Does Periodontitis Affect the Association of Biological Aging with Mortality?

Journal of Dental Research, Journal Year: 2023, Volume and Issue: 102(8), P. 909 - 918

Published: June 26, 2023

The prevalence of periodontitis is increasing with the aging global population. Periodontitis has been suggested to accelerate and increase mortality. present nationwide prospective cohort study aimed determine whether could modify association biological all-cause cause-specific mortality in middle-aged older adults. Participants ≥40 y age from Third National Health Nutrition Examination Survey (NHANES III) were included ( n = 6,272). Phenotypic acceleration (PhenoAgeAccel) was used evaluate process. Moderate/severe defined using a half-reduced Centers for Disease Control Prevention American Academy Periodontology case definition. Multivariable Cox proportional hazard regression conducted estimate between PhenoAgeAccel risk, followed by effect modification analysis test modified association. During median follow-up 24.5 y, 3,600 (57.4%) deaths occurred. positive relationships nonlinear. After adjusting potential confounders, highest quartile associated increased individuals no/mild (hazard ratio Q4 vs. Q1 [HR Q4vs.Q1 ] 1.789; 95% confidence interval [CI], 1.541–2.076). In contrast, enhanced patients moderate/severe (HR 2.446 [2.100–2.850]). Periodontal status significantly P interaction 0.012). subgroup analyses, modifying observed adults (40–59 y), females, non-Hispanic Whites. Although showed similar trend, × did not reach statistical significance. conclusion, might enhance Hence, maintaining enhancing periodontal health expected become an intervention slow extend life span.

Language: Английский

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Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague–Dawley rats via the P38 MAPK signaling pathway

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 28, 2023

Periodontitis is one of the most common oral diseases and has been shown to be a risk factor for systemic diseases. Our aim was investigate relationship between periodontitis cognitive impairment explore role P38 MAPK signaling pathway in this process.We established model by ligating first molars SD rats with silk thread injecting Porphyromonas gingivalis (P. gingivalis) or P. plus inhibitor SB203580 at same time ten weeks. We assessed alveolar bone resorption spatial learning memory using microcomputed tomography Morris water maze test, respectively. used transcriptome sequencing genetic differences groups. The gingival tissue, peripheral blood hippocampal tissue were cytokines TNF-α, IL-1β, IL-6, IL-8 C reactive protein (CRP) enzyme-linked immunosorbent assay (ELISA) reverse transcription polymerase chain reaction (RT-PCR). observed presence hippocampus paraffin-fluorescence situ hybridization (FISH). determined activation microglia immunofluorescence. Finally, Western blot analysis employed determine expression amyloid precursor (APP), β-site APP-cleaving enzyme 1 (BACE1) P38MAPK activation.We demonstrated that ligature-induced injection into subgingival could lead impairment. Transcriptome results suggested there neurodegenerative group, MWM test showed reduced ability mild (MCI) rats. found high levels inflammatory factors (TNF-α, IL-8) CRP gingiva, hippocampus, APP BACE1 upregulated, as activation. Activated also hippocampus. inhibitors mitigated all these changes.Our findings strongly suggest topical application increases burden central nervous systems (CNS) neuroinflammation induced leads impaired It can modulate processing. Therefore, may serve linking

Language: Английский

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Periodontal disease and subsequent risk of cardiovascular outcome and all-cause mortality: A meta-analysis of prospective studies

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(9), P. e0290545 - e0290545

Published: Sept. 8, 2023

Studies reported periodontal disease (PD) is associated with many systemic diseases, including cardiovascular outcomes and all-cause mortality. However, the precise mechanistic link for these relationship remained unclear. We therefore performed a meta-analysis of cohort studies to investigate association PD risk systematically searched databases PubMed, EmBase, Cochrane library identify eligible until April 2023. The investigated included major adverse events (MACEs), coronary heart (CHD), myocardial infarction (MI), stroke, cardiac death, summary relative (RR) 95% confidence interval (CI) were calculated using random-effects model. Thirty-nine 4,389,263 individuals selected final meta-analysis. noted elevated MACEs (RR: 1.24; 95%CI: 1.15–1.34; P <0.001), CHD 1.20; 1.12–1.29; MI 1.14; 1.06–1.22; = 0.001), stroke 1.26; 1.15–1.37; death 1.42; 1.10–1.84; 0.007), mortality 1.31; 1.07–1.61; 0.010). Sensitivity analyses indicated pooled conclusions are robustness. associations ardiovascular could affected by region, study design, definition, follow-up duration, quality. This found in patients, intervention should be applied prevent outcomes.

