Impact of periodontitis on type 2 diabetes: a bioinformatic analysis DOI Creative Commons
Xindi Wei, Xiaomeng Zhang, Ruiying Chen

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 29, 2024

Abstract Background Periodontitis is strongly associated with type 2 diabetes (T2D) that results in serious complications and mortality. However, the pathogenic role of periodontitis development T2D underlain mechanism have not been fully elucidated. Methods A Mendelian randomization (MR) was performed to estimate causality between two diseases. Bioinformatics tools, including gene ontology pathway enrichment analyses, were employed analyze common differentially expressed genes (DEGs) T2D. MR colocalization analyses then utilized investigate causal associations potential expression risk Single cell-type analysis further detect cellular localization these genes. Results Genetically predicted a higher (OR, 1.469; 95% CI, 1.117–1.930; P = 0.006) insulin resistance (OR 1.034; 95%CI 1.001–1.068; 0.041). 79 DEGs identified demonstrated mainly CXC receptor chemokine binding interleutin-17 signaling pathway. The integration GWAS quantitative trait locis from peripheral blood genetically prioritized 6 candidate genes, ( RAP2A , MCUR1 ) 4 protective WNK1, NFIX, FOS, PANX1 periodontitis-related Enriched natural killer cells, 4.909; CI 1.849–13.039; 0.001) high influence on T2D, exhibited strong genetic evidence (coloc.abf-PPH4 0.632). Conclusions This study used multi-omics method explore revealed molecular mechanisms using bioinformatics tools. FOS NFIX WNK1 may play important roles pathogenesis shedding light drug targets.

Language: Английский

Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe) DOI Creative Commons
David Herrera, Mariano Sanz, Lior Shapira

et al.

Journal Of Clinical Periodontology, Journal Year: 2023, Volume and Issue: 50(6), P. 819 - 841

Published: March 20, 2023

Abstract Aim To explore the implications for dentists and family doctors of association between periodontal systemic diseases role in managing non‐communicable (NCDs) promoting healthy lifestyles. Materials Methods The consensus reports previous Focused Workshops on associations periodontitis diabetes (2017) cardiovascular (2019) formed technical reviews to underpin discussions both topics. For with respiratory diseases, a systematic review was specifically commissioned Workshop discussions. Working groups prepared proposals independently, then were discussed approved at plenary meetings. Results Periodontitis is independently associated diabetes, chronic obstructive pulmonary disease (COPD), sleep apnea COVID‐19 complications. Dentists should collaborate NCDs, implementing strategies early detection primary care centres or dental settings. Family be informed about their consequences, oral health professionals (OHPs) relevance NCDs risk factors. Conclusions Closer collaboration OHPs important management Pathways case medicine practices developed evaluated.

Language: Английский

Citations

127
Periodontal diseases and cardiovascular diseases, diabetes, and respiratory diseases: Summary of the consensus report by the European Federation of Periodontology and WONCA Europe DOI Creative Commons
David Herrera, Mariano Sanz, Lior Shapira

et al.

European Journal of General Practice, Journal Year: 2024, Volume and Issue: 30(1)

Published: March 21, 2024

Periodontitis is a chronic inflammatory non-communicable disease (NCD) characterised by the destruction of tooth-supporting apparatus (periodontium), including alveolar bone, presence periodontal pockets, and bleeding on probing.

Language: Английский

Citations

28
Microbes Saving Lives and Reducing Suffering DOI Creative Commons
Kenneth N. Timmis, Zeynep Ceren Karahan, Juan L. Ramos

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

Citations

4
Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis DOI

Angela J. Villar,

Stefanía Paladini,

João Cossatis

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

7
Periodontitis: An often-neglected complication of diabetes DOI Open Access
Marina George Kudiyirickal, Joseph M Pappachan

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(3), P. 318 - 325

Published: March 15, 2024

The bidirectional association between type 2 diabetes mellitus (T2DM) and periodontitis is now well established, resulting in periodontal disease being considered as the 6th major complication of (DM) after car-diovascular disease, eye neuropathy, nephropathy, peripheral vascular disease. DM can worsen virulence invasiveness pathogenic oral microbial flora aggravating local inflammation infection those with On other hand, chemical immunological mediators released into circulation part systemic insulin resistance worsening T2DM. Periodontitis if undiagnosed or left untreated also result eventual tooth loss. A study by Xu et al World Journal Diabetes examined predictive factors associated Chinese patients prevalence was found to be 75.7% this study. Based on logistic regression analysis, for higher risk were low brushing frequency [odds ratio (OR) = 4.3], high triglycerides (TG; OR 3.31), total cholesterol (TC; 2.87), glycated hemoglobin (HbA1c; 2.55), age (OR 1.05) while education level protective 0.53). However, most influential variables HbA1c followed age, TC, TG, level, frequency, sex random forest model (this showed sensitivity predicting risk). good understanding predictors T2DM important prevention, early detection susceptible patients, intervention improve health enable long-term glycaemic control observed .

