Epilepsia, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 16, 2024
Despite growing interest in the potential use of exogenous ketones for treatment epilepsy, their impact on seizures and gut microbiome mycobiome remain unclear.
Language: Английский
Advanced Gut & Microbiome Research, Journal Year: 2024, Volume and Issue: 2024(1)
Published: Jan. 1, 2024
Long‐standing theories link genetics, environmental factors, and microbial dysbiosis as causes of neurological diseases. Even though the role human gut mycobiome in these disorders has drawn a lot attention, recent research begun to shed light on another component, mycobiome, its potential involvement In an effort comprehend connection between illnesses, this exploratory investigation concentrates complex interactions fungal populations central nervous system. This study investigates mechanisms through which fungus species their metabolites impact brain health disease progression by evaluating body literature discoveries. It also how affects blood–brain barrier’s integrity, control neurotransmitters, immune system modulation. The outcomes provide new information therapeutic approaches that target component microbiota imply changes composition function contribute onset is necessary conduct more studies clarify precise underpinning mycobiome’s illnesses investigate possibility diagnostic based
Language: Английский
Citations
2
BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Nov. 29, 2024
Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as nonalcoholic (NAFLD), is becoming the most common chronic disease. The gut microbiome regarded to play a crucial role in MAFLD, but specific changes of microbiome, especially fungi, different stages MAFLD are not well understood. This study aimed observe longitudinal colon bacteria and fungi mice at feeding duration high-fat high-fructose diet (HFHFD), explore association between progression MAFLD. Twenty-eight male C57BL6J were randomly assigned normal (ND) group HFHFD group. At 8th 16th weeks, sacrificed compare diversity, composition, co-abundance network contents among groups. HFHFD-8W exhibited increases Candida Dorea, decreases Oscillospira Prevotella comparison ND-8W mice, HFHFD-16W had Bacteroides, Candida, Desulfovibrio, Lactobacillus, Rhodotorula, Akkermansia, Aspergillus, Sterigmatomyces, Vishniacozyma ND-16W mice. And compared Penicillium, Talaromyces Wallemia. Spearman GEE correlation analysis revealed that Lactobacillus positively correlated with NAFLD activity score (NAS). Gut microbiota mycobiota undergo diverse Not applicable.
Language: Английский
Citations
2
Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 36, P. 100738 - 100738
Published: Feb. 17, 2024
We conducted a retrospective cohort study of medical records from large, Maryland, U.S.-based pediatric primary care patients for potential associations between antibacterial, antifungal and antiviral prescriptions subsequent suicidal thoughts and/or behaviors. Using first suicide-related diagnosis as the outcome prior prescription antifungal, use exposure, we employed series multivariate Cox proportional hazards models. These models examined hazard developing newly recognized behaviors, controlling age, sex, race, insurance, number encounters during period, mood disorder chronic health conditions. constructed same stratified by groups with without recorded mental or behavioral (MBHD). Suicidal behaviors were associated previous an medication (HR 1.31, 95 %‐CI 1.05–1.64) well total such medications prescribed 1.04, 1.01–1.08), strongest relationship among three more 1.44, 1.06–1.96). Among individual medications, association was antibacterial 1.28, 1.03–1.60). Correlations subgroup no Infections treated antimicrobial increased risks who had not diagnosis. This group should be considered levels vigilance interventions directed at suicide screening prevention. National Institutes Health, Stanley Medical Research Institute.
Language: Английский
Citations
1
Immunological Investigations, Journal Year: 2024, Volume and Issue: 53(8), P. 1177 - 1204
Published: Aug. 8, 2024
Background Ulcerative colitis (UC) and Crohn's disease (CD) are two subtypes of inflammatory bowel (IBD) with rapidly increased incidence worldwide. Although multiple factors contribute to the occurrence progression IBD, role intestinal fungal species (gut mycobiota) in regulating severity these conditions has been increasingly recognized. C-type lectin receptors (CLRs) on hematopoietic cells, including Dectin-1, Dectin-2, Dectin-3, Mincle DC-SIGN, a group pattern recognition (PRRs) that primarily recognize fungi mediate defense responses, such as oxidative stress. Recent studies have demonstrated indispensable CLRs protecting colon from inflammation mucosal damage.
Language: Английский
Citations
1
Nutrition and Diabetes, Journal Year: 2024, Volume and Issue: 14(1)
Published: Sept. 3, 2024
Type 2 diabetes mellitus (T2DM) is globally recognized as a significant health concern, with diabetic foot (DF) identified severe long-term complication that can lead to tissue death or amputation. The discovery of the impact mycobiota, diverse group multicellular eukaryotes in gut microbiome, on onset endocrine disorders holds great significance. Therefore, this research aimed examine variations fungal mycobiome and identify potential biomarkers for T2DM T2DM-DF. Fecal blood samples were collected from 33 individuals T2DM, 32 T2DM-DF, healthy without any conditions (HC). Blood used laboratory parameters analysis, while total DNA was extracted fecal sequenced using Illumina 18s rRNA. Bioinformatics tools employed analyze abundance diversity, revealing differentially expressed species signature fungi distinguished between HC groups. Firstly, alterations some observed among three groups, which also differed diversity T2DM-DF significantly group; however, more pronounced changes Additionally, two altered phyla, Ascomycota Basidiomycota, higher but lower Basidiomycota both compared group. Furthermore, top 15 showing at level included notable decrease Rhodotorula_mucilaginosa patients substantial increase unclassified_g_Candida specifically seen only not those diagnosed HC. Thirdly, KEGG enzyme expression across alteration function within T2DM. Subsequently, accurately each group, random forest utilized rank fungi. Notably, 11 distinguishing HC, eight could discriminate receiver operating characteristic curve (ROC) analysis demonstrated enhanced accuracy predicted outcomes. These findings suggest are closely associated progression complications DF, offering promising prospects diagnosis treatment.
Language: Английский
Citations
0
Epilepsia, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 16, 2024
Despite growing interest in the potential use of exogenous ketones for treatment epilepsy, their impact on seizures and gut microbiome mycobiome remain unclear.
Language: Английский
Citations
0