SDÜ Tıp Fakültesi Dergisi,
Journal Year:
2023,
Volume and Issue:
30(4), P. 754 - 762
Published: Dec. 30, 2023
Obezite,
genetik,
çevresel
faktörler
ve
bunların
karmaşık
etkileşimleri
tarafından
yönetilen
birçok
kronik
hastalık
ile
ilişkilidir.
Genetiğin
obeziteye
yatkınlıkta
önemli
rol
oynadığı
riskine
%70'e
kadar
katkıda
bulunabileceği
tahmin
edilmektedir.
Yapılan
genetik
çalışmalar,
genlerin
bulunduğunu
doğrulamıştır.
Genlerdeki
anomaliler,
Bardet-
Biedl
Prader-Willi
sendromları
gibi
obezite
ile
ilişkili
bozukluklardan
doğrudan
sorumludur.
Genetik
epidemiyolojik
yaklaşımlar,
özellikle
genom
çapında
ilişkilendirme
çalışmaları,
insan
obezitesinde
önemli
oynayan
çok
sayıda
geni
tanımlamıştır.
Gelecekte,
genetiğinin
daha
fazla
araştırılması,
tedavisi
için
yararlı
teşhis
testleri
geliştirmeye
yardımcı
olabilir.
Bu
derleme
genetiği
hakkında
güncel
literatür
desteklenmiş
bilgiler
aktarılmıştır.
Frontiers in Behavioral Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: April 9, 2025
The
dorsal
raphe
nucleus
is
a
critical
node
for
affective
and
motivated
circuits
in
the
brain.
Though
typically
known
as
serotonergic
hub,
also
highly
enriched
variety
of
neuropeptides.
Recent
advances
biotechnology
behavioral
modeling
have
led
to
resurgence
neuropeptide
research,
allowing
investigators
target
unique
peptide
systems
with
unprecedented
clarity.
Here,
we
review
discuss
multiple
consider
how
their
activity
may
contribute
reward
aversion.
While
this
not
an
exhaustive
review,
short
overview
will
highlight
many
opportunities
available
refine
our
understanding
By
more
thoroughly
studying
neuropeptides,
reveal
novel
pathways
design
effective
therapeutics
tailor
treatments
millions
patients.
Frontiers in Cellular Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Sept. 6, 2023
Cortical
layer
6b
is
considered
by
many
to
be
a
remnant
of
the
subplate
that
forms
during
early
stages
neocortical
development,
but
its
role
in
adult
not
well
understood.
Its
neuronal
complement
has
only
recently
become
subject
systematic
studies,
and
axonal
projections
synaptic
input
structures
have
remained
largely
unexplored
despite
decades
research
into
function.
In
recent
years,
however,
(L6b)
attracted
increasing
attention
functional
beginning
elucidated.
this
review,
I
will
attempt
provide
an
overview
what
currently
known
about
excitatory
inhibitory
neurons
layer,
their
pre-
postsynaptic
connectivity,
implications.
Similarities
differences
between
different
cortical
areas
highlighted.
Finally,
are
highly
responsive
several
neuropeptides
such
as
orexin/hypocretin,
neurotensin
cholecystokinin,
some
cases
exclusively.
They
also
strongly
controlled
neurotransmitters
acetylcholine
norepinephrine.
The
interaction
these
neuromodulators
with
L6b
microcircuitry
consequences
discussed.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 13, 2024
Alcohol
use
disorders
(AUDs)
impose
an
enormous
societal
and
financial
burden,
world-wide,
alcohol
misuse
is
the
7th
leading
cause
of
premature
death1.
Despite
this,
there
are
currently
only
3
FDA
approved
pharmacological
treatments
for
treatment
AUDs
in
United
States.
The
neurotensin
(Nts)
system
has
long
been
implicated
modulating
behaviors
associated
with
misuse.
Recently,
a
novel
compound,
SBI-553,
that
biases
action
Nts
receptor
1
(NTSR1)
activation,
shown
promise
preclinical
models
psychostimulant
Here
we
investigate
efficacy
this
compound
to
alter
ethanol-mediated
comprehensive
battery
experiments
assessing
ethanol
consumption,
behavioral
responses
ethanol,
sensitivity
metabolism.
Additionally,
investigated
behavior
avoidance
cognitive
assays
monitor
potential
side
effects
SBI-553.
We
find
SBI-553
reduces
binge-like
consumption
mice
without
altering
or
object
recognition.
also
observe
sex-dependent
differences
physiological
sequential
injections
mice.
In
rats,
show
attenuates
interoceptive
(using
Pavlovian
drug
discrimination
task).
Our
data
suggest
targeting
NTSR1
signaling
may
be
promising
attenuate
misuse,
adds
body
literature
suggests
common
downstream
target
involved
psychoactive
multiple
reinforcing
substances.
Appetite,
Journal Year:
2024,
Volume and Issue:
200, P. 107540 - 107540
Published: June 7, 2024
Chronic
pain
and
obesity
frequently
occur
together.
An
ideal
therapy
would
alleviate
without
weight
gain,
most
optimally,
could
promote
loss.
The
neuropeptide
neurotensin
(Nts)
has
been
separately
implicated
in
reducing
but
it
be
a
common
actionable
target
for
both
obesity?
Here
we
review
the
current
knowledge
of
Nts
signaling
via
its
receptors
modulating
body
processing.
Evaluating
mechanism
by
which
impacts
ingestive
behavior,
weight,
analgesia
potential
to
identify
physiologic
mechanisms
underlying
comorbidities,
whether
may
targets
both.