Language: Английский

Citations

5
Periodontal Disease and Obstructive Sleep Apnea: Shared Mechanisms, Clinical Implications, and Future Research Directions DOI Creative Commons
Serena Incerti Parenti,

Claudio Cesari,

Veronica Della Godenza

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 542 - 542

Published: Jan. 8, 2025

This review explores the emerging relationship between obstructive sleep apnea (OSA) and periodontal disease (PD), emphasizing shared inflammatory pathways, overlapping risk factors, potential systemic health implications. Both conditions are characterized by chronic inflammation oxidative stress, which independently contribute to cardiovascular disease, diabetes, other disorders. Evidence suggests a bidirectional relationship, with OSA-related hypoxia exacerbating tissue breakdown PD-induced potentially influencing OSA severity. However, causative nature of PD remains uncertain, largely due inconsistencies in diagnostic criteria, methodological variability, study heterogeneity. highlights essential role systematic reviews (SRs) synthesizing current evidence, identifying research gaps, guiding future studies. To maximize their impact, SRs should adhere rigorous quality standards, improve transparency data reporting, address heterogeneity included Future focus on longitudinal interventional designs, standardize protocols, investigate biomarkers, oral microbiome profiles, mediators elucidate mechanisms linking PD. Multidisciplinary collaboration dental specialists is crucial advancing evidence-based strategies that patient outcomes broader implications these often coexisting conditions.

Language: Английский

Citations

0
Unveiling the Resistome Landscape in Peri-Implant Health and Disease DOI Open Access
Lucinda J. Bessa, Conceição Egas, João Botelho

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 931 - 931

Published: Jan. 31, 2025

Background: The human oral microbiome is a critical reservoir for antibiotic resistance; however, subgingival peri-implant biofilms remain underexplored in this context. We aimed to explore the prevalence and distribution of resistance genes (ARGs) metagenomes derived from saliva biofilms. Methods: A total 100 metagenome datasets 40 individuals were retrieved Sequence Read Archive (SRA) database. Of these, 20 had exclusively healthy implants both affected with peri-implantitis. ARGs their taxonomic assignments identified using ABRicate tool, plasmid detection was performed PlasmidFinder. Results: Four replicons 72 metagenomes, 55 distinct 13 classes detected 89 metagenomes. conferring macrolides-lincosamides-streptogramins, tetracyclines, beta-lactams, fluoroquinolones most prevalent. msr(D) mef(A) showed highest prevalence, except samples implants, where ranked fourth. pairwise PERMANOVA principal coordinate analysis based on Jaccard distances revealed that exhibited significantly greater ARG diversity than biofilm (p < 0.05). However, no significant differences observed between peri-implantitis-affected groups > origins also analyzed understand potential impact microbial communities. Conclusions: Resistome profiles associated health disease higher salivary abundance compared samples.

Language: Английский

Citations

0
Air Pollution and Oral Health: An Overall Insight From Genetic Causality DOI Creative Commons

Ziyang Zheng,

Mingzhang Xu, Yifei Wang

et al.

International Dental Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

A growing body of epidemiological data consistently links air pollution to various adverse health outcomes. However, the potential connection between and risk oral diseases remains underexplored. This study utilized a two-sample Mendelian randomization approach assess causal relationship diseases. Six categories were considered as exposures: nitrogen oxides (NOx), dioxide (NO2), particulate matter (PM2.5, PM2.5-10, PM10), PM2.5 absorbance. The outcomes included 18 health-related drawn from Finngen R10 dataset, Gene-Lifestyle Interactions in Dental Endpoints consortium, Oncoarray cavity oropharyngeal cancer consortium. Sensitivity analyses performed validate primary inverse-variance weighted estimates using methods such median, mode, MR Egger. analysis demonstrated detrimental effect on multiple conditions, yielding 5 positive associations including with leukoplakia, gingivitis periodontitis; PM2.5-10 pulp periapical diseases, NO2 periodontitis, cavity, salivary glands jaws tests showed no evidence heterogeneity or pleiotropy, affirming robustness findings. highlights impact health, emphasizing need for further research into underlying mechanisms interactions. These findings reinforce importance implementing environmental interventions mitigate associated risks health.

Language: Английский

Citations

0
Periodontal Treatment to Improve General Health and Manage Systemic Diseases DOI

Yanlin Zeng,

Dongjia Lin,

A. Chen

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 245 - 260

Published: Jan. 1, 2025

Language: Английский

Citations

0
The relationship between periodontal disease and cancer: Insights from a Systematic Literature Network Analysis DOI
Alice Villar, Bruna Cunha Mendes,

M. S. Viegas

et al.

Cancer Epidemiology, Journal Year: 2024, Volume and Issue: 91, P. 102595 - 102595

Published: June 14, 2024

Language: Английский

Citations

3