Language: Английский

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Role of oral health in heart and vascular health: A population-based study

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0301466 - e0301466

Published: April 18, 2024

Background and aim Conditions such as hypertension, cardiovascular diseases, hypercholesterolemia, are a major public health challenge. This study investigates the influence of oral indicators, including gum bleeding, active dental caries, tooth mobility, loss, on their prevalence in Hungary, considering socioeconomic, demographic, lifestyle factors. Materials methods Data from 2019 Hungarian European Health Interview Survey with 5,603 participants informed this analysis. were accessed records maintained by Department Informatics at University Debrecen between September November 2023. Variable selection employed elastic net regularization k-fold cross-validation, leading to high-performing predictors for weighted multiple logistic regression models. Sensitivity analysis confirmed findings’ validity. Results Significant links found poor chronic cardiac conditions. Multiple teeth extractions increased hypertension risk (OR = 1.67, 95% CI: [1.01–2.77]); prosthetics had an OR 1.45 [1.20–1.75]. Gum bleeding was associated higher disease 1.69 [1.30–2.21]) hypercholesterolemia risks 1.40 [1.09–1.81]). Conclusions Oral improvement may reduce underscores health’s role multidisciplinary management.

Language: Английский

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The additive effect of periodontitis with hypertension on risk of systemic disease and mortality

Journal of Periodontology, Journal Year: 2022, Volume and Issue: 93(7), P. 1024 - 1035

Published: April 23, 2022

Abstract Background Recent evidence suggests that periodontitis (PD) causes hypertension, which is a precursor to development of other systemic diseases. The aim this study was examine the effect hypertension and PD on risk subsequent disease. Methods This longitudinal cohort included 244,393 UK Biobank participants who were free disease than at baseline. Self‐reported responses painful gums or loose teeth surrogates for PD. Hypertensives identified by clinical diagnosis, elevated blood pressure (≥140/90 mmHg). Systemic diseases including cancer, cardiovascular (CVD), diabetes from linked diagnostic codes. Multivariable Cox proportional hazard models used quantify all‐cause mortality, stratified hypertensive status. Results average age population 55.4 years (standard deviation [SD:] 8.1 years), 130,220 (53.3%) female. At baseline, 131,566 (53.8%) 4.5% reported incidence rates all higher in non‐hypertensive same In hypertensives, an additive observed risks CVD (adjusted ratio [HR]: 1.35, 95% confidence interval [CI]: 1.21–1.53) respiratory (HR: 1.11, CI: 0.95–1.30) compared healthy controls. Conclusions with have exacerbated several Future interventional studies should consider periodontal treatment outcomes targeted populations.

Language: Английский

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Oral diseases are associated with cognitive function in adults over 60 years old

Oral Diseases, Journal Year: 2023, Volume and Issue: 30(5), P. 3480 - 3488

Published: Oct. 9, 2023

Abstract Objective To investigate the bidirectional association between oral diseases and cognitive function comprehensively. Subjects Methods This cross sectional study utilized data from National Health Nutrition Examination Survey. Oral include periodontitis, dental caries, tooth loss (end point of disease resulting in extraction). Cognitive included three domains: memory, processing speed, executive function. A global score was then derived sum domains. cognition associations were examined using various statistical models: (1) Regress on function; (2) disease; (3) Structural equation modelling treating as latent variables. Results There 2508 participants aged 60+ who had both information. Associations observed (Odds ratio OR cog‐>periodontitis 0.95, 95% Confidence Interval [0.92, 0.99]; β cog‐>caries −0.13, [−0.23, −0.04]; cog‐>tooth −0.03 [−0.04, −0.01]; loss‐>cog −0.04 [−0.06, −0.02]; caries‐>cog periodontitis‐>cog −0.39 [−0.69, −0.10]). Significant correlation also found these structural model ( r −0.22, [−0.34, Conclusions robust approaches among aging population.

