Foods,
Journal Year:
2025,
Volume and Issue:
14(4), P. 579 - 579
Published: Feb. 10, 2025
Allyl
isothiocyanate
(AITC)
is
a
low-molecular-weight
natural
chemical
predominantly
obtained
from
the
autolysis
of
sinigrin,
glucosinolate
found
in
cruciferous
vegetables
like
mustard,
horseradish,
and
wasabi.
AITC
has
sparked
widespread
interest
due
to
its
various
biological
actions,
which
include
strong
antioxidant,
anti-inflammatory,
antibacterial,
anticancer
capabilities.
This
compound
offers
promising
potential
several
fields,
particularly
food
preservation,
medicine,
enhancing
quality
through
means.
AITC's
effectiveness
against
broad
spectrum
microorganisms,
including
foodborne
pathogens
spoilage
agents,
makes
it
an
attractive
alternative
synthetic
preservatives.
The
extend
shelf
life
perishable
foods
important
tool
for
production,
meeting
rising
customer
demand
additives.
In
addition
antimicrobial
effects,
demonstrates
significant
anti-inflammatory
activity,
reducing
levels
pro-inflammatory
cytokines
modulating
key
signaling
pathways,
could
make
valuable
managing
chronic
inflammatory
conditions.
Furthermore,
emerging
research
highlights
cancer
prevention
treatment,
as
been
demonstrated
induce
apoptosis
inhibit
cell
increase
lines,
offering
approach
chemoprevention.
review
delves
into
structure,
metabolism,
bioavailability
freshly
produced
AITC,
providing
comprehensive
overview
beneficial
properties.
Challenges
related
volatility,
dosage
optimization,
regulatory
considerations
are
also
discussed,
alongside
future
directions
enhance
stability
efficacy
AITC-based
formulations.
findings
underscore
role
versatile
bioactive
with
known
support
human
health
sustainable
industry.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8375 - 8375
Published: July 31, 2024
The
rising
incidence
of
colorectal
cancer
(CRC)
and
gastric
(GC)
worldwide,
coupled
with
the
limited
effectiveness
current
chemotherapeutic
agents,
has
prioritized
search
for
new
therapeutic
options.
Natural
substances,
which
often
exhibit
cytostatic
properties,
hold
significant
promise
in
this
area.
This
review
evaluates
anticancer
properties
three
natural
alkaloids-berberine,
sanguinarine,
chelerythrine-against
CRC
GC.
In
vivo
vitro
studies
have
demonstrated
that
these
substances
can
reduce
tumor
volume
inhibit
epithelial-mesenchymal
transition
(EMT)
tumors.
At
molecular
level,
alkaloids
disrupt
key
signaling
pathways
cells,
including
mTOR,
MAPK,
EGFR,
PI3K/AKT,
NF-κB.
Additionally,
they
immunomodulatory
effects,
leading
to
induction
programmed
cell
death
through
both
apoptosis
autophagy.
Notably,
shown
synergistic
effects
when
combined
classical
agents
such
as
cyclophosphamide,
5-fluorouracil,
cetuximab,
erlotinib.
Furthermore,
berberine
ability
restore
sensitivity
individuals
originally
resistant
cisplatin
Given
findings,
compounds
emerge
a
promising
option
chemotherapy
malignant
gastrointestinal
tumors,
particularly
cases
treatment
However,
more
research
is
necessary
fully
understand
their
potential.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 381 - 381
Published: Jan. 4, 2025
Enterohemorrhagic
Escherichia
coli
(EHEC)
is
a
common
pathotype
of
E.
that
causes
numerous
outbreaks
foodborne
illnesses.
EHEC
zoonotic
pathogen
transmitted
from
animals
to
humans.
Ruminants,
particularly
cattle,
are
considered
important
reservoirs
for
virulent
strains.
Humans
can
become
infected
with
through
the
consumption
contaminated
food
and
water
or
direct
contact
O157:H7
one
most
commonly
reported
illnesses
in
developed
countries.
The
formation
attaching
effacing
(A/E)
lesions
on
intestinal
epithelium,
combined
Shiga
toxin
production,
hallmark
infection
lead
lethal
hemolytic–uremic
syndrome
(HUS).
For
phage-dependent
regulation
antibiotic
treatment
contraindicated,
as
it
may
exacerbate
limiting
therapeutic
options
supportive
care.
