In Silico Design of Natural Inhibitors of ApoE4 from the Plant Moringa oleifera: Molecular Docking and Ab Initio Fragment Molecular Orbital Calculations DOI Creative Commons
Divya Shaji,

Yoshinobu Nagura,

Haruna Sabishiro

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8035 - 8035

Published: Dec. 11, 2023

Alzheimer's disease (AD) is a neurological disease, and its signs symptoms appear slowly over time. Although current treatments can alleviate symptoms, they cannot prevent the from progressing. To accurately diagnose treat it therefore necessary to establish effective methods for diagnosis. Apolipoprotein E4 (ApoE4), most frequent genetic risk factor AD, expressed in more than half of patients with making an attractive target AD therapy. We used molecular docking simulations, classical mechanics optimizations, ab initio fragment orbital (FMO) calculations investigate specific interactions between ApoE4 naturally occurring compounds found plant Moringa Oleifera. According FMO calculations, quercetin had highest binding affinity among sixteen because hydroxyl groups generated strong hydrogen bonds residues Trp11, Asp12, Arg15, Asp130. As result, we proposed various derivatives by introducing group into studied their properties. The data clearly showed that adding improved capacity ApoE4. Furthermore, Asp130 were discovered be required significant derivatives. They higher our previously epicatechin Accordingly, results evaluated using method will useful designing potent inhibitors as candidate agent treatment.

Language: Английский

A Comparative Review of Key Isothiocyanates and Their Health Benefits DOI Open Access
Julia B. Olayanju, Dragica Božić, Uma Naidoo

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 757 - 757

Published: March 7, 2024

Isothiocyanates are biologically active products resulting from the hydrolysis of glucosinolates predominantly present in cruciferous vegetables belonging to Brassicaceae family. Numerous studies have demonstrated diverse bioactivities various isothiocyanates, encompassing anticarcinogenic, anti-inflammatory, and antioxidative properties. Nature harbors distinct isothiocyanate precursors, such as glucoraphanin gluconastrin, each characterized by unique structures, physical properties, pharmacological potentials. This comprehensive review aims consolidate current understanding Moringa mainly 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate), comparing this compound with other well-studied isothiocyanates sulforaphane phenyl ethyl isothiocyanates. The focus is directed toward elucidating differences similarities efficacy these compounds agents anticancer,

Language: Английский

Citations

19
Environmental, industrial, and health benefits of Moringa oleifera DOI Creative Commons

Harshika Mahaveerchand,

Abdul Ajees Abdul Salam

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: 23(5), P. 1497 - 1556

Published: March 18, 2024

Abstract The rise of air, water, and soil pollution poses a significant threat to global health, leading widespread disease premature mortality. Soil health is vital, ensuring the production safe food, but it compromised by pollutants such as heavy metals, pesticides, plastics, excessive fertilization, resulting in depletion beneficial microorganisms subsequently groundwater contamination. Water bodies are polluted due contamination from industrial effluents, domestic wastewater, agricultural runoff, oil spillage, further intensifying environmental pollution. On other hand, atmospheric pollution, characterized high emissions gases, volatile compounds, greenhouse not only impacts climate also serious risks human respiratory diseases, cardiovascular issues, increased cancer risks. Thus, strategic utilization traditional plants emerges potent tool for restoration improving health. possess natural filtering capabilities, absorbing soil, thus mitigating their adverse effects. Through phytoremediation, can be actively used extract remove contaminants, contributing detoxification water quality. Additionally, offer various benefits. Moringa oleifera or drumstick plant belonging Moringaceae family one indigenous with wide applications, that grown extreme arid conditions. Since ancient times, this has been treating skin infections, anaemia, blood impurities. This thrives diverse climates addressing over 300 different aliments. Rich phytochemicals bioactive M. serve superfood, offering nutritional values exhibiting potential drug development fewer side Extensive research elucidated properties applications , however, in-depth needed identify molecules, phytochemicals, protein compounds involved, which will aid understanding mechanisms action plant's functions. Although studies have reported several individual attributes there no comprehensive study available its applications. review covers findings past three decades provides detailed outline parts, environmental, industrial, food aspects documented date.

Language: Английский

Citations

15
Effectiveness of lycopene dietary enrichment for growth performance, digestive enzymes, blood health, immunity, and antioxidant status of common carp (Cyprinus carpio) against chronic glyphosate toxicity DOI
Rabia Tahir,

Samra,

Fozia Afzal

et al.

Aquaculture, Journal Year: 2024, Volume and Issue: 590, P. 741084 - 741084

Published: May 12, 2024

Language: Английский

Citations

6
The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update DOI Creative Commons

Monica Ramakrishnan,

Jed W. Fahey, Andrew W. Zimmerman

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 30, 2024

Neuroinflammation in response to environmental stressors is an important common pathway a number of neurological and psychiatric disorders. Responses immune-mediated stress can lead epigenetic changes the development neuropsychiatric Isothiocyanates (ITC) have shown promise combating oxidative inflammation nervous system as well organ systems. While sulforaphane from broccoli most widely studied ITC for biomedical applications, their precursor glucosinolates are found many species cruciferous other vegetables including moringa. In this review, we examine both clinical pre-clinical studies on amelioration disorders (neurodevelopmental, neurodegenerative, other) 2018 present, documentation protocols several ongoing studies. During time, there been 16 (9 randomized controlled trials), which reported effect autism spectrum disorder schizophrenia. We also review over 80 preclinical examining treatment brain-related dysfunctions The evidence date reveals great potential treating these conditions with minimal toxicity. authors call well-designed trials further translation potent phytochemicals into therapeutic practice.