Language: Английский

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MODERN METHODS OF CHRONIC PERIODONTITIS TREATMENT (LITERATURE REVIEW)

The actual problems in dentistry, Journal Year: 2025, Volume and Issue: 20(4), P. 28 - 39

Published: Feb. 10, 2025

Subject of the study. The article is a literature review dedicated to personalized approach medical and preventive measures for chronic periodontitis, considering diversity factors contributing development progression this pathology. goal study conduct descriptive analysis domestic foreign literary sources determine structuring information on features modern periodontitis treatment. Methodology. Modern data Russian international have been studied using scientific library databases such as PubMed, Elibrary, Cochrane. has analyzed by over past 9 years based following keywords: non-surgical treatment, ultrasound, photodynamic laser therapy, antimicrobial antibiotic phytotherapy. Results. conducted suggests that highly prevalent condition, associated with various local common risk factors. Depending identified, an differs includes both general treatments. Conclusions. Many researchers evaluate effectiveness high-tech fairly simple, but effective methods influencing state microbiota periodontal pockets, increasing activity systemic protection patient's organism, means normalizing microcirculation, oxidative stress. importance commitment cooperation attending physician, need maintain good oral hygiene timely visits dental clinic regular sessions in order prolong remission phase emphasized. Thus, improvement treatment important task, while introduction products consisting herbal components possessing pronounced anti-inflammatory, decongestant properties, corresponding especially relevant.

Language: Английский

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The role of periodontitis in the development of atherosclerotic cardiovascular disease in participants with the components of metabolic syndrome: a systematic review and meta-analysis

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(6)

Published: May 27, 2024

Language: Английский

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Facile minocycline deployment in gingiva using a dissolvable microneedle patch for the adjunctive treatment of periodontal disease

Bioengineering & Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

Minocycline is a commonly used drug for adjunctive therapy in periodontal disease. However, the current mainstream local medications primarily rely on intra-pocket administration, which, while avoiding side effects of traditional systemic drugs, presents challenges such as inconvenience, discomfort, and need professional assistance, thus affecting patient compliance. Herein, we introduce minocycline-loaded dissolvable microneedle (Mino-DMN) patch that allows efficient delivery minocycline to gingiva treatment periodontitis. A two-step casting micro-molding process involving vacuum drying freeze employed concentrate part limit its diffusion into backing. The resulting Mino-DMN features an array minocycline-enriched gelatin MNs with porous HA microneedles can penetrate enough mechanical strength quickly release gingival tissue, ensuring prolonged residence minimizing loss saliva. In vivo experiments show inhibits pro-inflammatory factors, promotes anti-inflammatory stimulates bone formation, surpassing topical application comparable inconvenient discomfort administration Periocline®. This proposed offers simple, efficient, user-friendly strategy

Language: Английский

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Higher Prevalence of Tooth Loss in People With Abdominal Obesity but Normal Weight: Findings From the United States and Scottish Populations

Clinical and Experimental Dental Research, Journal Year: 2024, Volume and Issue: 10(6)

Published: Nov. 19, 2024

ABSTRACT Objectives Previous research has shown that people with obesity are at a higher risk of tooth loss; however, it is unclear whether abdominal (e.g., high waist circumference) associated loss among individuals without obesity. This study aims to investigate the association between and who not obese. Material Methods Two cross‐sectional surveys were used: United States' National Health Nutrition Examination Survey (NHANES) 1999–2012 ( n = 19,436) Scottish (SHeS) 2008–2014 4243). Tooth was measured by number remaining teeth: 20 over, 1–19, edentulous. Abdominal defined categorizing circumference into three levels: normal, high, very high. Ordinal logistic regression used model Results For living obesity, prevalence loss, effect different women men. women, increased chance 64% (odds ratio [OR]: 1.64, 95% confidence interval [CI]: 1.16–2.34) in NHANES 196% (OR: 2.96, CI: 1.47–5.97) SHeS. men, 41% 1.41, 1.06–1.87) 65% 1.65, 1.02–2.73) Conclusions indicated substantially this distinctively men women. These findings suggest those obese but have may be an important target population for oral health prevention strategies.

Language: Английский

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