Results IVW results showed that per 1‐SD increment in (odds ratio, OR = 1.115; 95% confidence interval [CI] 1.064–1.169; p < .001) (OR 1.117; CI 1.052–1.185; .001), but not WCadjBMI, significantly associated an increased risk periodontitis/loose teeth. Moreover, estimates consistent across other MR. However, a was identified. Conclusions presented evidence supports previous epidemiological findings by showing genetic liability biological this warrant further investigation.

Language: Английский

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Multiple Chronic Diseases Associated With Tooth Loss Among the US Adult Population

Frontiers in Big Data, Journal Year: 2022, Volume and Issue: 5

Published: July 1, 2022

Half of US adults aged 20-64 years have lost at least one permanent tooth; in six 65 and over the USA is edentulous. Tooth loss edentulism interfere with nutritional intake quality life. Although selected chronic diseases (e.g., diabetes) been identified as possible risk factors for tooth loss, data on multiple having two or more concurrent (multimorbidity) relation to are lacking. Therefore, this study aimed assess association between diseases, multimorbidity, adults.We performed a secondary analysis using 2012 Behavioral Risk Factor Surveillance System (BRFSS), national cross-sectional telephone survey studying health conditions behaviors among (≥18 years) who non-institutionalized residents. Variables were derived from BRFSS Standard Core Questionnaire. Descriptive including means, standard deviations (SDs), percentages was calculated. Sample weights applied. The stepwise multinomial logistic regression method used examine relationship several loss. Separate models multimorbidity all than 18 years, 18-64 respectively.Among samples (n = 471,107, mean age 55 60% female), 55% reported losing no 30% five teeth, 10% but not 5% teeth. After adjusting demographic characteristics, socioeconomic status, smoking, BMI, dental care, that associated obstructive pulmonary disease (COPD) [adjusted ratio (adj. RR) 2.18, 95% confidence interval (CI) 2.08-2.29]; diabetes RR 1.49, CI 1.44-1.56); arthritis 1.44-1.54); cardiovascular 1.38, 1.30-1.45); stroke 1.31, 1.24-1.40); kidney 1.16, 1.08-1.25); cancer 1.05, 1.01-1.11); asthma 1.07, 1.02-1.12). For those remained significant mentioned, albeit magnitude appeared be comparative smaller. In addition, likely (loss teeth: adj. 1.17, 1.14-1.19; 1.78, 1.73-1.82; edentulous: 2.03, 1.96-2.10).Multiple People edentulous disease. findings will help identify populations increased oral problems deficits, thus assessment should evaluated further an important component illness care.

Language: Английский

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Association of periodontitis and gingivitis with stroke: A systematic review and meta-analysis

Dental and Medical Problems, Journal Year: 2023, Volume and Issue: 61(3), P. 407 - 415

Published: Jan. 26, 2023

Background.Stroke is among the leading causes of morbidity and mortality.Chronic inflammatory conditions may lead to atherosclerosis a subsequent stroke.Objectives.This systematic review meta-analysis aimed association periodontitis gingivitis with stroke.Methods.An electronic search PubMed, Ovid EMBASE, MEDLINE, Web Science, Cochrane Central Register Controlled Trials (CENTRAL), Science Citation Index, Database Abstracts Reviews Effects (DARE), various clinical trial registries was conducted include studies published up February 2022.Data retrieved by 2 independent reviewers.The Stata software, v. 13, used conduct meta-analysis. Results. Thirteen stated an between periodontitis, determined based on attachment loss (CAL), stroke.Meanwhile, 6 described gingivitis, gingival index (GI), stroke.Out 5 also investigated CAL, which means included 14 in total.The total number participants from 35,937, they were all above 17 years age.There significant stroke its types.There types 13 (ES (effect size): 1.32; 95% CI (confidence interval): 1.04-1.60),and (ES: 1.17; CI: 0.42-1.92).Conclusions.This indicated periodontal disease case-control, cohort cross-sectional studies.The findings need be further substantiated prospective optimal sample size.

Language: Английский

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Process mining and data mining applications in the domain of chronic diseases: A systematic review

Artificial Intelligence in Medicine, Journal Year: 2023, Volume and Issue: 144, P. 102645 - 102645

Published: Aug. 30, 2023

The widespread use of information technology in healthcare leads to extensive data collection, which can be utilised enhance patient care and manage chronic illnesses. Our objective is summarise previous studies that have used mining or process methods the context diseases order identify research trends future opportunities. review covers articles pertain application on were published between 2000 2022. Articles sourced from PubMed, Web Science, EMBASE, Google Scholar based predetermined inclusion exclusion criteria. A total 71 met criteria included review. Based literature results, we detected a growing trend diabetes research. Additionally, distinct increase model clinical pathways cancer was observed. Frequently, this takes form collaborative integration mining, traditional statistical methods. In light approach, meticulous selection their underlying assumptions essential when integrating these with Another notable challenge lack standardised guidelines for reporting medical field. Furthermore, there pressing need interpretation results.

Language: Английский

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The additive effect of periodontitis with hypertension on risk of systemic disease and mortality

Journal of Periodontology, Journal Year: 2022, Volume and Issue: 93(7), P. 1024 - 1035

Published: April 23, 2022

Abstract Background Recent evidence suggests that periodontitis (PD) causes hypertension, which is a precursor to development of other systemic diseases. The aim this study was examine the effect hypertension and PD on risk subsequent disease. Methods This longitudinal cohort included 244,393 UK Biobank participants who were free disease than at baseline. Self‐reported responses painful gums or loose teeth surrogates for PD. Hypertensives identified by clinical diagnosis, elevated blood pressure (≥140/90 mmHg). Systemic diseases including cancer, cardiovascular (CVD), diabetes from linked diagnostic codes. Multivariable Cox proportional hazard models used quantify all‐cause mortality, stratified hypertensive status. Results average age population 55.4 years (standard deviation [SD:] 8.1 years), 130,220 (53.3%) female. At baseline, 131,566 (53.8%) 4.5% reported incidence rates all higher in non‐hypertensive same In hypertensives, an additive observed risks CVD (adjusted ratio [HR]: 1.35, 95% confidence interval [CI]: 1.21–1.53) respiratory (HR: 1.11, CI: 0.95–1.30) compared healthy controls. Conclusions with have exacerbated several Future interventional studies should consider periodontal treatment outcomes targeted populations.

Language: Английский

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