In
response
this
challenge
growing
threat
resistance,
phytochemicals
have
emerged
promising
antivirulence
agents.
These
plant-derived
compounds
target
bacterial
virulence
mechanisms
without
promoting
resistance.
Therefore,
aim
study
summarize
recent
knowledge
use
targeting
EHEC.
We
focused
molecular
basis
their
action,
principal
determinants
ABSTRACT
Scope
Brassica
vegetables
contain
unique
compounds
known
as
glucosinolates
(GSLs),
which,
when
hydrolyzed
by
plant
or
microbial
myrosinase,
form
bioactive
isothiocyanates
(ITCs)
that
offer
health
benefits
to
the
host.
The
present
study
evaluated
impact
of
cooked
broccoli
(broccoli
myrosinase
inactivated)
consumption
on
cecal
metabolism
glucoraphanin
(GRP)
in
lean
and
obese
mice
characterized
changes
microbiota
following
broccoli‐containing
diets.
Methods
results
Twenty
20
diet‐induced
(DIO)
were
randomized
consume
control
supplemented
diets
for
7
days.
Cooked
increased
ex
vivo
GRP
hydrolysis
contents
collected
from
mice,
led
production
sulforaphane
(SF),
sulforaphane‐cysteine
(SF‐CYS),
total
ITC,
colonic
NAD(P)H:
Quinone
Oxidoreductase
(NQO1)
activity.
Further
investigation
revealed
abundance
health‐promoting
gut
microbiota,
including
Lachnospiraceae
NK4A136
group
Dubosiella
newyorkensis
,
Peptococcaseae
family,
Blautia
genus,
an
amplicon
sequence
variation
(ASV)
Oscillospiraceae
family
exhibited
negative
correlation
with
ITC
production.
Conclusion
These
finding
suggest
enhances
produce
more
ITCs
inform
future
strategies
toward
altering
GSL
promote
both
individuals.
Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 912 - 912
Published: March 7, 2025
Glucosinolates
(GSLs)
are
sulfur-containing
compounds
predominantly
found
in
cruciferous
vegetables
such
as
broccoli,
kale,
and
Brussels
sprouts,
recognized
for
their
health-promoting
properties.
Upon
consumption,
GSLs
undergo
hydrolysis
by
the
enzyme
myrosinase,
resulting
bioactive
like
isothiocyanates
specific
indole
glucosinolate
degradation
products,
indole-3-carbinol
(I3C)
3,3′-diindolylmethane
(DIM),
which
contribute
to
a
range
of
health
benefits,
including
anti-cancer,
anti-inflammatory,
cardioprotective
effects.
This
review
explores
structure,
metabolism,
bioavailability
GSLs.
Recent
evidence
supports
protective
role
chronic
diseases,
with
mechanisms
modulation
oxidative
stress,
inflammation,
detoxification
pathways.
Furthermore,
innovative
strategies
enhance
GSL
bioactivity,
biofortification,
genetic
introgression,
optimized
food
processing
methods,
have
been
examined.
These
approaches
seek
increase
content
edible
plants,
thereby
maximizing
benefits.
comprehensive
provides
insights
into
dietary
recommendations,
impact
preparation,
recent
advances
enhancement,
highlighting
significant
potential
these
promoting
human
preventing
diseases.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
4-Isothiocyanato-1-butene
(4-BITC)
is
a
crucial
plant
isothiocyanate;
however,
its
flavor
profile
in
microwave
rapeseed
oil
and
anti-inflammatory
properties
have
not
been
elucidated
detail.
Therefore,
this
study,
the
distribution
of
4-BITC
45
oils
was
quantitated
using
selected
ion
monitoring,
with
concentrations
ranging
from
0.29
to
8.63
mg/kg.
The
odor
activity
values
ranged
4
123.
In
lipopolysaccharide
(LPS)-induced
RAW264.7
cell
model,
exerted
dose-dependent
effects,
which
resulted
remarkable
differences
20
lipid
mediators
between
LPS
groups.
Kyoto
Encyclopedia
Genes
Genomes
analysis
revealed
that
downregulated
proinflammatory
oxylipins
by
modulating
CYP,
LOX,
COX
pathways,
thereby
preventing
arachidonic
acid
metabolism
disorders.
Molecular
docking
further
confirmed
inhibited
PI3K/Akt/NF-κB
signaling
cascade
alleviate
inflammation.