Language: Английский

Citations

6
Chronic cypermethrin induced toxicity and molecular fate assessment within common carp (Cyprinus carpio) using multiple biomarkers approach and its novel therapeutic detoxification DOI
Rabia Tahir,

Samra,

Abdul Ghaffar

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 357, P. 142096 - 142096

Published: April 23, 2024

Language: Английский

Citations

4
Polyphenols in different parts of Moringa oleifera lam.: Composition, antioxidant and neuroprotective potential DOI
Qian Gao, Xiaoxiao Liu,

Jinglan Shi

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 475, P. 143207 - 143207

Published: Feb. 4, 2025

Language: Английский

Citations

0
Molecular assessment of NMDAR subunits and neuronal apoptosis in the trigeminal ganglion in a model of male migraine-induced rats following Moringa oleifera alcoholic extract administration DOI Creative Commons
Ahmad Vafaeian, Ali Vafaei, Mohammad Reza Parvizi

et al.

BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 4, 2025

Migraine, a common disorder marked by severe and repetitive headaches, has been linked to the involvement of NMDA receptor (NMDAR), responsible for glutamate signaling. Moringa oleifera (M. oleifera), recognized its anti-inflammatory properties therapeutic potential in various conditions, investigated. This study aims assess efficacy precise mechanisms M. treatment migraine, which evidence is limited. Rats were stratified into four distinct groups. The control group did not undergo migraine-induction protocol. Post-induction, "sumatriptan" was administered sumatriptan injections, "treatment" received oral extract, "vehicle" provided with solvent treatment. Behavioral evaluations encompassing Von Frey's hot plate assessments, addition qPCR analysis targeting Nr2a, Nr2b, Bax, Bcl-2, Caspase-3, conducted. Fery's tests revealed notable decrease triggering pressure temperature within vehicle when compared other groups (both ps < 0.001). Nr2a expression levels both cohorts exhibited significantly higher values than those observed (p 0.001, p = 0.001) 0.002). Conversely, no substantial alterations Nr2b or Bcl-2 across 0.404, 0.976). Notably, heightened expressions Caspase-3 Bax evident relative 0.013, 0.010). extract appears mitigate symptoms migraine inhibiting apoptosis, suggesting treatment; however, additional research investigating wider range pathways necessary. Not applicable.

Language: Английский

Citations

0
Unveiling the Miracle Tree: Therapeutic Potential of Moringa oleifera in Chronic Disease Management and Beyond DOI Creative Commons
Edgar Yebrán Villegas-Vázquez, Rocío Gómez-Cansino, Gabriel Marcelino-Pérez

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 634 - 634

Published: March 5, 2025

Moringa oleifera (MO) has gained recognition as a potent natural intervention for preventing and managing chronic diseases (CDs) due to its diverse phytochemical composition pharmacological properties. Rich in antioxidants, polyphenols, flavonoids, glucosinolates, MO exerts anti-inflammatory, anti-hyperglycemic, cardioprotective, anti-obesity effects. These properties make it valuable therapeutic agent CDs, including diabetes, cardiovascular diseases, obesity, neurodegenerative disorders, cancer. MO’s ability modulate oxidative stress inflammation—key drivers of CDs—highlights significant role disease prevention treatment. enhances insulin sensitivity, regulates lipid profiles blood pressure, reduces inflammation, protects against damage. also modulates key signaling pathways involved cancer liver prevention. Studies suggest that extracts possess anticancer activity by modulating apoptosis, inhibiting tumor cell proliferation, interacting with pathways, YAP/TAZ, Nrf2-Keap1, TLR4/NF-κB, Wnt/β-catenin. However, challenges such variability bioactive compounds, taste acceptability, inconsistent clinical outcomes limit their widespread application. While preclinical studies support efficacy, large-scale trials, standardized formulations, advanced delivery methods are needed optimize potential. multifunctional applications promising sustainable solution combating especially resource-limited settings.

Language: Английский

Citations

0
Auranofin-loaded chitosan-lipid hybrid nanoparticle protects against the in-vitro/in-vivo model of Parkinson’s disease via modulation of GSK-3β/ Nrf2/HO-1 signaling DOI

Divya Soni,

Yogesh Garg,

Shubham Upadhyay

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177523 - 177523

Published: March 1, 2025

Language: Английский

Citations

0
Recent Perspectives on the Pharmacological, Nutraceutical, Functional, and Therapeutic Properties of Moringa oleifera Plant DOI Creative Commons

Muhammad Tayyab Arshad,

Sammra Maqsood, Ali Ikram

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT The “miracle tree,” Moringa oleifera , has gained so much attention because of its spectacular nutritional profile and potential health benefits, making it one the candidates for functional food product creation. benefits M. are presented here in this review alongside antioxidant conformation, bioactive constituents, macro‐ micronutrient conformation. is rapidly becoming a key effective component formulating healthy foodstuffs outstanding anti‐inflammatory, antimicrobial, antidiabetic, antioxidant, neuroprotective activities. Investigation into usage moringa products foods like dairy substitutes, powders, supplements, drinks, even snacks also part review. Notwithstanding auspicious there contests with development such as issues sensory perception, active ingredient constancy, budget constraints. Maintainable plant‐based demand across sphere pushing novelty industry. To improve current scalability suitability moringa‐based foods, concludes call additional investigation.

Language: Английский

Citations

0